{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T10:09:50Z","timestamp":1766830190064,"version":"3.37.3"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100020084","name":"Guangzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["2023A04J1113"],"award-info":[{"award-number":["2023A04J1113"]}],"id":[{"id":"10.13039\/501100020084","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["GZC20231929"],"award-info":[{"award-number":["GZC20231929"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.bbr.2024.115178","type":"journal-article","created":{"date-parts":[[2024,8,3]],"date-time":"2024-08-03T02:05:37Z","timestamp":1722650737000},"page":"115178","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Frontiers and hotspots evolution in anti-inflammatory studies for Alzheimer\u2019s disease"],"prefix":"10.1016","volume":"472","author":[{"given":"Shan","family":"Wu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanjie","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chuanchi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"47","key":"10.1016\/j.bbr.2024.115178_bib1","doi-asserted-by":"crossref","first-page":"7894","DOI":"10.1523\/JNEUROSCI.1576-23.2023","article-title":"Alzheimer's targeted treatments: focus on amyloid and inflammation","volume":"43","author":"Iwatsubo","year":"2023","journal-title":"J. Neurosci."},{"issue":"7918","key":"10.1016\/j.bbr.2024.115178_bib2","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/s41586-022-04919-3","article-title":"Inflammatory memory and tissue adaptation in sickness and in health","volume":"607","author":"Naik","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.bbr.2024.115178_bib3","article-title":"Alzheimer's disease and inflammatory biomarkers positively correlate in plasma in the UK-ADRC cohort","author":"Foley","year":"2023","journal-title":"Alzheimers Dement"},{"issue":"4","key":"10.1016\/j.bbr.2024.115178_bib4","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/S1474-4422(15)70016-5","article-title":"Neuroinflammation in Alzheimer's disease","volume":"14","author":"Heneka","year":"2015","journal-title":"Lancet Neurol."},{"issue":"7","key":"10.1016\/j.bbr.2024.115178_bib5","doi-asserted-by":"crossref","first-page":"6518","DOI":"10.3390\/ijms24076518","article-title":"Inflammatory processes in Alzheimer's disease-pathomechanism, diagnosis and treatment: a review","volume":"24","author":"Twarowski","year":"2023","journal-title":"Int J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.bbr.2024.115178_bib6","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1148\/radiol.09090626","article-title":"Bibliometric indicators: quality measurements of scientific publication","volume":"255","author":"Durieux","year":"2010","journal-title":"Radiology"},{"key":"10.1016\/j.bbr.2024.115178_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2021.113932","article-title":"Frontier and hot topics in electrochemiluminescence sensing technology based on CiteSpace bibliometric analysis","volume":"201","author":"Liu","year":"2022","journal-title":"Biosens. Bioelectron."},{"issue":"2","key":"10.1016\/j.bbr.2024.115178_bib8","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1002\/alz.12694","article-title":"Global estimates on the number of persons across the Alzheimer's disease continuum","volume":"19","author":"Holzapfel","year":"2023","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.bbr.2024.115178_bib9","unstructured":"World Health Organization Dementia. [(accessed on 3 February 2022)]. Available online: \u3008https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/dementia\u3009."},{"issue":"4","key":"10.1016\/j.bbr.2024.115178_bib10","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S1474-4422(22)00087-4","article-title":"Dynamics of neuroinflammation in Alzheimer's disease","volume":"21","author":"Smirnov","year":"2022","journal-title":"Lancet Neurol."},{"issue":"22","key":"10.1016\/j.bbr.2024.115178_bib11","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adl1123","article-title":"Rejuvenation of peripheral immune cells attenuates Alzheimer's disease-like pathologies and behavioral deficits in a mouse model","volume":"10","author":"Sun","year":"2024","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bbr.2024.115178_bib12","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.clinbiochem.2019.04.001","article-title":"Neuro-inflammation and anti-inflammatory treatment options for Alzheimer's disease","volume":"72","author":"Ozben","year":"2019","journal-title":"Clin. Biochem"},{"issue":"1","key":"10.1016\/j.bbr.2024.115178_bib13","article-title":"Novel method for collecting hippocampal interstitial fluid extracellular vesicles (EVISF) reveals sex-dependent changes in microglial EV proteome in response to A\u03b2 pathology","volume":"13","author":"Pait","year":"2024","journal-title":"J. Extra Vesicles"},{"key":"10.1016\/j.bbr.2024.115178_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2024.110020","article-title":"Microglia and TREM2","author":"Pocock","year":"2024","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/j.bbr.2024.115178_bib15","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s13024-023-00682-9","article-title":"Sleep restoration by optogenetic targeting of GABAergic neurons reprograms microglia and ameliorates pathological phenotypes in an Alzheimer's disease model","volume":"18","author":"Zhao","year":"2023","journal-title":"Mol. Neurodegener."},{"issue":"1","key":"10.1016\/j.bbr.2024.115178_bib16","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1186\/s12974-023-02913-8","article-title":"Cytokine enrichment in deep cerebellar nuclei is contributed by multiple glial populations and linked to reduced amyloid plaque pathology","volume":"20","author":"Gaunt","year":"2023","journal-title":"J. Neuroinflamm."},{"issue":"1","key":"10.1016\/j.bbr.2024.115178_bib17","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12974-023-02951-2","article-title":"iPSC-derived PSEN2 (N141I) astrocytes and microglia exhibit a primed inflammatory phenotype","volume":"21","author":"Sullivan","year":"2024","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.bbr.2024.115178_bib18","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.2147\/JIR.S350109","article-title":"Microglia-mediated neuroinflammation: a potential target for the treatment of cardiovascular diseases","volume":"15","author":"Wang","year":"2022","journal-title":"J. Inflamm. Res"},{"issue":"1","key":"10.1016\/j.bbr.2024.115178_bib19","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1038\/s41467-022-29552-6","article-title":"Microglial NF-\u03baB drives tau spreading and toxicity in a mouse model of tauopathy","volume":"13","author":"Wang","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbr.2024.115178_bib20","doi-asserted-by":"crossref","DOI":"10.1177\/1756286420935676","article-title":"Diclofenac reduces the risk of Alzheimer's disease: a pilot analysis of NSAIDs in two US veteran populations","volume":"13","author":"Stuve","year":"2020","journal-title":"Ther. Adv. Neurol. Disord."},{"issue":"6","key":"10.1016\/j.bbr.2024.115178_bib21","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1007\/s10787-023-01347-1","article-title":"Targeting memory loss with aspirin, a molecular mechanism perspective for future therapeutic approaches","volume":"31","author":"Gholami","year":"2023","journal-title":"Inflammopharmacology"},{"issue":"6","key":"10.1016\/j.bbr.2024.115178_bib22","doi-asserted-by":"crossref","first-page":"2827","DOI":"10.1007\/s10787-023-01347-1","article-title":"Targeting memory loss with aspirin, a molecular mechanism perspective for future therapeutic approaches","volume":"31","author":"Gholami","year":"2023","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.bbr.2024.115178_bib23","doi-asserted-by":"crossref","first-page":"261","DOI":"10.3389\/fphar.2020.00261","article-title":"Pharmacotherapy of Alzheimer's Disease: Seeking Clarity in a Time of Uncertainty","volume":"11","author":"Husna Ibrahim","year":"2020","journal-title":"Front Pharm."},{"key":"10.1016\/j.bbr.2024.115178_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/s41582-023-00915-x","article-title":"Inflammasomes in neurological disorders - mechanisms and therapeutic potential","author":"Ravichandran","year":"2024","journal-title":"Nat. Rev. Neurol."},{"issue":"1","key":"10.1016\/j.bbr.2024.115178_bib25","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12974-023-03003-5","article-title":"Peripheral blood amyloid-\u03b2 involved in the pathogenesis of Alzheimer's disease via impacting on peripheral innate immune cells","volume":"21","author":"Shi","year":"2024","journal-title":"J. Neuroinflamm."},{"issue":"1","key":"10.1016\/j.bbr.2024.115178_bib26","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/s12979-024-00445-0","article-title":"Neuroinflammation in Alzheimer's disease: insights from peripheral immune cells","volume":"21","author":"Zhang","year":"2024","journal-title":"Immun. Ageing"},{"issue":"7790","key":"10.1016\/j.bbr.2024.115178_bib27","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1038\/s41586-019-1895-7","article-title":"Clonally expanded CD8 T cells patrol the cerebrospinal fluid in Alzheimer's disease","volume":"577","author":"Gate","year":"2020","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.bbr.2024.115178_bib28","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1002\/acn3.51320","article-title":"IMSVISUAL, ERN-EYE Consortium. Artificial intelligence extension of the OSCAR-IB criteria","volume":"8","author":"Petzold","year":"2021","journal-title":"Ann. Clin. Transl. Neurol."},{"issue":"1","key":"10.1016\/j.bbr.2024.115178_bib29","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1007\/s11682-017-9732-9","article-title":"Association of longitudinal white matter degeneration and cerebrospinal fluid biomarkers of neurodegeneration, inflammation and Alzheimer's disease in late-middle-aged adults","volume":"13","author":"Racine","year":"2019","journal-title":"Brain Imaging Behav."},{"issue":"9","key":"10.1016\/j.bbr.2024.115178_bib30","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1038\/s41591-022-01926-9","article-title":"Anti-inflammatory clearance of amyloid-\u03b2 by a chimeric Gas6 fusion protein","volume":"28","author":"Jung","year":"2022","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbr.2024.115178_bib31","article-title":"Advanced nanomaterials as microglia modulators in the treatment of central nervous system disorders","author":"Battaglini","year":"2023","journal-title":"Adv. Health Mater."},{"issue":"1","key":"10.1016\/j.bbr.2024.115178_bib32","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/s40035-023-00393-7","article-title":"Nanotechnology for microglial targeting and inhibition of neuroinflammation underlying Alzheimer's pathology","volume":"13","author":"Gebril","year":"2024","journal-title":"Transl. Neurodegener."},{"issue":"2","key":"10.1016\/j.bbr.2024.115178_bib33","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1002\/ame2.12224","article-title":"Classic mechanisms and experimental models for the anti-inflammatory effect of traditional Chinese medicine","volume":"5","author":"Hongzhi","year":"2022","journal-title":"Anim. Model Exp. Med."},{"key":"10.1016\/j.bbr.2024.115178_bib34","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/8340192","article-title":"Modified Huang-Lian-Jie-Du Decoction Ameliorates A\u03b2 Synaptotoxicity in a Murine Model of Alzheimer's Disease","volume":"2019","author":"Liu","year":"2019","journal-title":"Oxid. Med Cell Longev."},{"issue":"1","key":"10.1016\/j.bbr.2024.115178_bib35","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13195-021-00779-7","article-title":"Huanglian Jiedu decoction remodels the periphery microenvironment to inhibit Alzheimer's disease progression based on the \"brain-gut\" axis through multiple integrated omics","volume":"13","author":"Gu","year":"2021","journal-title":"Alzheimers Res Ther."},{"key":"10.1016\/j.bbr.2024.115178_bib36","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2023.1140945","article-title":"Molecular mechanisms of Huanglian Jiedu decoction in treating Alzheimer's disease by regulating microbiome via network pharmacology and molecular docking analysis","volume":"13","author":"Zheng","year":"2023","journal-title":"Front Cell Infect. Microbiol"},{"issue":"12","key":"10.1016\/j.bbr.2024.115178_bib37","doi-asserted-by":"crossref","first-page":"1893","DOI":"10.1002\/ptr.5203","article-title":"Anti-inflammatory effects of ginsenosides Rg5, Rz1, and Rk1: inhibition of TNF-\u03b1-induced NF-\u03baB, COX-2, and iNOS transcriptional expression","volume":"28","author":"Lee","year":"2014","journal-title":"Phytother. Res"},{"issue":"5","key":"10.1016\/j.bbr.2024.115178_bib38","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1038\/s41401-022-01022-1","article-title":"Ginsenoside Rg1 in neurological diseases: From bench to bedside","volume":"44","author":"Yang","year":"2023","journal-title":"Acta Pharm. Sin."},{"key":"10.1016\/j.bbr.2024.115178_bib39","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.1077222","article-title":"A novel strategy for bioactive natural products targeting NLRP3 inflammasome in Alzheimer's disease","volume":"13","author":"Yang","year":"2023","journal-title":"Front Pharm."},{"key":"10.1016\/j.bbr.2024.115178_bib40","doi-asserted-by":"crossref","first-page":"3295","DOI":"10.2147\/DDDT.S380612","article-title":"The Role of Traditional Chinese Medicine Natural Products in \u03b2-Amyloid Deposition and Tau Protein Hyperphosphorylation in Alzheimer's Disease","volume":"17","author":"Yan","year":"2023","journal-title":"Drug Des. Devel Ther."},{"issue":"6","key":"10.1016\/j.bbr.2024.115178_bib41","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.1002\/ptr.8192","article-title":"Phytomedicine for neurodegenerative diseases: The road ahead","volume":"38","author":"Madhubala","year":"2024","journal-title":"Phytother. Res"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432824003346?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432824003346?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T10:05:06Z","timestamp":1725012306000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432824003346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":41,"alternative-id":["S0166432824003346"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2024.115178","relation":{},"ISSN":["0166-4328"],"issn-type":[{"type":"print","value":"0166-4328"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Frontiers and hotspots evolution in anti-inflammatory studies for Alzheimer\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2024.115178","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115178"}}