{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T05:24:43Z","timestamp":1780118683162,"version":"3.54.0"},"reference-count":108,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.bbr.2022.113866","type":"journal-article","created":{"date-parts":[[2022,3,31]],"date-time":"2022-03-31T06:57:57Z","timestamp":1648709877000},"page":"113866","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["S-Adenosyl-Methionine alleviates sociability aversion and reduces changes in gene expression in a mouse model of social hierarchy"],"prefix":"10.1016","volume":"427","author":[{"given":"Maria","family":"Becker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Abaev","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Pinhasov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asher","family":"Ornoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2022.113866_bib1","doi-asserted-by":"crossref","first-page":"341","DOI":"10.31887\/DCNS.2019.21.4\/enestler","article-title":"Unraveling the epigenetic landscape of depression: focus on early life stress","volume":"21","author":"Torres-Berr\u00edo","year":"2019","journal-title":"Dialog-. Clin. Neurosci."},{"key":"10.1016\/j.bbr.2022.113866_bib2","first-page":"9","article-title":"The epigenetics of Alzheimer\u2019s disease: factors and therapeutic implications","author":"Liu","year":"2018","journal-title":"Front. Genet."},{"key":"10.1016\/j.bbr.2022.113866_bib3","doi-asserted-by":"crossref","first-page":"4440","DOI":"10.3390\/ijms22094440","article-title":"Insights into the pathophysiology of psychiatric symptoms in central nervous system disorders: implications for early and differential diagnosis","volume":"22","author":"Menculini","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbr.2022.113866_bib4","doi-asserted-by":"crossref","first-page":"682","DOI":"10.12998\/wjcc.v3.i8.682","article-title":"Depressive symptoms in neurodegenerative diseases","volume":"3","author":"Baquero","year":"2015","journal-title":"World J. Clin. cases"},{"key":"10.1016\/j.bbr.2022.113866_bib5","first-page":"11","article-title":"Pathways connecting late-life depression and dementia","author":"Linnemann","year":"2020","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbr.2022.113866_bib6","doi-asserted-by":"crossref","first-page":"281","DOI":"10.31887\/DCNS.2014.16.3\/rbagot","article-title":"Epigenetic signaling in psychiatric disorders: stress and depression","volume":"16","author":"Bagot","year":"2014","journal-title":"Dialog-. Clin. Neurosci."},{"key":"10.1016\/j.bbr.2022.113866_bib7","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.jgg.2013.06.004","article-title":"DNA methylation, behavior and early life adversity","volume":"40","author":"Szyf","year":"2013","journal-title":"J. Genet. Genom."},{"key":"10.1016\/j.bbr.2022.113866_bib8","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1097\/JCP.0000000000000064","article-title":"Oral SAMe in persistent treatment-refractory bipolar depression: a double-blind, randomized clinical trial","volume":"34","author":"Murphy","year":"2014","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.bbr.2022.113866_bib9","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1080\/01612840.2017.1392161","article-title":"S-adenosyl methionine (SAMe) for depression in adults","volume":"40","author":"Wilson","year":"2019","journal-title":"Issues Ment. Health Nurs."},{"key":"10.1016\/j.bbr.2022.113866_bib10","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.3390\/ijms18081711","article-title":"Epigenomics of major depressive disorders and schizophrenia: early life decides","volume":"18","author":"Hoffmann","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbr.2022.113866_bib11","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1136\/jnnp.53.12.1096","article-title":"Cerebrospinal fluid S-adenosylmethionine in depression and dementia: effects of treatment with parenteral and oral S-adenosylmethionine","volume":"53","author":"Bottiglieri","year":"1990","journal-title":"J. Neurol., Neurosurg., Psychiatry"},{"key":"10.1016\/j.bbr.2022.113866_bib12","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1176\/appi.ajp.2009.09081198","article-title":"S-adenosyl methionine (SAMe) augmentation of serotonin reuptake inhibitors for antidepressant nonresponders with major depressive disorder: a double-blind, randomized clinical trial","volume":"167","author":"Papakostas","year":"2010","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.bbr.2022.113866_bib13","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1016\/j.euroneuro.2018.07.098","article-title":"Adjunctive S-adenosylmethionine (SAMe) in treating non-remittent major depressive disorder: an 8-week double-blind, randomized, controlled trial","volume":"28","author":"Sarris","year":"2018","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.bbr.2022.113866_bib14","doi-asserted-by":"crossref","first-page":"1158S","DOI":"10.1093\/ajcn\/76.5.1158S","article-title":"Role of S-adenosyl-l-methionine in the treatment of depression: a review of the evidence","volume":"76","author":"Mischoulon","year":"2002","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.bbr.2022.113866_bib15","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.bbr.2016.12.008","article-title":"Genetic predisposition to high anxiety- and depression-like behavior coincides with diminished DNA methylation in the adult rat amygdala","volume":"320","author":"McCoy","year":"2017","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2022.113866_bib16","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2016.173","article-title":"Consistently altered expression of gene sets in postmortem brains of individuals with major psychiatric disorders","volume":"6","author":"Darby","year":"2016","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.bbr.2022.113866_bib17","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.ntt.2018.01.005","article-title":"S-adenosyl methionine prevents ASD like behaviors triggered by early postnatal valproic acid exposure in very young mice","volume":"71","author":"Ornoy","year":"2019","journal-title":"Neurotoxicology Teratol."},{"issue":"21","key":"10.1016\/j.bbr.2022.113866_bib18","doi-asserted-by":"crossref","first-page":"5278","DOI":"10.3390\/ijms20215278","article-title":"Gender related changes in gene expression induced by valproic acid in a mouse model of autism and the correction by S-adenosyl methionine. does it explain the gender differences in autistic like behavior?","volume":"20","author":"Weinstein \u2013","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbr.2022.113866_bib19","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.3390\/ijms20051074","article-title":"Prevention or amelioration of autism-like symptoms in animal models: will it bring us closer to treating human ASD?","volume":"20","author":"Ornoy","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbr.2022.113866_bib20","first-page":"21","article-title":"Prenatal S-adenosine methionine (SAMe) induces changes in gene expression in the brain of newborn mice that are prevented by co-administration of valproic acid (VPA)","author":"Weinstein-Fudim","year":"2020","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.bbr.2022.113866_bib21","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1101\/gr.089185.108","article-title":"Epigenetic profiling at mouse imprinted gene clusters reveals novel epigenetic and genetic features at differentially methylated regions","volume":"19","author":"Dindot","year":"2009","journal-title":"Genome Res."},{"key":"10.1016\/j.bbr.2022.113866_bib22","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1161\/CIRCRESAHA.107.171025","article-title":"Epigenetic regulation of vascular endothelial gene expression","volume":"102","author":"Matouk","year":"2008","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbr.2022.113866_bib23","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-017-01077-3","article-title":"DNA methylation and transcriptional trajectories during human development and reprogramming of isogenic pluripotent stem cells","volume":"8","author":"Roost","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbr.2022.113866_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1005583","article-title":"DNA methylation landscapes of human fetal development","volume":"11","author":"Slieker","year":"2015","journal-title":"PLoS Genet."},{"key":"10.1016\/j.bbr.2022.113866_bib25","doi-asserted-by":"crossref","first-page":"445","DOI":"10.2217\/epi.12.37","article-title":"Sensitive periods in epigenetics: bringing us closer to complex behavioral phenotypes","volume":"4","author":"Nagy","year":"2012","journal-title":"Epigenomics"},{"key":"10.1016\/j.bbr.2022.113866_bib26","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1016\/j.tins.2013.08.002","article-title":"Perinatal programming of adult hippocampal structure and function; emerging roles of stress, nutrition and epigenetics","volume":"36","author":"Lucassen","year":"2013","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.bbr.2022.113866_bib27","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.jad.2010.03.018","article-title":"Selective breeding for dominant and submissive behavior in Sabra mice","volume":"126","author":"Feder","year":"2010","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.bbr.2022.113866_bib28","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3390\/diagnostics11010123","article-title":"Animal models of depression: what can they teach us about the human disease?","volume":"11","author":"Becker","year":"2021","journal-title":"Diagnostics"},{"key":"10.1016\/j.bbr.2022.113866_bib29","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-27988-9","article-title":"Social dominance predicts hippocampal glucocorticoid receptor recruitment and resilience to prenatal adversity","volume":"8","author":"Gross","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbr.2022.113866_bib30","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.bbr.2012.08.040","article-title":"Differential responses to distinct psychotropic agents of selectively bred dominant and submissive animals","volume":"236","author":"Nesher","year":"2013","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2022.113866_bib31","doi-asserted-by":"crossref","first-page":"10287","DOI":"10.1038\/srep10287","article-title":"Synapsin IIb as a functional marker of submissive behavior","volume":"5","author":"Nesher","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbr.2022.113866_bib32","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1016\/j.neurobiolaging.2015.02.015","article-title":"Early onset of cognitive impairment is associated with altered synaptic plasticity and enhanced hippocampal GluA1 expression in a mouse model of depression","volume":"36","author":"Gross","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbr.2022.113866_bib33","doi-asserted-by":"crossref","first-page":"1700089","DOI":"10.1002\/prca.201700089","article-title":"Effect of social interactions on hippocampal protein expression in animal dominant and submissive model of behavioral disorders","volume":"11","author":"Borovok","year":"2017","journal-title":"Proteom. \u2013 Clin. Appl."},{"key":"10.1016\/j.bbr.2022.113866_bib34","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jneumeth.2007.05.035","article-title":"Reduction of dominant or submissive behaviors as models for antimanic or antidepressant drug testing: technical considerations","volume":"165","author":"Malatynska","year":"2007","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.bbr.2022.113866_bib35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0003067","article-title":"Unusual repertoire of vocalizations in the BTBR T+tf\/J mouse model of autism","volume":"3","author":"Scattoni","year":"2008","journal-title":"PloS One"},{"key":"10.1016\/j.bbr.2022.113866_bib36","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/0003-3472(65)90041-2","article-title":"Reflex-ontogeny and behavioural development of the mouse","volume":"13","author":"Fox","year":"1965","journal-title":"Anim. Behav."},{"key":"10.1016\/j.bbr.2022.113866_bib37","series-title":"Diagnostic and Statistical Manual Of Mental Disorders","author":"American Psychiatric Association (APA)","year":"2013"},{"key":"10.1016\/j.bbr.2022.113866_bib38","first-page":"327","article-title":"Behavioral despair in mice: a primary screening test for antidepressants","volume":"229","author":"Porsolt","year":"1977","journal-title":"Arch. Int. De. Pharmacodyn. Et. De. Ther."},{"key":"10.1016\/j.bbr.2022.113866_bib39","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1093\/brain\/aww050","article-title":"Activational and effort-related aspects of motivation: neural mechanisms and implications for psychopathology","volume":"139","author":"Salamone","year":"2016","journal-title":"Brain"},{"key":"10.1016\/j.bbr.2022.113866_bib40","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1196\/annals.1417.003","article-title":"Dopamine signaling in the dorsal striatum is essential for motivated behaviors: lessons from dopamine-deficient mice","volume":"1129","author":"Palmiter","year":"2008","journal-title":"Ann. N. Y Acad. Sci."},{"key":"10.1016\/j.bbr.2022.113866_bib41","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1037\/bul0000102","article-title":"Gender differences in depression in representative national samples: Meta-analyses of diagnoses and symptoms","volume":"143","author":"Salk","year":"2017","journal-title":"Psychol. Bull."},{"key":"10.1016\/j.bbr.2022.113866_bib42","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/j.jad.2013.12.011","article-title":"Gender differences in major depressive disorder: results from the Netherlands study of depression and anxiety","volume":"156","author":"Schuch","year":"2014","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.bbr.2022.113866_bib43","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.pneurobio.2019.01.006","article-title":"Sex differences in depression: Insights from clinical and preclinical studies","volume":"176","author":"Eid","year":"2019","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.bbr.2022.113866_bib44","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.psychres.2010.12.027","article-title":"Gender differences in 12-week antidepressant treatment outcomes for a naturalistic secondary care cohort: the CRESCEND study","volume":"189","author":"Yang","year":"2011","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.bbr.2022.113866_bib45","doi-asserted-by":"crossref","first-page":"1445","DOI":"10.1176\/appi.ajp.157.9.1445","article-title":"Gender differences in treatment response to sertraline versus imipramine in chronic depression","volume":"157","author":"Kornstein","year":"2000","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.bbr.2022.113866_bib46","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1097\/01.jcp.0000168879.03169.ce","article-title":"Sex differences in antidepressant response in recent antidepressant clinical trials","volume":"25","author":"Khan","year":"2005","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.bbr.2022.113866_bib47","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.eurpsy.2003.05.002","article-title":"Differential effects of milnacipran, fluvoxamine and paroxetine for depression, especially in gender","volume":"18","author":"Morishita","year":"2003","journal-title":"Eur. Psychiatry.: J. Assoc. Eur. Psychiatr."},{"key":"10.1016\/j.bbr.2022.113866_bib48","doi-asserted-by":"crossref","first-page":"62","DOI":"10.4088\/JCP.12m07841","article-title":"Influence of sex and menopausal status on response, remission, and recurrence in patients with recurrent major depressive disorder treated with venlafaxine extended release or fluoxetine: analysis of data from the PREVENT study","volume":"75","author":"Kornstein","year":"2013","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.bbr.2022.113866_bib49","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1111\/j.1742-7843.2009.00516.x","article-title":"Sex differences in animal models of depression and antidepressant response","volume":"106","author":"Dalla","year":"2010","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.bbr.2022.113866_bib50","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/j.physbeh.2007.10.020","article-title":"Sex differences in the effects of two stress paradigms on dopaminergic neurotransmission","volume":"93","author":"Dalla","year":"2008","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbr.2022.113866_bib51","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.physbeh.2009.05.011","article-title":"Sex differences in oxidant\/antioxidant balance under a chronic mild stress regime","volume":"98","author":"Kamper","year":"2009","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbr.2022.113866_bib52","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/j.neuroscience.2004.04.044","article-title":"Sex differences in behavioral, neurochemical and neuroendocrine effects induced by the forced swim test in rats","volume":"126","author":"Drossopoulou","year":"2004","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2022.113866_bib53","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.yfrne.2018.05.003","article-title":"The impact of sex as a biological variable in the search for novel antidepressants","volume":"50","author":"Williams","year":"2018","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.bbr.2022.113866_bib54","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1038\/s41386-018-0195-5","article-title":"Early life stress leads to sex differences in development of depressive-like outcomes in a mouse model","volume":"44","author":"Goodwill","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2022.113866_bib55","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.bbr.2016.05.009","article-title":"Sex-specific effects of early life stress on social interaction and prefrontal cortex dendritic morphology in young rats","volume":"310","author":"Farrell","year":"2016","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2022.113866_bib56","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.neubiorev.2019.04.010","article-title":"Stress, epigenetics and depression: a systematic review","volume":"102","author":"Park","year":"2019","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbr.2022.113866_bib57","doi-asserted-by":"crossref","first-page":"397","DOI":"10.31887\/DCNS.2019.21.4\/ebinder","article-title":"Epigenetics and depression","volume":"21","author":"Penner-Goeke","year":"2019","journal-title":"Dialog-. Clin. Neurosci."},{"key":"10.1016\/j.bbr.2022.113866_bib58","doi-asserted-by":"crossref","first-page":"e656","DOI":"10.4088\/JCP.16r11113","article-title":"As work group of the American psychiatric association council on, R. S-adenosylmethionine (SAMe) for neuropsychiatric disorders: a clinician-oriented review of research","volume":"78","author":"Sharma","year":"2017","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.bbr.2022.113866_bib59","doi-asserted-by":"crossref","first-page":"35","DOI":"10.2174\/1871527314666150821103825","article-title":"A comprehensive review on the efficacy of S-Adenosyl-L-methionine in major depressive disorder","volume":"15","author":"De Berardis","year":"2016","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.bbr.2022.113866_bib60","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/s12991-020-00298-z","article-title":"S-Adenosylmethionine (SAMe) in major depressive disorder (MDD): a clinician-oriented systematic review","volume":"19","author":"Cuomo","year":"2020","journal-title":"Ann. Gen. Psychiatry"},{"key":"10.1016\/j.bbr.2022.113866_bib61","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1055\/s-0035-1549928","article-title":"Is S-adenosyl methionine (SAMe) for depression only effective in males? A Re-analysis of data from a randomized clinical trial","volume":"48","author":"Sarris","year":"2015","journal-title":"Pharmacopsychiatry"},{"key":"10.1016\/j.bbr.2022.113866_bib62","first-page":"160","article-title":"One-carbon metabolism nutrient status and plasma S-adenosylmethionine concentrations in middle-aged and older Chinese in Singapore","volume":"3","author":"Inoue-Choi","year":"2012","journal-title":"Int J. Mol. Epidemiol. Genet"},{"key":"10.1016\/j.bbr.2022.113866_bib63","first-page":"21","article-title":"S-adenosine methionine (SAMe) and valproic acid (VPA) as epigenetic modulators: special emphasis on their interactions affecting nervous tissue during pregnancy","author":"Ornoy","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbr.2022.113866_bib64","first-page":"22","article-title":"Diabetes during pregnancy: a maternal disease complicating the course of pregnancy with long-term deleterious effects on the offspring","author":"Ornoy","year":"2021","journal-title":"Clin. Rev. Int. J. Mol. Sci."},{"key":"10.1016\/j.bbr.2022.113866_bib65","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1177\/2045125312436572","article-title":"Serum brain-derived neurotrophic factor, vascular endothelial growth factor and leptin levels in patients with a diagnosis of severe major depressive disorder with melancholic features","volume":"2","author":"Kotan","year":"2012","journal-title":"Ther. Adv. Psychopharmacol."},{"key":"10.1016\/j.bbr.2022.113866_bib66","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.jad.2019.04.080","article-title":"Reduced vascular endothelial growth factor levels in the cerebrospinal fluid in patients with treatment resistant major depression and the effects of electroconvulsive therapy-A pilot study","volume":"253","author":"Kranaster","year":"2019","journal-title":"J. Affect Disord."},{"key":"10.1016\/j.bbr.2022.113866_bib67","doi-asserted-by":"crossref","first-page":"2360","DOI":"10.1038\/sj.npp.1301358","article-title":"Increasing the levels of insulin-like growth factor-I by an IGF binding protein inhibitor produces anxiolytic and antidepressant-like effects","volume":"32","author":"Malberg","year":"2007","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2022.113866_bib68","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1152\/physrev.00031.2008","article-title":"Role and therapeutic potential of VEGF in the nervous system","volume":"89","author":"Ruiz de Almodovar","year":"2009","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbr.2022.113866_bib69","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1126\/science.2479986","article-title":"Vascular endothelial growth factor is a secreted angiogenic mitogen","volume":"246","author":"Leung","year":"1989","journal-title":"Science"},{"key":"10.1016\/j.bbr.2022.113866_bib70","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jad.2011.07.021","article-title":"Increased plasma VEGF levels in major depressive or manic episodes in patients with mood disorders","volume":"136","author":"Lee","year":"2012","journal-title":"J. Affect Disord."},{"key":"10.1016\/j.bbr.2022.113866_bib71","doi-asserted-by":"crossref","first-page":"11946","DOI":"10.1073\/pnas.182296499","article-title":"Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo","volume":"99","author":"Jin","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbr.2022.113866_bib72","doi-asserted-by":"crossref","first-page":"468","DOI":"10.3109\/15622975.2011.624549","article-title":"Low plasma vascular endothelial growth factor (VEGF) associated with completed suicide","volume":"13","author":"Isung","year":"2012","journal-title":"World J. Biol. Psychiatry: Off. J. World Fed. Soc. Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2022.113866_bib73","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1126\/science.1083328","article-title":"Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants","volume":"301","author":"Santarelli","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.bbr.2022.113866_bib74","doi-asserted-by":"crossref","first-page":"2395","DOI":"10.1038\/sj.npp.1301041","article-title":"Hippocampal cytogenesis correlates to escitalopram-mediated recovery in a chronic mild stress rat model of depression","volume":"31","author":"Jayatissa","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2022.113866_bib75","doi-asserted-by":"crossref","first-page":"4647","DOI":"10.1073\/pnas.0610282104","article-title":"VEGF is an essential mediator of the neurogenic and behavioral actions of antidepressants","volume":"104","author":"Warner-Schmidt","year":"2007","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bbr.2022.113866_bib76","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/0014-5793(87)80066-2","article-title":"The human insulin-like growth factor II gene contains two development-specific promoters","volume":"214","author":"de Pagter-Holthuizen","year":"1987","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbr.2022.113866_bib77","doi-asserted-by":"crossref","first-page":"1849","DOI":"10.3390\/ijms22041849","article-title":"Insulin-like growth factor 2 as a possible neuroprotective agent and memory enhancer-its comparative expression, processing and signaling in mammalian CNS","volume":"22","author":"Beletskiy","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbr.2022.113866_bib78","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2015.49","article-title":"Genome-wide methylation study on depression: differential methylation and variable methylation in monozygotic twins","volume":"5","author":"C\u00f3rdova-Palomera","year":"2015","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.bbr.2022.113866_bib79","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/1471-2202-13-110","article-title":"The neuronal insulin sensitizer dicholine succinate reduces stress-induced depressive traits and memory deficit: possible role of insulin-like growth factor 2","volume":"13","author":"Cline","year":"2012","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.bbr.2022.113866_bib80","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1186\/1471-2202-14-144","article-title":"Stress susceptibility-specific phenotype associated with different hippocampal transcriptomic responses to chronic tricyclic antidepressant treatment in mice","volume":"14","author":"Lisowski","year":"2013","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.bbr.2022.113866_bib81","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/4651031","article-title":"Combined fluoxetine and metformin treatment potentiates antidepressant efficacy increasing IGF2 expression in the dorsal hippocampus","volume":"2019","author":"Poggini","year":"2019","journal-title":"Neural Plast."},{"key":"10.1016\/j.bbr.2022.113866_bib82","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/0167-0115(93)90332-3","article-title":"Fluoxetine induced insulin-like growth factor II (IGF-II) changes in hypothalami of normal, exercised and food restricted rats","volume":"48","author":"Lauterio","year":"1993","journal-title":"Regul. Pept."},{"key":"10.1016\/j.bbr.2022.113866_bib83","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.neuropharm.2014.10.011","article-title":"Insulin-like growth factor 2 mitigates depressive behavior in a rat model of chronic stress","volume":"89","author":"Luo","year":"2015","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2022.113866_bib84","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12915-017-0352-z","article-title":"The landscape of sex-differential transcriptome and its consequent selection in human adults","volume":"15","author":"Gershoni","year":"2017","journal-title":"BMC Biol."},{"key":"10.1016\/j.bbr.2022.113866_bib85","first-page":"31","article-title":"Sex differences in gene expression and regulatory networks across 29 human tissues","author":"Lopes-Ramos","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbr.2022.113866_bib86","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1038\/nrg2415","article-title":"Sex-specific genetic architecture of human disease","volume":"9","author":"Ober","year":"2008","journal-title":"Nat. Rev. Genet."},{"key":"10.1016\/j.bbr.2022.113866_bib87","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1534\/genetics.110.123729","article-title":"The resolution of sexual antagonism by gene duplication","volume":"187","author":"Connallon","year":"2011","journal-title":"Genetics"},{"key":"10.1016\/j.bbr.2022.113866_bib88","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.neuron.2008.01.025","article-title":"Know your place: neural processing of social hierarchy in humans","volume":"58","author":"Zink","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2022.113866_bib89","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/j.conb.2010.08.006","article-title":"Neural basis of social status hierarchy across species","volume":"20","author":"Chiao","year":"2010","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.bbr.2022.113866_bib90","doi-asserted-by":"crossref","first-page":"936","DOI":"10.14348\/molcells.2015.0233","article-title":"Synapsin isoforms and synaptic vesicle trafficking","volume":"38","author":"Song","year":"2015","journal-title":"Mol. Cells"},{"key":"10.1016\/j.bbr.2022.113866_bib91","doi-asserted-by":"crossref","first-page":"260","DOI":"10.5498\/wjp.v5.i3.260","article-title":"Role of presynaptic phosphoprotein synapsin II in schizophrenia","volume":"5","author":"Molinaro","year":"2015","journal-title":"World J. Psychiatry"},{"key":"10.1016\/j.bbr.2022.113866_bib92","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/npp.2012.186","article-title":"Epigenetic regulation of synapsin genes in mood disorders","volume":"38","author":"Cruceanu","year":"2013","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2022.113866_bib93","first-page":"313","article-title":"Repeated stress induces dendritic spine loss in the rat medial prefrontal cortex","volume":"16","author":"Radley","year":"2006","journal-title":"Cereb. cortex (N. Y., N. Y.: 1991"},{"key":"10.1016\/j.bbr.2022.113866_bib94","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1073\/pnas.0706679105","article-title":"Stress blunts serotonin- and hypocretin-evoked EPSCs in prefrontal cortex: role of corticosterone-mediated apical dendritic atrophy","volume":"105","author":"Liu","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbr.2022.113866_bib95","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1038\/nm.2886","article-title":"Decreased expression of synapse-related genes and loss of synapses in major depressive disorder","volume":"18","author":"Kang","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbr.2022.113866_bib96","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1007\/BF03401726","article-title":"Distinct roles of synapsin I and synapsin II during neuronal development","volume":"4","author":"Ferreira","year":"1998","journal-title":"Mol. Med."},{"key":"10.1016\/j.bbr.2022.113866_bib97","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1126\/science.8178158","article-title":"Aberrant neurites and synaptic vesicle protein deficiency in synapsin II-depleted neurons","volume":"264","author":"Ferreira","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.bbr.2022.113866_bib98","doi-asserted-by":"crossref","first-page":"9225","DOI":"10.1073\/pnas.92.20.9225","article-title":"Suppression of synapsin II inhibits the formation and maintenance of synapses in hippocampal culture","volume":"92","author":"Ferreira","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbr.2022.113866_bib99","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1017\/S1461145712000363","article-title":"H3K4 tri-methylation in synapsin genes leads to different expression patterns in bipolar disorder and major depression","volume":"16","author":"Cruceanu","year":"2013","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.bbr.2022.113866_bib100","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1186\/s12888-016-0989-0","article-title":"DNA hypomethylation of Synapsin II CpG islands associates with increased gene expression in bipolar disorder and major depression","volume":"16","author":"Cruceanu","year":"2016","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.bbr.2022.113866_bib101","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/S0006-3223(01)01176-3","article-title":"Long-term treatment with S-adenosylmethionine induces changes in presynaptic CaM kinase II and synapsin I","volume":"50","author":"Consogno","year":"2001","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2022.113866_bib102","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1007\/s10802-017-0299-0","article-title":"Maternal prenatal stress and other developmental risk factors for adolescent depression: spotlight on sex differences","volume":"46","author":"Maxwell","year":"2018","journal-title":"J. Abnorm. Child Psychol."},{"key":"10.1016\/j.bbr.2022.113866_bib103","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1111\/acps.12996","article-title":"The association between subjective maternal stress during pregnancy and offspring clinically diagnosed psychiatric disorders","volume":"139","author":"Brannigan","year":"2019","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.bbr.2022.113866_bib104","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1080\/17446651.2017.1356222","article-title":"Developmental origins of the human hypothalamic-pituitary-adrenal axis","volume":"12","author":"Howland","year":"2017","journal-title":"Expert Rev. Endocrinol. Metab."},{"key":"10.1016\/j.bbr.2022.113866_bib105","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1017\/S0954579418000056","article-title":"Associations of prenatal depressive symptoms with DNA methylation of HPA axis-related genes and diurnal cortisol profiles in primary school-aged children","volume":"31","author":"Stonawski","year":"2019","journal-title":"Dev. Psychopathol."},{"key":"10.1016\/j.bbr.2022.113866_bib106","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/s41467-017-01077-3","article-title":"DNA methylation and transcriptional trajectories during human development and reprogramming of isogenic pluripotent stem cells","volume":"8","author":"Roost","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbr.2022.113866_bib107","doi-asserted-by":"crossref","first-page":"401","DOI":"10.2217\/epi.15.119","article-title":"DNA methylation dynamics in neurogenesis","volume":"8","author":"Wang","year":"2016","journal-title":"Epigenomics"},{"issue":"Suppl 3","key":"10.1016\/j.bbr.2022.113866_bib108","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1289\/ehp.00108s3511","article-title":"Critical periods of vulnerability for the developing nervous system: evidence from humans and animal models","volume":"108","author":"Rice","year":"2000","journal-title":"Environ. Health Perspect."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432822001346?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432822001346?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T13:33:37Z","timestamp":1759066417000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432822001346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":108,"alternative-id":["S0166432822001346"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2022.113866","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"S-Adenosyl-Methionine alleviates sociability aversion and reduces changes in gene expression in a mouse model of social hierarchy","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2022.113866","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113866"}}