{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:42:14Z","timestamp":1792798934942,"version":"4.5.0"},"reference-count":252,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.bbr.2024.115212","type":"journal-article","created":{"date-parts":[[2024,8,24]],"date-time":"2024-08-24T14:45:03Z","timestamp":1724510703000},"page":"115212","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":60,"special_numbering":"C","title":["Heavy metals exposure and Alzheimer\u2019s disease: Underlying mechanisms and advancing therapeutic approaches"],"prefix":"10.1016","volume":"476","author":[{"given":"Norah A.","family":"Althobaiti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2024.115212_bib1","first-page":"3","article-title":"Introductory chapter: introducing heavy metals","volume":"1","author":"Koller","year":"2018","journal-title":"Heavy Met."},{"key":"10.1016\/j.bbr.2024.115212_bib2","first-page":"133","article-title":"Heavy metal toxicity and the environment","volume":"101","author":"Tchounwou","year":"2012","journal-title":"Exp. Suppl."},{"issue":"2","key":"10.1016\/j.bbr.2024.115212_bib3","first-page":"72","article-title":"Environmental pollution by heavy metal: an overview","volume":"3","author":"Timothy","year":"2019","journal-title":"Chemistry"},{"key":"10.1016\/j.bbr.2024.115212_bib4","series-title":"Environmental Contaminants and Neurological Disorders","first-page":"69","article-title":"Heavy metals and neurological disorders: from exposure to preventive interventions","author":"Rehman","year":"2021"},{"issue":"9","key":"10.1016\/j.bbr.2024.115212_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e19496","article-title":"Environmental pollutants and their effects on human health","volume":"9","author":"Shetty","year":"2023","journal-title":"Heliyon"},{"issue":"1","key":"10.1016\/j.bbr.2024.115212_bib6","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12995-021-00302-6","article-title":"The impact of chronic co-exposure to different heavy metals on small fibers of peripheral nerves. A study of metal industry workers","volume":"16","author":"Koszewicz","year":"2021","journal-title":"J. Occup. Med. Toxicol."},{"key":"10.1016\/j.bbr.2024.115212_bib7","article-title":"Toxic mechanisms of five heavy metals: mercury, lead, chromium, cadmium, and arsenic","volume":"227","author":"Balali-Mood","year":"2021","journal-title":"Front. Pharm."},{"issue":"2","key":"10.1016\/j.bbr.2024.115212_bib8","doi-asserted-by":"crossref","first-page":"60","DOI":"10.2478\/intox-2014-0009","article-title":"Toxicity, mechanism and health effects of some heavy metals","volume":"7","author":"Jaishankar","year":"2014","journal-title":"Interdiscip. Toxicol."},{"key":"10.1016\/j.bbr.2024.115212_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.643972","article-title":"Toxic mechanisms of five heavy metals: mercury, lead, chromium, cadmium, and arsenic","volume":"12","author":"Balali-Mood","year":"2021","journal-title":"Front. Pharm."},{"key":"10.1016\/j.bbr.2024.115212_bib10","unstructured":"G.A. Engwa, P.U. Ferdinand, F.N. Nwalo, M.N. Unachukwu, Mechanism and health effects of heavy metal toxicity in humans. Poisoning in the modern world-new tricks for an old dog, vol. 10, 2019, pp. 70\u201390."},{"key":"10.1016\/j.bbr.2024.115212_bib11","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1289\/ehp.877559","article-title":"Metal toxicity in the central nervous system","volume":"75","author":"Clarkson","year":"1987","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.bbr.2024.115212_bib12","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1007\/978-3-319-96511-6_2","article-title":"Mechanistic effect of heavy metals in neurological disorder and brain cancer","author":"Agnihotri","year":"2019","journal-title":"Netw. Mutagens Environ. Toxicol."},{"key":"10.1016\/j.bbr.2024.115212_bib13","first-page":"1","article-title":"Biochemical mechanisms of aluminium and other metals exposure, their brain entry mechanisms, effects on blood brain barrier and important pharmacokinetic parameters in neurological disorders","author":"Ishaq","year":"2021","journal-title":"Biochem. Mech. Alum. Induc. Neurol. Disord."},{"issue":"6","key":"10.1016\/j.bbr.2024.115212_bib14","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1007\/s11011-023-01230-6","article-title":"Anti-inflammatory, anti-apoptotic, and neuroprotective potentials of anethole in Parkinson\u2019s disease-like motor and non-motor symptoms induced by rotenone in rats","volume":"38","author":"Moradi Vastegani","year":"2023","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.bbr.2024.115212_bib15","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1053\/j.apmr.2003.12.007","article-title":"Stroke and neurodegenerative disorders. 4. Neurodegenerative disorders","volume":"85","author":"Bryant","year":"2004","journal-title":"Arch. Phys. Med. Rehabil."},{"key":"10.1016\/j.bbr.2024.115212_bib16","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.etap.2016.09.016","article-title":"Heavy metals (Pb, Cd, As and MeHg) as risk factors for cognitive dysfunction: a general review of metal mixture mechanism in brain","volume":"48","author":"Karri","year":"2016","journal-title":"Environ. Toxicol. Pharm."},{"key":"10.1016\/j.bbr.2024.115212_bib17","article-title":"Metal-induced autoimmunity in neurological disorders: a review of current understanding and future directions","author":"Bj\u00f8rklund","year":"2023","journal-title":"Autoimmun. Rev."},{"issue":"1","key":"10.1016\/j.bbr.2024.115212_bib18","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1503\/cmaj.060790","article-title":"Lead and mercury exposures: interpretation and action","volume":"176","author":"Brodkin","year":"2007","journal-title":"CMAJ"},{"issue":"5","key":"10.1016\/j.bbr.2024.115212_bib19","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1351\/pac200274050793","article-title":"\"Heavy metals\" a meaningless term? (IUPAC Technical Report)","volume":"74","author":"Duffus","year":"2002","journal-title":"Pure Appl. Chem."},{"key":"10.1016\/j.bbr.2024.115212_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fpls.2020.00359","article-title":"Phytoremediation: a promising approach for revegetation of heavy metal-polluted land","volume":"11","author":"Yan","year":"2020","journal-title":"Front. Plant Sci."},{"key":"10.1016\/j.bbr.2024.115212_bib21","first-page":"103","article-title":"Heavy metal contamination: an alarming threat to environment and human health","author":"Mishra","year":"2019","journal-title":"Environ. Biotechnol.: Sustain. Future"},{"issue":"3","key":"10.1016\/j.bbr.2024.115212_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.jksus.2022.101865","article-title":"Impact of heavy metals on the environment and human health: novel therapeutic insights to counter the toxicity","volume":"34","author":"Mitra","year":"2022","journal-title":"J. King Saud. Univ. - Sci."},{"issue":"2","key":"10.1016\/j.bbr.2024.115212_bib23","first-page":"1","article-title":"Lead: properties, history, and applications","volume":"1","author":"Boldyrev","year":"2018","journal-title":"WikiJ. Sci."},{"key":"10.1016\/j.bbr.2024.115212_bib24","series-title":"Lead and Zinc: Threats and Opportunities in the Years Ahead","author":"Anyadike","year":"2002"},{"key":"10.1016\/j.bbr.2024.115212_bib25","series-title":"Lead: Chemistry, Analytical Aspects, Environmental Impact and Health Effects","author":"Casas","year":"2011"},{"issue":"23","key":"10.1016\/j.bbr.2024.115212_bib26","doi-asserted-by":"crossref","first-page":"16006","DOI":"10.3390\/ijerph192316006","article-title":"Potential health risks of lead exposure from early life through later life: implications for public health education","volume":"19","author":"Olufemi","year":"2022","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"2","key":"10.1016\/j.bbr.2024.115212_bib27","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1515\/intox-2015-0009","article-title":"Lead toxicity: a review","volume":"8","author":"Wani","year":"2015","journal-title":"Interdiscip. Toxicol."},{"key":"10.1016\/j.bbr.2024.115212_bib28","unstructured":"J.M. Miller,\u00a0Lead Poisoning, 2023 [Available from: \u3008https:\/\/kidshealth.org\/en\/parents\/lead-poisoning.html#:~:text=Their%20bodies%20absorb%20lead%20more,in%20homes%20built%20before%201978\u3009."},{"issue":"3","key":"10.1016\/j.bbr.2024.115212_bib29","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.cpem.2017.07.010","article-title":"An update on childhood lead poisoning","volume":"18","author":"Hauptman","year":"2017","journal-title":"Clin. Pediatr. Emerg. Med."},{"key":"10.1016\/j.bbr.2024.115212_bib30","unstructured":"Lead poisoning, 2023 [Available from: \u3008https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/lead-poisoning-and-health#:~:text=Sources%20and%20routes%20of%20exposure&text=ingestion%20of%20lead%2Dcontaminated%20dust,hand%2Dto%2Dmouth%20behaviour\u3009."},{"issue":"2","key":"10.1016\/j.bbr.2024.115212_bib31","first-page":"11","article-title":"Effects of high doseLead toxication on liver, kidneys, heart, brain and blood in rabbits: an experimental study","volume":"2","author":"Durgut","year":"2008","journal-title":"J. Appl. Biol. Sci."},{"issue":"1","key":"10.1016\/j.bbr.2024.115212_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2478\/intox-2019-0001","article-title":"The pathway of lead through the mother's body to the child","volume":"12","author":"R\u00cdsov\u00c1","year":"2019","journal-title":"Interdiscip. Toxicol."},{"issue":"1","key":"10.1016\/j.bbr.2024.115212_bib33","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1515\/REVEH.2009.24.1.15","article-title":"Neurotoxic effects and biomarkers of lead exposure: a review","volume":"24","author":"Sanders","year":"2009","journal-title":"Rev. Environ. Health"},{"issue":"1","key":"10.1016\/j.bbr.2024.115212_bib34","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s00128-020-03088-1","article-title":"A review on cadmium exposure in the population and intervention strategies against cadmium toxicity","volume":"106","author":"Wang","year":"2021","journal-title":"Bull. Environ. Contam. Toxicol."},{"issue":"60","key":"10.1016\/j.bbr.2024.115212_bib35","doi-asserted-by":"crossref","first-page":"89874","DOI":"10.1007\/s11356-022-23620-6","article-title":"Metabolic effects of long-term cadmium exposure: an overview","volume":"29","author":"Chen","year":"2022","journal-title":"Environ. Sci. Pollut. Res."},{"issue":"11","key":"10.1016\/j.bbr.2024.115212_bib36","doi-asserted-by":"crossref","first-page":"3782","DOI":"10.3390\/ijerph17113782","article-title":"The effects of cadmium toxicity","volume":"17","author":"Genchi","year":"2020","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"5","key":"10.1016\/j.bbr.2024.115212_bib37","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1007\/s13280-023-01831-6","article-title":"Our evolved understanding of the human health risks of mercury","volume":"52","author":"Basu","year":"2023","journal-title":"Ambio"},{"issue":"1","key":"10.1016\/j.bbr.2024.115212_bib38","doi-asserted-by":"crossref","first-page":"105","DOI":"10.3390\/ijerph14010105","article-title":"Global sources and pathways of mercury in the context of human health","volume":"14","author":"Sundseth","year":"2017","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"9","key":"10.1016\/j.bbr.2024.115212_bib39","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1080\/10643389.2017.1326277","article-title":"Cycling of mercury in the environment: sources, fate, and human health implications: a review","volume":"47","author":"Beckers","year":"2017","journal-title":"Crit. Rev. Environ. Sci. Technol."},{"key":"10.1016\/j.bbr.2024.115212_bib40","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10661-019-7528-7","article-title":"The relative impact of toxic heavy metals (THMs)(arsenic (As), cadmium (Cd), chromium (Cr)(VI), mercury (Hg), and lead (Pb)) on the total environment: an overview","volume":"191","author":"Rahman","year":"2019","journal-title":"Environ. Monit. Assess."},{"key":"10.1016\/j.bbr.2024.115212_bib41","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1016\/j.envint.2018.10.059","article-title":"Knowledge and awareness of health effects related to the use of mercury in artisanal and small-scale gold mining in Suriname","volume":"122","author":"Ottenbros","year":"2019","journal-title":"Environ. Int."},{"issue":"22","key":"10.1016\/j.bbr.2024.115212_bib42","doi-asserted-by":"crossref","DOI":"10.5696\/2156-9614-9.22.190612","article-title":"Mercury contamination from dental amalgam","volume":"9","author":"Tibau","year":"2019","journal-title":"J. Health Pollut."},{"issue":"6","key":"10.1016\/j.bbr.2024.115212_bib43","doi-asserted-by":"crossref","first-page":"344","DOI":"10.3961\/jpmph.2012.45.6.344","article-title":"Human exposure and health effects of inorganic and elemental mercury","volume":"45","author":"Park","year":"2012","journal-title":"J. Prev. Med. Public Health"},{"issue":"3","key":"10.1016\/j.bbr.2024.115212_bib44","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.envres.2009.12.006","article-title":"Ranking the contributions of commercial fish and shellfish varieties to mercury exposure in the United States: implications for risk communication","volume":"110","author":"Groth","year":"2010","journal-title":"Environ. Res."},{"issue":"8","key":"10.1016\/j.bbr.2024.115212_bib45","first-page":"186","article-title":"Mercury exposure and children's health","volume":"40","author":"Bose-O'Reilly","year":"2010","journal-title":"Curr. Probl. Pediatr. Adolesc. Health Care"},{"key":"10.1016\/j.bbr.2024.115212_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2021.111782","article-title":"Arsenic in the geo-environment: a review of sources, geochemical processes, toxicity and removal technologies","volume":"203","author":"Raju","year":"2022","journal-title":"Environ. Res."},{"key":"10.1016\/j.bbr.2024.115212_bib47","unstructured":"M. Benkherouf, Life cycle assessment of arsenic removal methods: M. Benkherouf, 2018."},{"issue":"5","key":"10.1016\/j.bbr.2024.115212_bib48","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3961\/jpmph.14.036","article-title":"Environmental source of arsenic exposure","volume":"47","author":"Chung","year":"2014","journal-title":"J. Prev. Med. Public Health"},{"issue":"1","key":"10.1016\/j.bbr.2024.115212_bib49","doi-asserted-by":"crossref","first-page":"185","DOI":"10.2138\/rmg.2014.79.3","article-title":"Arsenic speciation and sorption in natural environments","volume":"79","author":"Campbell","year":"2014","journal-title":"Rev. Mineral. Geochem."},{"key":"10.1016\/j.bbr.2024.115212_bib50","series-title":"Handbook of Arsenic Toxicology","first-page":"1","article-title":"Arsenic: chemistry, occurrence, and exposure","author":"Flora","year":"2015"},{"issue":"5","key":"10.1016\/j.bbr.2024.115212_bib51","doi-asserted-by":"crossref","first-page":"253","DOI":"10.3961\/jpmph.14.036","article-title":"Environmental source of arsenic exposure","volume":"47","author":"Chung","year":"2014","journal-title":"J. Prev. Med Public Health"},{"key":"10.1016\/j.bbr.2024.115212_bib52","unstructured":"I.W.G.o.t.E.o.C.R.t. Humans, Arsenic, metals, fibres, and dusts. IARC monographs on the evaluation of carcinogenic risks to humans, vol. 100(no. PT C), 2012, 11."},{"key":"10.1016\/j.bbr.2024.115212_bib53","series-title":"Arsenic in Drinking Water","author":"Water","year":"1999"},{"key":"10.1016\/j.bbr.2024.115212_bib54","doi-asserted-by":"crossref","first-page":"5675","DOI":"10.1007\/s00216-018-0906-0","article-title":"Speciation analysis of arsenic in seafood and seaweed: Part I\u2014evaluation and optimization of methods","volume":"410","author":"Wolle","year":"2018","journal-title":"Anal. Bioanal. Chem."},{"issue":"3","key":"10.1016\/j.bbr.2024.115212_bib55","doi-asserted-by":"crossref","first-page":"128","DOI":"10.3390\/geosciences4030128","article-title":"Health effects associated with inhalation of airborne arsenic arising from mining operations","volume":"4","author":"Martin","year":"2014","journal-title":"Geosciences"},{"issue":"1-3","key":"10.1016\/j.bbr.2024.115212_bib56","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1016\/j.jhazmat.2009.01.079","article-title":"Assessing airborne PM-bound arsenic exposure risk in semiconductor manufacturing facilities","volume":"167","author":"Chou","year":"2009","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.bbr.2024.115212_bib57","first-page":"27","article-title":"Arsenic: a review on exposure pathways, accumulation, mobility and transmission into the human food chain","volume":"243","author":"Arslan","year":"2017","journal-title":"Rev. Environ. Contam. Toxicol."},{"issue":"7","key":"10.1016\/j.bbr.2024.115212_bib58","article-title":"Exposure factors in health risk assessment of heavy metal(loid)s in soil and sediment","volume":"13","author":"Mileti\u0107","year":"2023","journal-title":"Metals [Internet]"},{"issue":"15","key":"10.1016\/j.bbr.2024.115212_bib59","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.2174\/1389557520666200414161944","article-title":"Zinc poisoning-symptoms, causes, treatments","volume":"20","author":"Rahimzadeh","year":"2020","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.bbr.2024.115212_bib60","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/1480553","article-title":"Aluminum poisoning with emphasis on its mechanism and treatment of intoxication","volume":"2022","author":"Rahimzadeh","year":"2022","journal-title":"Emerg. Med. Int."},{"issue":"2","key":"10.1016\/j.bbr.2024.115212_bib61","doi-asserted-by":"crossref","first-page":"45","DOI":"10.2478\/intox-2019-0007","article-title":"Aluminium toxicosis: a review of toxic actions and effects","volume":"12","author":"Igbokwe","year":"2019","journal-title":"Interdiscip. Toxicol."},{"issue":"7","key":"10.1016\/j.bbr.2024.115212_bib62","first-page":"575","article-title":"Exposure-related health effects of silver and silver compounds: a review","volume":"49","author":"Drake","year":"2005","journal-title":"Ann. Occup. Hyg."},{"key":"10.1016\/j.bbr.2024.115212_bib63","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.yrtph.2018.08.007","article-title":"Toxicity of silver ions, metallic silver, and silver nanoparticle materials after in vivo dermal and mucosal surface exposure: a review","volume":"98","author":"Hadrup","year":"2018","journal-title":"Regul. Toxicol. Pharm."},{"issue":"6","key":"10.1016\/j.bbr.2024.115212_bib64","doi-asserted-by":"crossref","first-page":"3521","DOI":"10.1007\/s10653-022-01423-5","article-title":"Heavy metals and their sources, potential pollution situations and health risks for residents in Ad\u0131yaman province agricultural lands, T\u00fcrkiye","volume":"45","author":"Y\u0131lmaz","year":"2023","journal-title":"Environ. Geochem. Health"},{"key":"10.1016\/j.bbr.2024.115212_bib65","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00267-019-01234-y","article-title":"Critical review of exposure and effects: implications for setting regulatory health criteria for ingested copper","volume":"65","author":"Taylor","year":"2020","journal-title":"Environ. Manag."},{"key":"10.1016\/j.bbr.2024.115212_bib66","doi-asserted-by":"crossref","DOI":"10.3389\/fenvs.2023.1260317","article-title":"Comprehensive human health risk assessment of heavy metal contamination in urban soils: insights from selected metropolitan zones","volume":"11","author":"Ayaz","year":"2023","journal-title":"Front. Environ. Sci."},{"key":"10.1016\/j.bbr.2024.115212_bib67","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1007\/s41748-018-0035-0","article-title":"Distribution and multivariate pollution risks assessment of heavy metals and natural radionuclides around abandoned iron-ore mines in North Central Nigeria","volume":"2","author":"Isinkaye","year":"2018","journal-title":"Earth Syst. Environ."},{"issue":"47","key":"10.1016\/j.bbr.2024.115212_bib68","doi-asserted-by":"crossref","first-page":"70686","DOI":"10.1007\/s11356-022-22705-6","article-title":"A comprehensive review on human health effects of chromium: insights on induced toxicity","volume":"29","author":"Hossini","year":"2022","journal-title":"Environ. Sci. Pollut. Res."},{"issue":"7","key":"10.1016\/j.bbr.2024.115212_bib69","first-page":"167","article-title":"Chromium toxicity and its health hazards","volume":"3","author":"Shekhawat","year":"2015","journal-title":"Int. J. Adv. Res."},{"issue":"4","key":"10.1016\/j.bbr.2024.115212_bib70","first-page":"685","article-title":"The impact of nickel on human health","volume":"13","author":"Duda-Chodak","year":"2008","journal-title":"J. Elem."},{"issue":"1","key":"10.1016\/j.bbr.2024.115212_bib71","first-page":"23","article-title":"Assessment of dermal exposure and skin condition of workers exposed to nickel at a South African base metal refinery","volume":"54","author":"Du Plessis","year":"2010","journal-title":"Ann. Occup. Hyg."},{"key":"10.1016\/j.bbr.2024.115212_bib72","doi-asserted-by":"crossref","DOI":"10.3389\/ftox.2022.837579","article-title":"Role of environmental toxicants on neurodegenerative disorders","volume":"4","author":"Nabi","year":"2022","journal-title":"Front. Toxicol."},{"issue":"9","key":"10.1016\/j.bbr.2024.115212_bib73","doi-asserted-by":"crossref","first-page":"198","DOI":"10.3390\/toxics9090198","article-title":"Molecular mechanisms of environmental metal neurotoxicity: a focus on the interactions of metals with synapse structure and function","volume":"9","author":"Carmona","year":"2021","journal-title":"Toxics"},{"issue":"9","key":"10.1016\/j.bbr.2024.115212_bib74","doi-asserted-by":"crossref","DOI":"10.3390\/toxics9090198","article-title":"Molecular mechanisms of environmental metal neurotoxicity: a focus on the interactions of metals with synapse structure and function","volume":"9","author":"Carmona","year":"2021","journal-title":"Toxics"},{"issue":"1","key":"10.1016\/j.bbr.2024.115212_bib75","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13024-019-0333-5","article-title":"The neuropathological diagnosis of Alzheimer\u2019s disease","volume":"14","author":"DeTure","year":"2019","journal-title":"Mol. Neurodegener."},{"issue":"24","key":"10.1016\/j.bbr.2024.115212_bib76","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25245789","article-title":"Comprehensive review on Alzheimer's disease: causes and treatment","volume":"25","author":"Breijyeh","year":"2020","journal-title":"Molecules"},{"issue":"4","key":"10.1016\/j.bbr.2024.115212_bib77","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.3233\/JAD-200282","article-title":"Heavy metals exposure and Alzheimer's disease and related dementias","volume":"76","author":"Bakulski","year":"2020","journal-title":"J. Alzheimers Dis."},{"issue":"4","key":"10.1016\/j.bbr.2024.115212_bib78","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.3390\/biomedicines11041161","article-title":"Metals in Alzheimer's disease","volume":"11","author":"Babi\u0107 Leko","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.bbr.2024.115212_bib79","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.taap.2018.07.015","article-title":"Risk of Alzheimer's disease with metal concentrations in whole blood and urine: a case\u2013control study using propensity score matching","volume":"356","author":"Yang","year":"2018","journal-title":"Toxicol. Appl. Pharm."},{"issue":"1","key":"10.1016\/j.bbr.2024.115212_bib80","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-20305-5","article-title":"Lead-exposure associated miRNAs in humans and Alzheimer\u2019s disease as potential biomarkers of the disease and disease processes","volume":"12","author":"Wen","year":"2022","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.bbr.2024.115212_bib81","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/S1001-9294(13)60045-0","article-title":"Neurotoxicity and biomarkers of lead exposure: a review","volume":"28","author":"Liu","year":"2013","journal-title":"Chin. Med. Sci. J."},{"key":"10.1016\/j.bbr.2024.115212_bib82","doi-asserted-by":"crossref","unstructured":"H.R. Pohl, N. Roney, H.G. Abadin,\u00a0Metal ions affecting the neurological system. Metal Ions in Toxicology: The Royal Society of Chemistry, 2010, pp. 247\u201362.","DOI":"10.1039\/9781849732116-00247"},{"issue":"4","key":"10.1016\/j.bbr.2024.115212_bib83","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.3233\/JAD-151018","article-title":"Early-life exposure to lead (Pb) alters the expression of microRNA that target proteins associated with Alzheimer\u2019s disease","volume":"51","author":"Masoud","year":"2016","journal-title":"J. Alzheimer's\u00a0Dis."},{"key":"10.1016\/j.bbr.2024.115212_bib84","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.neuro.2013.07.010","article-title":"Enhanced taupathy and AD-like pathology in aged primate brains decades after infantile exposure to lead (Pb)","volume":"39","author":"Bihaqi","year":"2013","journal-title":"Neurotoxicology"},{"issue":"1","key":"10.1016\/j.bbr.2024.115212_bib85","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.taap.2007.08.001","article-title":"New and evolving concepts in the neurotoxicology of lead.","volume":"225","author":"White","year":"2007","journal-title":"Toxicol. Appl. Pharm."},{"issue":"6","key":"10.1016\/j.bbr.2024.115212_bib86","doi-asserted-by":"crossref","first-page":"665","DOI":"10.2217\/epi.12.58","article-title":"Epigenetics of early-life lead exposure and effects on brain development","volume":"4","author":"Senut","year":"2012","journal-title":"Epigenomics"},{"issue":"7","key":"10.1016\/j.bbr.2024.115212_bib87","doi-asserted-by":"crossref","first-page":"935","DOI":"10.7150\/ijbs.4499","article-title":"The role of \u03b1-synuclein and tau hyperphosphorylation-mediated autophagy and apoptosis in lead-induced learning and memory injury","volume":"8","author":"Zhang","year":"2012","journal-title":"Int. J. Biol. Sci."},{"key":"10.1016\/j.bbr.2024.115212_bib88","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.toxlet.2019.11.009","article-title":"Environmental lead exposure aggravates the progression of Alzheimer's disease in mice by targeting on blood brain barrier","volume":"319","author":"Wu","year":"2020","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.bbr.2024.115212_bib89","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.toxlet.2018.06.1065","article-title":"Lead exposure induces Alzheimers\u2019s disease (AD)-like pathology and disturbes cholesterol metabolism in the young rat brain","volume":"296","author":"Zhou","year":"2018","journal-title":"Toxicol. Lett."},{"issue":"1","key":"10.1016\/j.bbr.2024.115212_bib90","doi-asserted-by":"crossref","first-page":"27","DOI":"10.3233\/JAD-2008-14103","article-title":"Identification of miRNA changes in Alzheimer's disease brain and CSF yields putative biomarkers and insights into disease pathways","volume":"14","author":"Cogswell","year":"2008","journal-title":"J. Alzheimer's\u00a0Dis."},{"issue":"4","key":"10.1016\/j.bbr.2024.115212_bib91","doi-asserted-by":"crossref","first-page":"1971","DOI":"10.1074\/jbc.M807530200","article-title":"MicroRNA-298 and microRNA-328 regulate expression of mouse \u03b2-amyloid precursor protein-converting enzyme 1","volume":"284","author":"Boissonneault","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.bbr.2024.115212_bib92","doi-asserted-by":"crossref","first-page":"276","DOI":"10.3390\/cells9020276","article-title":"miRNAs as biomarkers in disease: latest findings regarding their role in diagnosis and prognosis","volume":"9","author":"Condrat","year":"2020","journal-title":"Cells"},{"issue":"24","key":"10.1016\/j.bbr.2024.115212_bib93","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1212\/01.wnl.0000437306.37850.22","article-title":"Reduced expression of hsa-miR-27a-3p in CSF of patients with Alzheimer disease","volume":"81","author":"Sala Frigerio","year":"2013","journal-title":"Neurology"},{"issue":"1","key":"10.1016\/j.bbr.2024.115212_bib94","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12940-017-0288-3","article-title":"Genome-wide gene by lead exposure interaction analysis identifies UNC5D as a candidate gene for neurodevelopment","volume":"16","author":"Wang","year":"2017","journal-title":"Environ. Health"},{"issue":"2","key":"10.1016\/j.bbr.2024.115212_bib95","doi-asserted-by":"crossref","first-page":"779","DOI":"10.3233\/JAD-210307","article-title":"Novel plasma miRNAs as biomarkers and therapeutic targets of Alzheimer\u2019s disease at the prodromal stage","volume":"83","author":"He","year":"2021","journal-title":"J. Alzheimer's\u00a0Dis."},{"issue":"6","key":"10.1016\/j.bbr.2024.115212_bib96","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.3390\/cells9061345","article-title":"Mitochondrial MicroRNAs in aging and neurodegenerative diseases","volume":"9","author":"John","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.bbr.2024.115212_bib97","doi-asserted-by":"crossref","DOI":"10.1016\/j.bone.2021.116058","article-title":"Expression profiling of mitochondria-associated microRNAs during osteogenic differentiation of human MSCs","volume":"151","author":"Zheng","year":"2021","journal-title":"Bone"},{"issue":"6","key":"10.1016\/j.bbr.2024.115212_bib98","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1158\/0008-5472.CAN-18-2505","article-title":"Mitochondrial miRNA determines chemoresistance by reprogramming metabolism and regulating mitochondrial transcription","volume":"79","author":"Fan","year":"2019","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.bbr.2024.115212_bib99","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10534-021-00360-7","article-title":"Mechanisms associated with the dysregulation of mitochondrial function due to lead exposure and possible implications on the development of Alzheimer\u2019s disease","volume":"35","author":"Bandaru","year":"2022","journal-title":"BioMetals"},{"key":"10.1016\/j.bbr.2024.115212_bib100","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2023.102990","article-title":"Lead aggravates Alzheimer's disease pathology via mitochondrial copper accumulation regulated by COX17","volume":"69","author":"Huang","year":"2024","journal-title":"Redox Biol."},{"issue":"10","key":"10.1016\/j.bbr.2024.115212_bib101","first-page":"1752","article-title":"Lead exposure aggravates A\u03b2(1-42)-induced microglial activation and copper ion accumulation in microglial cells","volume":"43","author":"Chen","year":"2023","journal-title":"Nan Fang. Yi Ke Da Xue Xue Bao"},{"key":"10.1016\/j.bbr.2024.115212_bib102","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.650930","article-title":"Cadmium, an environmental contaminant, exacerbates Alzheimer\u2019s pathology in the aged mice\u2019s brain","volume":"13","author":"Ali","year":"2021","journal-title":"Front. Aging Neurosci."},{"issue":"4","key":"10.1016\/j.bbr.2024.115212_bib103","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1097\/WAD.0000000000000579","article-title":"Effect of neurotoxin exposure on blood biomarkers of neurodegeneration and Alzheimer disease","volume":"37","author":"Schubert","year":"2023","journal-title":"Alzheimer Dis. Assoc. Disord."},{"issue":"6","key":"10.1016\/j.bbr.2024.115212_bib104","doi-asserted-by":"crossref","DOI":"10.3390\/antiox9060492","article-title":"Cadmium-induced oxidative stress: focus on the central nervous system","volume":"9","author":"Branca","year":"2020","journal-title":"Antioxidants"},{"issue":"1","key":"10.1016\/j.bbr.2024.115212_bib105","doi-asserted-by":"crossref","first-page":"125","DOI":"10.3892\/etm.2012.562","article-title":"The effect of cadmium on A\u03b2 levels in APP\/PS1 transgenic mice","volume":"4","author":"Li","year":"2012","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.bbr.2024.115212_bib106","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1007\/s10534-014-9719-6","article-title":"Heavy metals toxicity: effect of cadmium ions on amyloid beta protein 1\u201342. Possible implications for Alzheimer\u2019s disease","volume":"27","author":"Notarachille","year":"2014","journal-title":"Biometals"},{"key":"10.1016\/j.bbr.2024.115212_bib107","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2023.1303111","article-title":"Alzheimer's disease: the role of extrinsic factors in its development, an investigation of the environmental enigma","volume":"14","author":"Suresh","year":"2023","journal-title":"Front. Neurol."},{"issue":"1","key":"10.1016\/j.bbr.2024.115212_bib108","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3233\/JAD-221205","article-title":"APP\/PS1 gene-environmental cadmium interaction aggravates the progression of Alzheimer's disease in mice via the blood-brain barrier, amyloid-\u03b2, and inflammation","volume":"94","author":"Liu","year":"2023","journal-title":"J. Alzheimers Dis."},{"issue":"7","key":"10.1016\/j.bbr.2024.115212_bib109","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1016\/j.freeradbiomed.2008.07.011","article-title":"Cadmium activates the mitogen-activated protein kinase (MAPK) pathway via induction of reactive oxygen species and inhibition of protein phosphatases 2A and 5","volume":"45","author":"Chen","year":"2008","journal-title":"Free Radic. Biol. Med."},{"issue":"5","key":"10.1016\/j.bbr.2024.115212_bib110","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.freeradbiomed.2010.12.032","article-title":"Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death","volume":"50","author":"Chen","year":"2011","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbr.2024.115212_bib111","doi-asserted-by":"crossref","first-page":"3221","DOI":"10.1007\/s00018-016-2223-0","article-title":"Role of Nrf2\/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism","volume":"73","author":"Loboda","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"issue":"6","key":"10.1016\/j.bbr.2024.115212_bib112","doi-asserted-by":"crossref","first-page":"904","DOI":"10.3390\/biom10060904","article-title":"NRF2 regulation processes as a source of potential drug targets against neurodegenerative diseases","volume":"10","author":"Cores","year":"2020","journal-title":"Biomolecules"},{"key":"10.1016\/j.bbr.2024.115212_bib113","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13024-021-00445-4","article-title":"Adiponectin-mimetic novel nonapeptide rescues aberrant neuronal metabolic-associated memory deficits in Alzheimer\u2019s disease","volume":"16","author":"Ali","year":"2021","journal-title":"Mol. Neurodegener."},{"issue":"10","key":"10.1016\/j.bbr.2024.115212_bib114","first-page":"702","article-title":"KMS99220 exerts anti-inflammatory effects, activates the Nrf2 signaling and interferes with IKK, JNK and p38 MAPK via HO-1","volume":"42","author":"Lee","year":"2019","journal-title":"Mol. Cells"},{"issue":"8","key":"10.1016\/j.bbr.2024.115212_bib115","doi-asserted-by":"crossref","first-page":"2854","DOI":"10.1093\/cercor\/bhx164","article-title":"Inhibition of c-Jun N-terminal kinase protects against brain damage and improves learning and memory after traumatic brain injury in adult mice","volume":"28","author":"Rehman","year":"2018","journal-title":"Cereb. Cortex"},{"issue":"25","key":"10.1016\/j.bbr.2024.115212_bib116","doi-asserted-by":"crossref","first-page":"12516","DOI":"10.1073\/pnas.1819541116","article-title":"NRF2\/ARE pathway negatively regulates BACE1 expression and ameliorates cognitive deficits in mouse Alzheimer\u2019s models","volume":"116","author":"Bahn","year":"2019","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"23","key":"10.1016\/j.bbr.2024.115212_bib117","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20236010","article-title":"Effects of cadmium on ZO-1 tight junction integrity of the blood brain barrier","volume":"20","author":"Branca","year":"2019","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.bbr.2024.115212_bib118","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1177\/096032719601500507","article-title":"Cadmium-induced alterations in blood-brain barrier permeability and its possible correlation with decreased microvessel antioxidant potential in rat","volume":"15","author":"Shukla","year":"1996","journal-title":"Hum. Exp. Toxicol."},{"issue":"6","key":"10.1016\/j.bbr.2024.115212_bib119","doi-asserted-by":"crossref","first-page":"492","DOI":"10.3390\/antiox9060492","article-title":"Cadmium-induced oxidative stress: focus on the central nervous system","volume":"9","author":"Branca","year":"2020","journal-title":"Antioxidants"},{"issue":"6","key":"10.1016\/j.bbr.2024.115212_bib120","article-title":"Cadmium-induced oxidative stress: focus on the central nervous system","volume":"9","author":"Branca","year":"2020","journal-title":"Antioxidants [Internet]"},{"key":"10.1016\/j.bbr.2024.115212_bib121","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/898034","article-title":"Cadmium and its neurotoxic effects","volume":"2013","author":"Wang","year":"2013","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.bbr.2024.115212_bib122","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1007\/s00204-015-1540-7","article-title":"Cadmium-induced cell death of basal forebrain cholinergic neurons mediated by muscarinic M1 receptor blockade, increase in GSK-3\u03b2 enzyme, \u03b2-amyloid and tau protein levels","volume":"90","author":"Del Pino","year":"2016","journal-title":"Arch. Toxicol."},{"issue":"5","key":"10.1016\/j.bbr.2024.115212_bib123","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1111\/j.1742-7843.2005.pto_174.x","article-title":"Cadmium effects on brain acetylcholinesterase activity and antioxidant status of adult rats: modulation by zinc, calcium and L-cysteine co-administration","volume":"97","author":"Carageorgiou","year":"2005","journal-title":"Basic Clin. Pharm. Toxicol."},{"issue":"10","key":"10.1016\/j.bbr.2024.115212_bib124","doi-asserted-by":"crossref","first-page":"3709","DOI":"10.1016\/j.fct.2012.07.016","article-title":"Behavior and brain enzymatic changes after long-term intoxication with cadmium salt or contaminated potatoes","volume":"50","author":"Gon\u00e7alves","year":"2012","journal-title":"Food Chem. Toxicol."},{"issue":"2","key":"10.1016\/j.bbr.2024.115212_bib125","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/S0006-8993(01)02022-4","article-title":"Cadmium toxicity in synaptic neurotransmission in the brain","volume":"894","author":"Minami","year":"2001","journal-title":"Brain Res."},{"issue":"5","key":"10.1016\/j.bbr.2024.115212_bib126","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001324","article-title":"Enhancement of asynchronous release from fast-spiking interneuron in human and rat epileptic neocortex","volume":"10","author":"Jiang","year":"2012","journal-title":"PLoS Biol."},{"key":"10.1016\/j.bbr.2024.115212_bib127","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1146\/annurev-physiol-021113-170338","article-title":"Molecular mechanisms for synchronous, asynchronous, and spontaneous neurotransmitter release","volume":"76","author":"Kaeser","year":"2014","journal-title":"Annu. Rev. Physiol."},{"key":"10.1016\/j.bbr.2024.115212_bib128","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.freeradbiomed.2020.05.017","article-title":"Cadmium desynchronizes neurotransmitter release in the neuromuscular junction: key role of ROS","volume":"155","author":"Tsentsevitsky","year":"2020","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbr.2024.115212_bib129","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1007\/s11011-020-00649-5","article-title":"Mercury and Alzheimer\u2019s disease: a look at the links and evidence","volume":"36","author":"Azar","year":"2021","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.bbr.2024.115212_bib130","first-page":"105","article-title":"Alkyl mercury-induced toxicity: multiple mechanisms of action","volume":"240","author":"Risher","year":"2017","journal-title":"Rev. Environ. Contam. Toxicol."},{"key":"10.1016\/j.bbr.2024.115212_bib131","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1007\/s12011-018-1380-4","article-title":"Mercury involvement in neuronal damage and in neurodegenerative diseases","volume":"187","author":"Cariccio","year":"2019","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.bbr.2024.115212_bib132","first-page":"1","article-title":"Mercury toxicity and neurodegenerative effects","author":"Carocci","year":"2014","journal-title":"Rev. Environ. Contam. Toxicol."},{"key":"10.1016\/j.bbr.2024.115212_bib133","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.2147\/NDT.S84266","article-title":"Role of apolipoprotein E in neurodegenerative diseases","author":"Giau","year":"2015","journal-title":"Neuropsychiatr. Dis. Treat."},{"issue":"4","key":"10.1016\/j.bbr.2024.115212_bib134","first-page":"511","article-title":"Insights into the potential role of mercury in Alzheimer\u2019s disease","volume":"67","author":"Bj\u00f8rklund","year":"2019","journal-title":"J. Mol. Neurosci."},{"issue":"6","key":"10.1016\/j.bbr.2024.115212_bib135","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.neuro.2009.08.001","article-title":"Methylmercury induces neuropathological changes with tau hyperphosphorylation mainly through the activation of the c-jun-N-terminal kinase pathway in the cerebral cortex, but not in the hippocampus of the mouse brain","volume":"30","author":"Fujimura","year":"2009","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.bbr.2024.115212_bib136","first-page":"511","article-title":"Insights into the potential role of mercury in Alzheimer\u2019s disease","volume":"67","author":"Bj\u00f8rklund","year":"2019","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.bbr.2024.115212_bib137","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12979-017-0108-1","article-title":"Neuroinflammation and neurohormesis in the pathogenesis of Alzheimer\u2019s disease and Alzheimer-linked pathologies: modulation by nutritional mushrooms","volume":"15","author":"Trovato Salinaro","year":"2018","journal-title":"Immun. Ageing"},{"issue":"4","key":"10.1016\/j.bbr.2024.115212_bib138","doi-asserted-by":"crossref","first-page":"625","DOI":"10.2131\/jts.39.625","article-title":"Mercury-induced amyloid-beta (A\u03b2) accumulation in the brain is mediated by disruption of A\u03b2 transport","volume":"39","author":"Kim","year":"2014","journal-title":"J. Toxicol. Sci."},{"issue":"41","key":"10.1016\/j.bbr.2024.115212_bib139","doi-asserted-by":"crossref","first-page":"12787","DOI":"10.1523\/JNEUROSCI.3657-09.2009","article-title":"The \u03b2-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential","volume":"29","author":"Vassar","year":"2009","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.bbr.2024.115212_bib140","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0378-4274(03)00242-X","article-title":"Ebselen protects against methylmercury-induced inhibition of glutamate uptake by cortical slices from adult mice","volume":"144","author":"Farina","year":"2003","journal-title":"Toxicol. Lett."},{"issue":"3","key":"10.1016\/j.bbr.2024.115212_bib141","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1097\/01.ftd.0000160275.85450.32","article-title":"Methylmercury: recent advances in the understanding of its neurotoxicity","volume":"27","author":"Aschner","year":"2005","journal-title":"Ther. Drug Monit."},{"issue":"2","key":"10.1016\/j.bbr.2024.115212_bib142","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.envint.2006.08.005","article-title":"Methylmercury genotoxicity: a novel effect in human cell lines of the central nervous system","volume":"33","author":"Crespo-L\u00f3pez","year":"2007","journal-title":"Environ. Int."},{"issue":"4","key":"10.1016\/j.bbr.2024.115212_bib143","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jtemb.2012.02.004","article-title":"The toxicology of mercury and its compounds","volume":"26","author":"Syversen","year":"2012","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.bbr.2024.115212_bib144","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1007\/s00204-004-0575-y","article-title":"Mitochondrial viability and apoptosis induced by aluminum, mercuric mercury and methylmercury in cell lines of neural origin","volume":"78","author":"Toimela","year":"2004","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.bbr.2024.115212_bib145","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s10787-019-00580-x","article-title":"Activation of microglia and astrocytes: a roadway to neuroinflammation and Alzheimer\u2019s disease","volume":"27","author":"Kaur","year":"2019","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.bbr.2024.115212_bib146","doi-asserted-by":"crossref","DOI":"10.1177\/07482337241229471","article-title":"Serum levels of inflammatory cytokines in mercury mining workers in a precarious situation: a preliminary study","author":"Salda\u00f1a-Villanueva","year":"2024","journal-title":"Toxicol. Ind. Health"},{"issue":"12","key":"10.1016\/j.bbr.2024.115212_bib147","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1289\/ehp.0900855","article-title":"Mercury induces an unopposed inflammatory response in human peripheral blood mononuclear cells in vitro","volume":"117","author":"Gardner","year":"2009","journal-title":"Environ. Health Perspect."},{"issue":"5","key":"10.1016\/j.bbr.2024.115212_bib148","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1002\/jat.3411","article-title":"Activation of interleukin-6 and-8 expressions by methylmercury in human U937 macrophages involves RelA and p50","volume":"37","author":"Yamamoto","year":"2017","journal-title":"J. Appl. Toxicol."},{"issue":"5","key":"10.1016\/j.bbr.2024.115212_bib149","doi-asserted-by":"crossref","first-page":"307","DOI":"10.3109\/00207454.2013.833510","article-title":"Microglia, neuroinflammation, and beta-amyloid protein in Alzheimer's disease","volume":"124","author":"Cai","year":"2014","journal-title":"Int. J. Neurosci."},{"key":"10.1016\/j.bbr.2024.115212_bib150","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.neurobiolaging.2018.12.019","article-title":"Proinflammatory and anti-inflammatory cytokines in the CSF of patients with Alzheimer's disease and their correlation with cognitive decline","volume":"76","author":"Taipa","year":"2019","journal-title":"Neurobiol. Aging"},{"issue":"3","key":"10.1016\/j.bbr.2024.115212_bib151","first-page":"483","article-title":"Effects of chronic exposure to cadmium, lead and mercury of brain biogenic amines in the rat","volume":"15","author":"Hrdina","year":"1976","journal-title":"Res. Commun. Chem. Pathol. Pharm."},{"issue":"4","key":"10.1016\/j.bbr.2024.115212_bib152","first-page":"610","article-title":"Safety evaluation of mercury based Ayurvedic formulation (Sidh Makardhwaj) on brain cerebrum, liver & kidney in rats","volume":"139","author":"Kumar","year":"2014","journal-title":"Indian J. Med. Res."},{"key":"10.1016\/j.bbr.2024.115212_bib153","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.lfs.2016.01.033","article-title":"Methylmercury affects cerebrovascular reactivity to angiotensin II and acetylcholine via Rho-kinase and nitric oxide pathways in mice","volume":"147","author":"Islam","year":"2016","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.bbr.2024.115212_bib154","first-page":"142","article-title":"Effect of chronic exposure by mercury contaminated rice on neurotransmitter level changes in rat brain","volume":"27","author":"Ji","year":"2006","journal-title":"Huan Jing ke Xue\u00a0=\u00a0Huanjing Kexue"},{"key":"10.1016\/j.bbr.2024.115212_bib155","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1007\/s00441-004-0878-6","article-title":"Mercury decreases the frequency of induced but not spontaneous clustering of acetylcholine receptors","volume":"316","author":"Miller","year":"2004","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.bbr.2024.115212_bib156","doi-asserted-by":"crossref","first-page":"1467","DOI":"10.1007\/BF00968992","article-title":"Presynaptic and postsynaptic effects of mercuric ions on guinea-pig ileum longitudinal muscle strip preparation","volume":"19","author":"Abram","year":"1994","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.bbr.2024.115212_bib157","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1590\/S0100-879X2007000300001","article-title":"Involvement of glutamate and reactive oxygen species in methylmercury neurotoxicity","volume":"40","author":"Aschner","year":"2007","journal-title":"Braz. J. Med. Biol. Res."},{"issue":"2\u20133","key":"10.1016\/j.bbr.2024.115212_bib158","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0197-0186(00)00023-1","article-title":"Methylmercury alters glutamate transport in astrocytes","volume":"37","author":"Aschner","year":"2000","journal-title":"Neurochem. Int."},{"issue":"4","key":"10.1016\/j.bbr.2024.115212_bib159","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/jnr.20375","article-title":"Mercury compounds disrupt neuronal glutamate transport in cultured mouse cerebellar granule cells","volume":"79","author":"Fonfr\u00eda","year":"2005","journal-title":"J. Neurosci. Res."},{"issue":"2","key":"10.1016\/j.bbr.2024.115212_bib160","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.tox.2008.05.011","article-title":"Methylmercury increases N-methyl-d-aspartate receptors on human SH-SY 5Y neuroblastoma cells leading to neurotoxicity","volume":"249","author":"Ndountse","year":"2008","journal-title":"Toxicology"},{"issue":"1","key":"10.1016\/j.bbr.2024.115212_bib161","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/1756-6606-5-30","article-title":"Mercury-induced toxicity of rat cortical neurons is mediated through N-methyl-d-Aspartate receptors","volume":"5","author":"Xu","year":"2012","journal-title":"Mol. Brain"},{"issue":"2","key":"10.1016\/j.bbr.2024.115212_bib162","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1515\/REVEH.2006.21.2.105","article-title":"Involvement of environmental mercury and lead in the etiology of neurodegenerative diseases","volume":"21","author":"Monnet-Tschudi","year":"2006","journal-title":"Rev. Environ. Health"},{"issue":"5","key":"10.1016\/j.bbr.2024.115212_bib163","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.envres.2010.01.007","article-title":"Arsenic species, AS3MT amount, and AS3MT gen expression in different brain regions of mouse exposed to arsenite","volume":"110","author":"S\u00e1nchez-Pe\u00f1a","year":"2010","journal-title":"Environ. Res."},{"issue":"2","key":"10.1016\/j.bbr.2024.115212_bib164","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1007\/s40572-014-0012-1","article-title":"The effects of arsenic exposure on neurological and cognitive dysfunction in human and rodent studies: a review","volume":"1","author":"Tyler","year":"2014","journal-title":"Curr. Environ. Health Rep."},{"issue":"2","key":"10.1016\/j.bbr.2024.115212_bib165","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.freeradbiomed.2011.04.008","article-title":"Arsenic-induced oxidative stress and its reversibility","volume":"51","author":"Flora","year":"2011","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.bbr.2024.115212_bib166","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1093\/toxsci\/63.1.29","article-title":"Effect of phosphate transporter and methylation inhibitor drugs on the disposition of arsenate and arsenite in rats","volume":"63","author":"Csanaky","year":"2001","journal-title":"Toxicol. Sci."},{"issue":"11","key":"10.1016\/j.bbr.2024.115212_bib167","doi-asserted-by":"crossref","first-page":"5239","DOI":"10.1158\/0008-5472.CAN-07-0074","article-title":"Arsenic induced mitochondrial DNA damage and altered mitochondrial oxidative function: implications for genotoxic mechanisms in mammalian cells","volume":"67","author":"Partridge","year":"2007","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbr.2024.115212_bib168","unstructured":"J.G. Bonetto, J.C. Perazzo, S.A. Puntarulo,\u00a0Reactive nitrogen species in brain after in vivo exposure to arsenic, 2020."},{"key":"10.1016\/j.bbr.2024.115212_bib169","series-title":"Arsenic Toxicity: Challenges and Solutions","first-page":"27","article-title":"Arsenic and oxidative stress: an overview","author":"Zargari","year":"2021"},{"issue":"1","key":"10.1016\/j.bbr.2024.115212_bib170","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1038\/s41398-022-01890-5","article-title":"Arsenic alters nitric oxide signaling similar to autism spectrum disorder and Alzheimer's disease-associated mutations","volume":"12","author":"Tripathi","year":"2022","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.bbr.2024.115212_bib171","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/j.chemosphere.2018.10.100","article-title":"Role of pigment epithelium-derived factor (PEDF) on arsenic-induced neuronal apoptosis","volume":"215","author":"Zhang","year":"2019","journal-title":"Chemosphere"},{"key":"10.1016\/j.bbr.2024.115212_bib172","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1007\/s11011-019-00467-4","article-title":"High fat diet deteriorates the memory impairment induced by arsenic in mice: a sub chronic in vivo study","volume":"34","author":"Alboghobeish","year":"2019","journal-title":"Metab. Brain Dis."},{"issue":"1","key":"10.1016\/j.bbr.2024.115212_bib173","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3390\/antiox10010023","article-title":"Potential therapeutic role of phytochemicals to mitigate mitochondrial dysfunctions in Alzheimer\u2019s disease","volume":"10","author":"Rahman","year":"2020","journal-title":"Antioxidants"},{"issue":"1","key":"10.1016\/j.bbr.2024.115212_bib174","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.toxlet.2012.02.021","article-title":"Arsenite exposure altered the expression of NMDA receptor and postsynaptic signaling proteins in rat hippocampus","volume":"211","author":"Luo","year":"2012","journal-title":"Toxicol. Lett."},{"issue":"4","key":"10.1016\/j.bbr.2024.115212_bib175","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.neuro.2008.05.004","article-title":"Moderate perinatal arsenic exposure alters neuroendocrine markers associated with depression and increases depressive-like behaviors in adult mouse offspring","volume":"29","author":"Martinez","year":"2008","journal-title":"Neurotoxicology"},{"issue":"11","key":"10.1016\/j.bbr.2024.115212_bib176","doi-asserted-by":"crossref","first-page":"1933","DOI":"10.1007\/s10495-006-0089-6","article-title":"Zinc induces ERK-dependent cell death through a specific Ras isoform","volume":"11","author":"Klein","year":"2006","journal-title":"Apoptosis"},{"issue":"2","key":"10.1016\/j.bbr.2024.115212_bib177","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/jat.3256","article-title":"Mitochondrial oxidative stress and dysfunction in arsenic neurotoxicity: a review","volume":"36","author":"Prakash","year":"2016","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.bbr.2024.115212_bib178","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s12011-020-02044-8","article-title":"Neurotoxic mechanism of arsenic: synergistic effect of mitochondrial instability, oxidative stress, and hormonal-neurotransmitter impairment","volume":"198","author":"Medda","year":"2020","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.bbr.2024.115212_bib179","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2021.103604","article-title":"Neuroglobin alleviates arsenic-induced neuronal damage","volume":"84","author":"Liu","year":"2021","journal-title":"Environ. Toxicol. Pharm."},{"key":"10.1016\/j.bbr.2024.115212_bib180","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.neuro.2021.05.008","article-title":"Arsenic induces autophagy-dependent apoptosis via Akt inactivation and AMPK activation signaling pathways leading to neuronal cell death","volume":"85","author":"Fu","year":"2021","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.bbr.2024.115212_bib181","doi-asserted-by":"crossref","unstructured":"R. Sharma, M. Abubakar, P. Bisht, M. Rachamalla, A. Kumar, K. Murti, et al., Arsenic Exposure and Amyloid Precursor Protein Processing: A Focus on Alzheimer's Disease, 2023.","DOI":"10.2174\/0118761429272806231020045840"},{"issue":"31","key":"10.1016\/j.bbr.2024.115212_bib182","doi-asserted-by":"crossref","first-page":"32700","DOI":"10.1074\/jbc.M404912200","article-title":"Arsenic transport by the human multidrug resistance protein 1 (MRP1\/ABCC1): evidence that a tri-glutathione conjugate is required","volume":"279","author":"Leslie","year":"2004","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.bbr.2024.115212_bib183","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s12011-014-0094-5","article-title":"Heavy metals and neurodegenerative diseases: an observational study","volume":"161","author":"Giacoppo","year":"2014","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.bbr.2024.115212_bib184","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.neuro.2019.07.007","article-title":"The role of zinc, copper, manganese and iron in neurodegenerative diseases","volume":"74","author":"Mezzaroba","year":"2019","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.bbr.2024.115212_bib185","article-title":"Link between aluminum and the pathogenesis of Alzheimer's disease: the integration of the aluminum and amyloid cascade hypotheses","volume":"2011","author":"Kawahara","year":"2011","journal-title":"Int. J. Alzheimer's\u00a0Dis."},{"key":"10.1016\/j.bbr.2024.115212_bib186","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.neuro.2014.02.004","article-title":"Oxidative stress and mitochondrial dysfunction in aluminium neurotoxicity and its amelioration: a review","volume":"41","author":"Kumar","year":"2014","journal-title":"Neurotoxicology"},{"issue":"5","key":"10.1016\/j.bbr.2024.115212_bib187","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1007\/s10787-023-01287-w","article-title":"Neuromodulatory effect of vardenafil on aluminium chloride\/D-galactose induced Alzheimer's disease in rats: emphasis on amyloid-beta, p-tau, PI3K\/Akt\/p53 pathway, endoplasmic reticulum stress, and cellular senescence","volume":"31","author":"Awad","year":"2023","journal-title":"Inflammopharmacology"},{"issue":"3","key":"10.1016\/j.bbr.2024.115212_bib188","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1080\/01480545.2022.2065291","article-title":"Role of aluminum exposure on Alzheimer's disease and related glycogen synthase kinase pathway","volume":"46","author":"Sanajou","year":"2023","journal-title":"Drug Chem. Toxicol."},{"key":"10.1016\/j.bbr.2024.115212_bib189","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2022.110173","article-title":"Essential metals in health and disease","author":"Jomova","year":"2022","journal-title":"Chem.-Biol. Interact."},{"key":"10.1016\/j.bbr.2024.115212_bib190","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s10534-018-0126-2","article-title":"Oxidative stress and neurodegeneration: the involvement of iron","volume":"31","author":"Carocci","year":"2018","journal-title":"Biometals"},{"key":"10.1016\/j.bbr.2024.115212_bib191","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12868-017-0369-9","article-title":"Iron oxide nanoparticles may damage to the neural tissue through iron accumulation, oxidative stress, and protein aggregation","volume":"18","author":"Yarjanli","year":"2017","journal-title":"BMC Neurosci."},{"issue":"9","key":"10.1016\/j.bbr.2024.115212_bib192","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11092421","article-title":"Why is iron deficiency\/anemia linked to Alzheimer's disease and its comorbidities, and how is it prevented?","volume":"11","author":"Fehsel","year":"2023","journal-title":"Biomedicines"},{"issue":"1","key":"10.1016\/j.bbr.2024.115212_bib193","article-title":"Copper and zinc isotopic excursions in the human brain affected by Alzheimer's disease","volume":"12","author":"Moynier","year":"2020","journal-title":"Alzheimer's\u00a0Dement.: Diagn.\u00a0Assess. Dis. Monit."},{"issue":"7","key":"10.1016\/j.bbr.2024.115212_bib194","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/j.neurobiolaging.2007.10.012","article-title":"Zinc and copper modulate Alzheimer A\u03b2 levels in human cerebrospinal fluid","volume":"30","author":"Strozyk","year":"2009","journal-title":"Neurobiol. Aging"},{"issue":"9","key":"10.1016\/j.bbr.2024.115212_bib195","doi-asserted-by":"crossref","first-page":"3751","DOI":"10.1074\/jbc.M116.754101","article-title":"Zinc and copper differentially modulate amyloid precursor protein processing by \u03b3-secretase and amyloid-\u03b2 peptide production","volume":"292","author":"Gerber","year":"2017","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.bbr.2024.115212_bib196","doi-asserted-by":"crossref","DOI":"10.3390\/nu15040972","article-title":"Copper induces cognitive impairment in mice via modulation of cuproptosis and CREB signaling","volume":"15","author":"Zhang","year":"2023","journal-title":"Nutrients"},{"key":"10.1016\/j.bbr.2024.115212_bib197","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3389\/fnagi.2013.00023","article-title":"Manganese neurotoxicity: new perspectives from behavioral, neuroimaging, and neuropathological studies in humans and non-human primates","volume":"5","author":"Guilarte","year":"2013","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.bbr.2024.115212_bib198","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40360-016-0099-0","article-title":"Manganese-induced neurotoxicity: a review of its behavioral consequences and neuroprotective strategies","volume":"17","author":"Peres","year":"2016","journal-title":"BMC Pharm. Toxicol."},{"issue":"4","key":"10.1016\/j.bbr.2024.115212_bib199","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1016\/j.neuro.2012.03.009","article-title":"Manganese exposure and cognitive deficits: a growing concern for manganese neurotoxicity","volume":"33","author":"Roels","year":"2012","journal-title":"Neurotoxicology"},{"issue":"5","key":"10.1016\/j.bbr.2024.115212_bib200","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1111\/j.1471-4159.2004.02455.x","article-title":"Increased plaque burden in brains of APP mutant MnSOD heterozygous knockout mice","volume":"89","author":"Li","year":"2004","journal-title":"J. Neurochem."},{"issue":"8","key":"10.1016\/j.bbr.2024.115212_bib201","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1096\/fj.09-132928","article-title":"Reduction of oxidative stress, amyloid deposition, and memory deficit by manganese superoxide dismutase overexpression in a transgenic mouse model of Alzheimer\u2019s disease","volume":"23","author":"Dumont","year":"2009","journal-title":"FASEB J."},{"key":"10.1016\/j.bbr.2024.115212_bib202","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/s10858-007-9176-4","article-title":"Positioning of the Alzheimer A\u03b2 (1\u201340) peptide in SDS micelles using NMR and paramagnetic probes","volume":"39","author":"Jarvet","year":"2007","journal-title":"J. Biomol. NMR"},{"issue":"3","key":"10.1016\/j.bbr.2024.115212_bib203","doi-asserted-by":"crossref","first-page":"865","DOI":"10.3233\/JAD-140534","article-title":"High manganese, a risk for Alzheimer's disease: high manganese induces amyloid-\u03b2 related cognitive impairment","volume":"42","author":"Tong","year":"2014","journal-title":"J. Alzheimer's\u00a0Dis."},{"issue":"1","key":"10.1016\/j.bbr.2024.115212_bib204","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1093\/toxsci\/kfq308","article-title":"Manganese induces tau hyperphosphorylation through the activation of ERK MAPK pathway in PC12 cells","volume":"119","author":"Cai","year":"2011","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.bbr.2024.115212_bib205","first-page":"1","article-title":"Heavy metal mediated progressive degeneration and its noxious effects on brain microenvironment","author":"Murumulla","year":"2023","journal-title":"Biol. Trace Elem. Res."},{"issue":"7","key":"10.1016\/j.bbr.2024.115212_bib206","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1007\/s11011-021-00765-w","article-title":"Role of metals in Alzheimer\u2019s disease","volume":"36","author":"Das","year":"2021","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.bbr.2024.115212_bib207","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12035-020-02096-w","article-title":"Molecular mechanisms of metal toxicity in the pathogenesis of Alzheimer\u2019s disease","volume":"58","author":"Kabir","year":"2021","journal-title":"Mol. Neurobiol."},{"issue":"12","key":"10.1016\/j.bbr.2024.115212_bib208","doi-asserted-by":"crossref","first-page":"29592","DOI":"10.3390\/ijms161226183","article-title":"Heavy metals and human health: mechanistic insight into toxicity and counter defense system of antioxidants","volume":"16","author":"Jan","year":"2015","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.bbr.2024.115212_bib209","doi-asserted-by":"crossref","first-page":"1843","DOI":"10.1016\/j.jmb.2019.01.018","article-title":"Metal toxicity links to Alzheimer's disease and neuroinflammation","volume":"431","author":"Huat","year":"2019","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bbr.2024.115212_bib210","first-page":"1","article-title":"Molecular mechanisms of aluminum neurotoxicity: update on adverse effects and therapeutic strategies","volume":"5","author":"Skalny","year":"2021"},{"issue":"7","key":"10.1016\/j.bbr.2024.115212_bib211","doi-asserted-by":"crossref","first-page":"552","DOI":"10.2174\/1570159X18666200122122512","article-title":"Role of oxidative stress and metal toxicity in the progression of Alzheimer\u2019s disease","volume":"18","author":"Birla","year":"2020","journal-title":"Curr. Neuropharmacol."},{"issue":"20","key":"10.1016\/j.bbr.2024.115212_bib212","doi-asserted-by":"crossref","first-page":"7660","DOI":"10.3390\/ijms21207660","article-title":"Copper toxicity links to pathogenesis of Alzheimer\u2019s disease and therapeutics approaches","volume":"21","author":"Ejaz","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bbr.2024.115212_bib213","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12035-020-02096-w","article-title":"Molecular mechanisms of metal toxicity in the pathogenesis of Alzheimer\u2019s disease","volume":"58","author":"Kabir","year":"2021","journal-title":"Mol. Neurobiol."},{"issue":"1","key":"10.1016\/j.bbr.2024.115212_bib214","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/S0162-0134(02)00461-0","article-title":"Molecular and cellular mechanisms of iron homeostasis and toxicity in mammalian cells","volume":"91","author":"Crichton","year":"2002","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.bbr.2024.115212_bib215","article-title":"An Update overview on mechanistic data and biomarker levels in cobalt and chromium-induced neurodegenerative diseases","author":"Ajibo","year":"2023","journal-title":"Biol. Trace Elem. Res."},{"issue":"1","key":"10.1016\/j.bbr.2024.115212_bib216","doi-asserted-by":"crossref","first-page":"3341","DOI":"10.1038\/s41598-023-29901-5","article-title":"Residue-specific binding of Ni(II) ions influences the structure and aggregation of amyloid beta (A\u03b2) peptides","volume":"13","author":"Berntsson","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbr.2024.115212_bib217","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/219840","article-title":"Chelation: harnessing and enhancing heavy metal detoxification\u2014a review","volume":"2013","author":"Sears","year":"2013","journal-title":"Sci. World J."},{"issue":"1","key":"10.1016\/j.bbr.2024.115212_bib218","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2174\/1389557043487583","article-title":"Chemical and biological considerations in the treatment of metal intoxications by chelating agents","volume":"4","author":"Andersen","year":"2004","journal-title":"Mini Rev. Med. Chem."},{"issue":"12","key":"10.1016\/j.bbr.2024.115212_bib219","doi-asserted-by":"crossref","first-page":"3787","DOI":"10.1007\/s00204-017-2100-0","article-title":"Metal chelators and neurotoxicity: lead, mercury, and arsenic","volume":"91","author":"Bj\u00f8rklund","year":"2017","journal-title":"Arch. Toxicol."},{"issue":"18","key":"10.1016\/j.bbr.2024.115212_bib220","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1056\/NEJMra022471","article-title":"The toxicology of mercury\u2014current exposures and clinical manifestations","volume":"349","author":"Clarkson","year":"2003","journal-title":"N. Engl. J. Med."},{"issue":"7","key":"10.1016\/j.bbr.2024.115212_bib221","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1080\/15563650903174828","article-title":"Dimercaptosuccinic acid (succimer; DMSA) in inorganic lead poisoning","volume":"47","author":"Bradberry","year":"2009","journal-title":"Clin. Toxicol."},{"issue":"3","key":"10.1016\/j.bbr.2024.115212_bib222","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jtemb.2006.02.002","article-title":"Co-administration of zinc and n-acetylcysteine prevents arsenic-induced tissue oxidative stress in male rats","volume":"20","author":"Modi","year":"2006","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.bbr.2024.115212_bib223","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.jtemb.2014.10.001","article-title":"Chelation in metal intoxication\u2014principles and paradigms","volume":"31","author":"Aaseth","year":"2015","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.bbr.2024.115212_bib224","series-title":"Metal Chelation in Medicine","first-page":"56","article-title":"Chelation therapy for heavy metals","author":"Nielsen","year":"2016"},{"key":"10.1016\/j.bbr.2024.115212_bib225","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.jtemb.2019.05.003","article-title":"Heavy metal toxicity: an update of chelating therapeutic strategies","volume":"54","author":"Kim","year":"2019","journal-title":"J. Trace Elem. Med. Biol."},{"issue":"3","key":"10.1016\/j.bbr.2024.115212_bib226","doi-asserted-by":"crossref","first-page":"457","DOI":"10.3233\/JAD-2009-1068","article-title":"Challenges associated with metal chelation therapy in Alzheimer's disease","volume":"17","author":"Hegde","year":"2009","journal-title":"J. Alzheimer's\u00a0Dis."},{"key":"10.1016\/j.bbr.2024.115212_bib227","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/219840","article-title":"Chelation: harnessing and enhancing heavy metal detoxification\u2013a review","volume":"2013","author":"Sears","year":"2013","journal-title":"ScientificWorldJournal"},{"issue":"4","key":"10.1016\/j.bbr.2024.115212_bib228","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1515\/jpem-2006-190404","article-title":"Impact of long-term iron chelation therapy on growth and endocrine functions in thalassaemia","volume":"19","author":"De Sanctis","year":"2006","journal-title":"J. Pediatr. Endocrinol. Metab."},{"key":"10.1016\/j.bbr.2024.115212_bib229","doi-asserted-by":"crossref","first-page":"8989","DOI":"10.1007\/s11356-020-12255-0","article-title":"Role of metallic pollutants in neurodegeneration: effects of aluminum, lead, mercury, and arsenic in mediating brain impairment events and autism spectrum disorder","volume":"28","author":"Kaur","year":"2021","journal-title":"Environ. Sci. Pollut. Res."},{"issue":"36","key":"10.1016\/j.bbr.2024.115212_bib230","doi-asserted-by":"crossref","first-page":"4540","DOI":"10.2174\/09298673113209990146","article-title":"Chemistry and pharmacological properties of some natural and synthetic antioxidants for heavy metal toxicity","volume":"20","author":"Flora","year":"2013","journal-title":"Curr. Med. Chem."},{"issue":"1","key":"10.1016\/j.bbr.2024.115212_bib231","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-18432-0","article-title":"Gallic and ascorbic acids supplementation alleviate cognitive deficits and neuropathological damage exerted by cadmium chloride in Wistar rats","volume":"12","author":"Adebiyi","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbr.2024.115212_bib232","doi-asserted-by":"crossref","first-page":"3718","DOI":"10.1007\/s12011-020-02497-x","article-title":"Resveratrol mitigates cerebral ischemic injury by altering levels of trace elements, toxic metal, lipid peroxidation, and antioxidant activity","volume":"199","author":"Ro","year":"2021","journal-title":"Biol. Trace Elem. Res."},{"issue":"2","key":"10.1016\/j.bbr.2024.115212_bib233","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3390\/antiox12020243","article-title":"A review of the role of curcumin in metal induced toxicity","volume":"12","author":"Smirnova","year":"2023","journal-title":"Antioxidants"},{"issue":"7","key":"10.1016\/j.bbr.2024.115212_bib234","first-page":"1277","article-title":"Heavy metal toxicosis and male fertility: the role of pentahydroxyflavone quercetin: a review","volume":"25","author":"Salihu","year":"2021","journal-title":"J. Appl. Sci. Environ. Manag."},{"key":"10.1016\/j.bbr.2024.115212_bib235","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.toxlet.2017.10.021","article-title":"Resveratrol attenuates oxidative damage through activating mitophagy in an in vitro model of Alzheimer\u2019s disease","volume":"282","author":"Wang","year":"2018","journal-title":"Toxicol. Lett."},{"issue":"5","key":"10.1016\/j.bbr.2024.115212_bib236","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1002\/med.20188","article-title":"Curcumin and its analogues: potential anticancer agents","volume":"30","author":"Agrawal","year":"2010","journal-title":"Med. Res. Rev."},{"key":"10.1016\/j.bbr.2024.115212_bib237","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2021.104675","article-title":"Quercetin improves the impairment in memory function and attenuates hippocampal damage in cadmium chloride-intoxicated male rats by suppressing acetylcholinesterase and concomitant activation of SIRT1 signaling","volume":"86","author":"Alshammari","year":"2021","journal-title":"J. Funct. Foods"},{"issue":"1","key":"10.1016\/j.bbr.2024.115212_bib238","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1038\/s41598-023-28893-6","article-title":"Gallic acid abates cadmium chloride toxicity via alteration of neurotransmitters and modulation of inflammatory markers in Wistar rats","volume":"13","author":"Ojo","year":"2023","journal-title":"Sci. Rep."},{"issue":"12","key":"10.1016\/j.bbr.2024.115212_bib239","doi-asserted-by":"crossref","first-page":"1311","DOI":"10.3390\/antiox9121311","article-title":"(Ascorb) ing Pb neurotoxicity in the developing brain","volume":"9","author":"Ahmad","year":"2020","journal-title":"Antioxidants"},{"issue":"16","key":"10.1016\/j.bbr.2024.115212_bib240","doi-asserted-by":"crossref","first-page":"2895","DOI":"10.3390\/ijerph16162895","article-title":"The neuroprotective role of coenzyme Q10 against lead acetate-induced neurotoxicity is mediated by antioxidant, anti-inflammatory and anti-apoptotic activities","volume":"16","author":"S. Yousef","year":"2019","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"8","key":"10.1016\/j.bbr.2024.115212_bib241","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1080\/15376516.2023.2231530","article-title":"Mirtazapine attenuated cadmium-induced neuronal intoxication by regulating Nrf2 and NF-\u03baB\/TLR4 signals","volume":"33","author":"Alharthy","year":"2023","journal-title":"Toxicol. Mech. Methods"},{"key":"10.1016\/j.bbr.2024.115212_bib242","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2022.153242","article-title":"Comparative efficacy of silibinin and nano-silibinin on lead poisoning in male wistar rats","volume":"475","author":"Mohammadi","year":"2022","journal-title":"Toxicology"},{"issue":"6","key":"10.1016\/j.bbr.2024.115212_bib243","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1517\/17425247.2016.1160890","article-title":"Nano drug delivery systems: a new paradigm for treating metal toxicity","volume":"13","author":"Yadav","year":"2016","journal-title":"Expert Opin. Drug Deliv."},{"issue":"1","key":"10.1016\/j.bbr.2024.115212_bib244","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1166\/jns.2009.005","article-title":"Metal chelators coupled with nanoparticles as potential therapeutic agents for Alzheimer's disease","volume":"1","author":"Liu","year":"2009","journal-title":"J. Nanoneurosci."},{"issue":"10","key":"10.1016\/j.bbr.2024.115212_bib245","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1021\/acs.chemrestox.2c00129","article-title":"Chemistry, pharmacology, and toxicology of monoisoamyl dimercaptosuccinic acid: a chelating agent for chronic metal poisoning","volume":"35","author":"Flora","year":"2022","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.bbr.2024.115212_bib246","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110871","article-title":"Comparative efficacy of nano and bulk monoisoamyl DMSA against arsenic-induced neurotoxicity in rats","volume":"132","author":"Naqvi","year":"2020","journal-title":"Biomed. Pharmacother."},{"issue":"6","key":"10.1016\/j.bbr.2024.115212_bib247","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1007\/s40495-022-00307-7","article-title":"Nano-mediated strategies for metal ion\u2013induced neurodegenerative disorders: focus on Alzheimer\u2019s and Parkinson\u2019s diseases","volume":"8","author":"Harini","year":"2022","journal-title":"Curr. Pharm. Rep."},{"issue":"5","key":"10.1016\/j.bbr.2024.115212_bib248","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1002\/fsn3.3096","article-title":"Curcumin-loaded cockle shell-derived calcium carbonate nanoparticles ameliorates lead-induced neurotoxicity in rats via attenuation of oxidative stress","volume":"11","author":"Mailafiya","year":"2023","journal-title":"Food Sci. Nutr."},{"issue":"5","key":"10.1016\/j.bbr.2024.115212_bib249","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1002\/fsn3.3096","article-title":"Curcumin-loaded cockle shell-derived calcium carbonate nanoparticles ameliorates lead-induced neurotoxicity in rats via attenuation of oxidative stress","volume":"11","author":"Mailafiya","year":"2023","journal-title":"Food Sci. Nutr."},{"key":"10.1016\/j.bbr.2024.115212_bib250","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jinorgbio.2015.01.001","article-title":"Quercetin encapsulation in modified silica nanoparticles: potential use against Cu(II)-induced oxidative stress in neurodegeneration","volume":"145","author":"Nday","year":"2015","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.bbr.2024.115212_bib251","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.2147\/IJN.S191878","article-title":"Superparamagnetic iron oxide nanoparticles combined with NGF and quercetin promote neuronal branching morphogenesis of PC12 cells","volume":"14","author":"Katebi","year":"2019","journal-title":"Int. J. Nanomed."},{"issue":"6","key":"10.1016\/j.bbr.2024.115212_bib252","doi-asserted-by":"crossref","first-page":"715","DOI":"10.2174\/0929867324666171026163144","article-title":"Peptides and their metal complexes in neurodegenerative diseases: from structural studies to nanomedicine prospects","volume":"25","author":"Trapani","year":"2018","journal-title":"Curr. Med. Chem."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432824003681?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432824003681?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T23:10:26Z","timestamp":1732230626000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432824003681"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":252,"alternative-id":["S0166432824003681"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2024.115212","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Heavy metals exposure and Alzheimer\u2019s disease: Underlying mechanisms and advancing therapeutic approaches","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2024.115212","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115212"}}