{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T19:33:35Z","timestamp":1780515215493,"version":"3.54.1"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,2]],"date-time":"2023-02-02T00:00:00Z","timestamp":1675296000000},"content-version":"am","delay-in-days":307,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,4,1]],"date-time":"2022-04-01T00:00:00Z","timestamp":1648771200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2022,4]]},"DOI":"10.1016\/j.bbr.2022.113767","type":"journal-article","created":{"date-parts":[[2022,1,22]],"date-time":"2022-01-22T02:42:30Z","timestamp":1642819350000},"page":"113767","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Long-term effects of pharmacological inhibition of anaplastic lymphoma kinase in neurofibromatosis 1 mutant mice"],"prefix":"10.1016","volume":"423","author":[{"given":"Destine","family":"Krenik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph B.","family":"Weiss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Raber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2022.113767_bib1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.tins.2012.12.002","article-title":"Modeling cognitive dysfunction in neurofibromatosis-1","volume":"36","author":"Diffs-Andrews","year":"2013","journal-title":"Trends Neurosci."},{"issue":"5","key":"10.1016\/j.bbr.2022.113767_bib2","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1111\/j.1469-8749.1995.tb12026.x","article-title":"Cognitive function and academic performance in children with neurofibromatosis type 1","volume":"37","author":"North","year":"1995","journal-title":"Dev. Med. Child Neurol."},{"issue":"2","key":"10.1016\/j.bbr.2022.113767_bib3","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1007\/s11910-996-0036-5","article-title":"Neurofibromatosis type 1: new insights into neurocognitive issues","volume":"6","author":"Acosta","year":"2006","journal-title":"Curr. Neurol. Neurosci. Rep."},{"issue":"2","key":"10.1016\/j.bbr.2022.113767_bib4","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/s11910-003-0064-3","article-title":"Neurocognitive dysfunction in children with neurofibromatosis type 1","volume":"3","author":"Rosser","year":"2003","journal-title":"Curr. Neurol. Neurosci. Rep."},{"issue":"4","key":"10.1016\/j.bbr.2022.113767_bib5","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1016\/S0022-3476(05)83163-4","article-title":"Neurofibromatosis type 1: the cognitive phenotype","volume":"124","author":"Hofman","year":"1994","journal-title":"J. Pediatr."},{"issue":"7","key":"10.1016\/j.bbr.2022.113767_bib6","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1212\/01.wnl.0000179303.72345.ce","article-title":"The nature and frequency of cognitive deficits in children with neurofibromatosis type 1","volume":"65","author":"Hyman","year":"2005","journal-title":"Neurology"},{"issue":"4","key":"10.1016\/j.bbr.2022.113767_bib7","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1600-0404.1997.tb00103.x","article-title":"Neuropsychological deficits in adults with neurofibromatosis type 1","volume":"95","author":"Zoller","year":"1997","journal-title":"Acta Neurol. Scand."},{"issue":"11","key":"10.1016\/j.bbr.2022.113767_bib8","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1177\/0883073813500849","article-title":"Prevalence of sleep disturbances in children with neurofibromatosis type 1","volume":"28","author":"Licis","year":"2013","journal-title":"J. Child Neurol."},{"issue":"6","key":"10.1016\/j.bbr.2022.113767_bib9","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1002\/ajmg.a.35915","article-title":"Sleep disturbance as part of the neurofibromatosis type 1 phenotype in adults","volume":"161A","author":"Leschziner","year":"2013","journal-title":"Am. J. Med. Genet. A"},{"issue":"4","key":"10.1016\/j.bbr.2022.113767_bib10","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1017\/S0012162205000460","article-title":"Psychological disturbance and sleep disorders in children with neurofibromatosis type 1","volume":"47","author":"Johnson","year":"2005","journal-title":"Dev. Med. Child Neurol."},{"key":"10.1016\/j.bbr.2022.113767_bib11","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1158\/0008-5472.CAN-14-1891","article-title":"The cyclic AMP pathway is a sex-specific modifier of glioma risk in type I neurofibromatosis patients","volume":"75","author":"Warrington","year":"2015","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbr.2022.113767_bib12","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/ana.24093","article-title":"Sex is a major determinant of neuronal dysfunction in neurofibromatosis type 1","volume":"75","author":"Diggs-Andrews","year":"2014","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbr.2022.113767_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2020.105030","article-title":"Mutant microglia exhibit sexually-dimorphic cyclic AMP-dependent purinergic defects","volume":"144","author":"Elmadany","year":"2020","journal-title":"Neurobiol. Dis."},{"issue":"8","key":"10.1016\/j.bbr.2022.113767_bib14","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1177\/088307380201700813","article-title":"Molecular and cellular mechanisms underlying the cognitive deficits associated with neurofibromatosis 1","volume":"17","author":"Costa","year":"2002","journal-title":"J. Child Neurol."},{"issue":"4","key":"10.1016\/j.bbr.2022.113767_bib15","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/86898","article-title":"Learning deficits, but normal development and tumor predisposition, in mice lacking exon 23a of Nf1","volume":"27","author":"Costa","year":"2001","journal-title":"Nat. Genet."},{"issue":"3","key":"10.1016\/j.bbr.2022.113767_bib16","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1038\/ng0397-281","article-title":"A mouse model for the learning and memory deficits associated with neurofibromatosis type I","volume":"15","author":"Silva","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbr.2022.113767_bib17","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.bbr.2017.01.003","article-title":"Genetic inhibition of Anaplastic Lymphoma Kinase rescues cognitive impairments in neurofibromatosis 1 mutant mice","volume":"321","author":"Weiss","year":"2017","journal-title":"Behav. Brain Res."},{"issue":"11","key":"10.1016\/j.bbr.2022.113767_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1005611","article-title":"Anaplastic lymphoma kinase acts in the Drosophila mushroom body to negatively regulate sleep","volume":"11","author":"Bai","year":"2015","journal-title":"PLoS Genet."},{"issue":"5538","key":"10.1016\/j.bbr.2022.113767_bib19","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1126\/science.1063097","article-title":"A circadian output in Drosophila mediated by neurofibromatosis-1 and Ras\/MAPK","volume":"293","author":"Williams","year":"2001","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.bbr.2022.113767_bib20","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0092-8674(90)90253-B","article-title":"A major segment of the neurofibromatosis type 1 gene: cDNA sequence, genomic structure, and point mutations","volume":"62","author":"Cawthon","year":"1990","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.bbr.2022.113767_bib21","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1016\/0092-8674(90)90024-9","article-title":"The neurofibromatosis type 1 gene encodes a protein related to GAP","volume":"62","author":"Xu","year":"1990","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.bbr.2022.113767_bib22","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1016\/0092-8674(90)90151-4","article-title":"The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins","volume":"63","author":"Ballester","year":"1990","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.bbr.2022.113767_bib23","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/0092-8674(90)90150-D","article-title":"The GAP-related domain of the neurofibromatosis type 1 gene product interacts with ras p21","volume":"63","author":"Martin","year":"1990","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.bbr.2022.113767_bib24","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/0092-8674(90)90149-9","article-title":"The catalytic domain of the neurofibromatosis type 1 gene product stimulates ras GTPase and complements ira mutants of S. cerevisiae","volume":"63","author":"Xu","year":"1990","journal-title":"Cell"},{"issue":"9","key":"10.1016\/j.bbr.2022.113767_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002281","article-title":"The receptor tyrosine kinase alk controls neurofibromin functions in Drosophila growth and learning","volume":"7","author":"Gouzi","year":"2011","journal-title":"PLoS Genet."},{"key":"10.1016\/j.bbr.2022.113767_bib26","article-title":"A Drosophila screen identifies neurofibromatosis-1 genetic modifiers involved in systemic and synaptic growth","volume":"2","author":"Walker","year":"2014","journal-title":"Rare Dis."},{"issue":"3","key":"10.1016\/j.bbr.2022.113767_bib27","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1016\/j.pbb.2011.10.024","article-title":"Anaplastic lymphoma kinase and leukocyte tyrosine kinase: functions and genetic interactions in learning, memory and adult neurogenesis","volume":"100","author":"Weiss","year":"2012","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.bbr.2022.113767_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1003958","article-title":"Genetic and functional studies implicate synaptic overgrowth and ring gland cAMP\/PKA signaling defects in the Drosophila melanogaster Neurofibromatosis-1 growth deficiency","volume":"9","author":"Walker","year":"2013","journal-title":"PLoS Genet."},{"issue":"5151","key":"10.1016\/j.bbr.2022.113767_bib29","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1126\/science.8122112","article-title":"Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma","volume":"263","author":"Morris","year":"1994","journal-title":"Science"},{"issue":"7215","key":"10.1016\/j.bbr.2022.113767_bib30","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1038\/nature07399","article-title":"Oncogenic mutations of ALK kinase in neuroblastoma","volume":"455","author":"Chen","year":"2008","journal-title":"Nature"},{"issue":"7215","key":"10.1016\/j.bbr.2022.113767_bib31","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1038\/nature07397","article-title":"Activating mutations in ALK provide a therapeutic target in neuroblastoma","volume":"455","author":"George","year":"2008","journal-title":"Nature"},{"issue":"7215","key":"10.1016\/j.bbr.2022.113767_bib32","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1038\/nature07261","article-title":"Identification of ALK as a major familial neuroblastoma predisposition gene","volume":"455","author":"Mosse","year":"2008","journal-title":"Nature"},{"issue":"7153","key":"10.1016\/j.bbr.2022.113767_bib33","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1038\/nature05945","article-title":"Identification of the transforming EML4-ALK fusion gene in non-small-cell lung cancer","volume":"448","author":"Soda","year":"2007","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.bbr.2022.113767_bib34","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1002\/gcc.1121","article-title":"ALK probe rearrangement in a t(2;11;2)(p23;p15;q31) translocation found in a prenatal myofibroblastic fibrous lesion: toward a molecular definition of an inflammatory myofibroblastic tumor family?","volume":"31","author":"Sirvent","year":"2001","journal-title":"Genes Chromosomes Cancer"},{"issue":"18","key":"10.1016\/j.bbr.2022.113767_bib35","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1056\/NEJMoa1006448","article-title":"Anaplastic lymphoma kinase inhibition in non-small-cell lung cancer","volume":"363","author":"Kwak","year":"2010","journal-title":"N. Engl. J. Med."},{"issue":"18","key":"10.1016\/j.bbr.2022.113767_bib36","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1056\/NEJMoa1007056","article-title":"Crizotinib in ALK-rearranged inflammatory myofibroblastic tumor","volume":"363","author":"Butrynski","year":"2010","journal-title":"N. Engl. J. Med."},{"issue":"5","key":"10.1016\/j.bbr.2022.113767_bib37","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1007\/s00280-014-2578-6","article-title":"Antitumor activity of the selective ALK inhibitor alectinib in models of intracranial metastases","volume":"74","author":"Kodama","year":"2014","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.bbr.2022.113767_bib38","doi-asserted-by":"crossref","DOI":"10.1007\/s11060-016-2184-z","article-title":"Alectinib's activity against CNS metastases from ALK-positive non-small cell lung cancer: a single institution case series","author":"Metro","year":"2016","journal-title":"J. Neurooncol."},{"key":"10.1016\/j.bbr.2022.113767_bib39","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.bbr.2017.06.024","article-title":"Pharmacological inhibition of Anaplastic Lymphoma Kinase rescues spatial memory impairments in neurofibromatosis 1 mutant mice","volume":"332","author":"Weiss","year":"2017","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2022.113767_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2021.147594","article-title":"Role of the parental NF1 carrier in effects of pharmacological inhibition of anaplastic lymphoma kinase in Neurofibromatosis 1 mutant mice","volume":"1769","author":"Krenik","year":"2021","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2022.113767_bib41","doi-asserted-by":"crossref","first-page":"3797","DOI":"10.1093\/hmg\/ddx264","article-title":"Neurofibromatosis type 1 alternative splicing is a key regulator of Ras\/ERK signaling and learning behaviors in mice","volume":"26","author":"Nguyen","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbr.2022.113767_bib42","doi-asserted-by":"crossref","first-page":"1583","DOI":"10.1038\/nn.3822","article-title":"Social learning and amygdala disruptions in Nf1 mice are rescued by blocking p21-activated kinase","volume":"17","author":"Molosh","year":"2014","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbr.2022.113767_bib43","doi-asserted-by":"crossref","first-page":"9155","DOI":"10.18632\/oncotarget.13551","article-title":"Neuroinflammatory and cognitive consequences of combined radiation and immunotherapy in a novel preclinical model","volume":"8","author":"McGinnis","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.bbr.2022.113767_bib44","doi-asserted-by":"crossref","first-page":"7701","DOI":"10.1523\/JNEUROSCI.0784-18.2018","article-title":"The Drosophila receptor tyrosine kinase Alk constrains long-term memory formation","volume":"38","author":"Gouzi","year":"2018","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2022.113767_bib45","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.neuroscience.2005.08.029","article-title":"Sex-differences in age-related cognitive decline in C57BL\/6J mice associated with increased brain microtubule-associated protein 2 and synaptophysin immunoreactivity","volume":"137","author":"Benice","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2022.113767_bib46","doi-asserted-by":"crossref","first-page":"5204","DOI":"10.1523\/JNEUROSCI.22-12-05204.2002","article-title":"Androgens protect against apolipoprotein E4-induced cognitive deficits","volume":"22","author":"Raber","year":"2002","journal-title":"J. Neurosci."},{"issue":"825","key":"10.1016\/j.bbr.2022.113767_bib47","article-title":"Short- and long-term effects of 56Fe irradiation on cognition and hippocampal DNA methylation and gene expression","volume":"17","author":"Impey","year":"2016","journal-title":"BMC Genom."},{"key":"10.1016\/j.bbr.2022.113767_bib48","doi-asserted-by":"crossref","first-page":"10227","DOI":"10.1038\/s41598-017-09191-4","article-title":"Bi-directional and shared epigenomic signatures following proton and 56Fe irradiation","volume":"7","author":"Impey","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbr.2022.113767_bib49","first-page":"179","article-title":"Combined effects of three high energy charged particle beams important for space flight on brain, behavioral and cognitive endpoints in B6D2F1 female and male mice","volume":"10","author":"Raber","year":"2019","journal-title":"Frontiers"},{"key":"10.1016\/j.bbr.2022.113767_bib50","doi-asserted-by":"crossref","first-page":"127","DOI":"10.2174\/1874609811003020127","article-title":"Effects of e4 on object recognition in the non-demented elderly","volume":"3","author":"Haley","year":"2010","journal-title":"Curr. Aging Sci."},{"key":"10.1016\/j.bbr.2022.113767_bib51","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.neuroscience.2007.03.005","article-title":"Effects of sex and APOE e4 on object recognition and spatial navigation in the elderly","volume":"147","author":"Berteau-Pavy","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2022.113767_bib52","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1038\/gim.2012.85","article-title":"Emotional functioning of patients with neurofibromatosis tumor suppressor syndrome","volume":"14","author":"Wang","year":"2012","journal-title":"Genet. Med."},{"key":"10.1016\/j.bbr.2022.113767_bib53","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/cge.12551","article-title":"Depression among adults with neurofibromatosis type 1: prevalence and impact on quality of life","volume":"88","author":"Cohen","year":"2015","journal-title":"Clin. Genet."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432822000353?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432822000353?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T13:30:05Z","timestamp":1759066205000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432822000353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4]]},"references-count":53,"alternative-id":["S0166432822000353"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2022.113767","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2022,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Long-term effects of pharmacological inhibition of anaplastic lymphoma kinase in neurofibromatosis 1 mutant mice","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2022.113767","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113767"}}