{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T22:53:09Z","timestamp":1791240789994,"version":"4.1.0"},"reference-count":101,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,5,1]],"date-time":"2023-05-01T00:00:00Z","timestamp":1682899200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2023,5]]},"DOI":"10.1016\/j.bbr.2023.114417","type":"journal-article","created":{"date-parts":[[2023,3,30]],"date-time":"2023-03-30T18:16:04Z","timestamp":1680200164000},"page":"114417","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":54,"special_numbering":"C","title":["Evaluating pain behaviours: Widely used mechanical and thermal methods in rodents"],"prefix":"10.1016","volume":"446","author":[{"given":"Akshat D.","family":"Modi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anavi","family":"Parekh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajan N.","family":"Pancholi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2023.114417_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2019.e01324","article-title":"Experimental spinal cord injury and behavioral tests in laboratory rats","volume":"5","author":"Ahmed","year":"2019","journal-title":"Heliyon"},{"key":"10.1016\/j.bbr.2023.114417_bib2","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1744-8069-1-36","article-title":"Detection of cold pain, cold allodynia and cold hyperalgesia in freely behaving rats","volume":"1","author":"Allchorne","year":"2005","journal-title":"Mol. Pain."},{"key":"10.1016\/j.bbr.2023.114417_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0014-2999(74)90195-2","article-title":"New hot plate tests to quantify antinociceptive and narcotic antagonist activities","volume":"27","author":"Ankier","year":"1974","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbr.2023.114417_bib4","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1097\/FBP.0000000000000026","article-title":"Assessment of thermal sensitivity in rats using the thermal place preference test: description and application in the study of oxaliplatin-induced acute thermal hypersensitivity and inflammatory pain models","volume":"25","author":"Balayssac","year":"2014","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.bbr.2023.114417_bib5","doi-asserted-by":"crossref","first-page":"1744","DOI":"10.1186\/1744-8069-1-18","article-title":"Spared nerve injury rats exhibit thermal hyperalgesia on an automated operant dynamic thermal escape task","volume":"1","author":"Baliki","year":"2005","journal-title":"Mol. Pain."},{"key":"10.1016\/j.bbr.2023.114417_bib6","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.jneumeth.2013.06.005","article-title":"A modified Hargreaves\u2019 method for assessing threshold temperatures for heat nociception","volume":"219","author":"Banik","year":"2013","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.bbr.2023.114417_bib7","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/0091-3057(79)90221-1","article-title":"Exposure to a nonfunctional hot plate as a factor in the assessment of morphine-induced analgesia and analgesic tolerance in rats","volume":"10","author":"Bardo","year":"1979","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.bbr.2023.114417_bib8","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.neuroscience.2011.12.041","article-title":"Tests and models of nociception and pain in rodents","volume":"211","author":"Barrot","year":"2012","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2023.114417_bib9","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S1474-4422(14)70024-9","article-title":"Painful and painless channelopathies","volume":"13","author":"Bennett","year":"2014","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.bbr.2023.114417_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.ynpai.2019.100040","article-title":"EPAC1 and EPAC2 promote nociceptor hyperactivity associated with chronic pain after spinal cord injury","volume":"7","author":"Berkey","year":"2020","journal-title":"Neurobiol. Pain."},{"key":"10.1016\/j.bbr.2023.114417_bib11","doi-asserted-by":"crossref","first-page":"249sr3","DOI":"10.1126\/scitranslmed.3008320","article-title":"Lost but making progress--where will new analgesic drugs come from","volume":"6","author":"Borsook","year":"2014","journal-title":"Sci. Transl. Med"},{"key":"10.1016\/j.bbr.2023.114417_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2022.113919","article-title":"Sex differences in choice-based thermal nociceptive tests in adult rats","volume":"429","author":"Bourgeois","year":"2022","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2023.114417_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0039765","article-title":"A novel behavioral assay for measuring cold sensation in mice","volume":"7","author":"Brenner","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbr.2023.114417_bib14","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.2522\/ptj.20160211","article-title":"Toward a transformed understanding: from pain and movement to pain with movement","volume":"96","author":"Butera","year":"2016","journal-title":"Phys. Ther."},{"key":"10.1016\/j.bbr.2023.114417_bib15","series-title":"Opioid Receptors, Methods in Molecular Biology","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1007\/978-1-0716-0884-5_17","article-title":"Mechanical nociception in mice and rats: measurement with automated von frey equipment","author":"Campana","year":"2021"},{"key":"10.1016\/j.bbr.2023.114417_bib16","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1021\/acschemneuro.0c00013","article-title":"A thermal place preference test for discovery of neuropathic pain drugs","volume":"11","author":"Caporoso","year":"2020","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.bbr.2023.114417_bib17","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1189\/jlb.3RU1015-451R","article-title":"A matter of time: study of circadian clocks and their role in inflammation","volume":"99","author":"Carter","year":"2016","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.bbr.2023.114417_bib18","first-page":"7","article-title":"Assessment of thermal pain sensation in rats and mice using the hargreaves test","author":"Cheah","year":"2017","journal-title":"BIO-Protoc."},{"key":"10.1016\/j.bbr.2023.114417_bib19","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1089\/neu.2018.5819","article-title":"Exercise-induced changes to the macrophage response in the dorsal root ganglia prevent neuropathic pain after spinal cord injury","volume":"36","author":"Chhaya","year":"2019","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.bbr.2023.114417_bib20","doi-asserted-by":"crossref","first-page":"525","DOI":"10.2217\/nmt-2016-0033","article-title":"Pain assessment tools for older adults with dementia in long-term care facilities: a systematic review","volume":"6","author":"Chow","year":"2016","journal-title":"Neurodegener. Dis. Manag"},{"key":"10.1016\/j.bbr.2023.114417_bib21","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1740-3391-2-2","article-title":"Daily rhythm of nociception in rats","volume":"2","author":"Christina","year":"2004","journal-title":"J. Circadian Rhythms"},{"key":"10.1016\/j.bbr.2023.114417_bib22","doi-asserted-by":"crossref","unstructured":"E. Cobos E. Portillo-Salido \u201cBedside-to-Bench\u201d Behavioral Outcomes in Animal Models of Pain: Beyond the Evaluation of Reflexes. CN 11, 560\u2013591. https:\/\/doi.org\/10.2174\/1570159X113119990041.","DOI":"10.2174\/1570159X113119990041"},{"key":"10.1016\/j.bbr.2023.114417_bib23","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1038\/nature05413","article-title":"An SCN9A channelopathy causes congenital inability to experience pain","volume":"444","author":"Cox","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.bbr.2023.114417_bib24","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.cell.2008.07.006","article-title":"Snapshot: ion channels and pain","volume":"134","author":"Delmas","year":"2008","journal-title":"Cell"},{"key":"10.1016\/j.bbr.2023.114417_bib25","doi-asserted-by":"crossref","DOI":"10.3791\/3247","article-title":"Acute and chronic tactile sensory testing after spinal cord injury in rats","author":"Detloff","year":"2012","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.bbr.2023.114417_bib26","doi-asserted-by":"crossref","first-page":"284","DOI":"10.3389\/fnmol.2017.00284","article-title":"Methods used to evaluate pain behaviors in rodents","volume":"10","author":"Deuis","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.bbr.2023.114417_bib27","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1080\/23328940.2016.1157668","article-title":"The thermal probe test: a novel behavioral assay to quantify thermal paw withdrawal thresholds in mice","volume":"3","author":"Deuis","year":"2016","journal-title":"Temperature"},{"key":"10.1016\/j.bbr.2023.114417_bib28","series-title":"Current Topics in Membranes","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S1063-5823(06)59016-7","article-title":"Touch","author":"Drew","year":"2007"},{"key":"10.1016\/j.bbr.2023.114417_bib29","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.jneumeth.2015.03.032","article-title":"A novel method for delivering ramped cooling reveals rat behaviours at innocuous and noxious temperatures: a comparative study of human psychophysics and rat behaviour","volume":"249","author":"Dunham","year":"2015","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.bbr.2023.114417_bib30","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/0166-4328(93)90035-O","article-title":"Structure of the rat\u2019s behaviour in the hot plate test","volume":"56","author":"Espejo","year":"1993","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2023.114417_bib31","doi-asserted-by":"crossref","first-page":"eaau5148","DOI":"10.1126\/sciadv.aau5148","article-title":"A new painkiller nanomedicine to bypass the blood-brain barrier and the use of morphine","volume":"5","author":"Feng","year":"2019","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bbr.2023.114417_bib32","first-page":"63454","article-title":"Mechanical conflict-avoidance assay to measure pain behavior in mice","author":"Gaffney","year":"2022","journal-title":"JoVE"},{"key":"10.1016\/j.bbr.2023.114417_bib33","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/0304-3940(89)90397-2","article-title":"Repeated exposure to sham testing procedures reduces reflex withdrawal and hot-plate latencies: attenuation of tonic descending inhibition","volume":"96","author":"Gamble","year":"1989","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbr.2023.114417_bib34","doi-asserted-by":"crossref","first-page":"1255","DOI":"10.1016\/j.jpain.2013.06.008","article-title":"An overview of animal models of pain: disease models and outcome measures","volume":"14","author":"Gregory","year":"2013","journal-title":"J. Pain."},{"key":"10.1016\/j.bbr.2023.114417_bib35","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.jpain.2010.06.011","article-title":"The influence of non-nociceptive factors on hot-plate latency in rats","volume":"12","author":"Gunn","year":"2011","journal-title":"J. Pain."},{"key":"10.1016\/j.bbr.2023.114417_bib36","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.brainres.2007.09.013","article-title":"Behavioral characterization and effect of clinical drugs in a rat model of pain following spinal cord compression","volume":"1185","author":"Hama","year":"2007","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2023.114417_bib37","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/0304-3959(88)90026-7","article-title":"A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia","volume":"32","author":"Hargreaves","year":"1988","journal-title":"Pain"},{"key":"10.1016\/j.bbr.2023.114417_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0150164","article-title":"Mechanical conflict system: a novel operant method for the assessment of nociceptive behavior","volume":"11","author":"Harte","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.bbr.2023.114417_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2020.113468","article-title":"Facial grimace testing as an assay of neuropathic pain-related behavior in a mouse model of cervical spinal cord injury","volume":"334","author":"Heinsinger","year":"2020","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbr.2023.114417_bib40","doi-asserted-by":"crossref","first-page":"20981","DOI":"10.1038\/s41598-020-77640-8","article-title":"The influence of rat strain on the development of neuropathic pain and comorbid anxio-depressive behaviour after nerve injury","volume":"10","author":"Hestehave","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbr.2023.114417_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1089\/neu.2008.0543","article-title":"Anatomical and functional outcomes following a precise, graded, dorsal laceration spinal cord injury in C57BL\/6 mice","volume":"26","author":"Hill","year":"2009","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.bbr.2023.114417_bib42","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/S0304-3959(98)00017-7","article-title":"The cold plate as a test of nociceptive behaviors: description and application to the study of chronic neuropathic and inflammatory pain models","volume":"75","author":"Jasmin","year":"1998","journal-title":"Pain"},{"key":"10.1016\/j.bbr.2023.114417_bib43","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1073\/pnas.0808487106","article-title":"TRPA1 acts as a cold sensor in vitro and in vivo","volume":"106","author":"Karashima","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbr.2023.114417_bib44","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1016\/j.spinee.2013.09.051","article-title":"Thermal hyperalgesia assessment for rats after spinal cord injury: developing a valid and useful pain index","volume":"14","author":"Kim","year":"2014","journal-title":"Spine J."},{"key":"10.1016\/j.bbr.2023.114417_bib45","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1089\/jmf.2012.2648","article-title":"Berberine ameliorates cold and mechanical allodynia in a rat model of diabetic neuropathy","volume":"16","author":"Kim","year":"2013","journal-title":"J. Med Food"},{"key":"10.1016\/j.bbr.2023.114417_bib46","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.neuroscience.2007.04.012","article-title":"Opioid modulation of reflex versus operant responses following stress in the rat","volume":"147","author":"King","year":"2007","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2023.114417_bib47","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/S0006-8993(03)03339-0","article-title":"Differential effects of stress on escape and reflex responses to nociceptive thermal stimuli in the rat","volume":"987","author":"King","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2023.114417_bib48","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1016\/j.pain.2010.05.021","article-title":"TRPM8, but not TRPA1, is required for neural and behavioral responses to acute noxious cold temperatures and cold-mimetics in vivo","volume":"150","author":"Knowlton","year":"2010","journal-title":"Pain"},{"key":"10.1016\/j.bbr.2023.114417_bib49","doi-asserted-by":"crossref","first-page":"555","DOI":"10.30802\/AALAS-CM-19-000062","article-title":"The study of pain in rats and mice","volume":"69","author":"Larson","year":"2019","journal-title":"Comp. Med."},{"key":"10.1016\/j.bbr.2023.114417_bib50","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1590\/S0100-879X2005000300016","article-title":"A novel hot-plate test sensitive to hyperalgesic stimuli and non-opioid analgesics","volume":"38","author":"Lavich","year":"2005","journal-title":"Braz. J. Med Biol. Res"},{"key":"10.1016\/j.bbr.2023.114417_bib51","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1016\/S0031-6997(24)01514-X","article-title":"Animal models of nociception","volume":"53","author":"Le Bars","year":"2001","journal-title":"Pharm. Rev."},{"key":"10.1016\/j.bbr.2023.114417_bib52","doi-asserted-by":"crossref","DOI":"10.1089\/neu.2022.0482","article-title":"Sex differences in pain: Spinal cord injury in female and male mice elicits behaviors related to neuropathic pain","author":"Lee","year":"2023","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.bbr.2023.114417_bib53","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1177\/154596830001400405","article-title":"An analysis of changes in sensory thresholds to mild tactile and cold stimuli after experimental spinal cord injury in the rat","volume":"14","author":"Lindsey","year":"2000","journal-title":"Neurorehab. Neural Repair"},{"key":"10.1016\/j.bbr.2023.114417_bib54","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.pain.2008.04.025","article-title":"The Kyoto protocol of IASP Basic Pain Terminology \u2606","volume":"137","author":"Loeser","year":"2008","journal-title":"Pain"},{"key":"10.1016\/j.bbr.2023.114417_bib55","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.celrep.2015.04.027","article-title":"The Nav1.9 channel is a key determinant of cold pain sensation and cold allodynia","volume":"11","author":"Lolignier","year":"2015","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbr.2023.114417_bib56","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/j.tips.2012.08.001","article-title":"Current challenges in translational pain research","volume":"33","author":"Mao","year":"2012","journal-title":"Trends Pharm. Sci."},{"key":"10.1016\/j.bbr.2023.114417_bib57","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1002\/term.2995","article-title":"Efficacy of human HC016 cell transplants on neuroprotection and functional recovery in a rat model of acute spinal cord injury","volume":"14","author":"Maqueda","year":"2020","journal-title":"J. Tissue Eng. Regen. Med"},{"key":"10.1016\/j.bbr.2023.114417_bib58","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.ejpain.2008.08.001","article-title":"Effects of Etanercept and Minocycline in a rat model of spinal cord injury","volume":"13","author":"Marchand","year":"2009","journal-title":"Eur. J. Pain."},{"key":"10.1016\/j.bbr.2023.114417_bib59","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0186250","article-title":"Susceptibility of different mouse strains to oxaliplatin peripheral neurotoxicity: phenotypic and genotypic insights","volume":"12","author":"Marmiroli","year":"2017","journal-title":"PLoS ONE"},{"key":"10.1016\/j.bbr.2023.114417_bib60","article-title":"Spinal cord transection-induced allodynia in rats \u2013 behavioral, physiopathological and pharmacological characterization","volume":"9","author":"M\u2019Dahoma","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbr.2023.114417_bib61","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/S0165-0270(01)00483-6","article-title":"Unilateral hot plate test: a simple and sensitive method for detecting central and peripheral hyperalgesia in mice","volume":"113","author":"Men\u00e9ndez","year":"2002","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.bbr.2023.114417_bib62","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0104458","article-title":"Significant determinants of mouse pain behaviour","volume":"9","author":"Minett","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbr.2023.114417_bib63","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/nrn2606","article-title":"Animal models of pain: progress and challenges","volume":"10","author":"Mogil","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbr.2023.114417_bib64","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.pain.2010.07.015","article-title":"The necessity of animal models in pain research","volume":"151","author":"Mogil","year":"2010","journal-title":"Pain"},{"key":"10.1016\/j.bbr.2023.114417_bib65","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1126\/science.1108609","article-title":"Impaired thermosensation in mice lacking TRPV3, a heat and camphor sensor in the skin","volume":"307","author":"Moqrich","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.bbr.2023.114417_bib66","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.jpain.2005.12.009","article-title":"Morphine antinociceptive potency on chemical, mechanical, and thermal nociceptive tests in the rat","volume":"7","author":"Morgan","year":"2006","journal-title":"J. Pain."},{"key":"10.1016\/j.bbr.2023.114417_bib67","first-page":"54","article-title":"Rodent analgesiometry: the hot plate, tail flick and Von Frey hairs","volume":"43","author":"Mulder","year":"2004","journal-title":"Conte Top. Lab Anim. Sci."},{"key":"10.1016\/j.bbr.2023.114417_bib68","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1124\/jpet.106.106377","article-title":"Preclinical assessment of candidate analgesic drugs: recent advances and future challenges","volume":"319","author":"Negus","year":"2006","journal-title":"J. Pharm. Exp. Ther."},{"key":"10.1016\/j.bbr.2023.114417_bib69","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.vascn.2012.04.006","article-title":"Comparison of manual and automated filaments for evaluation of neuropathic pain behavior in rats","volume":"66","author":"Nirogi","year":"2012","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"10.1016\/j.bbr.2023.114417_bib70","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0022-3565(25)30089-3","article-title":"Quantification of the analgesic activity of narcotic antagonists by a modified hot-plate procedure","volume":"192","author":"O\u2019Callaghan","year":"1975","journal-title":"J. Pharm. Exp. Ther."},{"key":"10.1016\/j.bbr.2023.114417_bib71","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0006-8993(82)90060-9","article-title":"Opiate analgesia: evidence for circadian rhythms in mice","volume":"249","author":"Oliverio","year":"1982","journal-title":"Brain Res"},{"key":"10.1016\/j.bbr.2023.114417_bib72","doi-asserted-by":"crossref","DOI":"10.1002\/cpns.53","article-title":"Measuring pain avoidance-like behavior in drug-dependent rats","volume":"85","author":"Pahng","year":"2018","journal-title":"Curr. Protoc. Neurosci."},{"key":"10.1016\/j.bbr.2023.114417_bib73","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/AJP.0b013e31829550c6","article-title":"Bidirectional associations between pain and physical activity in adolescents","volume":"30","author":"Rabbitts","year":"2014","journal-title":"Clin. J. Pain."},{"key":"10.1016\/j.bbr.2023.114417_bib74","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1097\/j.pain.0000000000001939","article-title":"The revised International Association for the Study of Pain definition of pain: concepts, challenges, and compromises","volume":"161","author":"Raja","year":"2020","journal-title":"Pain"},{"key":"10.1016\/j.bbr.2023.114417_bib75","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0210-19.2020","article-title":"The operant plantar thermal assay: a novel device for assessing thermal pain tolerance in mice","volume":"7","author":"Reker","year":"2020","journal-title":"eNeuro"},{"key":"10.1016\/j.bbr.2023.114417_bib76","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0103362","article-title":"The conditioned place preference test for assessing welfare consequences and potential refinements in a mouse bladder cancer model","volume":"9","author":"Roughan","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.bbr.2023.114417_bib77","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1007\/s11064-011-0414-5","article-title":"Upregulation of inflammatory mediators in a model of chronic pain after spinal cord injury","volume":"36","author":"Sandhir","year":"2011","journal-title":"Neurochem Res."},{"key":"10.1016\/j.bbr.2023.114417_bib78","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1152\/physrev.00025.2008","article-title":"Models and mechanisms of hyperalgesia and allodynia","volume":"89","author":"Sandk\u00fchler","year":"2009","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbr.2023.114417_bib79","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1093\/bja\/aeu346","article-title":"Experimental behaviour testing: pain","volume":"114","author":"Savage","year":"2015","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.bbr.2023.114417_bib80","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.cell.2009.04.019","article-title":"Dissociation of the opioid receptor mechanisms that control mechanical and heat pain","volume":"137","author":"Scherrer","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.bbr.2023.114417_bib81","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.cophys.2019.07.002","article-title":"Advances in assessment of pain behaviors and mechanisms of post-operative pain models","volume":"11","author":"Segelcke","year":"2019","journal-title":"Curr. Opin. Physiol."},{"key":"10.1016\/j.bbr.2023.114417_bib82","doi-asserted-by":"crossref","DOI":"10.1590\/s2175-97902022e19362","article-title":"Exploring the role of cAMP in gabapentin- mediated pain attenuating effects in chronic constriction injury model in rats","volume":"58","author":"Sharma","year":"2022","journal-title":"Braz. J. Pharm. Sci."},{"key":"10.1016\/j.bbr.2023.114417_bib83","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.neuropharm.2017.11.036","article-title":"Pharmacological validation of voluntary gait and mechanical sensitivity assays associated with inflammatory and neuropathic pain in mice","volume":"130","author":"Shepherd","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2023.114417_bib84","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1007\/s13311-018-0633-4","article-title":"Neuropathic pain after spinal cord injury: challenges and research perspectives","volume":"15","author":"Shiao","year":"2018","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.bbr.2023.114417_bib85","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/s12883-018-1047-y","article-title":"Comparison of electroencephalographic changes in response to acute electrical and thermal stimuli with the tail flick and hot plate test in rats administered with opiorphin","volume":"18","author":"Singh","year":"2018","journal-title":"BMC Neurol."},{"key":"10.1016\/j.bbr.2023.114417_bib86","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1038\/nmeth.2935","article-title":"Olfactory exposure to males, including men, causes stress and related analgesia in rodents","volume":"11","author":"Sorge","year":"2014","journal-title":"Nat. Methods"},{"key":"10.1016\/j.bbr.2023.114417_bib87","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1038\/sj.bjp.0706109","article-title":"Role of descending noradrenergic system and spinal \u03b1 2 -adrenergic receptors in the effects of gabapentin on thermal and mechanical nociception after partial nerve injury in the mouse: Gabapentin and central noradrenaline","volume":"144","author":"Tanabe","year":"2005","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbr.2023.114417_bib88","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.neubiorev.2019.03.009","article-title":"Pros and cons of clinically relevant methods to assess pain in rodents","volume":"100","author":"Tappe-Theodor","year":"2019","journal-title":"Neurosci. Biobehav Rev."},{"key":"10.1016\/j.bbr.2023.114417_bib89","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1111\/ejn.12643","article-title":"Studying ongoing and spontaneous pain in rodents--challenges and opportunities","volume":"39","author":"Tappe-Theodor","year":"2014","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bbr.2023.114417_bib90","doi-asserted-by":"crossref","first-page":"451","DOI":"10.30802\/AALAS-CM-19-000042","article-title":"A review of pain assessment methods in laboratory rodents","volume":"69","author":"Turner","year":"2019","journal-title":"Comp. Med"},{"key":"10.1016\/j.bbr.2023.114417_bib91","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1054\/jpai.2002.125186","article-title":"Low dose systemic morphine attenuates operant escape but facilitates innate reflex responses to thermal stimulation","volume":"3","author":"Vierck","year":"2002","journal-title":"J. Pain."},{"key":"10.1016\/j.bbr.2023.114417_bib92","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.jpain.2008.03.008","article-title":"Sex differences in thermal pain sensitivity and sympathetic reactivity for two strains of rat","volume":"9","author":"Vierck","year":"2008","journal-title":"J. Pain."},{"key":"10.1016\/j.bbr.2023.114417_bib93","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1590\/S0100-879X2004000300017","article-title":"An electronic pressure-meter nociception paw test for rats","volume":"37","author":"Vivancos","year":"2004","journal-title":"Braz. J. Med Biol. Res"},{"key":"10.1016\/j.bbr.2023.114417_bib94","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s10194-019-0963-6","article-title":"Behavioral and cognitive animal models in headache research","volume":"20","author":"Vuralli","year":"2019","journal-title":"J. Headache Pain."},{"key":"10.1016\/j.bbr.2023.114417_bib95","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/j.neulet.2006.01.058","article-title":"Comparison of three models of neuropathic pain in mice using a new method to assess cold allodynia: The double plate technique","volume":"399","author":"Walczak","year":"2006","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbr.2023.114417_bib96","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.applanim.2013.11.001","article-title":"Use of spontaneous behaviour measures to assess pain in laboratory rats and mice: how are we progressing","volume":"151","author":"Whittaker","year":"2014","journal-title":"Appl. Anim. Behav. Sci."},{"key":"10.1016\/j.bbr.2023.114417_bib97","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.jpain.2009.01.325","article-title":"Differentiating thermal allodynia and hyperalgesia using dynamic hot and cold plate in rodents","volume":"10","author":"Yalcin","year":"2009","journal-title":"J. Pain."},{"key":"10.1016\/j.bbr.2023.114417_bib98","doi-asserted-by":"crossref","first-page":"4355","DOI":"10.3390\/ijms21124355","article-title":"Overview of neurological mechanism of pain profile used for animal \u201cpain-like\u201d behavioral study with proposed analgesic pathways","volume":"21","author":"Yam","year":"2020","journal-title":"IJMS"},{"key":"10.1016\/j.bbr.2023.114417_bib99","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1093\/gerona\/glq024","article-title":"Effects of age on thermal sensitivity in the rat","volume":"65A","author":"Yezierski","year":"2010","journal-title":"J. Gerontol. Ser. A: Biol. Sci. Med. Sci."},{"key":"10.1016\/j.bbr.2023.114417_bib100","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s11916-009-0009-x","article-title":"Pain outcomes: a brief review of instruments and techniques","volume":"13","author":"Younger","year":"2009","journal-title":"Curr. Pain. Headache Rep."},{"key":"10.1016\/j.bbr.2023.114417_bib101","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1097\/ALN.0000000000003348","article-title":"Dorsal root ganglion stimulation alleviates pain-related behaviors in rats with nerve injury and osteoarthritis","volume":"133","author":"Yu","year":"2020","journal-title":"Anesthesiology"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432823001353?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432823001353?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T13:38:08Z","timestamp":1759066688000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432823001353"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":101,"alternative-id":["S0166432823001353"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2023.114417","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evaluating pain behaviours: Widely used mechanical and thermal methods in rodents","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2023.114417","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114417"}}