{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T05:27:15Z","timestamp":1740115635741,"version":"3.37.3"},"reference-count":40,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023231","name":"National Institute for International Education","doi-asserted-by":"publisher","award":["2022R1A2C1005251"],"award-info":[{"award-number":["2022R1A2C1005251"]}],"id":[{"id":"10.13039\/501100023231","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.bbr.2024.115368","type":"journal-article","created":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T14:55:01Z","timestamp":1733064901000},"page":"115368","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Oleanolic acid protects ethanol-induced memory impairments"],"prefix":"10.1016","volume":"480","author":[{"given":"Seung-Hee","family":"Han","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eunbi","family":"Cho","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jieun","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Somin","family":"Moon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Se Jin","family":"Jeon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0540-4739","authenticated-orcid":false,"given":"Dong Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung-Ho","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2024.115368_bib1","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1192\/bjp.156.5.635","article-title":"Alcohol and the brain","volume":"156","author":"Lishman","year":"1990","journal-title":"Br. J. Psychiatry"},{"issue":"3","key":"10.1016\/j.bbr.2024.115368_bib2","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s11065-007-9038-6","article-title":"Alcohol: effects on neurobehavioral functions and the brain","volume":"17","author":"Oscar-Berman","year":"2007","journal-title":"Neuropsychol. Rev."},{"issue":"1","key":"10.1016\/j.bbr.2024.115368_bib3","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/BF02740616","article-title":"Alcohol, astroglia, and brain development","volume":"15","author":"Guerri","year":"1997","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbr.2024.115368_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2020.172906","article-title":"Effect of alcohol use on the adolescent brain and behavior","volume":"192","author":"Lees","year":"2020","journal-title":"Pharm. Biochem Behav."},{"issue":"7","key":"10.1016\/j.bbr.2024.115368_bib5","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1111\/j.1530-0277.2006.00145.x","article-title":"Longitudinal brain magnetic resonance imaging study of the alcohol-preferring rat. Part I: adult brain growth","volume":"30","author":"Sullivan","year":"2006","journal-title":"Alcohol Clin. Exp. Res"},{"key":"10.1016\/j.bbr.2024.115368_bib6","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3389\/fnmol.2016.00008","article-title":"Alcohol, excitotoxicity and adult brain damage: an experimentally unproven chain-of-events","volume":"9","author":"Collins","year":"2016","journal-title":"Front Mol. Neurosci."},{"issue":"1","key":"10.1016\/j.bbr.2024.115368_bib7","doi-asserted-by":"crossref","first-page":"8","DOI":"10.4306\/pi.2012.9.1.8","article-title":"Alcohol and cognition in the elderly: a review","volume":"9","author":"Kim","year":"2012","journal-title":"Psychiatry Investig."},{"issue":"1","key":"10.1016\/j.bbr.2024.115368_bib8","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/alzrt157","article-title":"Alcohol-related dementia: an update of the evidence","volume":"5","author":"Ridley","year":"2013","journal-title":"Alzheimers Res Ther."},{"issue":"11","key":"10.1016\/j.bbr.2024.115368_bib9","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.3390\/ijerph6112783","article-title":"Alcohol-induced blackout","volume":"6","author":"Lee","year":"2009","journal-title":"Int. J. Environ. Res Public Health"},{"issue":"5","key":"10.1016\/j.bbr.2024.115368_bib10","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1111\/acer.13051","article-title":"Alcohol-induced blackouts: a review of recent clinical research with practical implications and recommendations for future studies","volume":"40","author":"Wetherill","year":"2016","journal-title":"Alcohol Clin. Exp. Res"},{"issue":"11","key":"10.1016\/j.bbr.2024.115368_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/nu16111680","article-title":"The effects of high-intensity interval training and moderate alcohol consumption on cognitive performance-a multidisciplinary intervention in young healthy adults","volume":"16","author":"Molina-Hidalgo","year":"2024","journal-title":"Nutrients"},{"issue":"6","key":"10.1016\/j.bbr.2024.115368_bib12","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1080\/09658211.2011.590508","article-title":"Reconstructing alcohol-induced memory blackouts","volume":"19","author":"Nash","year":"2011","journal-title":"Memory"},{"issue":"2","key":"10.1016\/j.bbr.2024.115368_bib13","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1097\/ADM.0b013e3181e1299d","article-title":"Alcohol-induced blackout. Phenomenology, biological basis, and gender differences","volume":"4","author":"Rose","year":"2010","journal-title":"J. Addict. Med"},{"issue":"8","key":"10.1016\/j.bbr.2024.115368_bib14","doi-asserted-by":"crossref","first-page":"981","DOI":"10.1038\/aps.2014.50","article-title":"Alcohol use disorders and current pharmacological therapies: the role of GABA(A) receptors","volume":"35","author":"Liang","year":"2014","journal-title":"Acta Pharm. Sin."},{"issue":"3","key":"10.1016\/j.bbr.2024.115368_bib15","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/nn1398","article-title":"Alcohol-induced motor impairment caused by increased extrasynaptic GABA(A) receptor activity","volume":"8","author":"Hanchar","year":"2005","journal-title":"Nat. Neurosci."},{"issue":"27","key":"10.1016\/j.bbr.2024.115368_bib16","doi-asserted-by":"crossref","first-page":"9905","DOI":"10.1523\/JNEUROSCI.1660-11.2011","article-title":"Ethanol enhances neurosteroidogenesis in hippocampal pyramidal neurons by paradoxical NMDA receptor activation","volume":"31","author":"Tokuda","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2024.115368_bib17","doi-asserted-by":"crossref","first-page":"254","DOI":"10.3389\/fncel.2015.00254","article-title":"Corticosterone enhances the potency of ethanol against hippocampal long-term potentiation via local neurosteroid synthesis","volume":"9","author":"Izumi","year":"2015","journal-title":"Front Cell Neurosci."},{"issue":"1","key":"10.1016\/j.bbr.2024.115368_bib18","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/nn776","article-title":"NMDA receptor antagonists sustain LTP and spatial memory: active processes mediate LTP decay","volume":"5","author":"Villarreal","year":"2002","journal-title":"Nat. Neurosci."},{"issue":"2","key":"10.1016\/j.bbr.2024.115368_bib19","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/S0959-4388(97)80012-8","article-title":"LTP, NMDA, genes and learning","volume":"7","author":"Cain","year":"1997","journal-title":"Curr. Opin. Neurobiol."},{"issue":"5","key":"10.1016\/j.bbr.2024.115368_bib20","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1523\/JNEUROSCI.20-05-01982.2000","article-title":"Neuroactive steroid 3alpha-hydroxy-5alpha-pregnan-20-one modulates electrophysiological and behavioral actions of ethanol","volume":"20","author":"VanDoren","year":"2000","journal-title":"J. Neurosci."},{"issue":"1-2","key":"10.1016\/j.bbr.2024.115368_bib21","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/S0006-8993(02)04266-X","article-title":"Effect of acute ethanol administration and acute allopregnanolone administration on spontaneous hippocampal pyramidal cell neural activity","volume":"967","author":"Tokunaga","year":"2003","journal-title":"Brain Res."},{"issue":"4","key":"10.1016\/j.bbr.2024.115368_bib22","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1080\/10520295.2021.1954691","article-title":"Effects of oleanolic acid on inflammation and metabolism in diabetic rats","volume":"97","author":"Iskender","year":"2022","journal-title":"Biotech. Histochem"},{"key":"10.1016\/j.bbr.2024.115368_bib23","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.ijbiomac.2021.06.109","article-title":"The novel nanocomplexes containing deoxycholic acid-grafted chitosan and oleanolic acid displays the hepatoprotective effect against CCl(4)-induced liver injury in vivo","volume":"185","author":"Xin","year":"2021","journal-title":"Int. J. Biol. Macromol."},{"issue":"6","key":"10.1016\/j.bbr.2024.115368_bib24","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2021.12079","article-title":"[Retracted] Anticancer and apoptotic activities of oleanolic acid are mediated through cell cycle arrest and disruption of mitochondrial membrane potential in HepG2 human hepatocellular carcinoma cells","volume":"23","author":"Zhu","year":"2021","journal-title":"Mol. Med Rep."},{"key":"10.1016\/j.bbr.2024.115368_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175954","article-title":"Effects of oleanolic acid and ursolic acid on depression-like behaviors induced by maternal separation in mice","volume":"956","author":"Kong","year":"2023","journal-title":"Eur. J. Pharm."},{"issue":"Pt A","key":"10.1016\/j.bbr.2024.115368_bib26","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1016\/j.neuropharm.2016.07.029","article-title":"Oleanolic acid ameliorates cognitive dysfunction caused by cholinergic blockade via TrkB-dependent BDNF signaling","volume":"113","author":"Jeon","year":"2017","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2024.115368_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115639","article-title":"Oleanolic acid alleviates the extrapyramidal symptoms and cognitive impairment induced by haloperidol through the striatal PKA signaling pathway in mice","volume":"168","author":"Kong","year":"2023","journal-title":"Biomed. Pharm."},{"issue":"4","key":"10.1016\/j.bbr.2024.115368_bib28","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.1021\/acs.jnatprod.9b01210","article-title":"Oleanolic acid ameliorates benign prostatic hyperplasia by regulating PCNA-dependent cell cycle progression in vivo and in vitro","volume":"83","author":"Cheon","year":"2020","journal-title":"J. Nat. Prod."},{"issue":"4","key":"10.1016\/j.bbr.2024.115368_bib29","doi-asserted-by":"crossref","first-page":"433","DOI":"10.4062\/biomolther.2015.184","article-title":"Salvia miltiorrhiza bunge blocks ethanol-induced synaptic dysfunction through regulation of NMDA receptor-dependent synaptic transmission","volume":"24","author":"Park","year":"2016","journal-title":"Biomol. Ther. (Seoul. )"},{"issue":"1","key":"10.1016\/j.bbr.2024.115368_bib30","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1124\/jpet.120.000376","article-title":"Oxysterols modulate the acute effects of ethanol on hippocampal N-methyl-d-aspartate receptors, long-term potentiation, and learning","volume":"377","author":"Izumi","year":"2021","journal-title":"J. Pharm. Exp. Ther."},{"key":"10.1016\/j.bbr.2024.115368_bib31","doi-asserted-by":"crossref","first-page":"56","DOI":"10.3389\/fendo.2011.00056","article-title":"Enhanced sensitivity to ethanol-induced inhibition of LTP in CA1 pyramidal neurons of socially isolated C57BL\/6J mice: role of neurosteroids","volume":"2","author":"Talani","year":"2011","journal-title":"Front. Endocrinol. (Lausanne)"},{"issue":"1","key":"10.1016\/j.bbr.2024.115368_bib32","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1002\/hipo.22356","article-title":"Ethanol inhibits long-term potentiation in hippocampal CA1 neurons, irrespective of lamina and stimulus strength, through neurosteroidogenesis","volume":"25","author":"Ramachandran","year":"2015","journal-title":"Hippocampus"},{"issue":"7","key":"10.1016\/j.bbr.2024.115368_bib33","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1111\/j.1460-9568.2007.05809.x","article-title":"GABAergic neurosteroids mediate the effects of ethanol on long-term potentiation in rat hippocampal slices","volume":"26","author":"Izumi","year":"2007","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bbr.2024.115368_bib34","first-page":"2159","article-title":"Effect of oleanolic acid on 5A-reductase activity, dpcs proliferation and gene expression correlated with androgenetic alopecia in vitro","volume":"35","author":"Cao","year":"2019","journal-title":"Acta Media Mediterr."},{"key":"10.1016\/j.bbr.2024.115368_bib35","doi-asserted-by":"crossref","first-page":"1215393","DOI":"10.1155\/2016\/1215393","article-title":"GABA-A receptor modulation and anticonvulsant, anxiolytic, and antidepressant activities of constituents from artemisia indica linn","volume":"2016","author":"Khan","year":"2016","journal-title":"Evid. Based Complement Altern. Med."},{"issue":"9","key":"10.1016\/j.bbr.2024.115368_bib36","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1111\/j.1755-5949.2012.00369.x","article-title":"Antiepileptic potential of ursolic acid stearoyl glucoside by GABA receptor stimulation","volume":"18","author":"Kazmi","year":"2012","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.bbr.2024.115368_bib37","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.ejphar.2015.06.037","article-title":"Ursolic acid enhances pentobarbital-induced sleeping behaviors via GABAergic neurotransmission in mice","volume":"762","author":"Jeon","year":"2015","journal-title":"Eur. J. Pharm."},{"issue":"3-4","key":"10.1016\/j.bbr.2024.115368_bib38","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1016\/j.fct.2012.01.007","article-title":"Ursolic acid reduces prostate size and dihydrotestosterone level in a rat model of benign prostatic hyperplasia","volume":"50","author":"Shin","year":"2012","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.bbr.2024.115368_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.alcohol.2020.04.002","article-title":"On the interaction between BDNF and serotonin systems: The effects of long-term ethanol consumption in mice","volume":"87","author":"Popova","year":"2020","journal-title":"Alcohol"},{"issue":"Pt A","key":"10.1016\/j.bbr.2024.115368_bib40","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.brainres.2015.03.025","article-title":"Corticostriatal BDNF and alcohol addiction","volume":"1628","author":"Logrip","year":"2015","journal-title":"Brain Res."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432824005242?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432824005242?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T07:48:53Z","timestamp":1739173733000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432824005242"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":40,"alternative-id":["S0166432824005242"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2024.115368","relation":{},"ISSN":["0166-4328"],"issn-type":[{"type":"print","value":"0166-4328"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oleanolic acid protects ethanol-induced memory impairments","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2024.115368","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115368"}}