{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T19:35:56Z","timestamp":1781033756888,"version":"3.54.1"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100006087","name":"National Autonomous University of Mexico Directorate General of Academic Staff Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006087","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["CVU-998761"],"award-info":[{"award-number":["CVU-998761"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005739","name":"Universidad Nacional Aut\u00f3noma de M\u00e9xico","doi-asserted-by":"publisher","award":["IN205622"],"award-info":[{"award-number":["IN205622"]}],"id":[{"id":"10.13039\/501100005739","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.bbr.2022.113947","type":"journal-article","created":{"date-parts":[[2022,5,26]],"date-time":"2022-05-26T11:54:21Z","timestamp":1653566061000},"page":"113947","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Environmental enrichment attenuates conditioned taste aversion through the restoration of BDNF levels in the insular cortex"],"prefix":"10.1016","volume":"430","author":[{"given":"Beatriz","family":"Guti\u00e9rrez-Vera","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Rivera-Olvera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha L.","family":"Escobar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.bbr.2022.113947_bib1","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1038\/nrn1970","article-title":"Enriched environments, experience-dependent plasticity and disorders of the nervous system","volume":"7","author":"Nithianantharajah","year":"2006","journal-title":"Nat. Rev. Neurosci."},{"issue":"5","key":"10.1016\/j.bbr.2022.113947_bib2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0064460","article-title":"Molecular mechanisms of environmental enrichment: impairments in Akt\/GSK3beta, neurotrophin-3 and CREB signaling","volume":"8","author":"Hu","year":"2013","journal-title":"PLoS One"},{"issue":"Pt A","key":"10.1016\/j.bbr.2022.113947_bib3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.neuropharm.2018.04.007","article-title":"Environmental enrichment effects on synaptic and cellular physiology of hippocampal neurons","volume":"145","author":"Ohline","year":"2019","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2022.113947_bib4","doi-asserted-by":"crossref","first-page":"51","DOI":"10.3389\/fnbeh.2018.00051","article-title":"Environmental enrichment expedites acquisition and improves flexibility on a temporal sequencing task in mice","volume":"12","author":"Rountree-Harrison","year":"2018","journal-title":"Front. Behav. Neurosci."},{"issue":"1","key":"10.1016\/j.bbr.2022.113947_bib5","doi-asserted-by":"crossref","first-page":"3422","DOI":"10.1038\/s41598-019-39467-w","article-title":"Enriched environment alleviates stress-induced dry-eye through the BDNF axis","volume":"9","author":"Sano","year":"2019","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.bbr.2022.113947_bib6","doi-asserted-by":"crossref","first-page":"2711","DOI":"10.1073\/pnas.0711863105","article-title":"BDNF is essential to promote persistence of long-term memory storage","volume":"105","author":"Bekinschtein","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbr.2022.113947_bib7","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.pnpbp.2017.02.025","article-title":"Environmental enrichment ameliorates chronic immobilisation stress-induced spatial learning deficits and restores the expression of BDNF, VEGF, GFAP and glucocorticoid receptors","volume":"76","author":"Shilpa","year":"2017","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"2","key":"10.1016\/j.bbr.2022.113947_bib8","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/hipo.20775","article-title":"Hippocampal epigenetic modification at the brain-derived neurotrophic factor gene induced by an enriched environment","volume":"21","author":"Kuzumaki","year":"2011","journal-title":"Hippocampus"},{"key":"10.1016\/j.bbr.2022.113947_bib9","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.neubiorev.2014.11.017","article-title":"Inoculation stress hypothesis of environmental enrichment","volume":"49","author":"Crofton","year":"2015","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"1","key":"10.1016\/j.bbr.2022.113947_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2006.08.016","article-title":"Therapeutic and protective effect of environmental enrichment against psychogenic and neurogenic stress","volume":"175","author":"Fox","year":"2006","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2022.113947_bib11","doi-asserted-by":"crossref","first-page":"97","DOI":"10.3389\/fncel.2014.00097","article-title":"Cellular and molecular mechanisms of immunomodulation in the brain through environmental enrichment","volume":"8","author":"Singhal","year":"2014","journal-title":"Front. Cell Neurosci."},{"issue":"2","key":"10.1016\/j.bbr.2022.113947_bib12","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/S0091-3057(97)00370-5","article-title":"The influence of postweaning housing conditions on drug-induced conditioned taste aversion","volume":"59","author":"Smith","year":"1998","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"2","key":"10.1016\/j.bbr.2022.113947_bib13","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.bbr.2006.01.012","article-title":"Environmental enrichment increases responding to contextual cues but decreases overall conditioned fear in the rat","volume":"169","author":"Barbelivien","year":"2006","journal-title":"Behav. Brain Res."},{"issue":"1","key":"10.1016\/j.bbr.2022.113947_bib14","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.bbr.2011.09.021","article-title":"Environmental enrichment reduces attribution of incentive salience to a food-associated stimulus","volume":"226","author":"Beckmann","year":"2012","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2022.113947_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2020.112806","article-title":"Short-term but not long-term exposure to an enriched environment facilitates the extinction of aversive memory","volume":"393","author":"Cavalcante","year":"2020","journal-title":"Behav. Brain. Res."},{"key":"10.1016\/j.bbr.2022.113947_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2015.09.034","article-title":"Brain-derived neurotrophic factor into adult neocortex strengthens a taste aversion memory","volume":"297","author":"Mart\u00ednez-Moreno","year":"2016","journal-title":"Behav. Brain Res."},{"issue":"4","key":"10.1016\/j.bbr.2022.113947_bib17","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/S0091-6773(76)91555-8","article-title":"Plasma corticosterone levels during recovery from LiCl produced taste aversions","volume":"16","author":"Smotherman","year":"1976","journal-title":"Behav. Biol."},{"issue":"11","key":"10.1016\/j.bbr.2022.113947_bib18","doi-asserted-by":"crossref","first-page":"4048","DOI":"10.1093\/cercor\/bhu119","article-title":"Environmental enrichment duration differentially affects behavior and neuroplasticity in adult mice","volume":"25","author":"Leger","year":"2015","journal-title":"Cereb. Cortex"},{"key":"10.1016\/j.bbr.2022.113947_bib19","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.nlm.2016.01.014","article-title":"Conditioned taste aversion prevents the long-lasting BDNF-induced enhancement of synaptic transmission in the insular cortex: a metaplastic effect","volume":"130","author":"Rivera-Olvera","year":"2016","journal-title":"Neurobiol. Learn Mem."},{"key":"10.1016\/j.bbr.2022.113947_bib20","doi-asserted-by":"crossref","DOI":"10.1016\/j.nlm.2021.107449","article-title":"Metaplastic regulation of neocortical long-term depression in vivo is sensitive to distinct phases of conditioned taste aversion","volume":"182","author":"Urrieta","year":"2021","journal-title":"Neurobiol. Learn Mem."},{"key":"10.1016\/j.bbr.2022.113947_bib21","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.psyneuen.2016.04.009","article-title":"Short-term environmental enrichment is sufficient to counter stress-induced anxiety and associated structural and molecular plasticity in basolateral amygdala","volume":"69","author":"Ashokan","year":"2016","journal-title":"Psychoneuroendocrinology"},{"issue":"1","key":"10.1016\/j.bbr.2022.113947_bib22","doi-asserted-by":"crossref","first-page":"14053","DOI":"10.1038\/s41598-020-70875-5","article-title":"Early-life short-term environmental enrichment counteracts the effects of stress on anxiety-like behavior, brain-derived neurotrophic factor and nuclear translocation of glucocorticoid receptors in the basolateral amygdala","volume":"10","author":"Hegde","year":"2020","journal-title":"Sci. Rep."},{"issue":"16","key":"10.1016\/j.bbr.2022.113947_bib23","doi-asserted-by":"crossref","first-page":"6159","DOI":"10.1523\/JNEUROSCI.0577-11.2011","article-title":"Environmental enrichment confers stress resiliency to social defeat through an infralimbic cortex-dependent neuroanatomical pathway","volume":"31","author":"Lehmann","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2022.113947_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2020.172993","article-title":"Differential impact of stress and environmental enrichment on corticolimbic circuits","volume":"197","author":"Smail","year":"2020","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"1","key":"10.1016\/j.bbr.2022.113947_bib25","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0091-3057(02)00782-7","article-title":"Psychological stress and environmental adaptation in enriched vs. impoverished housed rats","volume":"73","author":"Larsson","year":"2002","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.bbr.2022.113947_bib26","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.ijdevneu.2018.03.003","article-title":"Beneficial effects of environmental enrichment on behavior, stress reactivity and synaptophysin\/BDNF expression in hippocampus following early life stress","volume":"67","author":"Dandi","year":"2018","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.bbr.2022.113947_bib27","first-page":"1","article-title":"Combined effects of royal jelly and environmental enrichment against stress-induced cognitive and behavioral alterations in male rats: behavioral and molecular studies","author":"Ghorbanpour","year":"2021","journal-title":"Nutr. Neurosci."},{"issue":"3","key":"10.1016\/j.bbr.2022.113947_bib28","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.nbd.2008.11.004","article-title":"Brain-derived neurotrophic factor (BDNF) overexpression in the forebrain results in learning and memory impairments","volume":"33","author":"Cunha","year":"2009","journal-title":"Neurobiol. Dis."},{"issue":"3","key":"10.1016\/j.bbr.2022.113947_bib29","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1038\/nn.2505","article-title":"Acute and gradual increases in BDNF concentration elicit distinct signaling and functions in neurons","volume":"13","author":"Ji","year":"2010","journal-title":"Nat. Neurosci."},{"issue":"11","key":"10.1016\/j.bbr.2022.113947_bib30","article-title":"Differential involvement of brain-derived neurotrophic factor in reconsolidation and consolidation of conditioned taste aversion memory","volume":"7","author":"Wang","year":"2012","journal-title":"PLoS One"},{"issue":"7","key":"10.1016\/j.bbr.2022.113947_bib31","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1002\/dneu.22592","article-title":"Differential effects of transient and sustained activation of BDNF-TrkB signaling","volume":"78","author":"Guo","year":"2018","journal-title":"Dev. Neurobiol."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432822002157?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432822002157?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T13:33:45Z","timestamp":1759066425000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432822002157"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":31,"alternative-id":["S0166432822002157"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2022.113947","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Environmental enrichment attenuates conditioned taste aversion through the restoration of BDNF levels in the insular cortex","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2022.113947","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"113947"}}