{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T10:02:35Z","timestamp":1792404155909,"version":"4.4.0"},"reference-count":78,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.bbr.2022.114220","type":"journal-article","created":{"date-parts":[[2022,11,19]],"date-time":"2022-11-19T11:00:31Z","timestamp":1668855631000},"page":"114220","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["The effect of chronic stress on behaviors, inflammation and lymphocyte subtypes in male and female rats"],"prefix":"10.1016","volume":"439","author":[{"given":"Cai","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baiping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodi","family":"Pawluski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harry W.M.","family":"Steinbusch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U.","family":"Kirthana Kunikullaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cai","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2022.114220_bib1","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s00127-004-0728-6","article-title":"Is women's mental health more susceptible than men's to the influence of surrounding stress?","volume":"39","author":"Sandanger","year":"2004","journal-title":"Soc. Psychiatry Psychiatr. Epidemiol."},{"key":"10.1016\/j.bbr.2022.114220_bib2","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.jad.2004.09.008","article-title":"Gender differences in depression: findings from the STAR*D study","volume":"87","author":"Marcus","year":"2005","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.bbr.2022.114220_bib3","doi-asserted-by":"crossref","first-page":"5257","DOI":"10.1073\/pnas.1502843112","article-title":"Opinion: sex inclusion in basic research drives discovery","volume":"112","author":"Klein","year":"2015","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbr.2022.114220_bib4","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1111\/j.1749-6632.1997.tb48279.x","article-title":"The role of early adverse life events in the etiology of depression and posttraumatic stress disorder. Focus on corticotropin-releasing factor","volume":"821","author":"Heim","year":"1997","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bbr.2022.114220_bib5","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1146\/annurev.psych.48.1.191","article-title":"The effects of stressful life events on depression","volume":"48","author":"Kessler","year":"1997","journal-title":"Annu. Rev. Psychol."},{"key":"10.1016\/j.bbr.2022.114220_bib6","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0306-4530(94)00066-J","article-title":"The monocyte-T-lymphocyte hypothesis of major depression","volume":"20","author":"Maes","year":"1995","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbr.2022.114220_bib7","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/S0278-5846(01)00155-5","article-title":"The immune system, depression and the action of antidepressants","volume":"25","author":"Leonard","year":"2001","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2022.114220_bib8","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbi.2009.09.009","article-title":"Depression and immunity: a role for T cells","volume":"24","author":"Miller","year":"2010","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbr.2022.114220_bib9","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jad.2021.09.064","article-title":"T cell responses in depressed mice induced by chronic unpredictable mild stress","volume":"296","author":"Shi","year":"2022","journal-title":"J. Affect Disord."},{"key":"10.1016\/j.bbr.2022.114220_bib10","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s00005-019-00543-8","article-title":"The influence of antidepressants on the immune system","volume":"67","author":"Sza\u0142ach \u0141","year":"2019","journal-title":"Arch. Immunol. Et. Ther. Exp."},{"key":"10.1016\/j.bbr.2022.114220_bib11","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1037\/0033-2909.113.3.472","article-title":"Depression and immunity: a meta-analytic review","volume":"113","author":"Herbert","year":"1993","journal-title":"Psychol. Bull."},{"key":"10.1016\/j.bbr.2022.114220_bib12","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.bbr.2018.07.001","article-title":"Minocycline ameliorates depressive behaviors and neuro-immune dysfunction induced by chronic unpredictable mild stress in the rat","volume":"356","author":"Zhang","year":"2019","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2022.114220_bib13","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1080\/02646830500382102","article-title":"Stress and depression-induced immune dysfunction: implications for the development and progression of cancer","volume":"17","author":"Reiche","year":"2005","journal-title":"Int. Rev. Psychiatry"},{"key":"10.1016\/j.bbr.2022.114220_bib14","doi-asserted-by":"crossref","first-page":"3476","DOI":"10.1111\/ejn.15205","article-title":"Analysis of cytokine levels, T regulatory cells and serotonin content in patients with depression","volume":"53","author":"Obermanns","year":"2021","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bbr.2022.114220_bib15","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.jpsychires.2010.03.005","article-title":"Regulatory T cells increased while IL-1\u03b2 decreased during antidepressant therapy","volume":"44","author":"Himmerich","year":"2010","journal-title":"J. Psychiatr. Res"},{"key":"10.1016\/j.bbr.2022.114220_bib16","first-page":"547","article-title":"Leukocyte subsets in treatment-resistant major depression","volume":"51","author":"Kubera","year":"1999","journal-title":"Pol. J. Pharmacol."},{"key":"10.1016\/j.bbr.2022.114220_bib17","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1016\/S1567-5769(01)00190-4","article-title":"Effects of chronic mild stress on lymphocyte proliferative response. Participation of serum thyroid hormones and corticosterone","volume":"2","author":"Silberman","year":"2002","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bbr.2022.114220_bib18","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.jad.2021.09.064","article-title":"T cell responses in depressed mice induced by chronic unpredictable mild stress","volume":"296","author":"Shi","year":"2022","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.bbr.2022.114220_bib19","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1093\/cercor\/bhn225","article-title":"Sex differences in the effects of acute and chronic stress and recovery after long-term stress on stress-related brain regions of rats","author":"Lin","year":"2009","journal-title":"Cerebral cortex"},{"key":"10.1016\/j.bbr.2022.114220_bib20","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1007\/s00213-019-05326-9","article-title":"Stress, sex hormones, inflammation, and major depressive disorder: extending social signal transduction theory of depression to account for sex differences in mood disorders","volume":"236","author":"Slavich","year":"2019","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2022.114220_bib21","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1038\/cdd.2013.108","article-title":"Potent and multiple regulatory actions of microglial glucocorticoid receptors during CNS inflammation","volume":"20","author":"Carrillo-de Sauvage","year":"2013","journal-title":"Cell death Differ."},{"key":"10.1016\/j.bbr.2022.114220_bib22","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1038\/mp.2013.155","article-title":"Dynamic microglial alterations underlie stress-induced depressive-like behavior and suppressed neurogenesis","volume":"19","author":"Kreisel","year":"2014","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbr.2022.114220_bib23","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1038\/mp.2010.80","article-title":"The hippocampus in major depression: evidence for the convergence of the bench and bedside in psychiatric research?","volume":"16","author":"MacQueen","year":"2011","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbr.2022.114220_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bcp.2015.11.003","article-title":"Functional polarization of neuroglia: Implications in neuroinflammation and neurological disorders","volume":"103","author":"Jha","year":"2016","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbr.2022.114220_bib25","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.bbr.2015.05.062","article-title":"TNF-alpha inhibition prevents cognitive decline and maintains hippocampal BDNF levels in the unpredictable chronic mild stress rat model of depression","volume":"292","author":"\u015eahin","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2022.114220_bib26","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/j.bbi.2020.11.009","article-title":"Minocycline alleviates depression-like symptoms by rescuing decrease in neurogenesis in dorsal hippocampus via blocking microglia activation\/phagocytosis","volume":"91","author":"Bassett","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbr.2022.114220_bib27","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1007\/s11920-015-0618-5","article-title":"Sex differences in depression: does inflammation play a role?","volume":"17","author":"Derry","year":"2015","journal-title":"Curr. Psychiatry Rep."},{"key":"10.1016\/j.bbr.2022.114220_bib28","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/j.neuroscience.2005.06.068","article-title":"Chronic mild stress impact: are females more vulnerable?","volume":"135","author":"Dalla","year":"2005","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2022.114220_bib29","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1038\/nn.4661","article-title":"Viewpoints: how the hippocampus contributes to memory, navigation and cognition","volume":"20","author":"Lisman","year":"2017","journal-title":"Nat. Neurosci."},{"issue":"Suppl 3","key":"10.1016\/j.bbr.2022.114220_bib30","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/S0924-9338(02)00655-7","article-title":"The hippocampus and depression","volume":"17","author":"Sheline","year":"2002","journal-title":"Eur. Psychiatry. J. Assoc. Eur. Psychiatr."},{"key":"10.1016\/j.bbr.2022.114220_bib31","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.bbr.2018.07.001","article-title":"Minocycline ameliorates depressive behaviors and neuro-immune dysfunction induced by chronic unpredictable mild stress in the rat","volume":"356","author":"Zhang","year":"2019","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2022.114220_bib32","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.bbr.2019.01.045","article-title":"Minocycline ameliorates anxiety-related self-grooming behaviors and alters hippocampal neuroinflammation, GABA and serum cholesterol levels in female Sprague-Dawley rats subjected to chronic unpredictable mild stress","volume":"363","author":"Zhang","year":"2019","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2022.114220_bib33","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.bbr.2016.05.051","article-title":"Corticosterone and dopamine D2\/D3 receptors mediate the motivation for voluntary wheel running in C57BL\/6J mice","volume":"311","author":"Ebada","year":"2016","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2022.114220_bib34","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1093\/oxfordjournals.bmb.a011570","article-title":"The neuroendocrinology of depression and chronic stress","volume":"52","author":"Checkley","year":"1996","journal-title":"Br. Med. Bull."},{"key":"10.1016\/j.bbr.2022.114220_bib35","first-page":"1342","article-title":"Effects of ginsenosides on hypothalamic-pituitary-adrenal function and brain-derived neurotrophic factor in rats exposed to chronic unpredictable mild stress","volume":"36","author":"Liu","year":"2011","journal-title":"Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China J. Chin. Mater. Med."},{"key":"10.1016\/j.bbr.2022.114220_bib36","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/j.bbr.2015.02.009","article-title":"Sex differences in the stress response in SD rats","volume":"284","author":"Lu","year":"2015","journal-title":"Behav. Brain Res"},{"key":"10.1016\/j.bbr.2022.114220_bib37","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21051769","article-title":"EPA is more effective than DHA to improve depression-like behavior, Glia cell dysfunction and hippcampal apoptosis signaling in a chronic stress-induced rat model of depression","volume":"21","author":"Peng","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbr.2022.114220_bib38","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1136\/bmj.292.6524.859","article-title":"Glucocorticoid receptors and depression","volume":"292","author":"Whalley","year":"1986","journal-title":"Br. Med. J. Clin. Res. Ed."},{"key":"10.1016\/j.bbr.2022.114220_bib39","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1159\/000371468","article-title":"TLR2 involved in naive CD4+ T cells rescues stress-induced immune suppression by regulating Th1\/Th2 and Th17","volume":"22","author":"Zhao","year":"2015","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.bbr.2022.114220_bib40","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1159\/000343100","article-title":"Imbalance between Th17 and Treg cells may play an important role in the development of chronic unpredictable mild stress-induced depression in mice","volume":"20","author":"Hong","year":"2013","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.bbr.2022.114220_bib41","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.cyto.2018.07.015","article-title":"CD8(+) T cells promote cytokine responses to stress","volume":"113","author":"Clark","year":"2019","journal-title":"Cytokine"},{"key":"10.1016\/j.bbr.2022.114220_bib42","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jad.2005.07.008","article-title":"Th1, Th2, and Th3 cytokine alterations in major depression","volume":"88","author":"Myint","year":"2005","journal-title":"J. Affect Disord."},{"key":"10.1016\/j.bbr.2022.114220_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2020.112811","article-title":"Circulating T helper 17 and IFN-\u03b3 positive Th17 cells in major depressive disorder","volume":"394","author":"Ghosh","year":"2020","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2022.114220_bib44","first-page":"10","article-title":"The effect of stress on the defense systems","volume":"3","author":"Drago\u015f","year":"2010","journal-title":"J. Med. Life"},{"key":"10.1016\/j.bbr.2022.114220_bib45","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1017\/S1461145710000465","article-title":"Of depression and immunity: does sex matter?","volume":"13","author":"Pitychoutis","year":"2010","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.bbr.2022.114220_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbi.2017.02.006","article-title":"Sex differences in the neuro-immune consequences of stress: focus on depression and anxiety","volume":"67","author":"Bekhbat","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbr.2022.114220_bib47","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/j.1600-0897.2004.00177.x","article-title":"Gender difference in the non-specific and specific immune response in humans","author":"Bouman","year":"2004","journal-title":"Am. J. Reproductive Immunol."},{"key":"10.1016\/j.bbr.2022.114220_bib48","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0061186","article-title":"Sex bias in experimental immune-mediated, drug-induced liver injury in BALB\/c mice: suggested roles for Tregs, estrogen, and IL-6","volume":"8","author":"Cho","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.bbr.2022.114220_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbi.2009.09.009","article-title":"Depression and immunity: a role for T cells?","volume":"24","author":"Miller","year":"2010","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbr.2022.114220_bib50","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0928-8244(03)00202-5","article-title":"Regulation of innate and adaptive immunity by the female sex hormones oestradiol and progesterone","volume":"38","author":"Beagley","year":"2003","journal-title":"FEMS Immunol. Med. Microbiol."},{"key":"10.1016\/j.bbr.2022.114220_bib51","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1016\/j.etap.2013.12.013","article-title":"Chronic unpredictable mild stress impairs erythrocyte immune function and changes T-lymphocyte subsets in a rat model of stress-induced depression","volume":"37","author":"Guan","year":"2014","journal-title":"Environ. Toxicol. Pharmacol."},{"key":"10.1016\/j.bbr.2022.114220_bib52","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s10522-008-9138-6","article-title":"The immune risk profile is associated with age and gender: findings from three Swedish population studies of individuals 20-100 years of age","volume":"9","author":"Wikby","year":"2008","journal-title":"Biogerontology"},{"key":"10.1016\/j.bbr.2022.114220_bib53","first-page":"179","article-title":"Depression, gender and cellular immunity: influence of gender and severity of depression on the cellular immunity","volume":"28","author":"Fagniart","year":"2016","journal-title":"Psychiatr. Danub"},{"issue":"Suppl 1","key":"10.1016\/j.bbr.2022.114220_bib54","first-page":"S205","article-title":"Depression, family and cellular immunity: influence of family relationships and cellular immunity on the severity of depression","volume":"27","author":"Zdanowicz","year":"2015","journal-title":"Psychiatr. Danub"},{"key":"10.1016\/j.bbr.2022.114220_bib55","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jad.2009.10.018","article-title":"Altered expression of CD4(+)CD25(+) regulatory T cells and its 5-HT(1a) receptor in patients with major depression disorder","volume":"124","author":"Li","year":"2010","journal-title":"J. Affect Disord."},{"key":"10.1016\/j.bbr.2022.114220_bib56","article-title":"CD4+CD25+ regulatory T cell depletion modulates anxiety and depression-like behaviors in mice","volume":"7","author":"Kim","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.bbr.2022.114220_bib57","first-page":"1679","article-title":"Circulating cytotoxic T cells and natural killer cells as potential predictors for antidepressant response in melancholic depression","volume":"233","author":"Grosse","year":"2016","journal-title":"Restor. T Regul. Cell Popul. Antidepressant Ther., Psychopharmacol."},{"key":"10.1016\/j.bbr.2022.114220_bib58","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nature04753","article-title":"Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells","volume":"441","author":"Bettelli","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.bbr.2022.114220_bib59","doi-asserted-by":"crossref","first-page":"2597","DOI":"10.1038\/s41386-018-0154-1","article-title":"Resolution of inflammation-induced depression requires T lymphocytes and endogenous brain interleukin-10 signaling","volume":"43","author":"Laumet","year":"2018","journal-title":"Neuropsychopharmacol. Off. Publ. Am. Coll. Neuropsychopharmacol."},{"key":"10.1016\/j.bbr.2022.114220_bib60","article-title":"Role of Interleukin-6 in depressive disorder","volume":"21","author":"Ting","year":"2020"},{"key":"10.1016\/j.bbr.2022.114220_bib61","first-page":"7646","article-title":"Anti-depressant-like effect of sinomenine on chronic unpredictable mild stress-induced depression in a mouse model","volume":"24","author":"Liu","year":"2018","journal-title":"Med. Sci. Monit. Int. Med. J. Exp. Clin. Res."},{"key":"10.1016\/j.bbr.2022.114220_bib62","first-page":"2777","article-title":"Avicularin relieves depressive-like behaviors induced by chronic unpredictable mild stress in mice","volume":"25","author":"Shen","year":"2019","journal-title":"Med. Sci. Monit. Int. Med. J. Exp. Clin. Res."},{"key":"10.1016\/j.bbr.2022.114220_bib63","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1016\/j.bbr.2017.05.064","article-title":"Behavioral, inflammatory and neurochemical disturbances in LPS and UCMS-induced mouse models of depression","volume":"364","author":"Zhao","year":"2019","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2022.114220_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2020.113174","article-title":"Inhibition of the fatty acid amide hydrolase changes behaviors and brain catecholamines in a sex-specific manner in rats exposed to chronic unpredictable stress","volume":"227","author":"Jankovic","year":"2020","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbr.2022.114220_bib65","first-page":"14","article-title":"Sex difference in IL-6 modulation of cognition among Chinese individuals with major depressive disorder","volume":"70","author":"Qu","year":"2019","journal-title":"J. Clin. Neurosci. Off. J. Neurosurg. Soc. Australas."},{"key":"10.1016\/j.bbr.2022.114220_bib66","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.jad.2010.11.017","article-title":"Depression, cytokines and experimental pain: evidence for sex-related association patterns","volume":"131","author":"Euteneuer","year":"2011","journal-title":"J. Affect Disord."},{"key":"10.1016\/j.bbr.2022.114220_bib67","doi-asserted-by":"crossref","DOI":"10.1016\/j.psychres.2021.113723","article-title":"Plasma levels of interleukin-6 and antidepressant response to Paroxetine in Chinese depressive patients","volume":"297","author":"Dong","year":"2021","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.bbr.2022.114220_bib68","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/s12974-018-1054-3","article-title":"Microglial activation mediates chronic mild stress-induced depressive- and anxiety-like behavior in adult rats","volume":"15","author":"Wang","year":"2018","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.bbr.2022.114220_bib69","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.neuroscience.2013.04.060","article-title":"Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications","volume":"246","author":"Felger","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2022.114220_bib70","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.neuron.2020.06.002","article-title":"The bidirectional relationship of depression and inflammation: double trouble","volume":"107","author":"Beurel","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2022.114220_bib71","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1289\/ehp.7826135","article-title":"Central neurotransmitter function and its behavioral correlates in man","volume":"26","author":"Hanin","year":"1978","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.bbr.2022.114220_bib72","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1016\/S0091-3057(98)00200-7","article-title":"Neurotransmitter system interactions revealed by drug-induced changes in motivated behavior","volume":"62","author":"Montgomery","year":"1999","journal-title":"Pharm. Biochem Behav."},{"key":"10.1016\/j.bbr.2022.114220_bib73","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0278-5846(94)90023-X","article-title":"Serotonergic mechanisms in anxiety","volume":"18","author":"Eison","year":"1994","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"Suppl 10","key":"10.1016\/j.bbr.2022.114220_bib74","first-page":"31","article-title":"Clinical efficacy of reboxetine in major depression","volume":"61","author":"Schatzberg","year":"2000","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.bbr.2022.114220_bib75","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/00000441-198908000-00010","article-title":"Fluoxetine: an alternative to the tricyclics in the treatment of major depression","volume":"298","author":"Tacke","year":"1989","journal-title":"Am. J. Med. Sci."},{"issue":"Suppl 6","key":"10.1016\/j.bbr.2022.114220_bib76","first-page":"7","article-title":"Depression: the case for a monoamine deficiency","volume":"61","author":"Delgado","year":"2000","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.bbr.2022.114220_bib77","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.pnpbp.2013.04.009","article-title":"Monoamine neurocircuitry in depression and strategies for new treatments","volume":"45","author":"Hamon","year":"2013","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2022.114220_bib78","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.14014","article-title":"Sex differences in peripheral monoamine transmitter and related hormone levels in chronic stress mice with a depression-like phenotype","volume":"10","author":"Chen","year":"2022","journal-title":"PeerJ"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432822004892?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432822004892?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T13:37:55Z","timestamp":1759066675000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432822004892"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":78,"alternative-id":["S0166432822004892"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2022.114220","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effect of chronic stress on behaviors, inflammation and lymphocyte subtypes in male and female rats","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2022.114220","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"114220"}}