{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T22:54:43Z","timestamp":1789080883998,"version":"build-2803163510"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001409","name":"Department of Science and Technology, Ministry of Science and Technology, India","doi-asserted-by":"publisher","award":["SR\/FST\/College-054\/2017"],"award-info":[{"award-number":["SR\/FST\/College-054\/2017"]}],"id":[{"id":"10.13039\/501100001409","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.bbr.2024.115270","type":"journal-article","created":{"date-parts":[[2024,9,23]],"date-time":"2024-09-23T14:08:05Z","timestamp":1727100485000},"page":"115270","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Novel insights into famotidine as a GSK-3\u03b2 inhibitor: An explorative study in aluminium chloride-induced Alzheimer\u2019s disease rat model"],"prefix":"10.1016","volume":"476","author":[{"given":"Ronnita C.","family":"Sequeira","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8833-8943","authenticated-orcid":false,"given":"Angel","family":"Godad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2024.115270_bib1","article-title":"A neuroimaging biomarker for Individual Brain-Related Abnormalities In Neurodegeneration (IBRAIN): a cross-sectional study","volume":"65","author":"Zhao","year":"2023","journal-title":"EClin. Med."},{"key":"10.1016\/j.bbr.2024.115270_bib2","unstructured":"A. Kumar, J. Sidhu, A. Goyal, J.W. Tsao, Alzheimer Disease, StatPearls (2022) 1\u201327. \u3008https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK499922\/\u3009 (accessed November 5, 2023)."},{"key":"10.1016\/j.bbr.2024.115270_bib3","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/2589276","article-title":"Therapies for prevention and treatment of Alzheimer\u2019s disease","volume":"2016","author":"Mendiola-Precoma","year":"2016","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.bbr.2024.115270_bib4","doi-asserted-by":"crossref","first-page":"975","DOI":"10.3233\/JAD-160612","article-title":"Amyloid beta and phosphorylated tau accumulations cause abnormalities at synapses of Alzheimer\u2019s disease neurons","volume":"57","author":"Rajmohan","year":"2017","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.bbr.2024.115270_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbamcr.2020.118664","article-title":"Glycogen synthase kinase-3 signaling in Alzheimer\u2019s disease","volume":"1867","author":"Lauretti","year":"2020","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.bbr.2024.115270_bib6","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0301-0082(01)00011-9","article-title":"The multifaceted roles of glycogen synthase kinase 3\u03b2 in cellular signaling","volume":"65","author":"Grimes","year":"2001","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.bbr.2024.115270_bib7","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/4209475","article-title":"GSK-3\u03b2 at the intersection of neuronal plasticity and neurodegeneration","volume":"2019","author":"Jaworski","year":"2019","journal-title":"Neural Plast."},{"key":"10.1016\/j.bbr.2024.115270_bib8","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s11064-006-9128-5","article-title":"Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics","volume":"32","author":"Jope","year":"2007","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.bbr.2024.115270_bib9","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.pharmthera.2014.11.016","article-title":"Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases","volume":"0","author":"Beurel","year":"2015","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bbr.2024.115270_bib10","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1021\/acschemneuro.9b00068","article-title":"Why A\u03b242 Is Much More Toxic than A\u03b240","volume":"10","author":"Phillips","year":"2019","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.bbr.2024.115270_bib11","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1111\/j.1471-4159.2007.05194.x","article-title":"The GSK3 hypothesis of Alzheimer\u2019s disease","volume":"104","author":"Hooper","year":"2008","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbr.2024.115270_bib12","first-page":"86302","article-title":"GSK-3\u03b2, a pivotal kinase in Alzheimer disease","volume":"7","author":"Llorens-Mart\u00edn","year":"2014","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.bbr.2024.115270_bib13","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.2174\/1389557522666220420094317","article-title":"GSK-3\u03b2 and its inhibitors in Alzheimer\u2019s disease: a recent update","volume":"22","author":"Chauhan","year":"2022","journal-title":"Mini Rev. Med. Chem."},{"key":"10.1016\/j.bbr.2024.115270_bib14","doi-asserted-by":"crossref","first-page":"690","DOI":"10.3109\/14756366.2012.672413","article-title":"Famotidine inhibits glycogen synthase kinase-3\u03b2: an investigation by docking simulation and experimental validation","volume":"28","author":"Mohammad","year":"2013","journal-title":"J. Enzym. Inhib. Med. Chem."},{"key":"10.1016\/j.bbr.2024.115270_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2019.108823","article-title":"Famotidine has a neuroprotective effect on MK-801 induced toxicity via the Akt\/GSK-3\u03b2\/\u03b2-catenin signaling pathway in the SH-SY5Y cell line","volume":"314","author":"Unal","year":"2019","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.bbr.2024.115270_bib16","unstructured":"RCSB PDB: Homepage. https:\/\/www.rcsb.org\/. (Accessed 23 November 2023)."},{"key":"10.1016\/j.bbr.2024.115270_bib17","unstructured":"Marvin. https:\/\/chemaxon.com\/marvin. (Accessed 23 November 2023)."},{"key":"10.1016\/j.bbr.2024.115270_bib18","unstructured":"Center for Computational Structural Biology. https:\/\/ccsb.scripps.edu\/. (Accessed 23 November 2023)."},{"key":"10.1016\/j.bbr.2024.115270_bib19","unstructured":"Releases \u00b7 ccsb-scripps\/AutoDock-Vina. \u3008https:\/\/github.com\/ccsb-scripps\/AutoDock-Vina\/releases\u3009. (Accessed 23 November 2023)."},{"key":"10.1016\/j.bbr.2024.115270_bib20","unstructured":"Maestro | Schr\u00f6dinger. \u3008https:\/\/www.schrodinger.com\/products\/maestro\u3009. (Accessed 23 November 2023)."},{"key":"10.1016\/j.bbr.2024.115270_bib21","unstructured":"PLIP - Welcome. \u3008https:\/\/plip-tool.biotec.tu-dresden.de\/plip-web\/plip\/index\u3009. (Accessed 23 November 2023)."},{"key":"10.1016\/j.bbr.2024.115270_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2020.111829","article-title":"Aluminum chloride-induced amyloid \u03b2 accumulation and endoplasmic reticulum stress in rat brain are averted by melatonin","volume":"146","author":"Promyo","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.bbr.2024.115270_bib23","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2018.00244","article-title":"EGCG nanoparticles attenuate aluminum chloride induced neurobehavioral deficits, beta amyloid and tau pathology in a rat model of Alzheimer\u2019s disease","volume":"10","author":"Singh","year":"2018","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.bbr.2024.115270_bib24","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/210169","article-title":"Modulatory role of simvastatin against aluminium chloride-induced behavioural and biochemical changes in rats","volume":"2015","author":"Nampoothiri","year":"2015","journal-title":"Behav. Neurol."},{"key":"10.1016\/j.bbr.2024.115270_bib25","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0165-0270(84)90007-4","article-title":"Developments of a water-maze procedure for studying spatial learning in the rat","volume":"11","author":"Morris","year":"1984","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.bbr.2024.115270_bib26","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1073\/pnas.0307803100","article-title":"Glucocorticoid effects on object recognition memory require training-associated emotional arousal","volume":"101","author":"Okuda","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbr.2024.115270_bib27","first-page":"269","article-title":"Inhibitory effects of valproate on impairment of Y-maze alternation behavior induced by repeated electroconvulsive seizures and c-Fos protein levels in rat brains","volume":"65","author":"Hidaka","year":"2011","journal-title":"Acta Med. Okayama"},{"key":"10.1016\/j.bbr.2024.115270_bib28","doi-asserted-by":"crossref","unstructured":"O.H. Lowry, N.J. Rosebrough, A.L. Farr, R.J. Randall, Protein Measurement with the Folin Phenol Reagent, (1951). https:\/\/doi.org\/10.1016\/S0021-9258(19)52451-6.","DOI":"10.1016\/S0021-9258(19)52451-6"},{"key":"10.1016\/j.bbr.2024.115270_bib29","unstructured":"Claiborne, A.J., Handbook of Methods for Oxygen Radical Research, CRC Press, Boca Raton, Florida (1985) pp.283-284."},{"key":"10.1016\/j.bbr.2024.115270_bib30","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/0003-2697(78)90010-6","article-title":"An improved spectrophotometric assay for superoxide dismutase based on epinephrine autoxidation","volume":"90","author":"Sun","year":"1978","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bbr.2024.115270_bib31","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bbr.2024.115270_bib32","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","article-title":"A new and rapid colorimetric determination of acetylcholinesterase activity","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbr.2024.115270_bib33","unstructured":"Gabe, M. Techniques Histologiques. Massie e Cie, Paris, (1968) 1113 p."},{"key":"10.1016\/j.bbr.2024.115270_bib34","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.jtemb.2016.12.001","article-title":"Aluminium in brain tissue in familial Alzheimer\u2019s disease","volume":"40","author":"Mirza","year":"2017","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.bbr.2024.115270_bib35","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.3233\/JAD-140843","article-title":"Biomarkers for preclinical Alzheimer\u2019s disease","volume":"42","author":"Tan","year":"2014","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.bbr.2024.115270_bib36","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1006\/enrs.2002.4352","article-title":"Aluminum: impacts and disease","volume":"89","author":"Nayak","year":"2002","journal-title":"Environ. Res"},{"key":"10.1016\/j.bbr.2024.115270_bib37","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/S0006-8993(01)02406-4","article-title":"Co-involvement of mitochondria and endoplasmic reticulum in regulation of apoptosis: changes in cytochrome c, Bcl-2 and Bax in the hippocampus of aluminum-treated rabbits","volume":"903","author":"Ghribi","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2024.115270_bib38","first-page":"813","article-title":"The toxicology of aluminum in the brain: a review","volume":"21","author":"Yokel","year":"2000","journal-title":"Neurotoxicology"},{"key":"10.1016\/j.bbr.2024.115270_bib39","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/0006-8993(92)90647-R","article-title":"Aluminum(III) influences the permeability of the blood-brain barrier to [14C]sucrose in rats","volume":"569","author":"Favarato","year":"1992","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2024.115270_bib40","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3233\/JAD-2007-11107","article-title":"Comparative effects of Abeta(1-42)-Al complex from rat and human amyloid on rat endothelial cell cultures","volume":"11","author":"Drago","year":"2007","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.bbr.2024.115270_bib41","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1016\/j.jinorgbio.2005.06.015","article-title":"Acetylcholinesterase activation and enhanced lipid peroxidation after long-term exposure to low levels of aluminum on different mouse brain regions","volume":"99","author":"Kaizer","year":"2005","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.bbr.2024.115270_bib42","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1111\/j.1471-4159.1990.tb02352.x","article-title":"Cholinotoxic effects of aluminum in rat brain","volume":"54","author":"Gulya","year":"1990","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbr.2024.115270_bib43","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1080\/1028415X.2016.1144846","article-title":"Hesperidin ameliorates cognitive dysfunction, oxidative stress and apoptosis against aluminium chloride induced rat model of Alzheimer\u2019s disease","volume":"20","author":"Justin Thenmozhi","year":"2017","journal-title":"Nutr. Neurosci."},{"key":"10.1016\/j.bbr.2024.115270_bib44","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ejmech.2015.03.040","article-title":"Multi-target tacrine-coumarin hybrids: cholinesterase and monoamine oxidase B inhibition properties against Alzheimer\u2019s disease","volume":"95","author":"Xie","year":"2015","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bbr.2024.115270_bib45","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.biopha.2015.12.024","article-title":"The influence of common free radicals and antioxidants on development of Alzheimer\u2019s Disease","volume":"78","author":"Wojtunik-Kulesza","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbr.2024.115270_bib46","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0304-3940(98)00267-5","article-title":"Biphasic effect of aluminium on cholinergic enzyme of rat brain","volume":"248","author":"Kumar","year":"1998","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbr.2024.115270_bib47","doi-asserted-by":"crossref","first-page":"2013","DOI":"10.1089\/ars.2010.3208","article-title":"Reactive oxygen species in the regulation of synaptic plasticity and memory","volume":"14","author":"Massaad","year":"2011","journal-title":"Antioxid. Redox Signal."},{"key":"10.1016\/j.bbr.2024.115270_bib48","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1212\/01.WNL.0000156156.13641.BA","article-title":"Evidence of increased oxidative damage in subjects with mild cognitive impairment","volume":"64","author":"Keller","year":"2005","journal-title":"Neurology"},{"key":"10.1016\/j.bbr.2024.115270_bib49","article-title":"Role of pro-inflammatory cytokines released from microglia in Alzheimer\u2019s disease","volume":"3","author":"Wang","year":"2015","journal-title":"Ann. Transl. Med"},{"key":"10.1016\/j.bbr.2024.115270_bib50","doi-asserted-by":"crossref","DOI":"10.1096\/fasebj.2021.35.S1.04287","article-title":"Anti-inflammatory effects of famotidine","volume":"35","author":"George","year":"2021","journal-title":"FASEB J."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432824004261?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432824004261?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,22]],"date-time":"2024-11-22T04:12:39Z","timestamp":1732248759000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432824004261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":50,"alternative-id":["S0166432824004261"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2024.115270","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel insights into famotidine as a GSK-3\u03b2 inhibitor: An explorative study in aluminium chloride-induced Alzheimer\u2019s disease rat model","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2024.115270","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115270"}}