{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T02:58:02Z","timestamp":1784257082616,"version":"3.55.0"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,10,1]],"date-time":"2024-10-01T00:00:00Z","timestamp":1727740800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100017605","name":"Shaanxi University of Chinese Medicine","doi-asserted-by":"publisher","award":["306-17102032225"],"award-info":[{"award-number":["306-17102032225"]}],"id":[{"id":"10.13039\/501100017605","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017605","name":"Shaanxi University of Chinese Medicine","doi-asserted-by":"publisher","award":["2021GP01"],"award-info":[{"award-number":["2021GP01"]}],"id":[{"id":"10.13039\/501100017605","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017605","name":"Shaanxi University of Chinese Medicine","doi-asserted-by":"publisher","award":["2023GP07"],"award-info":[{"award-number":["2023GP07"]}],"id":[{"id":"10.13039\/501100017605","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017596","name":"Natural Science Basic Research Program of Shaanxi Province","doi-asserted-by":"publisher","award":["2024JC-YBQN-0947"],"award-info":[{"award-number":["2024JC-YBQN-0947"]}],"id":[{"id":"10.13039\/501100017596","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017596","name":"Natural Science Basic Research Program of Shaanxi Province","doi-asserted-by":"publisher","award":["2019JM-399"],"award-info":[{"award-number":["2019JM-399"]}],"id":[{"id":"10.13039\/501100017596","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017596","name":"Natural Science Basic Research Program of Shaanxi Province","doi-asserted-by":"publisher","award":["2022JM-523"],"award-info":[{"award-number":["2022JM-523"]}],"id":[{"id":"10.13039\/501100017596","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin Municipality","doi-asserted-by":"publisher","award":["21JCQNJC00010"],"award-info":[{"award-number":["21JCQNJC00010"]}],"id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2024,10]]},"DOI":"10.1016\/j.bbr.2024.115220","type":"journal-article","created":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T02:32:41Z","timestamp":1724812361000},"page":"115220","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["AQP4 is upregulated in schizophrenia and Its inhibition attenuates MK-801-induced schizophrenia-like behaviors in mice"],"prefix":"10.1016","volume":"475","author":[{"given":"Fa-yi","family":"Nie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ru-yi","family":"Jin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shan-shan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-wei","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si-meng","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-hang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hai-fa","family":"Qiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2024.115220_bib1","unstructured":"Global, regional, and national incidence, prevalence, and years lived with disability for 354 diseases and injuries for 195 countries and territories, 1990\u20132017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet. 2018;392:1789\u2013858."},{"key":"10.1016\/j.bbr.2024.115220_bib2","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/nrn.2017.125","article-title":"Genetic insights into the neurodevelopmental origins of schizophrenia","volume":"18","author":"Birnbaum","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbr.2024.115220_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2022.104894","article-title":"Schizophrenia: the new etiological synthesis","volume":"142","author":"Rantala","year":"2022","journal-title":"Neurosci. Biobehav Rev."},{"key":"10.1016\/j.bbr.2024.115220_bib4","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1038\/s41398-022-01904-2","article-title":"Beyond antipsychotics: a twenty-first century update for preclinical development of schizophrenia therapeutics","volume":"12","author":"Spark","year":"2022","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.bbr.2024.115220_bib5","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1080\/00325481.2021.2006514","article-title":"Neuroinflammation and oxidative stress in schizophrenia: are these opportunities for repurposing?","volume":"134","author":"Ansari","year":"2022","journal-title":"Post. Med"},{"key":"10.1016\/j.bbr.2024.115220_bib6","doi-asserted-by":"crossref","first-page":"892","DOI":"10.3389\/fpsyt.2019.00892","article-title":"Cytokine alterations in schizophrenia: an updated review","volume":"10","author":"Momtazmanesh","year":"2019","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.bbr.2024.115220_bib7","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.schres.2014.09.015","article-title":"Elevated serum levels of TNF-\u03b1, IL-6 and IL-18 in chronic schizophrenic patients","volume":"159","author":"Luo","year":"2014","journal-title":"Schizophr. Res"},{"key":"10.1016\/j.bbr.2024.115220_bib8","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1017\/S0033291719001995","article-title":"An update on the efficacy of anti-inflammatory agents for patients with schizophrenia: a meta-analysis","volume":"49","author":"\u00c7akici","year":"2019","journal-title":"Psychol. Med."},{"key":"10.1016\/j.bbr.2024.115220_bib9","doi-asserted-by":"crossref","first-page":"401","DOI":"10.3389\/fncel.2018.00401","article-title":"Astrocyte heterogeneity in the adult central nervous system","volume":"12","author":"Miller","year":"2018","journal-title":"Front Cell Neurosci."},{"key":"10.1016\/j.bbr.2024.115220_bib10","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1177\/1073858413504466","article-title":"Multiple roles for astrocytes as effectors of cytokines and inflammatory mediators","volume":"20","author":"Sofroniew","year":"2014","journal-title":"Neuroscientist"},{"key":"10.1016\/j.bbr.2024.115220_bib11","doi-asserted-by":"crossref","first-page":"1585","DOI":"10.1002\/glia.24221","article-title":"Emerging evidence for astrocyte dysfunction in schizophrenia","volume":"70","author":"de Oliveira Figueiredo","year":"2022","journal-title":"Glia"},{"key":"10.1016\/j.bbr.2024.115220_bib12","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/S2215-0366(19)30302-5","article-title":"Glial cells in schizophrenia: a unified hypothesis","volume":"7","author":"Dietz","year":"2020","journal-title":"Lancet Psychiatry"},{"key":"10.1016\/j.bbr.2024.115220_bib13","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1080\/14728222.2017.1398236","article-title":"The aquaporin-4 water channel as a potential drug target in neurological disorders","volume":"21","author":"Verkman","year":"2017","journal-title":"Expert Opin. Ther. Targets"},{"key":"10.1016\/j.bbr.2024.115220_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21051603","article-title":"Regulation of AQP4 in the Central Nervous System","volume":"21","author":"Vandebroek","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbr.2024.115220_bib15","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17081306","article-title":"Neuroimmunological implications of AQP4 in astrocytes","volume":"17","author":"Ikeshima-Kataoka","year":"2016","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.bbr.2024.115220_bib16","first-page":"1716","article-title":"AQP4knockout alleviates the lipopolysaccharideinduced inflammatory response in astrocytes via SPHK1\/MAPK\/AKT signaling","volume":"42","author":"Dai","year":"2018","journal-title":"Int J. Mol. Med"},{"key":"10.1016\/j.bbr.2024.115220_bib17","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.brainresbull.2021.02.014","article-title":"Inhibition of ERK1\/2 phosphorylation attenuates spinal cord injury induced astrocyte activation and inflammation through negatively regulating aquaporin-4 in rats","volume":"170","author":"Li","year":"2021","journal-title":"Brain Res Bull."},{"key":"10.1016\/j.bbr.2024.115220_bib18","doi-asserted-by":"crossref","DOI":"10.1177\/1744806918796057","article-title":"Correlation of TGN-020 with the analgesic effects via ERK pathway activation after chronic constriction injury","volume":"14","author":"Zhao","year":"2018","journal-title":"Mol. Pain."},{"key":"10.1016\/j.bbr.2024.115220_bib19","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s13760-015-0520-2","article-title":"A research update on the potential roles of aquaporin 4 in neuroinflammation","volume":"116","author":"Lan","year":"2015","journal-title":"Acta Neurol. Belg."},{"key":"10.1016\/j.bbr.2024.115220_bib20","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.bbi.2021.08.232","article-title":"The role of AQP4 in the pathogenesis of depression, and possible related mechanisms","volume":"98","author":"Genel","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbr.2024.115220_bib21","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1111\/cns.12267","article-title":"Involvement of aquaporin 4 in astrocyte function and neuropsychiatric disorders","volume":"20","author":"Xiao","year":"2014","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.bbr.2024.115220_bib22","doi-asserted-by":"crossref","first-page":"657","DOI":"10.3389\/fpsyt.2018.00657","article-title":"Human aquaporin 4 gene polymorphisms and haplotypes are associated with serum S100B level and negative symptoms of schizophrenia in a southern Chinese han population","volume":"9","author":"Wu","year":"2018","journal-title":"Front Psychiatry"},{"key":"10.1016\/j.bbr.2024.115220_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2020.00596","article-title":"Polymorphisms in the human aquaporin 4 gene are associated with Schizophrenia in the southern chinese han population: a case\u2013control study","volume":"11","author":"Wu","year":"2020","journal-title":"Front Psychiatry"},{"key":"10.1016\/j.bbr.2024.115220_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.psychres.2022.114658","article-title":"Identification of potential biomarkers and their correlation with immune infiltration cells in schizophrenia using combinative bioinformatics strategy","volume":"314","author":"Li","year":"2022","journal-title":"Psychiatry Res"},{"key":"10.1016\/j.bbr.2024.115220_bib25","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1080\/01913123.2021.2024633","article-title":"Distribution of Aquaporin-4 channels in hippocampus and prefrontal cortex in mk-801-treated balb\/c mice","volume":"46","author":"Ericek","year":"2022","journal-title":"Ultra Pathol."},{"key":"10.1016\/j.bbr.2024.115220_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2021.136098","article-title":"Minireview: animal model of schizophrenia from the perspective of behavioral pharmacology: effect of treatment on cognitive functions","volume":"761","author":"Vales","year":"2021","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbr.2024.115220_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2022.1024649","article-title":"The effects and mechanism of environmental enrichment on MK-801 induced cognitive impairment in rodents with schizophrenia","volume":"16","author":"Xu","year":"2022","journal-title":"Front Cell Neurosci."},{"key":"10.1016\/j.bbr.2024.115220_bib28","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/ajmg.b.32863","article-title":"Application of animal experimental models in the research of schizophrenia","volume":"186","author":"Wang","year":"2021","journal-title":"Am. J. Med. Genet B Neuropsychiatr. Genet"},{"key":"10.1016\/j.bbr.2024.115220_bib29","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/j.brainresbull.2019.05.017","article-title":"Anti-inflammatory treatment with beta-asarone improves impairments in social interaction and cognition in MK-801 treated mice","volume":"150","author":"Xiao","year":"2019","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.bbr.2024.115220_bib30","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/j.bbr.2014.07.017","article-title":"Donepezil and the alpha-7 agonist PHA 568487, but not risperidone, ameliorate spatial memory deficits in a subchronic MK-801 mouse model of cognitive impairment in schizophrenia","volume":"272","author":"Karamihalev","year":"2014","journal-title":"Behav. Brain Res"},{"key":"10.1016\/j.bbr.2024.115220_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2019.104538","article-title":"Astrocyte culture models: Molecular and function characterization of primary culture, immortalized astrocytes and C6 glioma cells","volume":"131","author":"Galland","year":"2019","journal-title":"Neurochem Int"},{"key":"10.1016\/j.bbr.2024.115220_bib32","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1007\/s11064-012-0722-4","article-title":"High-glucose and S100B stimulate glutamate uptake in C6 glioma cells","volume":"37","author":"Tramontina","year":"2012","journal-title":"Neurochem Res."},{"key":"10.1016\/j.bbr.2024.115220_bib33","article-title":"Exploring the core genes of schizophrenia based on bioinformatics analysis","volume":"13","author":"Feng","year":"2022","journal-title":"Genes"},{"key":"10.1016\/j.bbr.2024.115220_bib34","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1038\/s41467-019-09234-6","article-title":"Metascape provides a biologist-oriented resource for the analysis of systems-level datasets","volume":"10","author":"Zhou","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbr.2024.115220_bib35","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1007\/s12035-023-03636-w","article-title":"TGN-020 alleviate inflammation and apoptosis after cerebral ischemia-reperfusion injury in mice through glymphatic and ERK1\/2 signaling pathway","volume":"61","author":"Li","year":"2024","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbr.2024.115220_bib36","doi-asserted-by":"crossref","first-page":"2692","DOI":"10.1007\/s13311-021-01126-2","article-title":"Upregulation of AQP4 improves blood-brain barrier integrity and perihematomal Edema following intracerebral hemorrhage","volume":"18","author":"Jeon","year":"2021","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.bbr.2024.115220_bib37","article-title":"Retinoic acid supplementation rescues the social deficits in Fmr1 Knockout Mice","volume":"13","author":"Yang","year":"2022","journal-title":"Front Genet"},{"key":"10.1016\/j.bbr.2024.115220_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2020.155366","article-title":"Alteration in the expression of inflammatory cytokines in primary hippocampal astrocytes in response to MK-801 through ERK1\/2 and PI3K signals","volume":"138","author":"Zhu","year":"2021","journal-title":"Cytokine"},{"key":"10.1016\/j.bbr.2024.115220_bib39","doi-asserted-by":"crossref","DOI":"10.1177\/23982128211009148","article-title":"Astrocytes in schizophrenia","volume":"5","author":"Notter","year":"2021","journal-title":"Brain Neurosci. Adv."},{"key":"10.1016\/j.bbr.2024.115220_bib40","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1177\/0004867414531078","article-title":"Increased expression of astrocyte markers in schizophrenia: association with neuroinflammation","volume":"48","author":"Catts","year":"2014","journal-title":"Aust. N. Z. J. Psychiatry"},{"key":"10.1016\/j.bbr.2024.115220_bib41","doi-asserted-by":"crossref","first-page":"6391","DOI":"10.1523\/JNEUROSCI.6221-11.2012","article-title":"Genomic analysis of reactive astrogliosis","volume":"32","author":"Zamanian","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2024.115220_bib42","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1002\/jnr.23467","article-title":"Aquaporin 4-dependent expression of glial fibrillary acidic protein and tenascin-C in activated astrocytes in stab wound mouse brain and in primary culture","volume":"93","author":"Ikeshima-Kataoka","year":"2015","journal-title":"J. Neurosci. Res"},{"key":"10.1016\/j.bbr.2024.115220_bib43","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0145651","article-title":"Reactive transformation and increased BDNF signaling by Hippocampal astrocytes in response to MK-801","volume":"10","author":"Yu","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.bbr.2024.115220_bib44","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.mcn.2006.09.008","article-title":"Aquaporin-4 deficiency down-regulates glutamate uptake and GLT-1 expression in astrocytes","volume":"34","author":"Zeng","year":"2007","journal-title":"Mol. Cell. Neurosci."},{"key":"10.1016\/j.bbr.2024.115220_bib45","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.exer.2015.12.012","article-title":"Negative impact of AQP-4 channel inhibition on survival of retinal ganglion cells and glutamate metabolism after crushing optic nerve","volume":"146","author":"Nishikawa","year":"2016","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.bbr.2024.115220_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroscience.2024.06.016","article-title":"mGluR5 positive allosteric modulation prevents MK-801 induced increases in extracellular glutamate in the rat medial prefrontal cortex","author":"LaCrosse","year":"2024","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2024.115220_bib47","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1096\/fj.10-177279","article-title":"Proinflammatory role of aquaporin-4 in autoimmune neuroinflammation","volume":"25","author":"Li","year":"2011","journal-title":"Faseb J."},{"key":"10.1016\/j.bbr.2024.115220_bib48","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.lfs.2019.03.007","article-title":"TGN-020 alleviates edema and inhibits astrocyte activation and glial scar formation after spinal cord compression injury in rats","volume":"222","author":"Li","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.bbr.2024.115220_bib49","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.exer.2015.12.012","article-title":"Negative impact of AQP-4 channel inhibition on survival of retinal ganglion cells and glutamate metabolism after crushing optic nerve","volume":"146","author":"Nishikawa","year":"2016","journal-title":"Exp. Eye Res"},{"key":"10.1016\/j.bbr.2024.115220_bib50","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.mam.2012.01.002","article-title":"Aquaporins in drug discovery and pharmacotherapy","volume":"33","author":"Huber","year":"2012","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.bbr.2024.115220_bib51","doi-asserted-by":"crossref","first-page":"2056","DOI":"10.1007\/s12035-017-0439-0","article-title":"Aquaporin-4 as a new target against methamphetamine-induced brain alterations: focus on the neurogliovascular unit and motivational behavior","volume":"55","author":"Leitao","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbr.2024.115220_bib52","doi-asserted-by":"crossref","DOI":"10.1016\/j.yexcr.2022.113298","article-title":"Autophagy promotes membrane trafficking of NR2B to alleviate depression by inhibiting AQP4 expression in mice","volume":"419","author":"Liu","year":"2022","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.bbr.2024.115220_bib53","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1097\/YIC.0000000000000395","article-title":"Social withdrawal and neurocognitive correlates in schizophrenia","volume":"37","author":"De Donatis","year":"2022","journal-title":"Int. Clin. Psychopharmacol."},{"key":"10.1016\/j.bbr.2024.115220_bib54","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.psychres.2018.04.036","article-title":"Brain, blood, cerebrospinal fluid, and serum biomarkers in schizophrenia","volume":"265","author":"Mohammadi","year":"2018","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.bbr.2024.115220_bib55","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.neubiorev.2017.03.003","article-title":"Acute variations of cytokine levels after antipsychotic treatment in drug-naive subjects with a first-episode psychosis: a meta-analysis","volume":"77","author":"Capuzzi","year":"2017","journal-title":"Neurosci. Biobehav Rev."},{"key":"10.1016\/j.bbr.2024.115220_bib56","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1093\/ijnp\/pyy062","article-title":"Kinetics of cytokine levels during antipsychotic treatment in Schizophrenia: a meta-analysis","volume":"21","author":"Romeo","year":"2018","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.bbr.2024.115220_bib57","article-title":"The role of glial cells in mental illness: a systematic review on astroglia and microglia as potential players in schizophrenia and its cognitive and emotional aspects","volume":"18","author":"Laricchiuta","year":"2024","journal-title":"Front.\u00a0Cell Neurosci."},{"key":"10.1016\/j.bbr.2024.115220_bib58","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.neuint.2014.05.007","article-title":"High-mobility group box 1 up-regulates aquaporin 4 expression via microglia-astrocyte interaction","volume":"75","author":"Ohnishi","year":"2014","journal-title":"Neurochem.\u00a0Int."},{"key":"10.1016\/j.bbr.2024.115220_bib59","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.neuroscience.2016.01.003","article-title":"Aquaporin-4 mediates communication between astrocyte and microglia: Implications of neuroinflammation in experimental Parkinson\u2019s disease","volume":"317","author":"Sun","year":"2016","journal-title":"Neuroscience"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432824003760?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432824003760?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:19:56Z","timestamp":1777497596000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432824003760"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10]]},"references-count":59,"alternative-id":["S0166432824003760"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2024.115220","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2024,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"AQP4 is upregulated in schizophrenia and Its inhibition attenuates MK-801-induced schizophrenia-like behaviors in mice","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2024.115220","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115220"}}