{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T14:10:07Z","timestamp":1759068607561,"version":"3.44.0"},"reference-count":87,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2022,9]]},"DOI":"10.1016\/j.bbr.2022.114031","type":"journal-article","created":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T01:47:10Z","timestamp":1658972830000},"page":"114031","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Neonatal maternal deprivation facilitates the expression of a panic-like escape behavior in adult rats"],"prefix":"10.1016","volume":"434","author":[{"given":"Daiane Santos","family":"Rosa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alana Tercino","family":"Frias","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helo\u00edsa Helena","family":"Vilela-Costa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ailton","family":"Spiacci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Beatriz","family":"Sant\u2019Ana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo Junji","family":"Fusse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah","family":"Suchecki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alline Cristina","family":"Campos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thelma Anderson","family":"Lovick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"suffix":"Jr","given":"H\u00e9lio","family":"Zangrossi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2022.114031_bib1","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2020-1651","article-title":"Genes, environments, and time: the biology of adversity and resilience","volume":"147","author":"Boyce","year":"2021","journal-title":"Pediatrics"},{"key":"10.1016\/j.bbr.2022.114031_bib2","article-title":"Epigenetic basis of psychiatric disorders: a narrative review","volume":"20","author":"Panariello","year":"2021","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.bbr.2022.114031_bib3","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1176\/appi.ajp.2013.12070957","article-title":"Childhood maltreatment and psychopathology: a case for ecophenotypic variants as clinically and neurobiologically distinct subtypes","volume":"170","author":"Teicher","year":"2013","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.bbr.2022.114031_bib4","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.jad.2017.08.050","article-title":"Assessing the interplay of childhood adversities with more recent stressful life events and conditions in predicting panic pathology among adults from the general population","volume":"225","author":"Asselmann","year":"2018","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.bbr.2022.114031_bib5","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1001\/archgenpsychiatry.2008.513","article-title":"A genetically informed study of the association between childhood separation anxiety, sensitivity to CO2, panic disorder, and the effect of childhood parental loss","volume":"66","author":"Battaglia","year":"2009","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.bbr.2022.114031_bib6","doi-asserted-by":"crossref","first-page":"277","DOI":"10.31887\/DCNS.2015.17.3\/mbattaglia","article-title":"Separation anxiety: at the neurobiological crossroads of adaptation and illness","volume":"17","author":"Battaglia","year":"2015","journal-title":"Dialog. Clin. Neurosci."},{"key":"10.1016\/j.bbr.2022.114031_bib7","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.psychres.2009.03.008","article-title":"Examining the unique relationships between anxiety disorders and childhood physical and sexual abuse in the National Comorbidity Survey-Replication","volume":"177","author":"Cougle","year":"2010","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.bbr.2022.114031_bib8","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1001\/archpsyc.1992.01820020029004","article-title":"Childhood parental loss and adult psychopathology in women. A twin study perspective","volume":"49","author":"Kendler","year":"1992","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.bbr.2022.114031_bib9","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1176\/appi.ajp.2012.12070893","article-title":"The separation anxiety hypothesis of panic disorder revisited: a meta-analysis","volume":"170","author":"Kossowsky","year":"2013","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.bbr.2022.114031_bib10","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1002\/jts.21719","article-title":"Child physical abuse and adult mental health: a national study","volume":"25","author":"Sugaya","year":"2012","journal-title":"J. Trauma. Stress"},{"key":"10.1016\/j.bbr.2022.114031_bib11","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1196\/annals.1364.024","article-title":"Neurobiological consequences of early stress and childhood maltreatment: are results from human and animal studies comparable","author":"Teicher","year":"2006","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bbr.2022.114031_bib12","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.neubiorev.2015.01.015","article-title":"The maternal deprivation animal model revisited","volume":"51","author":"Marco","year":"2015","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbr.2022.114031_bib13","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/j.neuropharm.2011.09.011","article-title":"Stress during development alters anxiety-like behavior and hippocampal neurotransmission in male and female rats","volume":"62","author":"Barbosa Neto","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2022.114031_bib14","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.neubiorev.2008.09.001","article-title":"Early life stress as a risk factor for mental health: role of neurotrophins from rodents to non-human primates","volume":"33","author":"Cirulli","year":"2009","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbr.2022.114031_bib15","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.neubiorev.2009.09.002","article-title":"Disruptions of the mother-infant relationship and stress-related behaviours: altered corticosterone secretion does not explain everything","volume":"34","author":"Faturi","year":"2010","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbr.2022.114031_bib16","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1515\/REVNEURO.2000.11.4.383","article-title":"Long-term biobehavioral effects of maternal separation in the rat: consistent or confusing?","volume":"11","author":"Lehmann","year":"2000","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.bbr.2022.114031_bib17","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1111\/j.1369-1600.2011.00318.x","article-title":"Sex-dependent effects of maternal deprivation and adolescent cannabinoid treatment on adult rat behaviour","volume":"16","author":"Llorente-Berzal","year":"2011","journal-title":"Addict. Biol."},{"key":"10.1016\/j.bbr.2022.114031_bib18","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.neuroscience.2011.11.038","article-title":"Gender-dependent behavioral and biochemical effects of adolescent delta-9-tetrahydrocannabinol in adult maternally deprived rats","volume":"204","author":"Zamberletti","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2022.114031_bib19","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.neulet.2010.04.054","article-title":"Long-term consequences of early maternal deprivation in serotonergic activity and HPA function in adult rat","volume":"480","author":"Rentesi","year":"2010","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbr.2022.114031_bib20","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/0149-7634(83)90014-3","article-title":"Comparison between the behavioural effects of septal and hippocampal lesions: a review","volume":"7","author":"Gray","year":"1983","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbr.2022.114031_bib21","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.neubiorev.2004.03.005","article-title":"A two-dimensional neuropsychology of defense: fear\/anxiety and defensive distance","volume":"28","author":"McNaughton","year":"2004","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbr.2022.114031_bib22","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/s00441-013-1610-1","article-title":"Modeling panic disorder in rodents","volume":"354","author":"Moreira","year":"2013","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.bbr.2022.114031_bib23","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/S0149-7634(01)00060-4","article-title":"Modeling panic attacks","volume":"25","author":"Schenberg","year":"2001","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"Pt. 3","key":"10.1016\/j.bbr.2022.114031_bib24","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.neubiorev.2014.03.007","article-title":"Serotonin in anxiety and panic: contributions of the elevated T-maze","volume":"46","author":"Zangrossi","year":"2014","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbr.2022.114031_bib25","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.neuroscience.2015.08.045","article-title":"Serotonin in the dorsal periaqueductal gray inhibits panic-like defensive behaviors in rats exposed to acute hypoxia","volume":"307","author":"Spiacci","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2022.114031_bib26","doi-asserted-by":"crossref","first-page":"29","DOI":"10.31887\/DCNS.2014.16.1\/adayer","article-title":"Serotonin-related pathways and developmental plasticity: relevance for psychiatric disorders","volume":"16","author":"Dayer","year":"2014","journal-title":"Dialog. Clin. Neurosci."},{"key":"10.1016\/j.bbr.2022.114031_bib27","doi-asserted-by":"crossref","first-page":"117","DOI":"10.3389\/fncel.2017.00117","article-title":"The serotonin transporter and early life stress: translational perspectives","volume":"11","author":"Houwing","year":"2017","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.bbr.2022.114031_bib28","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.physbeh.2017.11.004","article-title":"An early experience of mild adversity involving temporary denial of maternal contact affects the serotonergic system of adult male rats and leads to a depressive-like phenotype and inability to adapt to a chronic social stress","volume":"184","author":"Diamantopoulou","year":"2018","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbr.2022.114031_bib29","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1177\/026988119100500414","article-title":"5-HT and mechanisms of defence","volume":"5","author":"Deakin","year":"1991","journal-title":"J. Psychopharmacol."},{"issue":"2009","key":"10.1016\/j.bbr.2022.114031_bib30","article-title":"Panic disorder: is the PAG involved?","author":"Dell-Ben","year":"2009","journal-title":"Neural Plast."},{"key":"10.1016\/j.bbr.2022.114031_bib31","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1177\/0269881113492900","article-title":"5-HT1A and 5-HT2A receptor control of a panic-like defensive response in the rat dorsomedial hypothalamic nucleus","volume":"27","author":"De Bortoli","year":"2013","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.bbr.2022.114031_bib32","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1177\/0269881113490328","article-title":"Functional topography of serotonergic systems supports the Deakin\/Graeff hypothesis of anxiety and affective disorders","volume":"27","author":"Paul","year":"2013","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.bbr.2022.114031_bib33","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0091-3057(94)00402-5","article-title":"Role of 5-HT receptor subtypes in the modulation of dorsal periaqueductal gray generated aversion","volume":"52","author":"Nogueira","year":"1995","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.bbr.2022.114031_bib34","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/S0014-2999(03)01970-8","article-title":"Serotonin in the dorsal periaqueductal gray modulates inhibitory avoidance and one-way escape behaviors in the elevated T-maze","volume":"473","author":"Zanoveli","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbr.2022.114031_bib35","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature15698","article-title":"Basomedial amygdala mediates top\u2013down control of anxiety and fear","volume":"527","author":"Adhikari","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.bbr.2022.114031_bib36","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2017.161","article-title":"Basolateral amygdala and stress-induced hyperexcitability affect motivated behaviors and addiction","volume":"7","author":"Sharp","year":"2017","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.bbr.2022.114031_bib37","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1590\/S0001-37652005000300009","article-title":"Does the panic attack activate the hypothalamic-pituitary-adrenal axis","volume":"77","author":"Graeff","year":"2005","journal-title":"An. Acad. Bras. Ci\u00eanc."},{"key":"10.1016\/j.bbr.2022.114031_bib38","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.pneurobio.2015.04.001","article-title":"The brain acid-base homeostasis and serotonin: a perspective on the use of carbon dioxide as human and rodent experimental model of panic","volume":"129","author":"Leibold","year":"2015","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.bbr.2022.114031_bib39","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1016\/j.neubiorev.2014.10.002","article-title":"Translational approach to studying panic disorder in rats: hits and misses","volume":"46","author":"Schenberg","year":"2014","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbr.2022.114031_bib40","first-page":"1426","article-title":"Measurement of hormones and blood gases during hypoxia in conscious cannulated rats","volume":"56","author":"Raff","year":"1984","journal-title":"J. Appl. Physiol. Respir. Environ. Exerc. Physiol."},{"key":"10.1016\/j.bbr.2022.114031_bib41","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1177\/02698811211058986","article-title":"Enhanced responsiveness to hypoxic panicogenic challenge in female rats in late diestrus is suppressed by short-term, low-dose fluoxetine: Involvement of the dorsal raphe nucleus and the dorsal periaqueductal gray","volume":"35","author":"Batistela","year":"2021","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.bbr.2022.114031_bib42","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/j.physbeh.2006.08.015","article-title":"Neonatal stress and litter composition alter sucrose intake in both rat dam and offspring","volume":"89","author":"Michaels","year":"2006","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbr.2022.114031_bib43","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0166-4328(03)00151-7","article-title":"Antipanic-like effect of serotonin reuptake inhibitors in the elevated T-maze","volume":"147","author":"Poltronieri","year":"2003","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2022.114031_bib44","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/S0091-3057(99)00261-0","article-title":"Behavioral effects of acute and chronic imipramine in the elevated T-maze model of anxiety","volume":"65","author":"Teixeira","year":"2000","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.bbr.2022.114031_bib45","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jneumeth.2005.06.008","article-title":"Specificity and efficacy of noradrenaline, serotonin depletion in discrete brain areas of Swiss mice by neurotoxins","volume":"150","author":"Dailly","year":"2006","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.bbr.2022.114031_bib46","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.bbr.2016.08.024","article-title":"Panic-modulating effects of alprazolam, moclobemide and sumatriptan in the rat elevated T-maze","volume":"315","author":"Sant\u2019Ana","year":"2016","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2022.114031_bib47","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1111\/1440-1681.12155","article-title":"Anandamide modulates the neuroendocrine responses induced by extracellular volume expansion","volume":"40","author":"Ruginsk","year":"2013","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.bbr.2022.114031_bib48","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0090726","article-title":"Evidence that the periaqueductal gray matter mediates the facilitation of panic-like reactions in neonatally-isolated adult rats","volume":"9","author":"Quintino-dos-Santos","year":"2014","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bbr.2022.114031_bib49","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.bbr.2018.02.020","article-title":"Daily maternal separations during stress hyporesponsive period decrease the thresholds of panic-like behaviors to electrical stimulation of the dorsal periaqueductal gray of the adult rat","volume":"344","author":"Borges-Aguiar","year":"2018","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2022.114031_bib50","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.bbr.2005.04.003","article-title":"Prenatal stress produces more behavioral alterations than maternal separation in the elevated plus-maze and in the elevated T-maze","volume":"163","author":"Estanislau","year":"2005","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2022.114031_bib51","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1192\/bjp.163.2.201","article-title":"Subtyping of panic disorder by symptom profile","volume":"163","author":"Briggs","year":"1993","journal-title":"Br. J. Psychiatry. J. Ment. Sci."},{"key":"10.1016\/j.bbr.2022.114031_bib52","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0165-1781(03)00132-X","article-title":"Respiratory panic disorder subtype: acute and long-term response to nortriptyline, a noradrenergic tricyclic antidepressant","volume":"120","author":"Nardi","year":"2003","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.bbr.2022.114031_bib53","doi-asserted-by":"crossref","first-page":"220","DOI":"10.3109\/10673229.2010.493744","article-title":"Panic disorder respiratory subtype: psychopathology, laboratory challenge tests, and response to treatment","volume":"18","author":"Freire","year":"2010","journal-title":"Harv. Rev. Psychiatry"},{"key":"10.1016\/j.bbr.2022.114031_bib54","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1017\/S0033291711001425","article-title":"A latent class approach to the external validation of respiratory and non-respiratory panic subtypes","volume":"42","author":"Roberson-Nay","year":"2012","journal-title":"Psychol. Med."},{"key":"10.1016\/j.bbr.2022.114031_bib55","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.pnpbp.2007.07.029","article-title":"Panic, suffocation false alarms, separation anxiety and endogenous opioids","volume":"32","author":"Preter","year":"2008","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2022.114031_bib56","doi-asserted-by":"crossref","DOI":"10.1113\/JP281953","article-title":"Advancing respiratory-cardiovascular physiology with the working heart-brainstem preparation over 25 years","volume":"600","author":"Paton","year":"2022","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbr.2022.114031_bib57","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1177\/0269881114552714","article-title":"Evidence of a suffocation alarm system sensitive to clinically-effective treatments with the panicolytics clonazepam and fluoxetine","volume":"28","author":"Schimitel","year":"2014","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.bbr.2022.114031_bib58","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.neuroscience.2017.02.022","article-title":"On the verge of a respiratory-type panic attack: selective activations of rostrolateral and caudoventrolateral periaqueductal gray matter following short-lasting escape to a low dose of potassium cyanide","volume":"348","author":"M\u00fcller","year":"2017","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2022.114031_bib59","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.1002\/j.2040-4603.2021.tb00175.x","article-title":"Sex-specific effects of stress on respiratory control: plasticity, adaptation, and dysfunction","volume":"11","author":"Tenorio-Lopes","year":"2021","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.bbr.2022.114031_bib60","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.bbr.2013.07.015","article-title":"Effect of insular cortex inactivation on autonomic and behavioral responses to acute hypoxia in conscious rats","volume":"253","author":"Casanova","year":"2013","journal-title":"Behav. Brain Res."},{"issue":"Pt. 3","key":"10.1016\/j.bbr.2022.114031_bib61","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.neubiorev.2014.03.010","article-title":"The Deakin\/Graeff hypothesis: focus on serotonergic inhibition of panic","volume":"46","author":"Paul","year":"2014","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbr.2022.114031_bib62","doi-asserted-by":"crossref","first-page":"207","DOI":"10.2174\/1871524911006030207","article-title":"The dual role of serotonin in defense and the mode of action of antidepressants on generalized anxiety and panic disorders","volume":"10","author":"Guilherme Graeff","year":"2010","journal-title":"Cent. Nerv. Syst. Agents Med. Chem."},{"key":"10.1016\/j.bbr.2022.114031_bib63","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1177\/026988119701100111","article-title":"The effect of central and systemic injection of the 5-HT1A receptor agonist 8-OHDPAT and the 5-HT1A receptor antagonist WAY100635 on periaqueductal grey-induced defence behaviour","volume":"11","author":"Beckett","year":"1997","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.bbr.2022.114031_bib64","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1002\/cne.902500408","article-title":"Differential origin of brainstem serotoninergic projections to the midbrain periaqueductal gray and superior colliculus of the rat","volume":"250","author":"Beitz","year":"1986","journal-title":"J. Comp. Neurol."},{"key":"10.1016\/j.bbr.2022.114031_bib65","doi-asserted-by":"crossref","first-page":"24","DOI":"10.3389\/fnmol.2014.00024","article-title":"Early-life stress induces persistent alterations in 5-ht1a receptor and serotonin transporter mrna expression in the adult rat brain","volume":"7","author":"Bravo","year":"2014","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.bbr.2022.114031_bib66","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.neures.2007.01.008","article-title":"Depressive behaviors and decreased expression of serotonin reuptake transporter in rats that experienced neonatal maternal separation","volume":"58","author":"Lee","year":"2007","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.bbr.2022.114031_bib67","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.brainres.2013.03.032","article-title":"Maternal separation alters serotonergic and HPA axis gene expression independent of separation duration in mice","volume":"1515","author":"Own","year":"2013","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2022.114031_bib68","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/S0006-8993(97)00433-2","article-title":"Serotonin 5-HT1A and 5-HT2\/1C receptors in the midbrain periaqueductal gray differentially modulate defensive rage behavior elicited from the medial hypothalamus of the cat","volume":"765","author":"Shaikh","year":"1997","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2022.114031_bib69","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/0006-8993(93)91643-7","article-title":"Activation of serotonin1A receptors inhibits midbrain periaqueductal gray neurons of the rat","volume":"612","author":"Behbehani","year":"1993","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2022.114031_bib70","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.brainres.2009.09.065","article-title":"Adverse early life experience and social stress during adulthood interact to increase serotonin transporter mRNA expression","volume":"1305","author":"Gardner","year":"2009","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2022.114031_bib71","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1016\/j.pnpbp.2008.11.017","article-title":"Functional correlates for 5-HT(1A) receptors in maternally deprived rats displaying anxiety and depression-like behaviors","volume":"33","author":"Lamb\u00e1s-Se\u00f1as","year":"2009","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2022.114031_bib72","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2021.135734","article-title":"Maternal separation increases pain sensitivity by reducing the activity of serotonergic neurons in the dorsal raphe nucleus and noradrenergic neurons in locus coeruleus","volume":"748","author":"Vilela","year":"2021","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbr.2022.114031_bib73","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.brainresbull.2013.03.003","article-title":"Maternal separation induces alterations of serotonergic system in different aged rats","volume":"95","author":"Xue","year":"2013","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.bbr.2022.114031_bib74","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2016.09.002","article-title":"Medullary 5-HT neurons: switch from tonic respiratory drive to chemoreception during postnatal development","volume":"344","author":"Cerpa","year":"2017","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2022.114031_bib75","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/j.neuroscience.2006.02.008","article-title":"Maternal separation alters serotonergic transporter densities and serotonergic 1A receptors in rat brain","volume":"140","author":"Vicentic","year":"2006","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2022.114031_bib76","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.neulet.2010.04.054","article-title":"Long-term consequences of early maternal deprivation in serotonergic activity and HPA function in adult rat","volume":"480","author":"Rentesi","year":"2010","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbr.2022.114031_bib77","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.bbr.2013.01.040","article-title":"Early maternal deprivation-induced modifications in the neurobiological, neurochemical and behavioral profile of adult rats","volume":"244","author":"Rentesi","year":"2013","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2022.114031_bib78","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1002\/syn.20033","article-title":"Effect of early life stress on serotonin responses in the hippocampus of young adult rats","volume":"53","author":"Van Riel","year":"2004","journal-title":"Synapse"},{"key":"10.1016\/j.bbr.2022.114031_bib79","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1017\/S1461145710000994","article-title":"Alterations in the central CRF system of two different rat models of comorbid depression and functional gastrointestinal disorders","volume":"14","author":"Bravo","year":"2011","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.bbr.2022.114031_bib80","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/S0893-133X(99)00093-7","article-title":"Effects of corticotropin-releasing factor on neuronal activity in the serotonergic dorsal raphe nucleus","volume":"22","author":"Kirby","year":"2000","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2022.114031_bib81","doi-asserted-by":"crossref","first-page":"R982","DOI":"10.1152\/ajpregu.00543.2016","article-title":"Acute hypoxia activates neuroendocrine, but not presympathetic, neurons in the paraventricular nucleus of the hypothalamus: differential role of nitric oxide","volume":"312","author":"Coldren","year":"2017","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.bbr.2022.114031_bib82","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1007\/s10517-021-05317-x","article-title":"Comparison of the adaptive capacity in old and young wistar rats to stress exposure and acute hypoxic hypoxia","volume":"171","author":"Kondashevskaya","year":"2021","journal-title":"Bull. Exp. Biol. Med."},{"key":"10.1016\/j.bbr.2022.114031_bib83","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.biopsycho.2009.09.001","article-title":"Neonatal maternal separation and neuroendocrine programming of the respiratory control system in rats","volume":"84","author":"Kinkead","year":"2010","journal-title":"Biol. Psychol."},{"key":"10.1016\/j.bbr.2022.114031_bib84","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2016.00432","article-title":"Neonatal maternal separation augments carotid body response to hypoxia in adult males but not female rats","volume":"7","author":"Soliz","year":"2016","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbr.2022.114031_bib85","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1017\/S0954579409990241","article-title":"Serotonin pathway gene-gene and gene-environment interactions influence behavioral stress response in infant rhesus macaques","volume":"22","author":"Kinnally","year":"2010","journal-title":"Dev. Psychopathol."},{"key":"10.1016\/j.bbr.2022.114031_bib86","doi-asserted-by":"crossref","first-page":"1757","DOI":"10.3389\/fgene.2020.601868","article-title":"Genetic and epigenetic consequence of early-life social stress on depression: role of serotonin-associated genes","volume":"11","author":"Soga","year":"2021","journal-title":"Front. Genet."},{"key":"10.1016\/j.bbr.2022.114031_bib87","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2020.595584","article-title":"Pharmacotherapy of anxiety disorders: current and emerging treatment options","volume":"11","author":"Garakani","year":"2020","journal-title":"Front. Psychiatry"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432822002996?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432822002996?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T13:36:20Z","timestamp":1759066580000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432822002996"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":87,"alternative-id":["S0166432822002996"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2022.114031","relation":{},"ISSN":["0166-4328"],"issn-type":[{"type":"print","value":"0166-4328"}],"subject":[],"published":{"date-parts":[[2022,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neonatal maternal deprivation facilitates the expression of a panic-like escape behavior in adult rats","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2022.114031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114031"}}