{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T03:33:38Z","timestamp":1790307218925,"version":"4.1.0"},"reference-count":84,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.bbr.2023.114713","type":"journal-article","created":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T12:33:55Z","timestamp":1697114035000},"page":"114713","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Magnetic resonance spectroscopy in the hippocampus of adult APP\/PS1 mice following chronic vitamin D deficiency"],"prefix":"10.1016","volume":"457","author":[{"given":"Dickson","family":"Wong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda","family":"Bellyou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco A.M.","family":"Prado","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivier","family":"Beauchet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9dric","family":"Annweiler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Montero-Odasso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7118-9096","authenticated-orcid":false,"given":"Robert","family":"Bartha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2023.114713_bib1","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/S0140-6736(15)01124-1","article-title":"Alzheimer\u2019s disease","volume":"388","author":"Scheltens","year":"2016","journal-title":"Lancet"},{"key":"10.1016\/j.bbr.2023.114713_bib2","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1056\/NEJMra0909142","article-title":"Alzheimer\u2019s disease","volume":"362","author":"Querfurth","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbr.2023.114713_bib3","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.tins.2008.06.005","article-title":"Neuronal calcium mishandling and the pathogenesis of Alzheimer\u2019s disease","volume":"31","author":"Bezprozvanny","year":"2008","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.bbr.2023.114713_bib4","doi-asserted-by":"crossref","first-page":"439","DOI":"10.3233\/JAD-130560","article-title":"CaV1.2 calcium channel expression in reactive astrocytes is associated with the formation of amyloid-\u03b2 plaques in an Alzheimer\u2019s disease mouse model","volume":"37","author":"Daschil","year":"2013","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"10.1016\/j.bbr.2023.114713_bib5","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1007\/s10059-011-0075-x","article-title":"Effects of Amyloid-\u03b2 peptides on voltage-gated L-Type Ca v1.2 and Ca v1.3 Ca 2+ channels","volume":"32","author":"Kim","year":"2011","journal-title":"Mol. Cells"},{"key":"10.1016\/j.bbr.2023.114713_bib6","doi-asserted-by":"crossref","first-page":"4713","DOI":"10.1074\/jbc.275.7.4713","article-title":"Enhancement of 45Ca2+ influx and voltage-dependent Ca2+ channel activity by \u03b2-amyloid-(1-40) in rat cortical synaptosomes and cultured cortical neurons. Modulation by the proinflammatory cytokine interleukin-1\u03b2","volume":"275","author":"MacManus","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbr.2023.114713_bib7","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1046\/j.1471-4159.1997.68010265.x","article-title":"Amyloid \u03b2 protein potentiates Ca2+ influx through L-type voltage- sensitive Ca2+ channels: A possible involvement of free radicals","volume":"68","author":"Ueda","year":"1997","journal-title":"J. Neurochem"},{"key":"10.1016\/j.bbr.2023.114713_bib8","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.ceca.2009.12.010","article-title":"Amyloid \u03b2 oligomers induce Ca2+ dysregulation and neuronal death through activation of ionotropic glutamate receptors","volume":"47","author":"Alberdi","year":"2010","journal-title":"Cell Calcium"},{"key":"10.1016\/j.bbr.2023.114713_bib9","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ceca.2009.12.014","article-title":"The dysregulation of intracellular calcium in Alzheimer disease","volume":"47","author":"Supnet","year":"2010","journal-title":"Cell Calcium"},{"key":"10.1016\/j.bbr.2023.114713_bib10","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.bbrc.2015.01.008","article-title":"Vitamin D cell signalling in health and disease","volume":"460","author":"Berridge","year":"2015","journal-title":"Biochem Biophys. Res Commun."},{"key":"10.1016\/j.bbr.2023.114713_bib11","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.21-01-00098.2001","article-title":"Vitamin D hormone confers neuroprotection in parallel with downregulation of L-type calcium channel expression in hippocampal neurons","author":"Brewer","year":"2001","journal-title":"Soc. Neurosci."},{"key":"10.1016\/j.bbr.2023.114713_bib12","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.ceca.2006.04.001","article-title":"Chronic 1\u03b1,25-(OH)2vitamin D3 treatment reduces Ca2+-mediated hippocampal biomarkers of aging","volume":"40","author":"Brewer","year":"2006","journal-title":"Cell Calcium"},{"key":"10.1016\/j.bbr.2023.114713_bib13","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1023\/B:BIRY.0000040196.65686.2f","article-title":"Mechanisms of neuroprotective action of vitamin D3","volume":"69","author":"Kalueff","year":"2004","journal-title":"Biochem. (Mosc. )"},{"key":"10.1016\/j.bbr.2023.114713_bib14","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jchemneu.2004.08.006","article-title":"Distribution of the Vitamin D receptor and 1\u03b1-hydroxylase in human brain","volume":"29","author":"Eyles","year":"2005","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.bbr.2023.114713_bib15","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1001\/archneur.65.10.1348","article-title":"Prevalence of vitamin D insufficiency in patients with Parkinson disease and Alzheimer disease","volume":"65","author":"Evatt","year":"2008","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.bbr.2023.114713_bib16","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1212\/WNL.0000000000000755","article-title":"Vitamin D and the risk of dementia and Alzheimer disease","volume":"83","author":"Littlejohns","year":"2014","journal-title":"Neurology"},{"key":"10.1016\/j.bbr.2023.114713_bib17","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1177\/0891988708327888","article-title":"Serum 25-hydroxyvitamin D concentration and cognitive impairment","volume":"22","author":"Llewellyn","year":"2009","journal-title":"J. Geriatr. Psychiatry Neurol."},{"key":"10.1016\/j.bbr.2023.114713_bib18","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1001\/archinternmed.2010.173","article-title":"Vitamin D and risk of cognitive decline in elderly persons","volume":"170","author":"Llewellyn","year":"2010","journal-title":"Arch. Intern Med"},{"key":"10.1016\/j.bbr.2023.114713_bib19","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1093\/gerona\/gls107","article-title":"Higher vitamin D dietary intake is associated with lower risk of Alzheimer\u2019s disease: A 7-year follow-up","volume":"67","author":"Annweiler","year":"2012","journal-title":"J. Gerontol. Ser. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.bbr.2023.114713_bib20","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1093\/gerona\/glp032","article-title":"Vitamin D is associated with cognitive function in elders receiving home health services","volume":"64","author":"Buell","year":"2009","journal-title":"J. Gerontol. - Ser. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.bbr.2023.114713_bib21","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1136\/jnnp.2008.165720","article-title":"Association between 25-hydroxyvitamin D levels and cognitive performance in middle-aged and older European men","volume":"80","author":"Lee","year":"2009","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.bbr.2023.114713_bib22","doi-asserted-by":"crossref","DOI":"10.1111\/acel.13670","article-title":"Vitamin D supplementation worsens Alzheimer\u2019s progression: Animal model and human cohort studies","author":"Lai","year":"2022","journal-title":"Aging Cell"},{"key":"10.1016\/j.bbr.2023.114713_bib23","first-page":"42","article-title":"Vitamin D deficiency impairs spatial learning in adult rats","volume":"17","author":"Taghizadeh","year":"2013","journal-title":"Iran. Biomed. J."},{"key":"10.1016\/j.bbr.2023.114713_bib24","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3109\/00207454.2010.523132","article-title":"Vitamin-D-free regimen intensifies the spatial learning deficit in Alzheimer\u2019s disease","volume":"121","author":"Taghizadeh","year":"2011","journal-title":"Int. J. Neurosci."},{"key":"10.1016\/j.bbr.2023.114713_bib25","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.3390\/biomedicines10081824","article-title":"The role of vitamin D in Alzheimer\u2019s disease: a transcriptional regulator of amyloidopathy and gliopathy","volume":"10","author":"Kang","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.bbr.2023.114713_bib26","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.bbr.2014.03.038","article-title":"No role for vitamin D or a moderate fat diet in aging induced cognitive decline and emotional reactivity in C57BL\/6 mice","volume":"267","author":"Brouwer-Brolsma","year":"2014","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2023.114713_bib27","doi-asserted-by":"crossref","first-page":"E4359","DOI":"10.1073\/pnas.1404477111","article-title":"Vitamin D prevents cognitive decline and enhances hippocampal synaptic function in aging rats","volume":"111","author":"Latimer","year":"2014","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbr.2023.114713_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0076362","article-title":"Vitamin D2-enriched button mushroom (Agaricus bisporus) improves memory in both wild type and APPswe\/PS1dE9 transgenic mice","volume":"8","author":"Bennett","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbr.2023.114713_bib29","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/bs.pbr.2015.03.005","article-title":"Importance of the ventral midline thalamus in driving hippocampal functions","volume":"219","author":"Cassel","year":"2015","journal-title":"Prog. Brain Res"},{"key":"10.1016\/j.bbr.2023.114713_bib30","doi-asserted-by":"crossref","unstructured":"L. B\u00e4ckman, S. Jones, A. Berger, \u2026 E.L.-, undefined 2005, Cognitive impairment in preclinical Alzheimer\u2019s disease: a meta-analysis., Psycnet.Apa.Org. 19 (2005) 520\u2013531. https:\/\/doi.org\/10.1037\/0894\u20134105.19.4.520.","DOI":"10.1037\/0894-4105.19.4.520"},{"key":"10.1016\/j.bbr.2023.114713_bib31","doi-asserted-by":"crossref","first-page":"375","DOI":"10.3233\/JAD-201137","article-title":"Effect of memantine treatment and combination with vitamin D supplementation on body composition in the APP\/PS1 mouse model of alzheimer\u2019s disease following chronic vitamin D deficiency","volume":"81","author":"Wong","year":"2021","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"10.1016\/j.bbr.2023.114713_bib32","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1006\/jmre.2001.2340","article-title":"The return of the frequency sweep: designing adiabatic pulses for contemporary NMR","volume":"153","author":"Garwood","year":"2001","journal-title":"J. Magn. Reson."},{"key":"10.1016\/j.bbr.2023.114713_bib33","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1002\/1522-2594(200010)44:4<641::AID-MRM19>3.0.CO;2-G","article-title":"Spectroscopic lineshape correction by QUECC: combined QUALITY deconvolution and eddy current correction","volume":"44","author":"Bartha","year":"2000","journal-title":"Magn. Reson Med"},{"key":"10.1016\/j.bbr.2023.114713_bib34","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1002\/mrm.1910130302","article-title":"Quality: quantification improvement by converting lineshapes to the lorentzian type","volume":"13","author":"de Graaf","year":"1990","journal-title":"Magn. Reson Med"},{"key":"10.1016\/j.bbr.2023.114713_bib35","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1002\/mrm.10443","article-title":"Quantitative proton short\u2010echo\u2010time LASER spectroscopy of normal human white matter and hippocampus at 4 Tesla incorporating macromolecule subtraction","volume":"49","author":"Kassem","year":"2003","journal-title":"Magn. Reson Med"},{"key":"10.1016\/j.bbr.2023.114713_bib36","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1137\/0111030","article-title":"An algorithm for least-squares estimation of nonlinear parameters","volume":"11","author":"Marquardt","year":"1963","journal-title":"J. Soc. Ind. Appl. Math."},{"key":"10.1016\/j.bbr.2023.114713_bib37","doi-asserted-by":"crossref","first-page":"1219","DOI":"10.1002\/mrm.20901","article-title":"Use of tissue water as a concentration reference for proton spectroscopic imaging","volume":"55","author":"Gasparovic","year":"2006","journal-title":"Magn. Reson Med"},{"key":"10.1016\/j.bbr.2023.114713_bib38","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1093\/brain\/awn146","article-title":"Ventricular enlargement as a possible measure of Alzheimer\u2019s disease progression validated using the Alzheimer\u2019s disease neuroimaging initiative database","volume":"131","author":"Nestor","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.bbr.2023.114713_bib39","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1002\/jmri.21449","article-title":"3D TrueFISP imaging of mouse brain at 4.7 T and 9.4 T","volume":"28","author":"Miraux","year":"2008","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.bbr.2023.114713_bib40","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/j.1601-183X.2006.00221.x","article-title":"Impaired spatial learning in the APPSwe+PSEN1\u0394E9 bigenic mouse model of Alzheimer\u2019s disease","volume":"6","author":"Reiserer","year":"2007","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.bbr.2023.114713_bib41","doi-asserted-by":"crossref","DOI":"10.3791\/1088","article-title":"Elevated plus maze for mice","author":"Komada","year":"2008","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.bbr.2023.114713_bib42","first-page":"626","article-title":"Rectangular confidence regions for the means of multivariate normal distributions","volume":"62","author":"\u0160id\u00e1k","year":"1967","journal-title":"J. Am. Stat. Assoc."},{"key":"10.1016\/j.bbr.2023.114713_bib43","doi-asserted-by":"crossref","DOI":"10.1186\/1748-717X-8-293","article-title":"Multiple comparisons permutation test for image based data mining in radiotherapy","volume":"8","author":"Chen","year":"2013","journal-title":"Radiat. Oncol."},{"key":"10.1016\/j.bbr.2023.114713_bib44","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1016\/S0140-6736(00)02246-7","article-title":"Longitudinal decline of the neuronal marker N-acetyl aspartate in Alzheimer\u2019s disease","volume":"355","author":"Adalsteinsson","year":"2000","journal-title":"Lancet"},{"key":"10.1016\/j.bbr.2023.114713_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pscychresns.2008.07.015","article-title":"Conversion to dementia in mild cognitive impairment is associated with decline of N-actylaspartate and creatine as revealed by magnetic resonance spectroscopy","volume":"173","author":"Pilatus","year":"2009","journal-title":"Psychiatry Res Neuroimag."},{"key":"10.1016\/j.bbr.2023.114713_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainres.2010.04.008","article-title":"Methamphetamine-induced neuronal protein NAT8L is the NAA biosynthetic enzyme: Implications for specialized acetyl coenzyme A metabolism in the CNS","volume":"1335","author":"Ariyannur","year":"2010","journal-title":"Brain Res"},{"key":"10.1016\/j.bbr.2023.114713_bib47","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11064-013-1199-5","article-title":"A guide to the metabolic pathways and function of metabolites observed in human brain 1H magnetic resonance spectra","volume":"39","author":"Rae","year":"2014","journal-title":"Neurochem Res"},{"key":"10.1016\/j.bbr.2023.114713_bib48","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1007\/s00259-008-0773-6","article-title":"Individual cerebral metabolic deficits in Alzheimer\u2019s disease and amnestic mild cognitive impairment: An FDG PET study","volume":"35","author":"del Sole","year":"2008","journal-title":"Eur. J. Nucl. Med Mol. Imaging"},{"key":"10.1016\/j.bbr.2023.114713_bib49","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1007\/s00259-012-2102-3","article-title":"Longitudinal imaging of Alzheimer pathology using [ 11C]PIB, [ 18F]FDDNP and [ 18F]FDG PET","volume":"39","author":"Ossenkoppele","year":"2012","journal-title":"Eur. J. Nucl. Med Mol. Imaging"},{"key":"10.1016\/j.bbr.2023.114713_bib50","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1093\/brain\/awp202","article-title":"The human brain utilizes lactate via the tricarboxylic acid cycle: A 13C-labelled microdialysis and high-resolution nuclear magnetic resonance study","volume":"132","author":"Gallagher","year":"2009","journal-title":"Brain"},{"key":"10.1016\/j.bbr.2023.114713_bib51","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1523\/JNEUROSCI.19-01-00034.1999","article-title":"An increase in lactate output by brain tissue serves to meet the energy needs of glutamate-activated neurons","volume":"19","author":"Schurr","year":"1999","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2023.114713_bib52","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1097\/01.WCB.0000063991.19746.11","article-title":"Lactate: A preferred fuel for human brain metabolism in vivo","volume":"23","author":"Smith","year":"2003","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"10.1016\/j.bbr.2023.114713_bib53","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbr.2012.07.016","article-title":"Age-related changes in brain metabolites and cognitive function in APP\/PS1 transgenic mice","volume":"235","author":"Chen","year":"2012","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2023.114713_bib54","doi-asserted-by":"crossref","first-page":"11906","DOI":"10.1073\/pnas.0505513102","article-title":"Monitoring disease progression in transgenic mouse models of Alzheimer\u2019s disease with proton magnetic resonance spectroscopy","volume":"102","author":"Marjanska","year":"2005","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbr.2023.114713_bib55","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0063643","article-title":"A longitudinal study of cognition, proton MR spectroscopy and synaptic and neuronal pathology in aging wild-type and A\u03b2PPswe-PS1dE9 Mice","volume":"8","author":"Jansen","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbr.2023.114713_bib56","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.1016\/j.neurobiolaging.2007.03.002","article-title":"Age related changes in brain metabolites observed by 1H MRS in APP\/PS1 mice","volume":"29","author":"Oberg","year":"2008","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbr.2023.114713_bib57","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1111\/ejn.13442","article-title":"Human tau increases amyloid \u03b2 plaque size but not amyloid \u03b2\u2010mediated synapse loss in a novel mouse model of Alzheimer\u2019s disease","volume":"44","author":"Jackson","year":"2016","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bbr.2023.114713_bib58","first-page":"4","article-title":"Longitudinal brain size measurements in APP\/PS1 transgenic mice","volume":"4","author":"Vincent","year":"2010","journal-title":"Magn. Reson Insights"},{"key":"10.1016\/j.bbr.2023.114713_bib59","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.neurobiolaging.2005.04.011","article-title":"In vivo MRI and histological evaluation of brain atrophy in APP\/PS1 transgenic mice","volume":"27","author":"Delatour","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbr.2023.114713_bib60","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1016\/j.nbd.2004.10.022","article-title":"Episodic-like memory deficits in the APPswe\/PS1dE9 mouse model of Alzheimer\u2019s disease: Relationships to \u03b2-amyloid deposition and neurotransmitter abnormalities","volume":"18","author":"Savonenko","year":"2005","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbr.2023.114713_bib61","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201800621","article-title":"Effects of quercetin intervention on cognition function in APP\/PS1 mice was affected by vitamin D status","volume":"62","author":"Lv","year":"2018","journal-title":"Mol. Nutr. Food Res"},{"key":"10.1016\/j.bbr.2023.114713_bib62","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.freeradbiomed.2020.10.007","article-title":"Vitamin D deficiency exacerbates Alzheimer-like pathologies by reducing antioxidant capacity","volume":"161","author":"Fan","year":"2020","journal-title":"Free Radic. Biol. Med"},{"key":"10.1016\/j.bbr.2023.114713_bib63","doi-asserted-by":"crossref","first-page":"7091","DOI":"10.1523\/JNEUROSCI.2711-13.2014","article-title":"1\u03b1, 25-dihydroxyvitamin D3 reduces cerebral Amyloid-\u03b2 accumulation and improves cognition in mouse models of Alzheimer\u2019s disease","volume":"34","author":"Durk","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2023.114713_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2019.107910","article-title":"Relative D3 vitamin deficiency and consequent cognitive impairment in an animal model of Alzheimer\u2019s disease: Potential involvement of collapsin response mediator protein-2","volume":"164","author":"Lin","year":"2020","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2023.114713_bib65","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1080\/01616412.2020.1787624","article-title":"Administration of Vitamin D3 and E supplements reduces neuronal loss\u200f and oxidative stress in a model of rats with Alzheimer\u2019s disease","author":"Mehrabadi","year":"2020","journal-title":"Neurol. Res"},{"key":"10.1016\/j.bbr.2023.114713_bib66","doi-asserted-by":"crossref","first-page":"6463","DOI":"10.1007\/s12035-017-0839-1","article-title":"Vitamin D improves neurogenesis and cognition in a mouse model of alzheimer\u2019s disease","volume":"55","author":"Morello","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbr.2023.114713_bib67","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1007\/s10787-017-0372-x","article-title":"Vitamin D3 attenuates cognitive deficits and neuroinflammatory responses in ICV-STZ induced sporadic Alzheimer\u2019s disease","volume":"26","author":"Yamini","year":"2018","journal-title":"Inflammopharmacology"},{"issue":"2008","key":"10.1016\/j.bbr.2023.114713_bib68","first-page":"1551","article-title":"Astroglial metabolic networks sustain hippocampal synaptic transmission","volume":"322","author":"Rouach","year":"1979","journal-title":"Science"},{"key":"10.1016\/j.bbr.2023.114713_bib69","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1161\/01.STR.21.3.397","article-title":"Immunohistochemical characterization of cerebrovascular amyloid in 46 autopsied cases using antibodies to \u00df protein and cystatin C","volume":"21","author":"Maruyama","year":"1990","journal-title":"Stroke"},{"key":"10.1016\/j.bbr.2023.114713_bib70","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22073604","article-title":"Vitamin d deficiency induces chronic pain and microglial phenotypic changes in mice","volume":"22","author":"Alessio","year":"2021","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.bbr.2023.114713_bib71","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1097\/WNR.0000000000000782","article-title":"Vitamin D3 repressed astrocyte activation following lipopolysaccharide stimulation in vitro and in neonatal rats","volume":"28","author":"Jiao","year":"2017","journal-title":"Neuroreport"},{"key":"10.1016\/j.bbr.2023.114713_bib72","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/nbm.1145","article-title":"Application of MRS to mouse models of neurodegenerative illness","volume":"20","author":"Choi","year":"2007","journal-title":"NMR Biomed."},{"key":"10.1016\/j.bbr.2023.114713_bib73","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1212\/WNL.42.7.1349","article-title":"Spectroscopic imaging of stroke in humans: Histopathology correlates of spectral changes","volume":"42","author":"Petroff","year":"1992","journal-title":"Neurology"},{"key":"10.1016\/j.bbr.2023.114713_bib74","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.tins.2010.12.001","article-title":"Astrocyte-neuron metabolic relationships: For better and for worse","volume":"34","author":"Allaman","year":"2011","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.bbr.2023.114713_bib75","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1177\/1073858405278321","article-title":"Reactive astrocytes in neural repair and protection","volume":"11","author":"Sofroniew","year":"2005","journal-title":"Neuroscientist"},{"key":"10.1016\/j.bbr.2023.114713_bib76","first-page":"13","article-title":"Reevaluating metabolism in Alzheimer\u2019s disease from the perspective of the astrocyte-neuron lactate shuttle model","volume":"2013","author":"Newington","year":"2013","journal-title":"J. Neurodegener. Dis."},{"key":"10.1016\/j.bbr.2023.114713_bib77","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0019191","article-title":"Amyloid beta resistance in nerve cell lines is mediated by the warburg effect","volume":"6","author":"Newington","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bbr.2023.114713_bib78","doi-asserted-by":"crossref","first-page":"37245","DOI":"10.1074\/jbc.M112.366195","article-title":"Overexpression of pyruvate dehydrogenase kinase 1 and lactate dehydrogenase A in nerve cells confers resistance to amyloid \u03b2 and other toxins by decreasing mitochondrial respiration and reactive oxygen species production","volume":"287","author":"Newington","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbr.2023.114713_bib79","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1002\/mrm.20946","article-title":"High magnetic field water and metabolite proton T1 and T2 relaxation in rat brain in vivo","volume":"56","author":"de Graaf","year":"2006","journal-title":"Magn. Reson Med"},{"key":"10.1016\/j.bbr.2023.114713_bib80","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/mrm.25088","article-title":"Effect of Carr\u2010Purcell refocusing pulse trains on transverse relaxation times of metabolites in rat brain at 9.4 Tesla","volume":"73","author":"Kumar Deelchand","year":"2015","journal-title":"Magn. Reson Med"},{"key":"10.1016\/j.bbr.2023.114713_bib81","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1002\/jmri.20285","article-title":"In vivo measurements of T1 relaxation times in mouse brain associated with different modes of systemic administration of manganese chloride","volume":"21","author":"Kuo","year":"2005","journal-title":"J. Magn. Reson. Imaging"},{"key":"10.1016\/j.bbr.2023.114713_bib82","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/hmg\/ddh019","article-title":"Mutant presenilins specifically elevate the levels of the 42 residue \u03b2-amyloid peptide in vivo: Evidence for augmentation of a 42-specific \u03b3 secretase","volume":"13","author":"Jankowsky","year":"2004","journal-title":"Hum. Mol. Genet"},{"key":"10.1016\/j.bbr.2023.114713_bib83","unstructured":"M. Kitazawa, Medeiros R., Laferla F.M., Transgenic mouse models of Alzheimer disease: developing a better model as a tool for therapeutic interventions,. Current Pharmaceutical Design. (n.d.). https:\/\/www.ingentaconnect.com\/content\/ben\/cpd\/2012\/00000018\/00000008\/art00011 (accessed August 4, 2022)."},{"key":"10.1016\/j.bbr.2023.114713_bib84","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1056\/NEJMra070553","article-title":"Vitamin D deficiency","volume":"357","author":"Holick","year":"2007","journal-title":"N. Engl. J. Med."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016643282300431X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016643282300431X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T13:42:03Z","timestamp":1759066923000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016643282300431X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":84,"alternative-id":["S016643282300431X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2023.114713","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Magnetic resonance spectroscopy in the hippocampus of adult APP\/PS1 mice following chronic vitamin D deficiency","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2023.114713","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114713"}}