{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T16:13:41Z","timestamp":1770740021787,"version":"3.49.0"},"reference-count":95,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.bbr.2022.113918","type":"journal-article","created":{"date-parts":[[2022,5,7]],"date-time":"2022-05-07T02:19:03Z","timestamp":1651889943000},"page":"113918","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Prophylactic zinc supplementation modulates hippocampal ionic zinc and partially remediates neurological recovery following repetitive mild head injury in mice"],"prefix":"10.1016","volume":"430","author":[{"given":"C.L.C.","family":"Neely","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.E.","family":"Barkey","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.M.","family":"Hernandez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.M.","family":"Flinn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2022.113918_bib1","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1538\/expanim.60.111","article-title":"Strain and sex differences in anxiety-like and social behaviors in C57BL\/6J and BALB\/cJ mice","volume":"60","author":"An","year":"2011","journal-title":"Exp. Anim."},{"key":"10.1016\/j.bbr.2022.113918_bib2","doi-asserted-by":"crossref","first-page":"351","DOI":"10.3389\/fnagi.2019.00351","article-title":"Regional distributions of iron, copper and zinc and their relationships with glia in a normal aging mouse model","volume":"11","author":"Ashraf","year":"2019","journal-title":"Front. Aging Neurosci."},{"issue":"3","key":"10.1016\/j.bbr.2022.113918_bib3","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/S0163-1047(87)90918-6","article-title":"Hormone state affects recovery from frontal cortex lesions in adult female rats","volume":"48","author":"Attella","year":"1987","journal-title":"Behav. Neural Biol."},{"issue":"3","key":"10.1016\/j.bbr.2022.113918_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0193839","article-title":"Untangling the R2* contrast in multiple sclerosis; a combined MRI-histology study at 7.0 Tesla","volume":"13","author":"Bagnato","year":"2018","journal-title":"PloS ONE"},{"key":"10.1016\/j.bbr.2022.113918_bib5","series-title":"\/Taylor & Francis","article-title":"Anxiety-related behaviors in mice. In J.J. Buccafusco (Ed.), Methods of Behavior Analysis in Neuroscience, 2nd ed","author":"Bailey","year":"2009"},{"issue":"3","key":"10.1016\/j.bbr.2022.113918_bib6","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1089\/neu.2009.1068","article-title":"Sex differences in outcome after mild traumatic brain injury","volume":"27","author":"Bazarian","year":"2010","journal-title":"J. Neurotrauma"},{"issue":"3","key":"10.1016\/j.bbr.2022.113918_bib7","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1093\/jnen\/nlab001","article-title":"The second NINDS\/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy","volume":"80","author":"Bieniek","year":"2021","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"7","key":"10.1016\/j.bbr.2022.113918_bib8","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s00702-010-0420-9","article-title":"Synergistic accumulation of iron and zinc by cultured astrocytes","volume":"117","author":"Bishop","year":"2010","journal-title":"J. Neural Transm."},{"issue":"13","key":"10.1016\/j.bbr.2022.113918_bib9","doi-asserted-by":"crossref","first-page":"2746","DOI":"10.1038\/npp.2009.118","article-title":"Behavioral disinhibition and reduced anxiety-like behaviors in monoamine oxidase B-deficient mice","volume":"34","author":"Bortolato","year":"2009","journal-title":"Neuropsychopharmacology"},{"issue":"2","key":"10.1016\/j.bbr.2022.113918_bib10","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.expneurol.2005.10.020","article-title":"Morris water maze search strategy analysis in PDAPP mice before and after experimental traumatic brain injury","volume":"197","author":"Brody","year":"2006","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbr.2022.113918_bib11","unstructured":"CDC - Centers for Disease Control and Prevention (2021). TBI: Get the Facts | Concussion | Traumatic Brain Injury | CDC Injury Center. Retrieved July 17, 2021, from http:\/\/www.cdc.gov\/traumaticbraininjury\/get_the_facts.html."},{"issue":"10","key":"10.1016\/j.bbr.2022.113918_bib12","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1080\/15216540500264554","article-title":"Zinc deficiency\u2010induced cell death","volume":"57","author":"Clegg","year":"2005","journal-title":"IUBMB Life"},{"issue":"5","key":"10.1016\/j.bbr.2022.113918_bib13","doi-asserted-by":"crossref","first-page":"1484S","DOI":"10.1093\/jn\/130.5.1484S","article-title":"Zinc transport in the brain: routes of zinc influx and efflux in neurons","volume":"130","author":"Colvin","year":"2000","journal-title":"J. Nutr."},{"issue":"7","key":"10.1016\/j.bbr.2022.113918_bib14","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1177\/1545968311435337","article-title":"Use of zinc as a treatment for traumatic brain injury in the rat effects on cognitive and behavioral outcomes","volume":"26","author":"Cope","year":"2012","journal-title":"Neurorehabil. Neural Repair"},{"issue":"5","key":"10.1016\/j.bbr.2022.113918_bib15","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/j.physbeh.2011.06.007","article-title":"Zinc supplementation provides behavioral resiliency in a rat model of traumatic brain injury","volume":"104","author":"Cope","year":"2011","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbr.2022.113918_bib16","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.expneurol.2016.02.017","article-title":"Effect of zinc supplementation on neuronal precursor proliferation in the rat hippocampus after traumatic brain injury","volume":"279","author":"Cope","year":"2016","journal-title":"Exp. Neurol."},{"issue":"3","key":"10.1016\/j.bbr.2022.113918_bib17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0033552","article-title":"The zinc dyshomeostasis hypothesis of Alzheimer\u2019s disease","volume":"7","author":"Craddock","year":"2012","journal-title":"PloS One"},{"issue":"2","key":"10.1016\/j.bbr.2022.113918_bib18","first-page":"1","article-title":"Zinc exacerbates tau pathology in a tau mouse model","volume":"64","author":"Craven","year":"2018","journal-title":"J. Alzheimer\u2019S. Dis."},{"issue":"3","key":"10.1016\/j.bbr.2022.113918_bib19","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1006\/nbdi.1997.0163","article-title":"Zinc metabolism in the brain: relevance to human neurodegenerative disorders","volume":"4","author":"Cuajungco","year":"1997","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbr.2022.113918_bib20","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3389\/fnmol.2012.00006","article-title":"The cytokine temporal profile in rat cortex after controlled cortical impact","volume":"5","author":"Dalgard","year":"2012","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.bbr.2022.113918_bib21","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.brainres.2013.07.014","article-title":"Progesterone\u2019s role in neuroprotection, a review of the evidence","volume":"1530","author":"Deutsch","year":"2013","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.bbr.2022.113918_bib22","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.neuroscience.2007.09.066","article-title":"Changes in the vesicular zinc pattern following traumatic brain injury","volume":"150","author":"Doering","year":"2007","journal-title":"Neuroscience"},{"issue":"4","key":"10.1016\/j.bbr.2022.113918_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0010131","article-title":"Chemical blocking of zinc ions in CNS increases neuronal damage following traumatic brain injury (TBI) in mice","volume":"5","author":"Doering","year":"2010","journal-title":"PloS One"},{"issue":"8","key":"10.1016\/j.bbr.2022.113918_bib24","doi-asserted-by":"crossref","first-page":"1676","DOI":"10.1089\/neu.2016.4636","article-title":"Acute or delayed treatment with anatabine improves spatial memory and reduces pathological sequelae at chronic timepoints after repetitive mild TBI","volume":"34","author":"Ferguson","year":"2017","journal-title":"J. Neurotrauma"},{"issue":"4","key":"10.1016\/j.bbr.2022.113918_bib25","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1016\/S0091-3057(99)00139-2","article-title":"Factor analysis shows that female rat behaviour is characterized primarily by activity, male rats are driven by sex and anxiety","volume":"64","author":"Fernandes","year":"1999","journal-title":"Pharmacol., Biochem. Behav."},{"issue":"5","key":"10.1016\/j.bbr.2022.113918_bib26","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1016\/j.physbeh.2004.10.009","article-title":"Enhanced zinc consumption causes memory deficits and increased brain levels of zinc","volume":"83","author":"Flinn","year":"2005","journal-title":"Physiol. Behav."},{"issue":"2","key":"10.1016\/j.bbr.2022.113918_bib27","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/0165-0270(87)90042-2","article-title":"A quinoline fluorescence method for visualizing and assaying the histochemically reactive zinc (bouton zinc) in the brain","volume":"20","author":"Frederickson","year":"1987","journal-title":"J. Neurosci. Methods"},{"issue":"1","key":"10.1016\/j.bbr.2022.113918_bib28","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jneumeth.2004.04.033","article-title":"Method for identifying neuronal cells suffering zinc toxicity by use of a novel fluorescent sensor","volume":"139","author":"Frederickson","year":"2004","journal-title":"J. Neurosci. Methods"},{"issue":"4","key":"10.1016\/j.bbr.2022.113918_bib29","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1037\/bne0000080","article-title":"Severity of spatial learning impairment in aging: development of a learning index for Performance in the Morris water maze","volume":"129","author":"Gallagher","year":"2015","journal-title":"Behav. Neurosci."},{"issue":"7","key":"10.1016\/j.bbr.2022.113918_bib30","article-title":"Repeated closed head injury in mice results in sustained motor and memory deficits and chronic cellular changes","volume":"11","author":"Hall","year":"2016","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.bbr.2022.113918_bib31","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3233\/JAD-2005-8209","article-title":"Imbalance between pro-oxidant and pro-antioxidant functions of zinc in disease","volume":"8","author":"Hao","year":"2005","journal-title":"J. Alzheimer\u2019S. Dis."},{"key":"10.1016\/j.bbr.2022.113918_bib32","first-page":"S173","article-title":"Neurotransmitter-mediated mechanisms of traumatic brain injury: acetylcholine and excitatory amino acids","volume":"9","author":"Hayes","year":"1992","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.bbr.2022.113918_bib33","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.brainres.2006.09.094","article-title":"Injured Fluoro-Jade-positive hippocampal neurons contain high levels of zinc after traumatic brain injury","volume":"1127","author":"Hellmich","year":"2007","journal-title":"Brain Res."},{"issue":"2","key":"10.1016\/j.bbr.2022.113918_bib34","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.neulet.2008.05.068","article-title":"Chelation of neurotoxic zinc levels does not improve neurobehavioral outcome after traumatic brain injury","volume":"440","author":"Hellmich","year":"2008","journal-title":"Neurosci. Lett."},{"issue":"5","key":"10.1016\/j.bbr.2022.113918_bib35","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s10522-006-9056-4","article-title":"NF-\u03baB, AP-1, Zinc-deficiency and aging","volume":"7","author":"Herbein","year":"2006","journal-title":"Biogerontology"},{"issue":"5","key":"10.1016\/j.bbr.2022.113918_bib36","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1089\/neu.2009.1238","article-title":"Diffuse brain injury elevates tonic glutamate levels and potassium-evoked glutamate release in discrete brain regions at two days post-injury: an enzyme-based microelectrode array study","volume":"27","author":"Hinzman","year":"2010","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.bbr.2022.113918_bib37","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2021.701317","article-title":"Raloxifene modulates microglia and rescues visual deficits and pathology after impact traumatic brain injury","volume":"15","author":"Honig","year":"2021","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.bbr.2022.113918_bib38","unstructured":"Howell, S.N. (2016). A longitudinal investigation into the effect of zinc and copper on spatial learning\/memory and social preference in a mouse model of late-onset Alzheimer\u2019s disease (Doctoral dissertation). Retrieved from Mason Archival Repository Service (MARS)."},{"key":"10.1016\/j.bbr.2022.113918_bib39","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.3389\/fneur.2020.01054","article-title":"Comparing glial fibrillary acidic protein (GFAP) in serum and plasma following mild traumatic brain injury in older adults","volume":"11","author":"Huebschmann","year":"2020","journal-title":"Front. Neurol."},{"key":"10.1016\/j.bbr.2022.113918_bib40","first-page":"341","article-title":"The impact of traumatic brain injuries: a global perspective","volume":"22","author":"Hyder","year":"2007","journal-title":"NeuroRehabilitation"},{"issue":"3","key":"10.1016\/j.bbr.2022.113918_bib41","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1101\/lm.70104","article-title":"Search strategies used by APP transgenic mice during navigation in the Morris water maze","volume":"11","author":"Janus","year":"2004","journal-title":"Learn. Mem."},{"issue":"1","key":"10.1016\/j.bbr.2022.113918_bib42","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jneumeth.2011.09.003","article-title":"A mouse model of human repetitive mild traumatic brain injury","volume":"203","author":"Kane","year":"2012","journal-title":"J. Neurosci. Methods"},{"issue":"17","key":"10.1016\/j.bbr.2022.113918_bib43","doi-asserted-by":"crossref","first-page":"6847","DOI":"10.1523\/JNEUROSCI.23-17-06847.2003","article-title":"Evidence for chelatable zinc in the extracellular space of the hippocampus, but little evidence for synaptic release of Zn","volume":"23","author":"Kay","year":"2003","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.bbr.2022.113918_bib44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/19390211.2017.1304486","article-title":"Impact of zinc supplementation on the clinical outcomes of patients with severe head trauma: a double-blind randomized clinical trial","volume":"15","author":"Khazdouz","year":"2017","journal-title":"J. Diet. Suppl."},{"issue":"5264","key":"10.1016\/j.bbr.2022.113918_bib45","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1126\/science.272.5264.1013","article-title":"The role of zinc in selective neuronal death after transient global cerebral ischemia","volume":"272","author":"Koh","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.bbr.2022.113918_bib46","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1258\/0023677041958945","article-title":"Experimental animal urine collection: a review","volume":"38","author":"Kurien","year":"2004","journal-title":"Lab. Anim."},{"key":"10.1016\/j.bbr.2022.113918_bib47","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.brainres.2010.03.034","article-title":"The relationship between transient zinc ion fluctuations and redox signaling in the pathways of secondary cellular injury: relevance to traumatic brain injury","volume":"1330","author":"Li","year":"2010","journal-title":"Brain Res."},{"issue":"7638","key":"10.1016\/j.bbr.2022.113918_bib48","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1038\/nature21029","article-title":"Neurotoxic reactive astrocytes are induced by activated microglia","volume":"541","author":"Liddelow","year":"2017","journal-title":"Nature"},{"key":"10.1016\/j.bbr.2022.113918_bib49","article-title":"Wheel-running behavior Is negatively impacted by zinc administration in a novel dual transgenic mouse model of AD","volume":"854","author":"Lippi","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.bbr.2022.113918_bib50","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.jneumeth.2018.12.018","article-title":"Perfusion alters free zinc levels in the rodent brain","volume":"315","author":"Lippi","year":"2019","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.bbr.2022.113918_bib51","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0163-7258(90)90021-S","article-title":"Ethologically-based animal models of anxiety disorders","volume":"46","author":"Lister","year":"1990","journal-title":"Pharmacol. Ther."},{"issue":"2","key":"10.1016\/j.bbr.2022.113918_bib52","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1227\/01.NEU.0000149008.73513.44","article-title":"Temporal window of vulnerability to repetitive experimental concussive brain injury","volume":"56","author":"Longhi","year":"2005","journal-title":"Neurosurgery"},{"key":"10.1016\/j.bbr.2022.113918_bib53","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1089\/neu.2020.6989","article-title":"Assessment of the effects of altered amyloid-beta clearance on behavior following repeat closed-head brain injury in amyloid-beta precursor protein humanized mice","volume":"38","author":"Maigler","year":"2021","journal-title":"J. Neurotrauma"},{"issue":"1","key":"10.1016\/j.bbr.2022.113918_bib54","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0197-0186(94)00173-R","article-title":"Metallothionein\/disulfide interactions, oxidative stress, and the mobilization of cellular zinc","volume":"27","author":"Maret","year":"1995","journal-title":"Neurochem. Int."},{"issue":"2","key":"10.1016\/j.bbr.2022.113918_bib55","doi-asserted-by":"crossref","first-page":"224","DOI":"10.3171\/jns.1986.64.2.0224","article-title":"Serum and urine zinc response in head-injured patients","volume":"64","author":"McClain","year":"1986","journal-title":"J. Neurosurg."},{"issue":"7","key":"10.1016\/j.bbr.2022.113918_bib56","doi-asserted-by":"crossref","DOI":"10.1177\/2325967120932306","article-title":"Sport-related concussion in female athletes: a systematic review","volume":"8","author":"McGroarty","year":"2020","journal-title":"Orthop. J. Sports Med."},{"issue":"3","key":"10.1016\/j.bbr.2022.113918_bib57","first-page":"S242","article-title":"Military-related traumatic brain injury and neurodegeneration","volume":"10","author":"McKee","year":"2014","journal-title":"Alzheimer\u2019S. Dement."},{"issue":"7","key":"10.1016\/j.bbr.2022.113918_bib58","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1097\/NEN.0b013e3181a9d503","article-title":"Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury","volume":"68","author":"McKee","year":"2009","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"4","key":"10.1016\/j.bbr.2022.113918_bib59","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1001\/jama.2017.8334","article-title":"Clinicopathological evaluation of chronic traumatic encephalopathy in players of American football","volume":"318","author":"Mez","year":"2017","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.bbr.2022.113918_bib60","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1096\/fj.201600781r","article-title":"Considering sex as a biological variable in preclinical research","volume":"31","author":"Miller","year":"2017","journal-title":"FASEB J."},{"issue":"6","key":"10.1016\/j.bbr.2022.113918_bib61","first-page":"708","article-title":"Zinc in traumatic brain injury: from neuroprotection to neurotoxicity","volume":"16","author":"Morris","year":"2012","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"issue":"18","key":"10.1016\/j.bbr.2022.113918_bib62","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1089\/neu.2012.2498","article-title":"Repetitive mild traumatic brain injury in a mouse model produces learning and memory deficits accompanied by histological changes","volume":"29","author":"Mouzon","year":"2012","journal-title":"J. Neurotrauma"},{"issue":"2","key":"10.1016\/j.bbr.2022.113918_bib63","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/ana.24064","article-title":"Chronic neuropathological and neurobehavioral changes in a repetitive mild traumatic brain injury model","volume":"75","author":"Mouzon","year":"2014","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbr.2022.113918_bib64","first-page":"2018","article-title":"The effect of gentle handling on depressive-like behavior in adult male mice: Considerations for human and rodent interactions in the laboratory","author":"Neely","year":"2018","journal-title":"Behav. Neurol."},{"key":"10.1016\/j.bbr.2022.113918_bib65","article-title":"Nest building behavior as an early indicator of behavioral deficits in mice","volume":"152","author":"Neely","year":"2019","journal-title":"JoVE"},{"issue":"4","key":"10.1016\/j.bbr.2022.113918_bib66","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3390\/brainsci9040074","article-title":"Localization of free and bound metal species through X-Ray synchrotron fluorescence microscopy in the rodent brain and their relation to behavior","volume":"9","author":"Neely","year":"2019","journal-title":"Brain Sci."},{"key":"10.1016\/j.bbr.2022.113918_bib67","unstructured":"Neely, C.L.C. (2015). The effect of dietary copper and zinc on fear extinction and motor coordination (Master\u2019s thesis). Retrieved from Mason Archival Repository Service (MARS)."},{"issue":"7","key":"10.1016\/j.bbr.2022.113918_bib68","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1089\/jwh.2013.4535","article-title":"Gender differences in awareness and outcomes during acute traumatic brain injury recovery","volume":"23","author":"Niemeier","year":"2014","journal-title":"J. Women\u2019S. Health"},{"key":"10.1016\/j.bbr.2022.113918_bib69","unstructured":"NINDS \u2013 National Institute of Neurological Disorders and Stroke. (2019). Traumatic Brain Injury Information Page: National Institute of Neurological Disorders and Stroke (NINDS). Retrieved February 02, 2021, from https:\/\/www.ninds.nih.gov\/Disorders\/All-Disorders\/Traumatic-Brain-Injury-Information-Page."},{"key":"10.1016\/j.bbr.2022.113918_bib70","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/glia.20065","article-title":"ZnT-1 expression in astroglial cells protects against zinc toxicity and slows the accumulation of intracellular zinc","volume":"48","author":"Nolte","year":"2004","journal-title":"Glia"},{"issue":"2","key":"10.1016\/j.bbr.2022.113918_bib71","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.bbr.2004.05.028","article-title":"Aspects of spatial memory and behavioral disinhibition in Tg2576 transgenic mice as a model of Alzheimer\u2019s disease","volume":"156","author":"Ognibene","year":"2005","journal-title":"Behav. Brain Res."},{"issue":"23","key":"10.1016\/j.bbr.2022.113918_bib72","doi-asserted-by":"crossref","first-page":"1861","DOI":"10.1089\/neu.2014.3680","article-title":"Chronic histopathological and behavioral outcomes of experimental traumatic brain injury in adult male animals","volume":"32","author":"Osier","year":"2015","journal-title":"J. Neurotrauma"},{"issue":"2161","key":"10.1016\/j.bbr.2022.113918_bib73","first-page":"0495","article-title":"Copper and zinc, biological role and significance of copper\/zinc imbalance","volume":"3","author":"Osredkar","year":"2011","journal-title":"J. Clin. Toxicol. S"},{"issue":"9","key":"10.1016\/j.bbr.2022.113918_bib74","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1089\/neu.2012.2650","article-title":"Inflammatory consequences in a rodent model of mild traumatic brain injury","volume":"30","author":"Perez-Polo","year":"2013","journal-title":"J. Neurotrauma"},{"issue":"2","key":"10.1016\/j.bbr.2022.113918_bib75","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1039\/C5MT00234F","article-title":"A time-course analysis of changes in cerebral metal levels following a controlled cortical impact","volume":"8","author":"Portbury","year":"2016","journal-title":"Metallomics"},{"issue":"2","key":"10.1016\/j.bbr.2022.113918_bib76","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.physbeh.2010.01.040","article-title":"Alterations in fear response and spatial memory in pre-and post-natal zinc supplemented rats: Remediation by copper","volume":"100","author":"Railey","year":"2010","journal-title":"Physiol. Behav."},{"issue":"6","key":"10.1016\/j.bbr.2022.113918_bib77","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1111\/joim.12909","article-title":"Modelling human pathology of traumatic brain injury in animal models","volume":"285","author":"Risling","year":"2019","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.bbr.2022.113918_bib78","doi-asserted-by":"crossref","DOI":"10.1177\/1179069519844020","article-title":"Sex differences in animal models of traumatic brain injury","volume":"13","author":"Rubin","year":"2019","journal-title":"J. Exp. Neurosci."},{"key":"10.1016\/j.bbr.2022.113918_bib79","first-page":"291","article-title":"Quantification of histochemical staining by color deconvolution","volume":"23","author":"Ruifrok","year":"2001","journal-title":"Anal. Quant. Cytol. Histol."},{"issue":"11","key":"10.1016\/j.bbr.2022.113918_bib80","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/nrn2734","article-title":"Zinc in the physiology and pathology of the CNS","volume":"10","author":"Sensi","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbr.2022.113918_bib81","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/s41582-018-0114-8","article-title":"Chronic traumatic encephalopathy \u2013 confusion and controversies","volume":"15","author":"Smith","year":"2019","journal-title":"Nat. Rev. Neurol."},{"issue":"1","key":"10.1016\/j.bbr.2022.113918_bib82","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1007\/s00401-009-0619-8","article-title":"Astrocytes: Biology and pathology","volume":"119","author":"Sofroniew","year":"2010","journal-title":"Acta Neuropathol."},{"issue":"3","key":"10.1016\/j.bbr.2022.113918_bib83","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S1474-4422(19)30020-1","article-title":"Primum non nocere: a call for balance when reporting on CTE","volume":"18","author":"Stewart","year":"2019","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.bbr.2022.113918_bib84","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.drugalcdep.2013.12.023","article-title":"Behavioral disinhibition in mice bred for high drinking in the dark (HDID) and HS controls increases following ethanol","volume":"136","author":"Tipps","year":"2014","journal-title":"Drug Alcohol Depend."},{"issue":"9","key":"10.1016\/j.bbr.2022.113918_bib85","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1002\/glia.23171","article-title":"Sexual dimorphism in the inflammatory response to traumatic brain injury","volume":"65","author":"Villapol","year":"2017","journal-title":"Glia"},{"issue":"13","key":"10.1016\/j.bbr.2022.113918_bib86","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1089\/neu.2012.2456","article-title":"The effect of injury severity on behavior: A phenotypic study of cognitive and emotional deficits after mild, moderate, and severe controlled cortical impact injury in mice","volume":"29","author":"Washington","year":"2012","journal-title":"J. Neurotrauma"},{"issue":"1","key":"10.1016\/j.bbr.2022.113918_bib87","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/bja\/aem131","article-title":"Pathophysiology of traumatic brain injury","volume":"99","author":"Werner","year":"2007","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.bbr.2022.113918_bib88","series-title":"Ggplot2: Elegant graphics for data analysis","author":"Wickham","year":"2009"},{"key":"10.1016\/j.bbr.2022.113918_bib89","doi-asserted-by":"crossref","first-page":"18","DOI":"10.3389\/fneur.2013.00018","article-title":"The role of markers of inflammation in traumatic brain injury","volume":"4","author":"Woodcock","year":"2013","journal-title":"Front. Neurol."},{"issue":"26","key":"10.1016\/j.bbr.2022.113918_bib90","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1056\/NEJMoa1404304","article-title":"Very early administration of progesterone for acute traumatic brain injury","volume":"371","author":"Wright","year":"2014","journal-title":"N. Engl. J. Med."},{"issue":"1","key":"10.1016\/j.bbr.2022.113918_bib91","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0055384","article-title":"High dose zinc supplementation induces hippocampal zinc deficiency and memory impairment with inhibition of BDNF signaling","volume":"8","author":"Yang","year":"2013","journal-title":"PloS One"},{"issue":"5","key":"10.1016\/j.bbr.2022.113918_bib92","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1080\/1028415021000033811","article-title":"Moderate zinc deficiency increases cell death after brain injury in the rat","volume":"5","author":"Yeiser","year":"2002","journal-title":"Nutr. Neurosci."},{"issue":"1","key":"10.1016\/j.bbr.2022.113918_bib93","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1089\/neu.1996.13.25","article-title":"Zinc supplementation is associated with improved neurologic recovery rate and visceral protein levels of patients with severe closed head injury","volume":"13","author":"Young","year":"1996","journal-title":"J. Neurotrauma"},{"issue":"10","key":"10.1016\/j.bbr.2022.113918_bib94","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1016\/S1474-4422(19)30282-0","article-title":"Association between plasma GFAP concentrations and MRI abnormalities in patients with CT-negative traumatic brain injury in the TRACK-TBI cohort: a prospective multicentre study","volume":"18","author":"Yue","year":"2019","journal-title":"Lancet Neurol."},{"issue":"4","key":"10.1016\/j.bbr.2022.113918_bib95","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/nrneurol.2013.9","article-title":"Biomarkers of mild traumatic brain injury in cerebrospinal fluid and blood","volume":"9","author":"Zetterberg","year":"2013","journal-title":"Nat. Rev. Neurol."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432822001863?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432822001863?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T13:32:21Z","timestamp":1759066341000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432822001863"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":95,"alternative-id":["S0166432822001863"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2022.113918","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prophylactic zinc supplementation modulates hippocampal ionic zinc and partially remediates neurological recovery following repetitive mild head injury in mice","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2022.113918","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113918"}}