{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:21:17Z","timestamp":1787235677051,"version":"build-2736575974"},"reference-count":71,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.bbr.2023.114834","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T21:48:39Z","timestamp":1703281719000},"page":"114834","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Sex differences in the anticompulsive-like effect of memantine: Involvement of nitric oxide pathway but not AMPA receptors"],"prefix":"10.1016","volume":"461","author":[{"given":"Breno Lopes","family":"Macedo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Friedrich","family":"Veloso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella Braun","family":"Dias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00falia Grigorini Mori","family":"Ayub","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4533-0495","authenticated-orcid":false,"given":"Vanessa","family":"Beijamini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2023.114834_bib1","doi-asserted-by":"crossref","unstructured":"American Psychiatric Association, Diagnostic and statistical manual of mental disorders, fifth, American Psychiatric Association, Arlington, VA, 2013.","DOI":"10.1176\/appi.books.9780890425596"},{"key":"10.1016\/j.bbr.2023.114834_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/brb3.3000","article-title":"Obsessive-compulsive disorder: etiology, neuropathology, and cognitive dysfunction","volume":"13","author":"Jalal","year":"2023","journal-title":"Brain Behav."},{"issue":"1","key":"10.1016\/j.bbr.2023.114834_bib3","first-page":"21","article-title":"Obsessive\u2013compulsive disorder","volume":"5","author":"Stein","year":"2019","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.bbr.2023.114834_bib4","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1097\/YIC.0000000000000314","article-title":"Clinical advances in obsessive-compulsive disorder: a position statement by the international college of obsessive-compulsive spectrum disorders","volume":"35","author":"Fineberg","year":"2020","journal-title":"Int. Clin. Psychopharmacol."},{"key":"10.1016\/j.bbr.2023.114834_bib5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fpsyt.2023.1065812","article-title":"Therapies for obsessive-compulsive disorder: current state of the art and perspectives for approaching treatment-resistant patients","volume":"14","author":"Swierkosz-lenart","year":"2023","journal-title":"Front. Psychiatry"},{"issue":"1","key":"10.1016\/j.bbr.2023.114834_bib6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s40360-021-00534-6","article-title":"Glutamatergic medications as adjunctive therapy for moderate to severe obsessive-compulsive disorder in adults: a systematic review and meta-analysis","volume":"22","author":"Hadi","year":"2021","journal-title":"BMC Pharmacol. Toxicol."},{"key":"10.1016\/j.bbr.2023.114834_bib7","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1021\/acschemneuro.7b00270","article-title":"Classics in chemical neuroscience: memantine","volume":"8","author":"Alam","year":"2017","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.bbr.2023.114834_bib8","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/s00109-020-01982-z","article-title":"Memantine in neurological disorders \u2013 schizophrenia and depression","volume":"99","author":"Czarnecka","year":"2021","journal-title":"J. Mol. Med."},{"key":"10.1016\/j.bbr.2023.114834_bib9","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/nrd1958","article-title":"Paradigm shift in neuroprotection by NMDA receptor blockade: memantine and beyond","volume":"5","author":"Lipton","year":"2006","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbr.2023.114834_bib10","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/acps.13568","article-title":"Pharmacological augmentation of serotonin reuptake inhibitors in patients with obsessive-compulsive disorder: a network meta-analysis","volume":"148","author":"Maiti","year":"2023","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.bbr.2023.114834_bib11","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ejphar.2008.06.100","article-title":"Aripiprazole inhibits marble-burying behavior via 5-hydroxytryptamine (5-HT)1A receptor-independent mechanisms","volume":"592","author":"Egashira","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbr.2023.114834_bib12","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1037\/a0016402","article-title":"The combined effects of memantine and fluoxetine on an animal model of obsessive compulsive disorder","volume":"17","author":"Wald","year":"2009","journal-title":"Exp. Clin. Psychopharmacol."},{"key":"10.1016\/j.bbr.2023.114834_bib13","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1038\/npp.2015.26","article-title":"Astroglial glutamate transporter deficiency increases synaptic excitability and leads to pathological repetitive behaviors in mice","volume":"40","author":"Aida","year":"2015","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2023.114834_bib14","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.physbeh.2019.01.013","article-title":"No effect of riluzole and memantine on learning deficit following quinpirole sensitization - An animal model of obsessive-compulsive disorder","volume":"204","author":"Janikova","year":"2019","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbr.2023.114834_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnbeh.2019.00100","article-title":"Increased fear memory and glutamatergic modulation in compulsive drinker rats selected by schedule-induced polydipsia","volume":"13","author":"Prados-Pardo","year":"2019","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.bbr.2023.114834_bib16","doi-asserted-by":"crossref","first-page":"2","DOI":"10.3390\/biom11071007","article-title":"Memantine and riluzole exacerbate, rather than ameliorate behavioral deficits induced by 8-oh-dpat sensitization in a spatial task","volume":"11","author":"Janikova","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.bbr.2023.114834_bib17","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1007\/s00213-022-06139-z","article-title":"Memantine treatment does not affect compulsive behavior or frontostriatal connectivity in an adolescent rat model for quinpirole-induced compulsive checking behavior","author":"Straathof","year":"2022","journal-title":"Psychopharmacol. (Berl.)"},{"key":"10.1016\/j.bbr.2023.114834_bib18","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jpsychires.2012.09.015","article-title":"Memantine add-on in moderate to severe obsessive-compulsive disorder: randomized double-blind placebo-controlled study","volume":"47","author":"Ghaleiha","year":"2013","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.bbr.2023.114834_bib19","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1007\/s00213-013-3067-z","article-title":"In a double-blind, randomized and placebo-controlled trial, adjuvant memantine improved symptoms in inpatients suffering from refractory obsessive-compulsive disorders (OCD)","volume":"228","author":"Haghighi","year":"2013","journal-title":"Psychopharmacol. (Berl.)"},{"key":"10.1016\/j.bbr.2023.114834_bib20","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.jpsychires.2018.07.008","article-title":"Efficacy and tolerability of adjunctive gabapentin and memantine in obsessive compulsive disorder: double-blind, randomized, placebo-controlled trial","volume":"104","author":"Farnia","year":"2018","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.bbr.2023.114834_bib21","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1055\/s-0043-120268","article-title":"Memantine augmentation improves symptoms in serotonin reuptake inhibitor-refractory obsessive-compulsive disorder: a randomized controlled trial","volume":"51","author":"Modarresi","year":"2018","journal-title":"Pharmacopsychiatry"},{"key":"10.1016\/j.bbr.2023.114834_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12888-021-03642-z","article-title":"Memantine augmentation of sertraline in the treatment of symptoms and executive function among patients with obsessive-compulsive disorder: a double-blind placebo-controlled, randomized clinical trial","volume":"22","author":"Askari","year":"2022","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.bbr.2023.114834_bib23","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0304-3940(01)01872-9","article-title":"The N-methyl-D-aspartate receptor channel blockers memantine, MRZ 2\/579 and other amino-alkyl-cyclohexanes antagonise 5-HT3 receptor currents in cultured HEK-293 and N1E-115 cell systems in a non-competitive manner","volume":"306","author":"Rammes","year":"2001","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbr.2023.114834_bib24","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1124\/mol.53.3.555","article-title":"Open-channel blockers at the human \u03b14\u03b22 neuronal nicotinic acetylcholine receptor","volume":"53","author":"Buisson","year":"1998","journal-title":"Mol. Pharmacol."},{"key":"10.1016\/j.bbr.2023.114834_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2022.105453","article-title":"Memantine has a nicotinic neuroprotective pathway in acute hippocampal slices after an NMDA insult","volume":"84","author":"Ferrer-Acosta","year":"2022","journal-title":"Toxicol. Vitr."},{"key":"10.1016\/j.bbr.2023.114834_bib26","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.bbr.2005.11.023","article-title":"Evidence for the involvement of L-arginine-nitric oxide-cyclic guanosine monophosphate pathway in the antidepressant-like effect of memantine in mice","volume":"168","author":"Almeida","year":"2006","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2023.114834_bib27","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.coph.2014.11.006","article-title":"Recent insights into the mode of action of memantine and ketamine","volume":"20","author":"Johnson","year":"2015","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.bbr.2023.114834_bib28","doi-asserted-by":"crossref","first-page":"8649","DOI":"10.1073\/pnas.1323920111","article-title":"Mechanisms underlying differential effectiveness of memantine and ketamine in rapid antidepressant responses","volume":"111","author":"Gideons","year":"2014","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bbr.2023.114834_bib29","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/j.neuropharm.2018.10.039","article-title":"S-ketamine reduces marble burying behaviour: Involvement of ventromedial orbitofrontal cortex and AMPA receptors","volume":"144","author":"Tosta","year":"2019","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2023.114834_bib30","article-title":"S-ketamine exerts sex- and dose-dependent anti-compulsive-like effect as monotherapy or in augmentation to fluoxetine","volume":"937","author":"Ayub","year":"2022","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbr.2023.114834_bib31","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.ejphar.2008.01.035","article-title":"Effects of glutamate-related drugs on marble-burying behavior in mice: implications for obsessive-compulsive disorder","volume":"586","author":"Egashira","year":"2008","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbr.2023.114834_bib32","doi-asserted-by":"crossref","first-page":"254","DOI":"10.21307\/ane-2017-059","article-title":"Marble burying as compulsive behaviors in male and female mice","volume":"77","author":"Taylor","year":"2017","journal-title":"Acta Neurobiol. Exp. (Wars. )."},{"key":"10.1016\/j.bbr.2023.114834_bib33","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s00213-009-1466-y","article-title":"Marble burying reflects a repetitive and perseverative behavior more than novelty-induced anxiety","volume":"204","author":"Thomas","year":"2009","journal-title":"Psychopharmacol. (Berl. )"},{"key":"10.1016\/j.bbr.2023.114834_bib34","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1097\/FBP.0b013e32833b33c5","article-title":"Cannabidiol inhibitory effect on marble-burying behaviour: involvement of CB1 receptors","volume":"21","author":"Casarotto","year":"2010","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.bbr.2023.114834_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.vascn.2020.106676","article-title":"Marble-burying behavior test as a murine model of compulsive- like behavior Pankaj","volume":"102","author":"Dixit","year":"2020","journal-title":"J. Pharmacol. Toxicol. Methods"},{"key":"10.1016\/j.bbr.2023.114834_bib36","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1080\/17460441.2018.1417379","article-title":"Lost in translation? A critical look at the role that animal models of obsessive compulsive disorder play in current drug discovery strategies","volume":"13","author":"Hoffman","year":"2018","journal-title":"Expert Opin. Drug Discov."},{"key":"10.1016\/j.bbr.2023.114834_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2020.135018","article-title":"Short or moderate-time exposure to the inhalational anesthetics isoflurane and sevoflurane does not alter the marble-burying behavior in mice","volume":"729","author":"Rocha","year":"2020","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbr.2023.114834_bib38","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/S0014-2999(03)01272-X","article-title":"The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review","volume":"463","author":"Prut","year":"2003","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbr.2023.114834_bib39","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.bbr.2011.02.010","article-title":"Predictive validity of a non-induced mouse model of compulsive-like behavior","volume":"221","author":"Greene-Schloesser","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2023.114834_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fpsyg.2013.00863","article-title":"Calculating and reporting effect sizes to facilitate cumulative science: a practical primer for t-tests and ANOVAs","volume":"4","author":"Lakens","year":"2013","journal-title":"Front. Psychol."},{"key":"10.1016\/j.bbr.2023.114834_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.bpc.2023.107114","article-title":"Nitric oxide modulates NMDA receptor through a negative feedback mechanism and regulates the dynamical behavior of neuronal postsynaptic components","volume":"303","author":"Sharma","year":"2023","journal-title":"Biophys. Chem."},{"key":"10.1016\/j.bbr.2023.114834_bib42","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/0896-6273(92)90130-6","article-title":"Effect of nitric oxide production on the redox modulatory site of the NMDA receptor-channel complex","volume":"8","author":"Lei","year":"1992","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2023.114834_bib43","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/j.1471-4159.1993.tb03580.x","article-title":"Nitric oxide synthase activity endogenously modulates NMDA receptors","volume":"61","author":"Manzoni","year":"1993","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbr.2023.114834_bib44","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.physbeh.2016.11.002","article-title":"Strain and sex based characterization of behavioral expressions in non-induced compulsive-like mice","volume":"168","author":"Mitra","year":"2017","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbr.2023.114834_bib45","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1111\/fcp.12051","article-title":"Cannabidiol reverses the mCPP-induced increase in marble-burying behavior","volume":"28","author":"Nardo","year":"2014","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.bbr.2023.114834_bib46","doi-asserted-by":"crossref","first-page":"3094","DOI":"10.1021\/acschemneuro.8b00593","article-title":"8-OH-DPAT induces compulsive-like deficit in spontaneous alternation behavior: reversal by MDMA but not citalopram","volume":"10","author":"Odland","year":"2019","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.bbr.2023.114834_bib47","doi-asserted-by":"crossref","unstructured":"A.U. Odland, L. Jessen, J.L. Kristensen, C.M. Fitzpatrick, J.T. Andreasen, The 5-hydroxytryptamine 2A receptor agonists DOI and 25CN-NBOH decrease marble burying and reverse 8-OH-DPAT-induced deficit in spontaneous alternation, Neuropharmacology. 183 (2021) 107838. https:\/\/doi.org\/10.1016\/j.neuropharm.2019.107838.","DOI":"10.1016\/j.neuropharm.2019.107838"},{"key":"10.1016\/j.bbr.2023.114834_bib48","doi-asserted-by":"crossref","first-page":"77","DOI":"10.3109\/13651501.2012.667114","article-title":"Guidelines for the pharmacological treatment of anxiety disorders, obsessive-compulsive disorder and posttraumatic stress disorder in primary care","volume":"16","author":"Bandelow","year":"2012","journal-title":"Int. J. Psychiatry Clin. Pract."},{"key":"10.1016\/j.bbr.2023.114834_bib49","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/0091-3057(91)90590-X","article-title":"Evaluation of marble-burying behavior as a model of anxiety","volume":"38","author":"Njung\u2019e","year":"1991","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.bbr.2023.114834_bib50","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.neuro.2015.08.010","article-title":"Low-level repeated exposure to diazinon and chlorpyrifos decrease anxiety-like behaviour in adult male rats as assessed by marble burying behaviour","volume":"50","author":"Savy","year":"2015","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.bbr.2023.114834_bib51","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.bbr.2017.06.018","article-title":"Effect of a change in housing conditions on body weight, behavior and brain neurotransmitters in male C57BL\/6J mice","volume":"333","author":"Pasquarelli","year":"2017","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2023.114834_bib52","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.biopha.2018.01.160","article-title":"Psychotomimetic-like behavioral effects of memantine in the mouse","volume":"100","author":"Kitanaka","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbr.2023.114834_bib53","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1097\/00008877-200505000-00004","article-title":"A comparison of the predictive therapeutic and undesired side-effects of the NMDA receptor antagonist in mice","volume":"16","author":"Kos","year":"2005","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.bbr.2023.114834_bib54","doi-asserted-by":"crossref","DOI":"10.1080\/19932820.2020.1808361","article-title":"Effects of haloperidol inhalation on MK-801- and memantine-induced locomotion in mice","volume":"15","author":"Ueno","year":"2020","journal-title":"Libyan J. Med."},{"key":"10.1016\/j.bbr.2023.114834_bib55","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.ejphar.2015.11.044","article-title":"Involvement of nitric oxide in anticompulsive-like effect of agmatine on marble-burying behaviour in mice","volume":"770","author":"Gawali","year":"2016","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbr.2023.114834_bib56","doi-asserted-by":"crossref","first-page":"14224","DOI":"10.1073\/pnas.1207461109","article-title":"Hippocampal nitric oxide contributes to sex difference in affective behaviors","volume":"109","author":"Hu","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bbr.2023.114834_bib57","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1097\/00001756-199703030-00013","article-title":"Sex differences in nitrite\/nitrate levels and antioxidant defense in rat brain","volume":"8","author":"Taskiran","year":"1997","journal-title":"Neuroreport"},{"key":"10.1016\/j.bbr.2023.114834_bib58","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2202-10-78","article-title":"Estrous cycle influences the expression of neuronal nitric oxide synthase in the hypothalamus and limbic system of female mice","volume":"10","author":"Sica","year":"2009","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.bbr.2023.114834_bib59","doi-asserted-by":"crossref","first-page":"5212","DOI":"10.1073\/pnas.91.11.5212","article-title":"Induction of calcium-dependent nitric oxide synthases by sex hormones","volume":"91","author":"Weiner","year":"1994","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bbr.2023.114834_bib60","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1097\/00001756-200401190-00018","article-title":"17\u03b2-estradiol regulates nNOS and eNOS activity in the hippocampus","volume":"15","author":"Groh\u00e9","year":"2004","journal-title":"Neuroreport"},{"key":"10.1016\/j.bbr.2023.114834_bib61","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.brainres.2010.10.090","article-title":"Hippocampal neuronal nitric oxide synthase (nNOS) is regulated by nicotine and stress in female but not in male rats","volume":"1368","author":"Keser","year":"2011","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2023.114834_bib62","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1007\/s00213-013-3284-5","article-title":"Sex-influence of nicotine and nitric oxide on motor coordination and anxiety-related neurophysiological responses","volume":"231","author":"Mu\u00f1oz-Casta\u00f1eda","year":"2014","journal-title":"Psychopharmacol. (Berl.)"},{"key":"10.1016\/j.bbr.2023.114834_bib63","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.bbr.2011.04.011","article-title":"Dietary arginine depletion reduces depressive-like responses in male, but not female, mice","volume":"223","author":"Workman","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2023.114834_bib64","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/sj.jcbfm.9600059","article-title":"Ischemic nitric oxide and poly (ADP-ribose) polymerase-1 in cerebral ischemia: male toxicity, female protection","volume":"25","author":"McCullough","year":"2005","journal-title":"J. Cereb. Blood Flow. Metab."},{"key":"10.1016\/j.bbr.2023.114834_bib65","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.brainresbull.2009.11.013","article-title":"Neurochemical and behavioural effects of acute and chronic memantine administration in rats: further support for NMDA as a new pharmacological target for the treatment of depression?","volume":"81","author":"R\u00e9us","year":"2010","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.bbr.2023.114834_bib66","first-page":"1","article-title":"Prenatal deltamethrin exposure-induced cognitive impairment in offspring is ameliorated by memantine through NMDAR\/BDNF signaling in hippocampus","volume":"12","author":"Zhang","year":"2018","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.bbr.2023.114834_bib67","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-020-01913-2","article-title":"Memantine ameliorates motor impairments and pathologies in a mouse model of neuromyelitis optica spectrum disorders","volume":"17","author":"Yick","year":"2020","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.bbr.2023.114834_bib68","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1016\/j.jpsychires.2022.05.026","article-title":"Brain-derived neurotrophic factor as a biomarker for obsessive-compulsive disorder: a meta-analysis","volume":"151","author":"Hao","year":"2022","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.bbr.2023.114834_bib69","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3389\/fnmol.2022.926572","article-title":"BDNF alleviates microglial inhibition and stereotypic behaviors in a mouse model of obsessive-compulsive disorder","volume":"15","author":"Luo","year":"2022","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.bbr.2023.114834_bib70","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/j.pbb.2006.08.011","article-title":"Enhancement of long-term spatial memory in adult rats by the noncompetitive NMDA receptor antagonists, memantine and neramexane","volume":"85","author":"Zoladz","year":"2006","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.bbr.2023.114834_bib71","first-page":"1","article-title":"Pharmacokinetics of memantine in rats and mice","author":"Beconi","year":"2012","journal-title":"PLoS Curr."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432823005521?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432823005521?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T13:43:36Z","timestamp":1759067016000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432823005521"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":71,"alternative-id":["S0166432823005521"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2023.114834","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sex differences in the anticompulsive-like effect of memantine: Involvement of nitric oxide pathway but not AMPA receptors","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2023.114834","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"114834"}}