{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T13:43:17Z","timestamp":1793194997930,"version":"4.5.0"},"reference-count":94,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.bbr.2024.115039","type":"journal-article","created":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T11:21:28Z","timestamp":1714994488000},"page":"115039","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"special_numbering":"C","title":["The effect of olanzapine on spatial memory impairment, depressive-like behavior, pain perception, and BDNF and synaptophysin expression following childhood chronic unpredictable mild stress in adult male and female rats"],"prefix":"10.1016","volume":"468","author":[{"given":"Zahra","family":"Tajabadi Farahani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salar","family":"Vaseghi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elham","family":"Rajabbeigi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Batool","family":"Ghorbani Yekta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2024.115039_bib1","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.neubiorev.2018.12.002","article-title":"Chronic unpredictable mild stress for modeling depression in rodents: meta-analysis of model reliability","volume":"99","author":"Antoniuk","year":"2019","journal-title":"Neurosci. Biobehav Rev."},{"issue":"3","key":"10.1016\/j.bbr.2024.115039_bib2","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/BF00187257","article-title":"Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant","volume":"93","author":"Willner","year":"1987","journal-title":"Psychopharmacology"},{"issue":"4","key":"10.1016\/j.bbr.2024.115039_bib3","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/s002130050456","article-title":"Validity, reliability and utility of the chronic mild stress model of depression: a 10-year review and evaluation","volume":"134","author":"Willner","year":"1997","journal-title":"Psychopharmacology"},{"issue":"1","key":"10.1016\/j.bbr.2024.115039_bib4","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/WNR.0000000000001554","article-title":"Melatonin ameliorated CUMS-induced depression-like behavior via restoring endoplasmic reticulum stress in rat hippocampus","volume":"32","author":"Wang","year":"2021","journal-title":"Neuroreport"},{"issue":"11","key":"10.1016\/j.bbr.2024.115039_bib5","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.1007\/s11064-021-03397-9","article-title":"Antidepressant-like effect of 3-n-butylphthalide in rats exposed to chronic unpredictable mild stress: modulation of brain-derived neurotrophic factor level and mtor activation in cortex","volume":"46","author":"Chen","year":"2021","journal-title":"Neurochem Res"},{"key":"10.1016\/j.bbr.2024.115039_bib6","unstructured":"K. Thomas, A. Saadabadi, Olanzapine, StatPearls, Treasure Island (FL), 2022."},{"key":"10.1016\/j.bbr.2024.115039_bib7","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.ibneur.2022.08.009","article-title":"Bio-behavioural changes in treatment-resistant socially isolated FSL rats show variable or improved response to combined fluoxetine-olanzapine versus olanzapine treatment","volume":"13","author":"Mncube","year":"2022","journal-title":"IBRO Neurosci. Rep."},{"issue":"5","key":"10.1016\/j.bbr.2024.115039_bib8","first-page":"672","article-title":"The protective effect of olanzapine on the hippocampal neuron of depression model rats via inhibiting NLRP3 inflammasome activation","volume":"50","author":"Yue","year":"2019","journal-title":"Sichuan Da Xue Xue Bao Yi Xue Ban."},{"key":"10.1016\/j.bbr.2024.115039_bib9","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.neuroscience.2018.11.015","article-title":"Brain sub\/region-specific effects of olanzapine on c-fos expression of chronically socially isolated rats","volume":"396","author":"Stanisavljevic","year":"2019","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2024.115039_bib10","first-page":"2682037","article-title":"Effects of antipsychotic drugs on the epigenetic modification of brain-derived neurotrophic factor gene expression in the hippocampi of chronic restraint stress rats","author":"Seo","year":"2018","journal-title":"Neural Plast. 2018"},{"issue":"12","key":"10.1016\/j.bbr.2024.115039_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23126827","article-title":"Recent advances on the role of brain-derived neurotrophic factor (BDNF) in neurodegenerative diseases","volume":"23","author":"Azman","year":"2022","journal-title":"Int J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.bbr.2024.115039_bib12","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.1007\/s00415-020-10299-3","article-title":"Serum BDNF discriminates Parkinson's disease patients with depression from without depression and reflect motor severity and gender differences","volume":"268","author":"Huang","year":"2021","journal-title":"J. Neurol."},{"key":"10.1016\/j.bbr.2024.115039_bib13","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.parkreldis.2017.05.012","article-title":"Association of low serum BDNF with depression in patients with Parkinson's disease","volume":"41","author":"Wang","year":"2017","journal-title":"Park. Relat. Disord."},{"issue":"1","key":"10.1016\/j.bbr.2024.115039_bib14","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1186\/s12906-023-04000-0","article-title":"A whole transcriptome profiling analysis for antidepressant mechanism of Xiaoyaosan mediated synapse loss via BDNF\/trkB\/PI3K signal axis in CUMS rats","volume":"23","author":"Meng","year":"2023","journal-title":"BMC Complement Med Ther."},{"key":"10.1016\/j.bbr.2024.115039_bib15","first-page":"1474841","article-title":"Acupuncture alleviates CUMS-induced depression-like behaviors by restoring prefrontal cortex neuroplasticity","author":"Li","year":"2023","journal-title":"Neural Plast. 2023"},{"issue":"1","key":"10.1016\/j.bbr.2024.115039_bib16","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/j.1750-3639.1993.tb00729.x","article-title":"Synapsin I, synapsin II, and synaptophysin: marker proteins of synaptic vesicles","volume":"3","author":"Thiel","year":"1993","journal-title":"Brain Pathol."},{"key":"10.1016\/j.bbr.2024.115039_bib17","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.steroids.2017.01.003","article-title":"Neuroprotective effect and mechanism of daucosterol palmitate in ameliorating learning and memory impairment in a rat model of Alzheimer's disease","volume":"119","author":"Ji","year":"2017","journal-title":"Steroids"},{"key":"10.1016\/j.bbr.2024.115039_bib18","first-page":"9268083","article-title":"Curcumin attenuates chronic unpredictable mild stress-induced depressive-like behaviors via restoring changes in oxidative stress and the activation of Nrf2 signaling pathway in rats","author":"Liao","year":"2020","journal-title":"Oxid. Med Cell Longev. 2020"},{"key":"10.1016\/j.bbr.2024.115039_bib19","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jad.2019.01.031","article-title":"The enriched environment ameliorates chronic unpredictable mild stress-induced depressive-like behaviors and cognitive impairment by activating the SIRT1\/miR-134 signaling pathway in hippocampus","volume":"248","author":"Shen","year":"2019","journal-title":"J. Affect Disord."},{"key":"10.1016\/j.bbr.2024.115039_bib20","unstructured":"Guide for the Care and Use of Laboratory Animals, Washington (DC), 2011."},{"issue":"3","key":"10.1016\/j.bbr.2024.115039_bib21","doi-asserted-by":"crossref","first-page":"247","DOI":"10.4103\/pr.pr_8_17","article-title":"Ameliorative effect of curcumin on olanzapine-induced obesity in sprague-dawley rats","volume":"9","author":"Parasuraman","year":"2017","journal-title":"Pharmacogn. Res"},{"issue":"3","key":"10.1016\/j.bbr.2024.115039_bib22","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1080\/10520295.2022.2150314","article-title":"Olanzapine treatment of lactating females causes testicular atrophy in prepuberal rat offspring","volume":"98","author":"Lima","year":"2023","journal-title":"Biotech. Histochem"},{"issue":"2","key":"10.1016\/j.bbr.2024.115039_bib23","article-title":"Effects of tadalafil on sexual behavior of male rats induced by chronic unpredictable mild stress","volume":"11","author":"Wang","year":"2023","journal-title":"Sex. Med"},{"issue":"5","key":"10.1016\/j.bbr.2024.115039_bib24","first-page":"398","article-title":"[Effects of chronic stress depression on the circadian rhythm of peripheral neuroendocrine hormone of rats","volume":"33","author":"Zhao","year":"2017","journal-title":"Zhongguo Ying Yong Sheng Li Xue Za Zhi"},{"key":"10.1016\/j.bbr.2024.115039_bib25","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jpsychires.2024.03.026","article-title":"Adolescent male rats show altered gut microbiota composition associated with depressive-like behavior after chronic unpredictable mild stress: differences from adult rats","volume":"173","author":"Wang","year":"2024","journal-title":"J. Psychiatr. Res"},{"key":"10.1016\/j.bbr.2024.115039_bib26","article-title":"The effect of acute crocin on behavioral changes and BDNF expression level in socially isolated rats","author":"Kamaei","year":"2023","journal-title":"Naunyn Schmiede Arch. Pharm."},{"key":"10.1016\/j.bbr.2024.115039_bib27","doi-asserted-by":"crossref","DOI":"10.1007\/s00213-024-06566-0","article-title":"Chronic REM sleep deprivation leads to manic- and OCD-related behaviors, and decreases hippocampal BDNF expression in female rats","author":"Abbasi","year":"2024","journal-title":"Psychopharmacol. (Berl. )"},{"issue":"1","key":"10.1016\/j.bbr.2024.115039_bib28","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/s43440-020-00161-8","article-title":"The effect of alpha lipoic acid on passive avoidance and social interaction memory, pain perception, and locomotor activity in REM sleep-deprived rats","volume":"73","author":"Mahdavi","year":"2021","journal-title":"Pharm. Rep."},{"key":"10.1016\/j.bbr.2024.115039_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2020.113023","article-title":"The role of sleep disturbances in depressive-like behavior with emphasis on alpha-ketoglutarate dehydrogenase activity in rats","volume":"224","author":"Kordestani-Moghadam","year":"2020","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbr.2024.115039_bib30","series-title":"Handbook of Behavioral Neuroscience","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/S1569-7339(10)70098-9","article-title":"CHAPTER 4.2 - the role of serotonin in depression","author":"Carr","year":"2010"},{"key":"10.1016\/j.bbr.2024.115039_bib31","first-page":"916","article-title":"The role of CA1 CB1 receptors on lithium-induced spatial memory impairment in rats","volume":"17","author":"Vaseghi","year":"2018","journal-title":"EXCLI J."},{"issue":"8","key":"10.1016\/j.bbr.2024.115039_bib32","doi-asserted-by":"crossref","first-page":"2154","DOI":"10.1007\/s11064-021-03353-7","article-title":"The effect of neuroaid (MLC901) on cholestasis-induced spatial memory impairment with respect to the expression of BAX, BCL-2, BAD, PGC-1alpha and TFAM genes in the hippocampus of male wistar rats","volume":"46","author":"Molaei","year":"2021","journal-title":"Neurochem Res."},{"issue":"2","key":"10.1016\/j.bbr.2024.115039_bib33","first-page":"164","article-title":"Effect of multi-epitope derived from HIV-1 on REM sleep deprivation-induced spatial memory impairment with respect to the level of immune factors in mice","volume":"25","author":"Lahimgarzadeh","year":"2022","journal-title":"Iran. J. Basic Med Sci."},{"key":"10.1016\/j.bbr.2024.115039_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2019.108895","article-title":"Synergistic but not additive effect between ACPA and lithium in the dorsal hippocampal region on spatial learning and memory in rats: isobolographic analyses","volume":"315","author":"Vaseghi","year":"2020","journal-title":"Chem. Biol. Inter."},{"key":"10.1016\/j.bbr.2024.115039_bib35","doi-asserted-by":"crossref","DOI":"10.1007\/s11064-023-03890-3","article-title":"The interaction effect of sleep deprivation and treadmill exercise in various durations on spatial memory with respect to the oxidative status of rats","author":"Kholghi","year":"2023","journal-title":"Neurochem Res"},{"issue":"3","key":"10.1016\/j.bbr.2024.115039_bib36","doi-asserted-by":"crossref","first-page":"242","DOI":"10.30802\/AALAS-JAALAS-19-000084","article-title":"Review of rodent euthanasia methods","volume":"59","author":"Shomer","year":"2020","journal-title":"J. Am. Assoc. Lab Anim. Sci."},{"key":"10.1016\/j.bbr.2024.115039_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2020.144601","article-title":"The neuroprotective effect of NeuroAid on morphine-induced amnesia with respect to the expression of TFAM, PGC-1alpha, DeltafosB and CART genes in the hippocampus of male Wistar rats","volume":"742","author":"Malboosi","year":"2020","journal-title":"Gene"},{"key":"10.1016\/j.bbr.2024.115039_bib38","doi-asserted-by":"crossref","DOI":"10.1007\/s11064-023-03970-4","article-title":"Possible involvement of perineuronal nets in anti-depressant effects of electroacupuncture in chronic-stress-induced depression in rats","author":"Zhang","year":"2023","journal-title":"Neurochem Res"},{"key":"10.1016\/j.bbr.2024.115039_bib39","doi-asserted-by":"crossref","DOI":"10.1111\/cns.14207","article-title":"Anti-neuroinflammation effects of transcutaneous auricular vagus nerve stimulation against depression-like behaviors via hypothalamic alpha7nAchR\/JAK2\/STAT3\/NF-kappaB pathway in rats exposed to chronic unpredictable mild stress","author":"Chen","year":"2023","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.bbr.2024.115039_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2023.109468","article-title":"Chronic oral ketamine prevents anhedonia and alters neuronal activation in the lateral habenula and nucleus accumbens in rats under chronic unpredictable mild stress","volume":"228","author":"Kingir","year":"2023","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2024.115039_bib41","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2022.09.013","article-title":"Repetitive transcranial magnetic stimulation improves depression-like behavior in rats by promoting neural stem cell proliferation and differentiation","volume":"524","author":"Jiang","year":"2022","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2024.115039_bib42","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.brainresbull.2022.07.001","article-title":"The environmental enrichment ameliorates chronic unpredictable mild stress-induced depressive-like behaviors and cognitive decline by inducing autophagy-mediated inflammation inhibition","volume":"187","author":"Xu","year":"2022","journal-title":"Brain Res Bull."},{"key":"10.1016\/j.bbr.2024.115039_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchemneu.2020.101768","article-title":"Valproic acid administration exerts protective effects against stress-related anhedonia in rats","volume":"105","author":"Goudarzi","year":"2020","journal-title":"J. Chem. Neuroanat."},{"issue":"6","key":"10.1016\/j.bbr.2024.115039_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e16544","article-title":"Spirocyclopiperazinium salt compound DXL-A-24 improves visceral sensation and gut microbiota in a rat model of irritable bowel syndrome","volume":"9","author":"Xu","year":"2023","journal-title":"Heliyon"},{"issue":"4","key":"10.1016\/j.bbr.2024.115039_bib45","first-page":"278","article-title":"[Involvement of Pirt \/TRPV1 signaling in acupuncture-induced reduction of visceral hypersensitivity in diarrhea-predominant irritable bowel syndrome rats","volume":"46","author":"Chen","year":"2021","journal-title":"Zhen Ci Yan Jiu"},{"issue":"4","key":"10.1016\/j.bbr.2024.115039_bib46","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1080\/10253890.2019.1687683","article-title":"Chronic stress influences nociceptive sensitivity of female rats in an estrous cycle-dependent manner","volume":"23","author":"Yang","year":"2020","journal-title":"Stress"},{"issue":"Pt A","key":"10.1016\/j.bbr.2024.115039_bib47","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.expneurol.2016.08.010","article-title":"Why depression and pain often coexist and mutually reinforce: role of the lateral habenula","volume":"284","author":"Li","year":"2016","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbr.2024.115039_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2021.113245","article-title":"Quercetin alleviates chronic unpredictable mild stress-induced depressive-like behaviors by promoting adult hippocampal neurogenesis via FoxG1\/CREB\/ BDNF signaling pathway","volume":"406","author":"Ma","year":"2021","journal-title":"Behav. Brain Res"},{"key":"10.1016\/j.bbr.2024.115039_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainresbull.2023.110838","article-title":"Electroacupuncture ameliorates chronic unpredictable mild stress-induced depression-like behavior and cognitive impairment through suppressing oxidative stress and neuroinflammation in rats","volume":"206","author":"Tong","year":"2024","journal-title":"Brain Res Bull."},{"key":"10.1016\/j.bbr.2024.115039_bib50","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.715354","article-title":"Rivaroxaban modulates TLR4\/Myd88\/NF-Kbeta signaling pathway in a dose-dependent manner with suppression of oxidative stress and inflammation in an experimental model of depression","volume":"12","author":"Abdelzaher","year":"2021","journal-title":"Front Pharm."},{"key":"10.1016\/j.bbr.2024.115039_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2023.114509","article-title":"The effects of acupuncture on depression by regulating BDNF-related balance via lateral habenular nucleus BDNF\/TrkB\/CREB signaling pathway in rats","volume":"451","author":"Tong","year":"2023","journal-title":"Behav. Brain Res"},{"issue":"12","key":"10.1016\/j.bbr.2024.115039_bib52","doi-asserted-by":"crossref","first-page":"7119","DOI":"10.1007\/s12035-022-03023-x","article-title":"Pinocembrin inhibits P2\u00d74 receptor-mediated pyroptosis in hippocampus to alleviate the behaviours of chronic pain and depression comorbidity in rats","volume":"59","author":"Yang","year":"2022","journal-title":"Mol. Neurobiol."},{"issue":"4","key":"10.1016\/j.bbr.2024.115039_bib53","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1021\/acschemneuro.2c00532","article-title":"Gallic acid improves comorbid chronic pain and depression behaviors by inhibiting P2\u00d77 receptor-mediated ferroptosis in the spinal cord of rats","volume":"14","author":"Yang","year":"2023","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.bbr.2024.115039_bib54","first-page":"8885729","article-title":"Effects of transcutaneous auricular vagus nerve stimulation on peripheral and central tumor necrosis factor alpha in rats with depression-chronic somatic pain comorbidity","author":"Guo","year":"2020","journal-title":"Neural Plast. 2020"},{"key":"10.1016\/j.bbr.2024.115039_bib55","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2023.105483","article-title":"Anxiolytic- and antidepressant-like effects of Bacillus coagulans Unique IS-2 mediate via reshaping of microbiome gut-brain axis in rats","volume":"163","author":"Satti","year":"2023","journal-title":"Neurochem Int"},{"key":"10.1016\/j.bbr.2024.115039_bib56","article-title":"Tanshinone IIA ameliorates chronic unpredictable mild stress-induced depression-like behavior and cognitive impairment in rats through the BDNF\/TrkB\/GAT1 signaling pathway","volume":"938","author":"Liu","year":"2022","journal-title":"Eur. J. Pharm."},{"issue":"2","key":"10.1016\/j.bbr.2024.115039_bib57","first-page":"237","article-title":"BDNF function and intracellular signaling in neurons","volume":"25","author":"Numakawa","year":"2010","journal-title":"Histol. Histopathol."},{"issue":"1","key":"10.1016\/j.bbr.2024.115039_bib58","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1586\/14737175.2014.863709","article-title":"The relationship between neurotrophins and bipolar disorder","volume":"14","author":"Wu","year":"2014","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.bbr.2024.115039_bib59","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2021.113346","article-title":"Memory impairment and depressive-like phenotype are accompanied by downregulation of hippocampal insulin and BDNF signaling pathways in prediabetic mice","volume":"237","author":"Zborowski","year":"2021","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbr.2024.115039_bib60","article-title":"Investigating the effect of crocin on memory deficits induced by total sleep deprivation (TSD) with respect to the BDNF, TrkB and ERK levels in the hippocampus of male Wistar rats","volume":"2698811211000762","author":"Looti Bashiyan","year":"2021","journal-title":"J. Psychopharmacol."},{"issue":"4","key":"10.1016\/j.bbr.2024.115039_bib61","article-title":"Brain-derived neurotrophic factor ameliorates learning deficits in a rat model of Alzheimer's disease induced by abeta1-42","volume":"10","author":"Zhang","year":"2015","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.bbr.2024.115039_bib62","doi-asserted-by":"crossref","first-page":"16442","DOI":"10.1038\/s41598-020-73576-1","article-title":"Lower brain-derived neurotrophic factor levels are associated with age-related memory impairment in community-dwelling older adults: the Sefuri study","volume":"10","author":"Mizoguchi","year":"2020","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.bbr.2024.115039_bib63","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1002\/cbin.11123","article-title":"Progesterone and fluoxetine treatments of postpartum depressive-like behavior in rat model","volume":"43","author":"Hu","year":"2019","journal-title":"Cell Biol. Int"},{"issue":"8","key":"10.1016\/j.bbr.2024.115039_bib64","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1097\/00005072-199708000-00011","article-title":"Loss of the presynaptic vesicle protein synaptophysin in hippocampus correlates with cognitive decline in Alzheimer disease","volume":"56","author":"Sze","year":"1997","journal-title":"J. Neuropathol. Exp. Neurol."},{"issue":"2","key":"10.1016\/j.bbr.2024.115039_bib65","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/0306-4522(94)00422-2","article-title":"Loss of synaptophysin-like immunoreactivity in the hippocampal formation is an early phenomenon in Alzheimer's disease","volume":"64","author":"Heinonen","year":"1995","journal-title":"Neuroscience"},{"issue":"5","key":"10.1016\/j.bbr.2024.115039_bib66","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1179\/1476830513Y.0000000085","article-title":"Synaptophysin and the dopaminergic system in hippocampus are involved in the protective effect of rutin against trimethyltin-induced learning and memory impairment","volume":"17","author":"Zhang","year":"2014","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.bbr.2024.115039_bib67","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.bbr.2014.03.047","article-title":"Cotinine reduces depressive-like behavior, working memory deficits, and synaptic loss associated with chronic stress in mice","volume":"268","author":"Grizzell","year":"2014","journal-title":"Behav. Brain Res."},{"issue":"1","key":"10.1016\/j.bbr.2024.115039_bib68","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1080\/00325481.2019.1701823","article-title":"New discoveries for an old drug: a review of recent olanzapine research","volume":"132","author":"Meftah","year":"2020","journal-title":"Post. Med"},{"issue":"3 Pt 1","key":"10.1016\/j.bbr.2024.115039_bib69","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1034\/j.1399-5618.2000.020307.x","article-title":"Does olanzapine have antidepressant properties? A retrospective preliminary study","volume":"2","author":"Ghaemi","year":"2000","journal-title":"Bipolar Disord."},{"key":"10.1016\/j.bbr.2024.115039_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchemneu.2022.102166","article-title":"Second-generation antipsychotic olanzapine attenuates behavioral and prefrontal cortex synaptic plasticity deficits in a neurodevelopmental schizophrenia-related rat model","volume":"125","author":"Apam-Castillejos","year":"2022","journal-title":"J. Chem. Neuroanat."},{"key":"10.1016\/j.bbr.2024.115039_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174383","article-title":"Ameliorating schizophrenia-like symptoms in vasopressin deficient male Brattleboro rat by chronic antipsychotic treatment","volume":"909","author":"Torok","year":"2021","journal-title":"Eur. J. Pharm."},{"issue":"5","key":"10.1016\/j.bbr.2024.115039_bib72","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1007\/s00213-020-05465-4","article-title":"Hippocampal and prefrontal cortical NMDA receptors mediate the interactive effects of olanzapine and lithium in memory retention in rats: the involvement of CAMKII-CREB signaling pathways","volume":"237","author":"Amiri","year":"2020","journal-title":"Psychopharmacol. (Berl. )"},{"issue":"1","key":"10.1016\/j.bbr.2024.115039_bib73","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1097\/jcp.0b013e31802dfff0","article-title":"Psychomotor and memory effects of haloperidol, olanzapine, and paroxetine in healthy subjects after short-term administration","volume":"27","author":"Morrens","year":"2007","journal-title":"J. Clin. Psychopharmacol."},{"issue":"2","key":"10.1016\/j.bbr.2024.115039_bib74","first-page":"27","article-title":"Cognitive effects of olanzapine treatment in schizophrenia","volume":"6","author":"McGurk","year":"2004","journal-title":"MedGenMed"},{"issue":"9","key":"10.1016\/j.bbr.2024.115039_bib75","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1177\/0269881112449396","article-title":"Reducing olanzapine-induced weight gain side effect by using betahistine: a study in the rat model","volume":"26","author":"Deng","year":"2012","journal-title":"J. Psychopharmacol."},{"issue":"1","key":"10.1016\/j.bbr.2024.115039_bib76","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.pbb.2010.05.009","article-title":"Olanzapine affects locomotor activity and meal size in male rats","volume":"97","author":"van der Zwaal","year":"2010","journal-title":"Pharm. Biochem Behav."},{"issue":"11","key":"10.1016\/j.bbr.2024.115039_bib77","doi-asserted-by":"crossref","first-page":"871","DOI":"10.2165\/00023210-200115110-00005","article-title":"Olanzapine: a review of its use in the treatment of bipolar I disorder","volume":"15","author":"Bhana","year":"2001","journal-title":"CNS Drugs"},{"issue":"Suppl 10","key":"10.1016\/j.bbr.2024.115039_bib78","first-page":"5","article-title":"Receptor pharmacology of neuroleptics: relation to clinical effects","volume":"60","author":"Richelson","year":"1999","journal-title":"J. Clin. Psychiatry"},{"issue":"9","key":"10.1016\/j.bbr.2024.115039_bib79","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.euroneuro.2018.05.016","article-title":"The affinity of antipsychotic drugs to dopamine and serotonin 5-HT(2) receptors determines their effects on prefrontal-striatal functional connectivity","volume":"28","author":"Tollens","year":"2018","journal-title":"Eur. Neuropsychopharmacol."},{"key":"10.1016\/j.bbr.2024.115039_bib80","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.neuropharm.2015.03.032","article-title":"Olanzapine augments the effect of selective serotonin reuptake inhibitors by suppressing GABAergic inhibition via antagonism of 5-HT(6) receptors in the dorsal raphe nucleus","volume":"95","author":"Asaoka","year":"2015","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2024.115039_bib81","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/j.brainresbull.2018.06.003","article-title":"Repeated olanzapine treatment mitigates PTSD like symptoms in rats with changes in cell signaling factors","volume":"140","author":"Reddy","year":"2018","journal-title":"Brain Res Bull."},{"issue":"8","key":"10.1016\/j.bbr.2024.115039_bib82","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1097\/FBP.0000000000000656","article-title":"Fenofibrate ameliorates olanzapine's side effects without altering its central effect: emphasis on FGF-21-adiponectin axis","volume":"32","author":"Galal","year":"2021","journal-title":"Behav. Pharm."},{"issue":"3","key":"10.1016\/j.bbr.2024.115039_bib83","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.pharep.2013.12.008","article-title":"The influence of aripiprazole, olanzapine and enriched environment on depressant-like behavior, spatial memory dysfunction and hippocampal level of BDNF in prenatally stressed rats","volume":"66","author":"Nowakowska","year":"2014","journal-title":"Pharm. Rep."},{"issue":"6","key":"10.1016\/j.bbr.2024.115039_bib84","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1016\/S1734-1140(09)70163-X","article-title":"Influences of chronic venlafaxine, olanzapine and nicotine on the hippocampal and cortical concentrations of brain-derived neurotrophic factor (BDNF)","volume":"61","author":"Czubak","year":"2009","journal-title":"Pharm. Rep."},{"issue":"2","key":"10.1016\/j.bbr.2024.115039_bib85","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.brainres.2004.06.089","article-title":"Post-stress changes in BDNF and Bcl-2 immunoreactivities in hippocampal neurons: effect of chronic administration of olanzapine","volume":"1","author":"Luo","year":"2004","journal-title":"Brain Res 1025"},{"issue":"6","key":"10.1016\/j.bbr.2024.115039_bib86","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.pnpbp.2010.05.013","article-title":"Effects of olanzapine on brain-derived neurotrophic factor gene promoter activity in SH-SY5Y neuroblastoma cells","volume":"34","author":"Lee","year":"2010","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"1","key":"10.1016\/j.bbr.2024.115039_bib87","doi-asserted-by":"crossref","first-page":"25","DOI":"10.9758\/cpn.2012.10.1.25","article-title":"Altered neuronal markers following treatment with mood stabilizer and antipsychotic drugs indicate an increased likelihood of neurotransmitter release","volume":"10","author":"Scarr","year":"2012","journal-title":"Clin. Psychopharmacol. Neurosci."},{"key":"10.1016\/j.bbr.2024.115039_bib88","doi-asserted-by":"crossref","first-page":"19581","DOI":"10.1038\/srep19581","article-title":"Olanzapine prevents the PCP-induced reduction in the neurite outgrowth of prefrontal cortical neurons via NRG1","volume":"6","author":"Zhang","year":"2016","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.bbr.2024.115039_bib89","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0165-1781(02)00028-8","article-title":"Sex differences in clinical response to olanzapine compared with haloperidol","volume":"110","author":"Goldstein","year":"2002","journal-title":"Psychiatry Res"},{"issue":"1","key":"10.1016\/j.bbr.2024.115039_bib90","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1017\/S146114571300093X","article-title":"Modelling olanzapine-induced weight gain in rats","volume":"17","author":"van der Zwaal","year":"2014","journal-title":"Int J. Neuropsychopharmacol."},{"issue":"1","key":"10.1016\/j.bbr.2024.115039_bib91","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00213-011-2555-2","article-title":"Gender-dependent consequences of chronic olanzapine in the rat: effects on body weight, inflammatory, metabolic and microbiota parameters","volume":"221","author":"Davey","year":"2012","journal-title":"Psychopharmacol. (Berl. )"},{"issue":"3","key":"10.1016\/j.bbr.2024.115039_bib92","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/j.neuropharm.2011.02.019","article-title":"Intermittent treatment with olanzapine causes sensitization of the metabolic side-effects in rats","volume":"62","author":"Boyda","year":"2012","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/j.bbr.2024.115039_bib93","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1017\/S1461145713000862","article-title":"Olanzapine depot formulation in rat: a step forward in modelling antipsychotic-induced metabolic adverse effects","volume":"17","author":"Skrede","year":"2014","journal-title":"Int J. Neuropsychopharmacol."},{"issue":"1","key":"10.1016\/j.bbr.2024.115039_bib94","doi-asserted-by":"crossref","first-page":"4739","DOI":"10.1038\/s41598-021-84235-4","article-title":"Olanzapine induced reproductive toxicity in male rats","volume":"11","author":"Ardic","year":"2021","journal-title":"Sci. Rep."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432824001955?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432824001955?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,22]],"date-time":"2024-05-22T18:03:12Z","timestamp":1716400992000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432824001955"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":94,"alternative-id":["S0166432824001955"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2024.115039","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The effect of olanzapine on spatial memory impairment, depressive-like behavior, pain perception, and BDNF and synaptophysin expression following childhood chronic unpredictable mild stress in adult male and female rats","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2024.115039","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115039"}}