{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T02:55:14Z","timestamp":1783565714965,"version":"3.55.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.bbr.2022.113905","type":"journal-article","created":{"date-parts":[[2022,4,28]],"date-time":"2022-04-28T12:34:22Z","timestamp":1651149262000},"page":"113905","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Myricitrin exhibits antidepressant-like effects and reduces IL-6 hippocampal levels in the chronic mild stress model"],"prefix":"10.1016","volume":"429","author":[{"given":"Marcela","family":"Pereira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isadora P.","family":"Siba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Acco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Correia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda R.","family":"Lapa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adair R.S.","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana P.","family":"Ruani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moacir G.","family":"Pizzolatti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Andreatini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2022.113905_bib1","doi-asserted-by":"crossref","first-page":"16065","DOI":"10.1038\/nrdp.2016.65","article-title":"Major depressive disorder","volume":"2","author":"Otte","year":"2016","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.bbr.2022.113905_bib2","doi-asserted-by":"crossref","first-page":"116","DOI":"10.3390\/ph13060116","article-title":"Pharmacological treatments for patients with treatment-resistant depression","volume":"13","author":"Ruberto","year":"2020","journal-title":"Pharmaceuticals"},{"issue":"1","key":"10.1016\/j.bbr.2022.113905_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/neu.2019.17","article-title":"Inflammation, insulin resistance and neuroprogression in depression","volume":"32","author":"Leonard","year":"2020","journal-title":"Acta Neuropsychiatr."},{"key":"10.1016\/j.bbr.2022.113905_bib4","series-title":"New Oxford Textbook of Psychiatry","first-page":"779","article-title":"Basic mechanisms of and treatment targets for depressive disorders","author":"Pereira","year":"2020"},{"issue":"1","key":"10.1016\/j.bbr.2022.113905_bib5","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1111\/ejn.14720","article-title":"Neuroinflammation and depression: a review","volume":"53","author":"Troubat","year":"2021","journal-title":"Eur. J. Neurosci."},{"issue":"49","key":"10.1016\/j.bbr.2022.113905_bib6","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.bbi.2015.06.001","article-title":"Cumulative meta-analysis of interleukins 6 and 1\u03b2, tumour necrosis factor \u03b1 and C-reactive protein in patients with major depressive disorder","volume":"2015","author":"Haapakoski","year":"2015","journal-title":"Brain Behav. Immun."},{"issue":"2","key":"10.1016\/j.bbr.2022.113905_bib7","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.neubiorev.2011.12.005","article-title":"Mechanistic explanations how cell-mediated immune activation, inflammation and oxidative and nitrosative stress pathways and their sequels and concomitants play a role in the pathophysiology of unipolar depression","volume":"36","author":"Leonard","year":"2012","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"5","key":"10.1016\/j.bbr.2022.113905_bib8","first-page":"4195","article-title":"Peripheral alterations in cytokine and chemokine levels after antidepressant drug treatment for Major Depressive Disorder: systematic review and meta-analysis","volume":"55","author":"K\u00f6hler","year":"2018","journal-title":"Mol. Neurobiol."},{"issue":"2","key":"10.1016\/j.bbr.2022.113905_bib9","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1124\/jpet.105.092825","article-title":"Analysis of the antinociceptive effect of the flavonoid myricitrin: evidence for a role of the L-arginine-nitric oxide and protein kinase C pathways","volume":"316","author":"Meotti","year":"2006","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbr.2022.113905_bib10","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.cbi.2015.01.030","article-title":"Myricitrin exhibits antioxidant, anti-inflammatory and antifibrotic activity in carbon tetrachloride-intoxicated mice","volume":"230","author":"Domitrovi\u0107","year":"2015","journal-title":"Chem. Biol. Interfaces"},{"key":"10.1016\/j.bbr.2022.113905_bib11","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.bbr.2016.08.048","article-title":"Myricitrin induces antidepressant-like effects and facilitates adult neurogenesis in mice","volume":"316","author":"Meyer","year":"2017","journal-title":"Behav. Brain Res."},{"issue":"10","key":"10.1016\/j.bbr.2022.113905_bib12","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1007\/s11064-009-9969-9","article-title":"The flavonoid glycosides, myricitrin, gossypin and naringin exert anxiolytic action in mice","volume":"34","author":"Fernandez","year":"2009","journal-title":"Neurochem. Res."},{"issue":"7","key":"10.1016\/j.bbr.2022.113905_bib13","doi-asserted-by":"crossref","first-page":"1636","DOI":"10.1016\/j.pnpbp.2011.06.002","article-title":"Myricitrin, a nitric oxide and protein kinase C inhibitor, exerts antipsychotic-like effects in animal models","volume":"35","author":"Pereira","year":"2011","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"9","key":"10.1016\/j.bbr.2022.113905_bib14","doi-asserted-by":"crossref","first-page":"2085","DOI":"10.1016\/j.neubiorev.2012.07.001","article-title":"Neurobiology of chronic mild stress: parallels to major depression","volume":"36","author":"Hill","year":"2012","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbr.2022.113905_bib15","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.ynstr.2016.08.002","article-title":"The chronic mild stress (CMS) model of depression: history, evaluation and usage","volume":"6","author":"Willner","year":"2016","journal-title":"Neurobiol. Stress"},{"issue":"11","key":"10.1016\/j.bbr.2022.113905_bib16","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1007\/s00702-019-02084-y","article-title":"Animal models of major depression: drawbacks and challenges","volume":"126","author":"Planchez","year":"2019","journal-title":"J. Neural Transm."},{"issue":"1","key":"10.1016\/j.bbr.2022.113905_bib17","doi-asserted-by":"crossref","first-page":"16579","DOI":"10.1038\/s41598-020-73503-4","article-title":"Improving reproducibility in animal research by splitting the study population into several \u2018mini-experiments\u2019","volume":"10","author":"von Kortzfleisch","year":"2020","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.bbr.2022.113905_bib18","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/BF02246218","article-title":"Attenuation of sucrose consumption in mice by chronic mild stress and its restoration by imipramine","volume":"117","author":"Monleon","year":"1995","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2022.113905_bib19","series-title":"Biostatistical Analysis","first-page":"718","author":"Zar","year":"1984"},{"issue":"5","key":"10.1016\/j.bbr.2022.113905_bib20","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1016\/S0278-5846(01)00333-5","article-title":"Evaluation of the face validity of reserpine administration as an animal model of depression\u2014Parkinson\u2019s disease association","volume":"26","author":"Skalisz","year":"2002","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"2","key":"10.1016\/j.bbr.2022.113905_bib21","first-page":"327","article-title":"Behavioral despair in mice: a primary screening test for antidepressants","volume":"229","author":"Porsolt","year":"1977","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"issue":"3","key":"10.1016\/j.bbr.2022.113905_bib22","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00213-004-2048-7","article-title":"Forced swimming test in mice: a review of antidepressant activity","volume":"177","author":"Petit-Demouliere","year":"2005","journal-title":"Psychopharmacology"},{"issue":"3","key":"10.1016\/j.bbr.2022.113905_bib23","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/BF00428203","article-title":"The tail suspension test: a new method for screening antidepressants in mice","volume":"85","author":"Steru","year":"1985","journal-title":"Psychopharmacology"},{"issue":"4\u20135","key":"10.1016\/j.bbr.2022.113905_bib24","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.neubiorev.2005.03.009","article-title":"The tail suspension test as a model for assessing antidepressant activity: review of pharmacological and genetic studies in mice","volume":"29","author":"Cryan","year":"2005","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbr.2022.113905_bib25","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.bbr.2017.06.032","article-title":"HBK-15 protects mice from stress-induced behavioral disturbances and changes in corticosterone, BDNF, and NGF levels","volume":"333","author":"Pytka","year":"2017","journal-title":"Behav. Brain Res."},{"issue":"5","key":"10.1016\/j.bbr.2022.113905_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001863","article-title":"Distinguishing between exploratory and confirmatory preclinical research will improve translation","volume":"12","author":"Kimmelman","year":"2014","journal-title":"PLoS Biol."},{"issue":"1","key":"10.1016\/j.bbr.2022.113905_bib27","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.bbr.2012.03.020","article-title":"Is unpredictable chronic mild stress (UCMS) a reliable model to study depression-induced neuroinflammation?","volume":"231","author":"Farooq","year":"2012","journal-title":"Behav. Brain Res."},{"issue":"2","key":"10.1016\/j.bbr.2022.113905_bib28","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1002\/ptr.6846","article-title":"The effect of geniposide on chronic unpredictable mild stress-induced depressive mice through BTK\/TLR4\/NF-\u03baB and BDNF\/TrkB signaling pathways","volume":"35","author":"Chen","year":"2021","journal-title":"Phytother. Res."},{"issue":"4","key":"10.1016\/j.bbr.2022.113905_bib29","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1093\/ilar.43.4.244","article-title":"Guidelines for the design and statistical analysis of experiments using laboratory animals","volume":"43","author":"Festing","year":"2002","journal-title":"ILAR J."},{"issue":"4","key":"10.1016\/j.bbr.2022.113905_bib30","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1097\/j.pain.0000000000000458","article-title":"Ensuring transparency and minimization of methodologic bias in preclinical pain research: PPRECISE considerations","volume":"157","author":"Andrews","year":"2016","journal-title":"Pain"},{"issue":"7","key":"10.1016\/j.bbr.2022.113905_bib31","article-title":"Reporting animal research: explanation and elaboration for the ARRIVE guidelines 2.0","volume":"18","author":"Percie du Sert","year":"2020","journal-title":"PLoS Biol."},{"key":"10.1016\/j.bbr.2022.113905_bib32","first-page":"81","article-title":"Blinding and randomization","volume":"257","author":"Bespalov","year":"2019"},{"key":"10.1016\/j.bbr.2022.113905_bib33","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.neubiorev.2016.02.017","article-title":"Mapping inflammation onto mood: Inflammatory mediators of anhedonia","volume":"64","author":"Swardfager","year":"2016","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"6","key":"10.1016\/j.bbr.2022.113905_bib34","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.3390\/ijms21062194","article-title":"Role of interleukin-6 in depressive disorder","volume":"21","author":"Ting","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bbr.2022.113905_bib35","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1006\/brbi.1999.0576","article-title":"Behavioral effects of infection with IL-6 adenovector","volume":"15","author":"Saki\u0107","year":"2001","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbr.2022.113905_bib36","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.brainresbull.2017.08.008","article-title":"Berberine attenuates depressive-like behaviors by suppressing neuro-inflammation in stressed mice","volume":"134","author":"Liu","year":"2017","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.bbr.2022.113905_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2019.577049","article-title":"Myricitrin blocks activation of NF-\u03baB and MAPK signaling pathways to protect nigrostriatum neuron in LPS-stimulated mice","volume":"337","author":"Yang","year":"2019","journal-title":"J. Neuroimmunol."},{"issue":"1","key":"10.1016\/j.bbr.2022.113905_bib38","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1080\/13880209.2019.1702704","article-title":"Progesterone exerts antidepressant-like effect in a mouse model of maternal separation stress through mitigation of neuroinflammatory response and oxidative stress","volume":"58","author":"Nouri","year":"2020","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.bbr.2022.113905_bib39","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.pbb.2015.04.001","article-title":"Antidepressant-like effects of oleoylethanolamide in a mouse model of chronic unpredictable mild stress","volume":"133","author":"Jin","year":"2015","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"1","key":"10.1016\/j.bbr.2022.113905_bib40","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/0034-5288(95)90036-5","article-title":"Effects of acute and chronic restraint on the adrenal gland weight and serum corticosterone concentration of mice and their faecal output of oocysts after infection with Eimeria apionodes","volume":"59","author":"Tuli","year":"1995","journal-title":"Res. Vet. Sci."},{"issue":"3","key":"10.1016\/j.bbr.2022.113905_bib41","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s12020-006-0016-1","article-title":"Interleukin-6 production and deregulation of the hypothalamic-pituitary-adrenal axis in patients with major depressive disorders","volume":"30","author":"Humphreys","year":"2006","journal-title":"Endocrine"},{"key":"10.1016\/j.bbr.2022.113905_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2020.105097","article-title":"Adult neurogenesis augmentation attenuates anhedonia and HPA axis dysregulation in a mouse model of chronic stress and depression","volume":"124","author":"Eliwa","year":"2021","journal-title":"Psychoneuroendocrinology"},{"issue":"12","key":"10.1016\/j.bbr.2022.113905_bib43","doi-asserted-by":"crossref","first-page":"28377","DOI":"10.3390\/ijms161226102","article-title":"Myricetin attenuates depressant-like behavior in mice subjected to repeated restraint stress","volume":"30:6","author":"Ma","year":"2015","journal-title":"Int. J. Mol. Sci."},{"issue":"25\u201326","key":"10.1016\/j.bbr.2022.113905_bib44","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1016\/j.lfs.2012.09.023","article-title":"Effects of fluoxetine, tianeptine and olanzapine on unpredictable chronic mild stress-induced depression-like behavior in mice","volume":"91","author":"Mutlu","year":"2012","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.bbr.2022.113905_bib45","doi-asserted-by":"crossref","first-page":"7566","DOI":"10.1038\/s41598-019-44052-2","article-title":"A comprehensive metabolomics investigation of hippocampus, serum, and feces affected by chronic fluoxetine treatment using the chronic unpredictable mild stress mouse model of depression","volume":"9","author":"Zhao","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbr.2022.113905_bib46","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.bbr.2016.03.049","article-title":"A novel isoquinoline compound abolishes chronic unpredictable mild stress-induced depressive-like behavior in mice","volume":"307","author":"Pesarico","year":"2016","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2022.113905_bib47","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.pnpbp.2014.06.001","article-title":"The antidepressant-like effect of 7-fluoro-1,3-diphenylisoquinoline-1-amine in the mouse forced swimming test is mediated by serotonergic and dopaminergic systems","volume":"54","author":"Pesarico","year":"2014","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432822001735?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432822001735?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T13:32:43Z","timestamp":1759066363000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432822001735"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":47,"alternative-id":["S0166432822001735"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2022.113905","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Myricitrin exhibits antidepressant-like effects and reduces IL-6 hippocampal levels in the chronic mild stress model","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2022.113905","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113905"}}