{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,16]],"date-time":"2025-10-16T10:12:36Z","timestamp":1760609556347,"version":"3.44.0"},"reference-count":35,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.bbr.2023.114708","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T02:33:56Z","timestamp":1696991636000},"page":"114708","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Nalmefene attenuates reinstatement of methamphetamine-seeking behavior in rats through group II metabotropic glutamate receptors (mGluR2\/3)"],"prefix":"10.1016","volume":"456","author":[{"given":"Yoko","family":"Nawata","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rina","family":"Ooishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Nishioku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taku","family":"Yamaguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2023.114708_bib1","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1111\/add.14234","article-title":"Global statistics on alcohol, tobacco, and illicit drug use: 2017 status report","volume":"113","author":"Peacock","year":"2018","journal-title":"Addiction"},{"key":"10.1016\/j.bbr.2023.114708_bib2","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1001\/jamapsychiatry.2020.0246","article-title":"Neurobiology, clinical presentation, and treatment of methamphetamine use disorder: a review","volume":"77","author":"Paulus","year":"2020","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.bbr.2023.114708_bib3","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.pneurobio.2005.04.003","article-title":"Mechanisms of neurotransmitter release by amphetamines: a review","volume":"75","author":"Sulzer","year":"2005","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.bbr.2023.114708_bib4","doi-asserted-by":"crossref","first-page":"442","DOI":"10.2174\/187152708786927813","article-title":"Targeting endogenous mu- and delta-opioid receptor systems for the treatment of drug addiction","volume":"7","author":"Shippenberg","year":"2008","journal-title":"CNS Neurol. Disord. Drug Targets"},{"key":"10.1016\/j.bbr.2023.114708_bib5","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/s41583-018-0028-x","article-title":"Opioid receptors: drivers to addiction?","volume":"19","author":"Darcq","year":"2018","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbr.2023.114708_bib6","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.neuropharm.2018.07.025","article-title":"Naltrexone and nalmefene attenuate cocaine place preference in male mice","volume":"140","author":"Windisch","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2023.114708_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2021.108590","article-title":"Nalmefene, a mu opioid receptor antagonist\/kappa opioid receptor partial agonist, potentiates cocaine motivation but not intake with extended access self-administration in adult male mice","volume":"192","author":"Windisch","year":"2021","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2023.114708_bib8","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1124\/pr.116.012484","article-title":"The nucleus accumbens: mechanisms of addiction across drug classes reflect the importance of glutamate homeostasis","volume":"68","author":"Scofield","year":"2016","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.bbr.2023.114708_bib9","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/0306-4522(93)90485-X","article-title":"Distribution of the messenger RNA for a metabotropic glutamate receptor, mGluR2, in the central nervous system of the rat","volume":"53","author":"Ohishi","year":"1993","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2023.114708_bib10","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0306-4522(01)00305-0","article-title":"Distribution of metabotropic glutamate receptor mGluR3 in the mouse CNS: differential location relative to pre- and postsynaptic sites","volume":"106","author":"Tamaru","year":"2001","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2023.114708_bib11","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S0022-3565(24)29296-X","article-title":"Unveiling the functions of presynaptic metabotropic glutamate receptors in the central nervous system","volume":"299","author":"Schoepp","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbr.2023.114708_bib12","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.bbr.2006.03.032","article-title":"The metabotropic glutamate 2\/3 receptor agonist LY404039 reduces alcohol-seeking but not alcohol self-administration in alcohol-preferring (P) rats","volume":"171","author":"Rodd","year":"2006","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2023.114708_bib13","doi-asserted-by":"crossref","first-page":"10726","DOI":"10.1523\/JNEUROSCI.3207-04.2004","article-title":"A role of ventral tegmental area glutamate in contextual cue-induced relapse to heroin seeking","volume":"24","author":"Bossert","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2023.114708_bib14","doi-asserted-by":"crossref","first-page":"4723","DOI":"10.1523\/JNEUROSCI.0176-04.2004","article-title":"Preferential effects of the metabotropic glutamate 2\/3 receptor agonist LY379268 on conditioned reinstatement versus primary reinforcement: comparison between cocaine and a potent conventional reinforcer","volume":"24","author":"Baptista","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2023.114708_bib15","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.neuropharm.2012.05.037","article-title":"Attenuation of methamphetamine seeking by the mGluR2\/3 agonist LY379268 in rats with histories of restricted and escalated self-administration","volume":"66","author":"Kufahl","year":"2013","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2023.114708_bib16","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1046\/j.1471-4159.1999.0731066.x","article-title":"The kappa-opioid agonist, U-69593, decreases acute amphetamine-evoked behaviors and calcium-dependent dialysate levels of dopamine and glutamate in the ventral striatum","volume":"73","author":"Gray","year":"1999","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbr.2023.114708_bib17","doi-asserted-by":"crossref","first-page":"3086","DOI":"10.1152\/jn.00855.2004","article-title":"Both kappa and mu opioid agonists inhibit glutamatergic input to ventral tegmental area neurons","volume":"93","author":"Margolis","year":"2005","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.bbr.2023.114708_bib18","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/0006-8993(93)91175-R","article-title":"Opioid receptor antagonist nalmefene stereospecifically inhibits glutamate release during global cerebral ischemia","volume":"632","author":"Graham","year":"1993","journal-title":"Brain Res"},{"key":"10.1016\/j.bbr.2023.114708_bib19","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.drugalcdep.2015.12.016","article-title":"Prevention of drug priming- and cue-induced reinstatement of MDMA-seeking behaviors by the CB1 cannabinoid receptor antagonist AM251","volume":"160","author":"Nawata","year":"2016","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.bbr.2023.114708_bib20","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1093\/ijnp\/pyy086","article-title":"Inhibition of monoacylglycerol lipase reduces the reinstatement of methamphetamine-seeking and anxiety-like behaviors in methamphetamine self-administered rats","volume":"22","author":"Nawata","year":"2019","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.bbr.2023.114708_bib21","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.pharmthera.2009.06.014","article-title":"Anti-relapse medications: preclinical models for drug addiction treatment","volume":"124","author":"Yahyavi-Firouz-Abadi","year":"2009","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bbr.2023.114708_bib22","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/S0893-133X(96)00097-8","article-title":"Dopamine overflow in the nucleus accumbens during extinction and reinstatement of cocaine self-administration behavior","volume":"15","author":"Neisewander","year":"1996","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2023.114708_bib23","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/S0893-133X(00)00100-7","article-title":"Context-specific enhancement of glutamate transmission by cocaine","volume":"23","author":"Bell","year":"2000","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2023.114708_bib24","doi-asserted-by":"crossref","first-page":"3531","DOI":"10.1523\/JNEUROSCI.23-08-03531.2003","article-title":"Prefrontal glutamate release into the core of the nucleus accumbens mediates cocaine-induced reinstatement of drug-seeking behavior","volume":"23","author":"McFarland","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2023.114708_bib25","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1523\/JNEUROSCI.5129-07.2008","article-title":"Glutamate release in the nucleus accumbens core is necessary for heroin seeking","volume":"28","author":"LaLumiere","year":"2008","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2023.114708_bib26","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.3390\/ijms17081216","article-title":"Distinct effects of nalmefene on dopamine uptake rates and kappa opioid receptor activity in the nucleus accumbens following chronic intermittent ethanol exposure","volume":"17","author":"Rose","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbr.2023.114708_bib27","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S0022-3565(25)23081-6","article-title":"Opiate-receptor antagonist improves metabolic recovery and limits neurochemical alterations associated with reperfusion after global brain ischemia in rats","volume":"255","author":"Faden","year":"1990","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbr.2023.114708_bib28","doi-asserted-by":"crossref","first-page":"6389","DOI":"10.1523\/JNEUROSCI.1007-05.2005","article-title":"Cystine\/glutamate exchange regulates metabotropic glutamate receptor presynaptic inhibition of excitatory transmission and vulnerability to cocaine seeking","volume":"25","author":"Moran","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2023.114708_bib29","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1111\/adb.12443","article-title":"mGluR2\/3 mediates short-term control of nicotine-seeking by acute systemic N-acetylcysteine","volume":"23","author":"Moro","year":"2018","journal-title":"Addict. Biol."},{"key":"10.1016\/j.bbr.2023.114708_bib30","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1007\/s12264-017-0140-3","article-title":"N-acetylaspartylglutamate inhibits heroin self-administration and heroin-seeking behaviors induced by cue or priming in rats","volume":"33","author":"Zhu","year":"2017","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.bbr.2023.114708_bib31","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.pbb.2017.08.012","article-title":"Antagonism of mGlu2\/3 receptors in the nucleus accumbens prevents oxytocin from reducing cued methamphetamine seeking in male and female rats","volume":"161","author":"Bernheim","year":"2017","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.bbr.2023.114708_bib32","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/sj.npp.1301438","article-title":"Pharmacological evidence for a motivational role of kappa-opioid systems in ethanol dependence","volume":"33","author":"Walker","year":"2008","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2023.114708_bib33","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2022.15425","article-title":"Analysis of urine drug test results from substance use disorder treatment practices and overdose mortality rates, 2013-2020","volume":"5","author":"Whitley","year":"2022","journal-title":"JAMA Netw. Open."},{"key":"10.1016\/j.bbr.2023.114708_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.drugpo.2021.103467","article-title":"Consuming illicit opioids during a drug overdose epidemic: Illicit fentanyls, drug discernment, and the radical transformation of the illicit opioid market","volume":"99","author":"Duhart Clarke","year":"2022","journal-title":"Int. J. Drug Policy"},{"key":"10.1016\/j.bbr.2023.114708_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2021.108019","article-title":"Treatment of overdose in the synthetic opioid era","volume":"233","author":"Skolnick","year":"2022","journal-title":"Pharmacol. Ther."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432823004266?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432823004266?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T13:42:13Z","timestamp":1759066933000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432823004266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":35,"alternative-id":["S0166432823004266"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2023.114708","relation":{},"ISSN":["0166-4328"],"issn-type":[{"type":"print","value":"0166-4328"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Nalmefene attenuates reinstatement of methamphetamine-seeking behavior in rats through group II metabotropic glutamate receptors (mGluR2\/3)","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2023.114708","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114708"}}