{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T04:04:05Z","timestamp":1793333045852,"version":"4.5.0"},"reference-count":84,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,2,1]],"date-time":"2022-02-01T00:00:00Z","timestamp":1643673600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2022,2]]},"DOI":"10.1016\/j.bbr.2021.113687","type":"journal-article","created":{"date-parts":[[2021,11,25]],"date-time":"2021-11-25T10:55:28Z","timestamp":1637837728000},"page":"113687","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Adolescent high-fructose corn syrup consumption leads to dysfunction in adult affective behaviors and mesolimbic proteins in male Sprague-Dawley rats"],"prefix":"10.1016","volume":"419","author":[{"given":"Alex M.","family":"Maya-Romero","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gina E.","family":"Dodd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine D.","family":"Landin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen K.","family":"Zaremba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar F.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mackenzie A.","family":"Bilbow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rhyce D.","family":"Hammaker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica L.","family":"Santerre-Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.bbr.2021.113687_bib1","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0006-8993(79)90349-4","article-title":"Synaptic density in human frontal cortex - developmental changes and effects of aging","volume":"163","author":"Huttenlocher","year":"1979","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2021.113687_bib2","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1111\/j.1749-6632.1991.tb15599.x","article-title":"Glial cells in development. In vivo and in vitro approaches","volume":"633","author":"Rakic","year":"1991","journal-title":"Ann. NY Acad. Sci."},{"key":"10.1016\/j.bbr.2021.113687_bib3","series-title":"The behavioral neuroscience of adolescence","author":"Spear","year":"2010"},{"issue":"4","key":"10.1016\/j.bbr.2021.113687_bib4","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.dcn.2011.06.008","volume":"1","author":"Gladwin","year":"2011","journal-title":"Dev. Cogn. Neurosci."},{"issue":"4","key":"10.1016\/j.bbr.2021.113687_bib5","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1093\/ajcn\/79.4.537","article-title":"Consumption of high-fructose corn syrup in beverages may play a role in the epidemic of obesity","volume":"79","author":"Bray","year":"2004","journal-title":"Am. J. Clin. Nutr."},{"issue":"24","key":"10.1016\/j.bbr.2021.113687_bib6","doi-asserted-by":"crossref","first-page":"4450","DOI":"10.1111\/bph.14500","article-title":"High-fructose corn syrup consumption in adolescent rats causes bipolar-like behavioural phenotype with hyperexcitability in hippocampal CA3-CA1 synapses","volume":"175","author":"Alten","year":"2018","journal-title":"Br. J. Pharm."},{"key":"10.1016\/j.bbr.2021.113687_bib7","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.pmedr.2016.04.003","article-title":"The relationship between physical activity and diet and young children\u2019s cognitive development: a systematic review","volume":"3","author":"Tandon","year":"2016","journal-title":"Prev. Med. Rep."},{"issue":"6","key":"10.1016\/j.bbr.2021.113687_bib8","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.amepre.2018.02.020","article-title":"Associations of prenatal and child sugar intake with child cognition","volume":"54","author":"Cohen","year":"2018","journal-title":"Am. J. Prev. Med."},{"issue":"4","key":"10.1016\/j.bbr.2021.113687_bib9","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1101\/lm.038000.114","article-title":"Impact of adolescent sucrose access on cognitive control, recognition memory, and parvalbumin immunoreactivity","volume":"22","author":"Reichelt","year":"2015","journal-title":"Learn Mem."},{"issue":"2","key":"10.1016\/j.bbr.2021.113687_bib10","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/hipo.22368","article-title":"Effects of sucrose and high fructose corn syrup consumption on spatial memory function and hippocampal neuroinflammation in adolescent rats","volume":"25","author":"Hsu","year":"2015","journal-title":"Hippocampus"},{"issue":"4","key":"10.1016\/j.bbr.2021.113687_bib11","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1080\/1028415X.2017.1378851","article-title":"Early-life sugar consumption has long-term negative effects on memory function in male rats","volume":"22","author":"Noble","year":"2019","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.bbr.2021.113687_bib12","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.psyneuen.2015.08.025","article-title":"High-fructose diet during periadolescent development increases depressive-like behavior and remodels the hypothalamic transcriptome in male rats","volume":"62","author":"Harrell","year":"2015","journal-title":"Psychoneuroendocrinology"},{"issue":"9","key":"10.1016\/j.bbr.2021.113687_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0003221","article-title":"Sucrose exposure in early life alters adult motivation and weight gain","volume":"3","author":"Frazier","year":"2008","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.bbr.2021.113687_bib14","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.neuropharm.2010.05.015","article-title":"Reduced alcohol drinking in adult rats exposed to sucrose during adolescence","volume":"59","author":"Vendruscolo","year":"2010","journal-title":"Neuropharmacology"},{"issue":"4","key":"10.1016\/j.bbr.2021.113687_bib15","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1017\/S1368980011003077","article-title":"Is there any relationship between dietary patterns and depression and anxiety in Chinese adolescents?","volume":"15","author":"Weng","year":"2012","journal-title":"Public Health Nutr."},{"issue":"13","key":"10.1016\/j.bbr.2021.113687_bib16","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1038\/s41386-018-0025-9","article-title":"Unlimited sucrose consumption during adolescence generates a depressive-like phenotype in adulthood","volume":"43","author":"Gueye","year":"2018","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"10.1016\/j.bbr.2021.113687_bib17","doi-asserted-by":"crossref","first-page":"20","DOI":"10.3945\/jn.116.238816","article-title":"Early-life sugar consumption affects the rat microbiome independently of obesity","volume":"147","author":"Noble","year":"2017","journal-title":"J. Nutr."},{"issue":"1","key":"10.1016\/j.bbr.2021.113687_bib18","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1038\/s41398-021-01309-7","article-title":"Gut microbial taxa elevated by dietary sugar disrupt memory function","volume":"11","author":"Noble","year":"2021","journal-title":"Transl. Psychiatry"},{"issue":"2","key":"10.1016\/j.bbr.2021.113687_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0009296","article-title":"Sugar overconsumption during adolescence selectively alters motivation and reward function in adult rats","volume":"5","author":"Vendruscolo","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.bbr.2021.113687_bib20","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.neuropharm.2017.11.021","article-title":"Protracted motivational dopamine-related deficits following adolescence sugar overconsumption","volume":"129","author":"Naneix","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2021.113687_bib21","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.appet.2016.12.019","article-title":"Preclinical evidence for the addiction potential of highly palatable foods: current developments related to maternal influence","volume":"115","author":"Wiss","year":"2017","journal-title":"Appetite"},{"issue":"6","key":"10.1016\/j.bbr.2021.113687_bib22","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1053\/j.gastro.2014.12.058","article-title":"Neural responses to macronutrients: hedonic and homeostatic mechanisms","volume":"148","author":"Tulloch","year":"2015","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbr.2021.113687_bib23","doi-asserted-by":"crossref","first-page":"152","DOI":"10.3389\/fncir.2013.00152","article-title":"Dopamine signaling in reward-related behaviors","volume":"7","author":"Baik","year":"2013","journal-title":"Front Neural Circuits"},{"issue":"4","key":"10.1016\/j.bbr.2021.113687_bib24","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1016\/S1053-8119(03)00253-2","article-title":"Feeding-induced dopamine release in dorsal striatum correlates with meal pleasantness ratings in healthy human volunteers","volume":"19","author":"Small","year":"2003","journal-title":"Neuroimage"},{"issue":"4","key":"10.1016\/j.bbr.2021.113687_bib25","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.pbb.2012.06.009","article-title":"The novel adenosine A(2A) antagonist prodrug MSX-4 is effective in animal models related to motivational and motor functions","volume":"102","author":"Santerre","year":"2012","journal-title":"Pharm. Biochem Behav."},{"key":"10.1016\/j.bbr.2021.113687_bib26","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.beproc.2016.02.008","article-title":"The pharmacology of effort-related choice behavior: dopamine, depression, and individual differences","volume":"127","author":"Salamone","year":"2016","journal-title":"Behav. Process."},{"key":"10.1016\/j.bbr.2021.113687_bib27","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/7854_2015_383","article-title":"Mesolimbic dopamine and the regulation of motivated behavior","volume":"27","author":"Salamone","year":"2016","journal-title":"Curr. Top. Behav. Neurosci."},{"issue":"3","key":"10.1016\/j.bbr.2021.113687_bib28","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/S0091-3057(97)00544-3","article-title":"The role of accumbens dopamine in lever pressing and response allocation: effects of 6-OHDA injected into core and dorsomedial shell","volume":"59","author":"Sokolowski","year":"1998","journal-title":"Pharm. Biochem Behav."},{"issue":"4","key":"10.1016\/j.bbr.2021.113687_bib29","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1007\/BF02245659","article-title":"Haloperidol and nucleus accumbens dopamine depletion suppress lever pressing for food but increase free food consumption in a novel food choice procedure","volume":"104","author":"Salamone","year":"1991","journal-title":"Psychopharmacology"},{"issue":"3\u20134","key":"10.1016\/j.bbr.2021.113687_bib30","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S0091-3057(01)00524-X","article-title":"D1 or D2 antagonism in nucleus accumbens core or dorsomedial shell suppresses lever pressing for food but leads to compensatory increases in chow consumption","volume":"69","author":"Nowend","year":"2001","journal-title":"Pharm. Biochem Behav."},{"issue":"4","key":"10.1016\/j.bbr.2021.113687_bib31","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1124\/pr.117.015107","article-title":"The Psychopharmacology of effort-related decision making: dopamine,\u00a0adenosine, and insights into the neurochemistry of motivation","volume":"70","author":"Salamone","year":"2018","journal-title":"Pharm. Rev."},{"issue":"3","key":"10.1016\/j.bbr.2021.113687_bib32","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1016\/0091-3057(93)90547-7","article-title":"The role of nucleus accumbens dopamine in responding on a continuous reinforcement operant schedule: a neurochemical and behavioral study","volume":"46","author":"McCullough","year":"1993","journal-title":"Pharm. Biochem Behav."},{"key":"10.1016\/j.bbr.2021.113687_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2018.101077","article-title":"PKG1alpha oxidation negatively regulates food seeking behaviour and reward","volume":"21","author":"Duraffourd","year":"2019","journal-title":"Redox Biol."},{"issue":"7","key":"10.1016\/j.bbr.2021.113687_bib34","doi-asserted-by":"crossref","first-page":"1424","DOI":"10.1007\/s11064-013-1040-1","article-title":"Protein kinase G regulates dopamine release, DeltaFosB expression, and locomotor activity after repeated cocaine administration: involvement of dopamine D2 receptors","volume":"38","author":"Lee","year":"2013","journal-title":"Neurochem Res."},{"issue":"5568","key":"10.1016\/j.bbr.2021.113687_bib35","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1126\/science.1069911","article-title":"Influence of gene action across different time scales on behavior","volume":"296","author":"Ben-Shahar","year":"2002","journal-title":"Science"},{"issue":"Suppl 1","key":"10.1016\/j.bbr.2021.113687_bib36","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.neuropharm.2008.06.075","article-title":"Biological substrates of reward and aversion: a nucleus accumbens activity hypothesis","volume":"56","author":"Carlezon","year":"2009","journal-title":"Neuropharmacology"},{"issue":"45","key":"10.1016\/j.bbr.2021.113687_bib37","doi-asserted-by":"crossref","first-page":"11665","DOI":"10.1523\/JNEUROSCI.3070-06.2006","article-title":"Brain reward regulated by AMPA receptor subunits in nucleus accumbens shell","volume":"26","author":"Todtenkopf","year":"2006","journal-title":"J. Neurosci."},{"issue":"7","key":"10.1016\/j.bbr.2021.113687_bib38","doi-asserted-by":"crossref","first-page":"952","DOI":"10.1038\/s41380-018-0252-9","article-title":"Glutamatergic neurometabolite levels in major depressive disorder: a systematic review and meta-analysis of proton magnetic resonance spectroscopy studies","volume":"24","author":"Moriguchi","year":"2019","journal-title":"Mol. Psychiatry"},{"issue":"2","key":"10.1016\/j.bbr.2021.113687_bib39","doi-asserted-by":"crossref","first-page":"117","DOI":"10.2174\/187152707780363258","article-title":"AMPA receptors in the therapeutic management of depression","volume":"6","author":"Bleakman","year":"2007","journal-title":"CNS Neurol. Disord. Drug Targets"},{"issue":"2","key":"10.1016\/j.bbr.2021.113687_bib40","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/S0361-9230(02)00859-6","article-title":"Effects of single or repeated restraint stress on GluR1 and GluR2 flip and flop mRNA expression in the hippocampal formation","volume":"59","author":"Rosa","year":"2002","journal-title":"Brain Res Bull."},{"issue":"1","key":"10.1016\/j.bbr.2021.113687_bib41","doi-asserted-by":"crossref","first-page":"17656","DOI":"10.1038\/s41598-017-18024-3","article-title":"Extracellular cyclic GMP modulates membrane expression of the GluA1 and GluA2 subunits of AMPA receptor in cerebellum: molecular mechanisms involved","volume":"7","author":"Cabrera-Pastor","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbr.2021.113687_bib42","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.neulet.2013.04.003","article-title":"Protein kinase G increases AMPA receptor GluR1 phosphorylation at serine 845 after repeated cocaine administration in the rat nucleus accumbens","volume":"544","author":"Seo","year":"2013","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbr.2021.113687_bib43","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.pbb.2015.05.003","article-title":"The role of dopamine D1 receptor transmission in effort-related choice behavior: Effects of D1 agonists","volume":"135","author":"Yohn","year":"2015","journal-title":"Pharm. Biochem Behav."},{"issue":"2","key":"10.1016\/j.bbr.2021.113687_bib44","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0166-4328(94)90108-2","article-title":"Anhedonia or anergia? effects of haloperidol and nucleus accumbens dopamine depletion on instrumental response selection in a T-maze cost\/benefit procedure","volume":"65","author":"Salamone","year":"1994","journal-title":"Behav. Brain Res."},{"issue":"97","key":"10.1016\/j.bbr.2021.113687_bib45","doi-asserted-by":"crossref","DOI":"10.3791\/52587-v","article-title":"The forced swim test as a model of depressive-like behavior","author":"Yankelevitch-Yahav","year":"2015","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.bbr.2021.113687_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2019.02.005","article-title":"Coping with the forced swim stressor: current state-of-the-art","volume":"364","author":"Molendijk","year":"2019","journal-title":"Behav. Brain Res."},{"issue":"8","key":"10.1016\/j.bbr.2021.113687_bib47","doi-asserted-by":"crossref","first-page":"1809","DOI":"10.1007\/s00213-013-3267-6","article-title":"Molecular and behavioral characterization of adolescent protein kinase C following high dose ethanol exposure","volume":"231","author":"Santerre","year":"2014","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2021.113687_bib48","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.neuroscience.2014.09.003","article-title":"Ethanol dose-dependently elicits opposing regulatory effects on hippocampal AMPA receptor GluA2 subunits through a zeta inhibitory peptide-sensitive kinase in adolescent and adult Sprague-Dawley rats","volume":"280","author":"Santerre","year":"2014","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2021.113687_bib49","author":"Administration","year":"2020","journal-title":"Added Sugars N. Nutr. Facts Label."},{"key":"10.1016\/j.bbr.2021.113687_bib50","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.1038\/ncomms3245","article-title":"Human-relevant levels of added sugar consumption increase female mortality and lower male fitness in mice","volume":"4","author":"Ruff","year":"2013","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.bbr.2021.113687_bib51","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1038\/oby.2005.136","article-title":"Consuming fructose-sweetened beverages increases body adiposity in mice","volume":"13","author":"J\u00fcrgens","year":"2005","journal-title":"Obes. Res."},{"key":"10.1016\/j.bbr.2021.113687_bib52","unstructured":"U.Do.HaH. Services Healthy People Object. 2020."},{"issue":"1","key":"10.1016\/j.bbr.2021.113687_bib53","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1037\/0735-7044.122.1.161","article-title":"A role for sweet taste: calorie predictive relations in energy regulation by rats","volume":"122","author":"Swithers","year":"2008","journal-title":"Behav. Neurosci."},{"issue":"9","key":"10.1016\/j.bbr.2021.113687_bib54","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1002\/oby.21920","article-title":"The effect of nonnutritive sweeteners added to a liquid diet on volume and caloric intake and weight gain in rats","volume":"25","author":"Bissonnette","year":"2017","journal-title":"Obes. (Silver Spring)"},{"issue":"10","key":"10.1016\/j.bbr.2021.113687_bib55","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1038\/npp.2014.84","article-title":"Role of dopamine D2 receptors in human reinforcement learning","volume":"39","author":"Eisenegger","year":"2014","journal-title":"Neuropsychopharmacology"},{"issue":"2","key":"10.1016\/j.bbr.2021.113687_bib56","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1037\/0033-295X.95.2.256","article-title":"A social-cognitive approach to motivation and personality","volume":"95","author":"Dweck","year":"1988","journal-title":"Psychol. Rev."},{"issue":"3","key":"10.1016\/j.bbr.2021.113687_bib57","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/BF00187257","article-title":"Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant","volume":"93","author":"Willner","year":"1987","journal-title":"Psychopharmacology"},{"issue":"2","key":"10.1016\/j.bbr.2021.113687_bib58","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.physbeh.2011.08.036","article-title":"Social isolation in adolescence alters behaviors in the forced swim and sucrose preference tests in female but not in male rats","volume":"105","author":"Hong","year":"2012","journal-title":"Physiol. Behav."},{"issue":"3","key":"10.1016\/j.bbr.2021.113687_bib59","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1016\/j.neuron.2012.10.021","article-title":"The mysterious motivational functions of mesolimbic dopamine","volume":"76","author":"Salamone","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2021.113687_bib60","doi-asserted-by":"crossref","first-page":"11829","DOI":"10.1038\/ncomms11829","article-title":"Activation of D2 dopamine receptor-expressing neurons in the nucleus accumbens increases motivation","volume":"7","author":"Soares-Cunha","year":"2016","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.bbr.2021.113687_bib61","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1038\/s41467-018-03272-2","article-title":"Accumbens dopamine D2 receptors increase motivation by decreasing inhibitory transmission to the ventral pallidum","volume":"9","author":"Gallo","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbr.2021.113687_bib62","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.bbr.2018.10.027","article-title":"Differences in the dopaminergic reward system in rats that passively and actively behave in the Porsolt test","volume":"359","author":"Wis\u0142owska-Stanek","year":"2019","journal-title":"Behav. Brain Res."},{"issue":"1","key":"10.1016\/j.bbr.2021.113687_bib63","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.bbr.2011.12.002","article-title":"Coping style and stress hormone responses in genetically heterogeneous rats: comparison with the Roman rat strains","volume":"228","author":"D\u00edaz-Mor\u00e1n","year":"2012","journal-title":"Behav. Brain Res."},{"issue":"4","key":"10.1016\/j.bbr.2021.113687_bib64","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s00213-013-2990-3","article-title":"Mesolimbic dopamine D(2) receptor plasticity contributes to stress resilience in rats subjected to chronic mild stress","volume":"227","author":"Zurawek","year":"2013","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2021.113687_bib65","first-page":"246","article-title":"Correlation of anxiety and depression levels with attitudes towards coping with Illness and sociodemographic characteristics in patients with a diagnosis of breast cancer","volume":"31","author":"Geyikci","year":"2018","journal-title":"J. Psychiatry Neurol. Sci."},{"issue":"6","key":"10.1016\/j.bbr.2021.113687_bib66","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1188\/19.CJON.583-590","article-title":"Active and passive coping strategies: comparing psychological distress, cortisol, and proinflammatory Cytokine levels in breast cancer survivors","volume":"23","author":"Perez-Tejada","year":"2019","journal-title":"Clin. J. Oncol. Nurs."},{"issue":"3","key":"10.1016\/j.bbr.2021.113687_bib67","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.neubiorev.2010.06.006","article-title":"Reconsidering anhedonia in depression: lessons from translational neuroscience","volume":"35","author":"Treadway","year":"2011","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"3","key":"10.1016\/j.bbr.2021.113687_bib68","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1177\/0963721412474460","article-title":"Parsing anhedonia: translational models of reward-processing deficits in psychopathology","volume":"22","author":"Treadway","year":"2013","journal-title":"Curr. Dir. Psychol. Sci."},{"issue":"3","key":"10.1016\/j.bbr.2021.113687_bib69","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1017\/S0033291709990468","article-title":"Approach and avoidance learning in patients with major depression and healthy controls: relation to anhedonia","volume":"40","author":"Chase","year":"2010","journal-title":"Psychol. Med"},{"issue":"8","key":"10.1016\/j.bbr.2021.113687_bib70","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1007\/s11920-013-0378-z","article-title":"Assessing the roles of stimulants\/stimulant-like drugs and dopamine-agonists in the treatment of bipolar depression","volume":"15","author":"Dell\u2019Osso","year":"2013","journal-title":"Curr. Psychiatry Rep."},{"issue":"7","key":"10.1016\/j.bbr.2021.113687_bib71","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1007\/s00213-015-4200-y","article-title":"When the party is over: depressive-like states in rats following termination of cortical D1 receptor overexpression","volume":"233","author":"Freund","year":"2016","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2021.113687_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2019.112053","article-title":"Chronic unpredictable mild stress-induced behavioral changes are coupled with dopaminergic hyperfunction and serotonergic hypofunction in mouse models of depression","volume":"372","author":"Lu","year":"2019","journal-title":"Behav. Brain Res."},{"issue":"4","key":"10.1016\/j.bbr.2021.113687_bib73","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1021\/acschemneuro.8b00360","article-title":"Chronic social isolation stress during peri-adolescence alters presynaptic dopamine terminal dynamics via augmentation in accumbal dopamine availability","volume":"10","author":"Karkhanis","year":"2019","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.bbr.2021.113687_bib74","first-page":"86","article-title":"Sugar consumption produces effects similar to early life stress exposure on hippocampal markers of neurogenesis and stress response","volume":"8","author":"Maniam","year":"2015","journal-title":"Front Mol. Neurosci."},{"key":"10.1016\/j.bbr.2021.113687_bib75","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.neuropharm.2016.09.010","article-title":"Disrupting GluA2 phosphorylation potentiates reinstatement of cocaine seeking","volume":"111","author":"Briand","year":"2016","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2021.113687_bib76","first-page":"1","article-title":"Is sugar a gateway drug?","volume":"1","author":"Liester","year":"2015","journal-title":"J. Drug Abus."},{"key":"10.1016\/j.bbr.2021.113687_bib77","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.neuroscience.2017.07.009","article-title":"The role of dopamine D2 receptors in the nucleus accumbens during taste-aversive learning and memory extinction after long-term sugar consumption","volume":"359","author":"Miranda","year":"2017","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.bbr.2021.113687_bib78","doi-asserted-by":"crossref","first-page":"16918","DOI":"10.1038\/s41598-019-53430-9","article-title":"Sucrose intake lowers mu-opioid and dopamine D2\/3 receptor availability in porcine brain","volume":"9","author":"Winterdahl","year":"2019","journal-title":"Sci. Rep."},{"issue":"9253","key":"10.1016\/j.bbr.2021.113687_bib79","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/S0140-6736(00)03643-6","article-title":"Brain dopamine and obesity","volume":"357","author":"Wang","year":"2001","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.bbr.2021.113687_bib80","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1046\/j.0953-816x.2000.01443.x","article-title":"Dopamine D(2) receptors regulate tyrosine hydroxylase activity and phosphorylation at Ser40 in rat striatum","volume":"13","author":"Lindgren","year":"2001","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bbr.2021.113687_bib81","doi-asserted-by":"crossref","first-page":"263","DOI":"10.3389\/fnmol.2018.00263","article-title":"Activation of protein kinase G after repeated cocaine administration is necessary for the phosphorylation of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor GluA1 at serine 831 in the rat nucleus accumbens","volume":"11","author":"Yang","year":"2018","journal-title":"Front Mol. Neurosci."},{"key":"10.1016\/j.bbr.2021.113687_bib82","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1016\/j.bbi.2017.12.013","article-title":"Increasing extracellular cGMP in cerebellum in vivo reduces neuroinflammation, GABAergic tone and motor in-coordination in hyperammonemic rats","volume":"69","author":"Cabrera-Pastor","year":"2018","journal-title":"Brain Behav. Immun."},{"issue":"1","key":"10.1016\/j.bbr.2021.113687_bib83","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.bandc.2009.10.013","article-title":"Developmental changes in dopamine neurotransmission in adolescence: behavioral implications and issues in assessment","volume":"72","author":"Wahlstrom","year":"2010","journal-title":"Brain Cogn."},{"issue":"23\u201324","key":"10.1016\/j.bbr.2021.113687_bib84","doi-asserted-by":"crossref","first-page":"3991","DOI":"10.1007\/s00213-016-4425-4","article-title":"Long-lasting effects of adolescent oxycodone exposure on reward-related behavior and gene expression in mice","volume":"233","author":"Sanchez","year":"2016","journal-title":"Psychopharmacology"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432821005751?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432821005751?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T13:30:59Z","timestamp":1759066259000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432821005751"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,2]]},"references-count":84,"alternative-id":["S0166432821005751"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2021.113687","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2022,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adolescent high-fructose corn syrup consumption leads to dysfunction in adult affective behaviors and mesolimbic proteins in male Sprague-Dawley rats","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2021.113687","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113687"}}