{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T20:07:42Z","timestamp":1792267662636,"version":"4.4.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.bbr.2023.114787","type":"journal-article","created":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T02:47:39Z","timestamp":1701398859000},"page":"114787","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Safinamide alleviates hyperalgesia via inhibiting hyperexcitability of DRG neurons in a mouse model of Parkinson's disease"],"prefix":"10.1016","volume":"459","author":[{"given":"Li-Ge","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng-Qi","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng-Jie","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Guo","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Min","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Feng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8564-0255","authenticated-orcid":false,"given":"Cheng-Jie","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2023.114787_bib1","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1002\/mds.24054","article-title":"Prevalence of pain in Parkinson's disease: a systematic review using the modified QUADAS tool","volume":"27","author":"Broen","year":"2012","journal-title":"Mov. Disord."},{"key":"10.1016\/j.bbr.2023.114787_bib2","first-page":"S37","article-title":"Management of pain in Parkinson's disease","volume":"10","author":"Buhmann","year":"2020","journal-title":"J. Park. Dis."},{"key":"10.1016\/j.bbr.2023.114787_bib3","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/ejp.942","article-title":"Effect of medical cannabis on thermal quantitative measurements of pain in patients with Parkinson's disease","volume":"21","author":"Shohet","year":"2017","journal-title":"Eur. J. Pain."},{"key":"10.1016\/j.bbr.2023.114787_bib4","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1159\/000337376","article-title":"Is there any clinically relevant cannabinoid-induced analgesia?","volume":"89","author":"Kraft","year":"2012","journal-title":"Pharmacology"},{"key":"10.1016\/j.bbr.2023.114787_bib5","first-page":"95","article-title":"Effects of safinamide on pain in fluctuating Parkinson's disease patients: a post-hoc analysis","volume":"7","author":"Cattaneo","year":"2017","journal-title":"J. Park. Dis."},{"key":"10.1016\/j.bbr.2023.114787_bib6","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1002\/mds.25751","article-title":"Randomized trial of safinamide add-on to levodopa in parkinson's disease with motor fluctuations","volume":"29","author":"Borgohain","year":"2014","journal-title":"Mov. Disord."},{"key":"10.1016\/j.bbr.2023.114787_bib7","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1001\/jamaneurol.2016.4467","article-title":"Assessment of safety and efficacy of safinamide as a levodopa adjunct in patients with Parkinson disease and motor fluctuations: a randomized clinical trial","volume":"74","author":"Schapira","year":"2017","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.bbr.2023.114787_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2020.108006","article-title":"Safinamide Inhibits in vivo Glutamate Release in a rat model of Parkinson's disease","volume":"167","author":"Pisano","year":"2020","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2023.114787_bib9","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1093\/brain\/awn102","article-title":"Sensory deficit in Parkinson's disease: evidence of a cutaneous denervation","volume":"131","author":"Nolano","year":"2008","journal-title":"Brain"},{"key":"10.1016\/j.bbr.2023.114787_bib10","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/ana.22351","article-title":"Pain and death: neurodegenerative disease mechanisms in the nociceptor","volume":"69","author":"Reichling","year":"2011","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbr.2023.114787_bib11","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1002\/j.1532-2149.2012.00134.x","article-title":"Contribution of genetic variants to pain susceptibility in Parkinson disease","volume":"16","author":"Greenbaum","year":"2012","journal-title":"Eur. J. Pain."},{"key":"10.1016\/j.bbr.2023.114787_bib12","doi-asserted-by":"crossref","first-page":"7635","DOI":"10.1073\/pnas.96.14.7635","article-title":"Sodium channels and pain","volume":"96","author":"Waxman","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbr.2023.114787_bib13","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1113\/jphysiol.2002.026559","article-title":"Sensory and electrophysiological properties of guinea-pig sensory neurones expressing nav 1.7 (PN1) Na+ channel alpha subunit protein","volume":"546","author":"Djouhri","year":"2003","journal-title":"J Physiol."},{"key":"10.1016\/j.bbr.2023.114787_bib14","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1038\/444831a","article-title":"Neurobiology: a channel sets the gain on pain","volume":"444","author":"Waxman","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.bbr.2023.114787_bib15","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1113\/jphysiol.2003.042127","article-title":"The TTX-resistant sodium channel Nav1.8 (SNS\/PN3): expression and correlation with membrane properties in rat nociceptive primary afferent neurons","volume":"550","author":"Djouhri","year":"2003","journal-title":"J. Physiol."},{"key":"10.1016\/j.bbr.2023.114787_bib16","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.pain.2003.12.035","article-title":"Changes in the expression of tetrodotoxin-sensitive sodium channels within dorsal root ganglia neurons in inflammatory pain","volume":"108","author":"Black","year":"2004","journal-title":"Pain"},{"key":"10.1016\/j.bbr.2023.114787_bib17","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/j.ejpain.2007.09.001","article-title":"Changes in the expression of NaV1.7, NaV1.8 and NaV1.9 in a distinct population of dorsal root ganglia innervating the rat knee joint in a model of chronic inflammatory joint pain","volume":"12","author":"Strickland","year":"2008","journal-title":"Eur. J. Pain."},{"key":"10.1016\/j.bbr.2023.114787_bib18","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1006\/mcne.1997.0657","article-title":"Regulation of expression of the sensory neuron-specific sodium channel SNS in inflammatory and neuropathic pain","volume":"10","author":"Okuse","year":"1997","journal-title":"Mol. Cell Neurosci."},{"key":"10.1016\/j.bbr.2023.114787_bib19","first-page":"17","article-title":"Association between mutations of SCN9A gene and pain related to parkinsonism","volume":"30","author":"Zhang","year":"2013","journal-title":"Zhonghua Yi Xue Yi Chuan Xue Za Zhi"},{"key":"10.1016\/j.bbr.2023.114787_bib20","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/bs.irn.2017.05.029","article-title":"Genes and nonmotor symptoms in Parkinson's disease","volume":"133","author":"Lim","year":"2017","journal-title":"Int Rev. Neurobiol."},{"key":"10.1016\/j.bbr.2023.114787_bib21","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1038\/nprot.2006.342","article-title":"Protocol for the MPTP mouse model of Parkinson's disease","volume":"2","author":"Jackson-Lewis","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bbr.2023.114787_bib22","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1002\/jnr.23577","article-title":"1-[2-(4-Benzyloxyphenoxy)ethyl]Imidazole Inhibits monoamine oxidase B and protects against neuronal loss and behavioral impairment in rodent models of Parkinson's disease","volume":"93","author":"Chung","year":"2015","journal-title":"J. Neurosci. Res"},{"key":"10.1016\/j.bbr.2023.114787_bib23","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s12640-020-00246-5","article-title":"The protective effect of safinamide in ischemic stroke mice and a brain endothelial cell line","volume":"38","author":"Xu","year":"2020","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.bbr.2023.114787_bib24","article-title":"Rasagiline is neuroprotective in A transgenic model of multiple system atrophy","volume":"15","author":"Stefanova","year":"2008","journal-title":"Eur. J. Neurol."},{"key":"10.1016\/j.bbr.2023.114787_bib25","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/nn1398","article-title":"Alcohol-induced motor impairment caused by increased extrasynaptic GABA(A) receptor activity","volume":"8","author":"Hanchar","year":"2005","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbr.2023.114787_bib26","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/s41589-020-00734-x","article-title":"Phospholipase iPLA2beta averts ferroptosis by eliminating a redox lipid death signal","volume":"17","author":"Sun","year":"2021","journal-title":"Nat. Chem. Biol."},{"key":"10.1016\/j.bbr.2023.114787_bib27","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev.pa.20.040180.002301","article-title":"Efficient analysis of experimental observations","volume":"20","author":"Dixon","year":"1980","journal-title":"Annu Rev. Pharm. Toxicol."},{"key":"10.1016\/j.bbr.2023.114787_bib28","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1210\/en.2013-1559","article-title":"Insulin-like growth factor-1 receptor-mediated inhibition of A-type K(+) current induces sensory neuronal hyperexcitability through the phosphatidylinositol 3-kinase and extracellular signal-regulated kinase 1\/2 pathways, independently of Akt","volume":"155","author":"Wang","year":"2014","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbr.2023.114787_bib29","doi-asserted-by":"crossref","first-page":"ra94","DOI":"10.1126\/scisignal.2005283","article-title":"Peripheral pain is enhanced by insulin-like growth factor 1 through A G protein-mediated stimulation of T-type calcium channels","volume":"7","author":"Zhang","year":"2014","journal-title":"Sci. Signal"},{"key":"10.1016\/j.bbr.2023.114787_bib30","doi-asserted-by":"crossref","first-page":"3764","DOI":"10.1152\/jn.00449.2003","article-title":"Axotomy-induced expression of calcium-activated chloride current in subpopulations of mouse dorsal root ganglion neurons","volume":"90","author":"Andre","year":"2003","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.bbr.2023.114787_bib31","doi-asserted-by":"crossref","first-page":"7253","DOI":"10.1007\/s12035-022-03034-8","article-title":"Inhibition of spinal 5-HT3 receptor and spinal dorsal horn neuronal excitability alleviates hyperalgesia in a rat model of Parkinson's disease","volume":"59","author":"Li","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbr.2023.114787_bib32","doi-asserted-by":"crossref","first-page":"4909","DOI":"10.1021\/jm070725e","article-title":"Solid-phase synthesis and insights into structure-activity relationships of safinamide analogues as potent and selective inhibitors of Type B monoamine oxidase","volume":"50","author":"Leonetti","year":"2007","journal-title":"J. Med Chem."},{"key":"10.1016\/j.bbr.2023.114787_bib33","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/j.expneurol.2007.11.022","article-title":"Rasagiline is neuroprotective in a transgenic model of multiple system atrophy","volume":"210","author":"Stefanova","year":"2008","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbr.2023.114787_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2020.113287","article-title":"Safinamide's potential in treating nondystrophic myotonias: inhibition of skeletal muscle voltage-gated sodium channels and skeletal muscle hyperexcitability in vitro and in vivo","volume":"328","author":"Desaphy","year":"2020","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbr.2023.114787_bib35","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1152\/physrev.00052.2017","article-title":"The role of voltage-gated sodium channels in pain signaling","volume":"99","author":"Bennett","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbr.2023.114787_bib36","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1097\/WCO.0000000000000711","article-title":"Pain in Parkinson's disease: new concepts in pathogenesis and treatment","volume":"32","author":"Rukavina","year":"2019","journal-title":"Curr. Opin. Neurol."},{"issue":"Suppl 1","key":"10.1016\/j.bbr.2023.114787_bib37","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1016\/j.pain.2013.06.022","article-title":"Glia and pain: is chronic pain a gliopathy?","volume":"154","author":"Ji","year":"2013","journal-title":"Pain"},{"key":"10.1016\/j.bbr.2023.114787_bib38","doi-asserted-by":"crossref","DOI":"10.3390\/cells9071687","article-title":"Inflammation in Parkinson's disease: mechanisms and therapeutic implications","volume":"9","author":"Pajares","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.bbr.2023.114787_bib39","doi-asserted-by":"crossref","DOI":"10.1038\/s41398-018-0318-0","article-title":"The role of convergent ion channel pathways in microglial phenotypes: a systematic review of the implications for neurological and psychiatric disorders","volume":"8","author":"Quagliato","year":"2018","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.bbr.2023.114787_bib40","doi-asserted-by":"crossref","DOI":"10.1186\/s13041-021-00870-y","article-title":"Synaptic potentiation of anterior cingulate cortex contributes to chronic pain of Parkinson's disease","volume":"14","author":"Zhou","year":"2021","journal-title":"Mol. Brain"},{"key":"10.1016\/j.bbr.2023.114787_bib41","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1002\/glia.22496","article-title":"Doxycycline restrains glia and confers neuroprotection in A 6-OHDA parkinson model","volume":"61","author":"Lazzarini","year":"2013","journal-title":"Glia"},{"key":"10.1016\/j.bbr.2023.114787_bib42","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202013076","article-title":"SGK1 inhibition in glia ameliorates pathologies and symptoms in Parkinson disease animal models","volume":"13","author":"Kwon","year":"2021","journal-title":"EMBO Mol. Med."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432823005053?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432823005053?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T13:43:46Z","timestamp":1759067026000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432823005053"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":42,"alternative-id":["S0166432823005053"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2023.114787","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Safinamide alleviates hyperalgesia via inhibiting hyperexcitability of DRG neurons in a mouse model of Parkinson's disease","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2023.114787","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114787"}}