{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T10:11:29Z","timestamp":1794305489929,"version":"4.9.0"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2023A1515011138"],"award-info":[{"award-number":["2023A1515011138"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010843","name":"Guangzhou Science, Technology and Innovation Commission","doi-asserted-by":"publisher","award":["2023A03J0214"],"award-info":[{"award-number":["2023A03J0214"]}],"id":[{"id":"10.13039\/501100010843","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372569"],"award-info":[{"award-number":["82372569"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82102668"],"award-info":[{"award-number":["82102668"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82002383"],"award-info":[{"award-number":["82002383"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.bbr.2024.115018","type":"journal-article","created":{"date-parts":[[2024,4,27]],"date-time":"2024-04-27T06:18:00Z","timestamp":1714198680000},"page":"115018","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["High-frequency rTMS alleviates cognitive impairment and regulates synaptic plasticity in the hippocampus of rats with cerebral ischemia"],"prefix":"10.1016","volume":"467","author":[{"given":"Jiena","family":"Hong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiemei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiantao","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yilong","family":"Shan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0339-2498","authenticated-orcid":false,"given":"Hongmei","family":"Wen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2024.115018_bib1","first-page":"80","article-title":"Post-stroke cognitive impairment: epidemiology, mechanisms and management","volume":"2","author":"Sun","year":"2014","journal-title":"Ann. Transl. Med."},{"key":"10.1016\/j.bbr.2024.115018_bib2","doi-asserted-by":"crossref","first-page":"e20","DOI":"10.1212\/WNL.0000000000007716","article-title":"Progression of cognitive decline before and after incident stroke","volume":"93","author":"Zheng","year":"2019","journal-title":"Neurology"},{"key":"10.1016\/j.bbr.2024.115018_bib3","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1007\/s00429-014-0848-z","article-title":"Evidence for Alzheimer's disease-linked synapse loss and compensation in mouse and human hippocampal CA1 pyramidal neurons","volume":"220","author":"Neuman","year":"2015","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.bbr.2024.115018_bib4","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1016\/j.neurobiolaging.2005.09.012","article-title":"Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment","volume":"27","author":"Scheff","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbr.2024.115018_bib5","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1743-0003-6-7","article-title":"Transcranial magnetic stimulation, synaptic plasticity and network oscillations","volume":"6","author":"Huerta","year":"2009","journal-title":"J. Neuroeng. Rehabil."},{"key":"10.1016\/j.bbr.2024.115018_bib6","doi-asserted-by":"crossref","first-page":"2578","DOI":"10.1093\/brain\/awu190","article-title":"Perforant path synaptic loss correlates with cognitive impairment and Alzheimer's disease in the oldest-old","volume":"137","author":"Robinson","year":"2014","journal-title":"Brain"},{"key":"10.1016\/j.bbr.2024.115018_bib7","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1212\/01.wnl.0000260698.46517.8f","article-title":"Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment","volume":"68","author":"Scheff","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.bbr.2024.115018_bib8","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3389\/fnagi.2019.00235","article-title":"High frequency repetitive transcranial magnetic stimulation alleviates cognitive impairment and modulates hippocampal synaptic structural plasticity in aged mice","volume":"11","author":"Ma","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.bbr.2024.115018_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2019.08.020","article-title":"A systematic review and meta-analysis of rTMS effects on cognitive enhancement in mild cognitive impairment and Alzheimer's disease","volume":"86","author":"Chou","year":"2020","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbr.2024.115018_bib10","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1002\/cpt.1574","article-title":"Transcranial magnetic and electrical stimulation in Alzheimer's disease and mild cognitive impairment: a review of randomized controlled trials","volume":"106","author":"Rajji","year":"2019","journal-title":"Clin. Pharmacol. Ther."},{"key":"10.1016\/j.bbr.2024.115018_bib11","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1503\/jpn.190060","article-title":"High-frequency versus theta burst transcranial magnetic stimulation for the treatment of poststroke cognitive impairment in humans","volume":"45","author":"Tsai","year":"2020","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.bbr.2024.115018_bib12","doi-asserted-by":"crossref","first-page":"977","DOI":"10.3389\/fneur.2020.00977","article-title":"Cerebral functional manipulation of repetitive transcranial magnetic stimulation in cognitive impairment patients after stroke: an fMRI study","volume":"11","author":"Li","year":"2020","journal-title":"Front. Neurol."},{"key":"10.1016\/j.bbr.2024.115018_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fncir.2020.563777","article-title":"Effects of rTMS treatment on cognitive impairment and resting-state brain activity in stroke patients: a randomized clinical trial","volume":"14","author":"Yin","year":"2020","journal-title":"Front. Neural Circuits"},{"key":"10.1016\/j.bbr.2024.115018_bib14","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1097\/PHM.0b013e3181d8a5b1","article-title":"Effect of repetitive transcranial magnetic stimulation on cognition and mood in stroke patients: a double-blind, sham-controlled trial","volume":"89","author":"Kim","year":"2010","journal-title":"Am. J. Phys. Med. Rehabil."},{"key":"10.1016\/j.bbr.2024.115018_bib15","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1007\/s11064-020-03161-5","article-title":"High-frequency rTMS improves cognitive function by regulating synaptic plasticity in cerebral ischemic rats","volume":"46","author":"Hong","year":"2021","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.bbr.2024.115018_bib16","article-title":"Surgery-related thrombosis critically affects the brain infarct volume in mice following transient middle cerebral artery occlusion","volume":"8","author":"Lin","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbr.2024.115018_bib17","doi-asserted-by":"crossref","first-page":"2875","DOI":"10.1161\/STROKEAHA.119.026652","article-title":"Validity and reliability of neurological scores in mice exposed to middle cerebral artery occlusion","volume":"50","author":"Bieber","year":"2019","journal-title":"Stroke"},{"key":"10.1016\/j.bbr.2024.115018_bib18","doi-asserted-by":"crossref","first-page":"559","DOI":"10.3389\/fphys.2017.00559","article-title":"Repetitive transcranial magnetic stimulation ameliorates cognitive impairment by enhancing neurogenesis and suppressing apoptosis in the hippocampus in rats with ischemic stroke","volume":"8","author":"Guo","year":"2017","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbr.2024.115018_bib19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0139892","article-title":"The effects of different repetitive transcranial magnetic stimulation (rTMS) protocols on cortical gene expression in a rat model of cerebral ischemic-reperfusion injury","volume":"10","author":"Ljubisavljevic","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.bbr.2024.115018_bib20","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s12031-009-9206-7","article-title":"Improvement of two-way active avoidance memory requires protein kinase a activation and brain-derived neurotrophic factor expression in the dorsal hippocampus","volume":"38","author":"Datta","year":"2009","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.bbr.2024.115018_bib21","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1007\/s12640-019-00090-2","article-title":"Alterations in synaptic plasticity and oxidative stress following long-term paracetamol treatment in rat brain","volume":"37","author":"Lalert","year":"2020","journal-title":"Neurotox. Res."},{"key":"10.1016\/j.bbr.2024.115018_bib22","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1016\/j.brs.2020.03.020","article-title":"Effects of high-frequency repetitive transcranial magnetic stimulation over the contralesional motor cortex on motor recovery in severe hemiplegic stroke: a randomized clinical trial","volume":"13","author":"Wang","year":"2020","journal-title":"Brain Stimul."},{"key":"10.1016\/j.bbr.2024.115018_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2018.101620","article-title":"Effects of high- and low-frequency repetitive transcranial magnetic stimulation on motor recovery in early stroke patients: evidence from a randomized controlled trial with clinical, neurophysiological and functional imaging assessments","volume":"21","author":"Du","year":"2019","journal-title":"Neuroimage Clin."},{"key":"10.1016\/j.bbr.2024.115018_bib24","doi-asserted-by":"crossref","first-page":"4589056","DOI":"10.1155\/2019\/4589056","article-title":"The effect of rTMS over the different targets on language recovery in stroke patients with global aphasia: a randomized sham-controlled study","volume":"2019","author":"Ren","year":"2019","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.bbr.2024.115018_bib25","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1177\/0269215516644771","article-title":"Repetitive transcranial magnetic stimulation as an alternative therapy for dysphagia after stroke: a systematic review and meta-analysis","volume":"31","author":"Liao","year":"2017","journal-title":"Clin. Rehabil."},{"key":"10.1016\/j.bbr.2024.115018_bib26","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.jad.2016.12.058","article-title":"Repetitive transcranial magnetic stimulation for the treatment of post-stroke depression: a systematic review and meta-analysis of randomized controlled clinical trials","volume":"211","author":"Shen","year":"2017","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.bbr.2024.115018_bib27","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.4103\/1673-5374.235251","article-title":"Effects of repetitive transcranial magnetic stimulation on cognitive function and cholinergic activity in the rat hippocampus after vascular dementia","volume":"13","author":"Zhang","year":"2018","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.bbr.2024.115018_bib28","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1177\/1545968319834900","article-title":"The effect of noninvasive brain stimulation on poststroke cognitive function: a systematic review","volume":"33","author":"van Lieshout","year":"2019","journal-title":"Neurorehabil. Neural Repair"},{"key":"10.1016\/j.bbr.2024.115018_bib29","article-title":"Repetitive transcranial magnetic stimulation for improving function after stroke","volume":"5","author":"Hao","year":"2013","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.bbr.2024.115018_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2023.1197422","article-title":"Repetitive transcranial magnetic stimulation for stroke rehabilitation: insights into the molecular and cellular mechanisms of neuroinflammation","volume":"14","author":"Sheng","year":"2023","journal-title":"Front Immunol."},{"key":"10.1016\/j.bbr.2024.115018_bib31","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1111\/j.1468-1331.2009.02746.x","article-title":"Role of 1 and 3 Hz repetitive transcranial magnetic stimulation on motor function recovery after acute ischaemic stroke","volume":"16","author":"Khedr","year":"2009","journal-title":"Eur. J. Neurol."},{"issue":"10","key":"10.1016\/j.bbr.2024.115018_bib32","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1177\/15353702231157922","article-title":"Changes in gene expression and neuroinflammation in the hippocampus of rats with poststroke cognitive impairment","volume":"248","author":"Chen","year":"2023","journal-title":"Exp. Biol. Med (Maywood)"},{"key":"10.1016\/j.bbr.2024.115018_bib33","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.brainresbull.2021.07.012","article-title":"Different combinations of high-frequency rTMS and cognitive training improve the cognitive function of cerebral ischemic rats","volume":"175","author":"Hong","year":"2021","journal-title":"Brain Res Bull."},{"issue":"2","key":"10.1016\/j.bbr.2024.115018_bib34","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1002\/ana.26509","article-title":"Neuroprotection of Low-Frequency Repetitive Transcranial Magnetic Stimulation after Ischemic Stroke in Rats","volume":"93","author":"Buetefisch","year":"2023","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbr.2024.115018_bib35","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s10571-016-0348-1","article-title":"Modulation of synaptic plasticity by exercise training as a basis for ischemic stroke rehabilitation","volume":"37","author":"Nie","year":"2017","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.bbr.2024.115018_bib36","doi-asserted-by":"crossref","first-page":"C1264","DOI":"10.1152\/ajpcell.00416.2019","article-title":"The cellular and molecular basis of in vivo synaptic plasticity in rodents","volume":"318","author":"Cheyne","year":"2020","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bbr.2024.115018_bib37","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.conb.2003.09.011","article-title":"Molecular mechanisms of active zone function","volume":"13","author":"Rosenmund","year":"2003","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.bbr.2024.115018_bib38","doi-asserted-by":"crossref","first-page":"61","DOI":"10.3389\/fnagi.2016.00061","article-title":"Hippocampal pathway plasticity is associated with the ability to form novel memories in older adults","volume":"8","author":"Antonenko","year":"2016","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.bbr.2024.115018_bib39","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.bbr.2018.10.001","article-title":"rTMS pre-treatment effectively protects against cognitive and synaptic plasticity impairments induced by simulated microgravity in mice","volume":"359","author":"Xiang","year":"2019","journal-title":"Behav. Brain Res"},{"key":"10.1016\/j.bbr.2024.115018_bib40","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/j.biopsych.2013.07.026","article-title":"Treating working memory deficits in schizophrenia: a review of the neurobiology","volume":"75","author":"Lett","year":"2014","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2024.115018_bib41","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1177\/1073858417734530","article-title":"GABA-from inhibition to cognition: emerging concepts","volume":"24","author":"Schmidt-Wilcke","year":"2018","journal-title":"Neuroscientist"},{"key":"10.1016\/j.bbr.2024.115018_bib42","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1186\/s12974-020-01981-4","article-title":"Tanshinone IIA attenuates neuroinflammation via inhibiting RAGE\/NF-\u03baB signaling pathway in vivo and in vitro.","volume":"17","author":"Ding","year":"2020","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.bbr.2024.115018_bib43","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/bs.vh.2016.10.004","article-title":"BDNF and hippocampal synaptic plasticity","volume":"104","author":"Leal","year":"2017","journal-title":"Vitam. Horm."},{"key":"10.1016\/j.bbr.2024.115018_bib44","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.neuint.2012.11.010","article-title":"Magnetic stimulation modulates structural synaptic plasticity and regulates BDNF-TrkB signal pathway in cultured hippocampal neurons","volume":"62","author":"Ma","year":"2013","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.bbr.2024.115018_bib45","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.3390\/brainsci11111532","article-title":"Modulation of long-term potentiation by gamma frequency transcranial alternating current stimulation in transgenic mouse models of Alzheimer's disease","volume":"11","author":"Jeong","year":"2021","journal-title":"Brain Sci."},{"key":"10.1016\/j.bbr.2024.115018_bib46","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1038\/381706a0","article-title":"Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus","volume":"381","author":"Figurov","year":"1996","journal-title":"Nature"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432824001748?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432824001748?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,27]],"date-time":"2024-11-27T05:43:56Z","timestamp":1732686236000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432824001748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":46,"alternative-id":["S0166432824001748"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2024.115018","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"High-frequency rTMS alleviates cognitive impairment and regulates synaptic plasticity in the hippocampus of rats with cerebral ischemia","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2024.115018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"115018"}}