{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,18]],"date-time":"2026-07-18T19:02:00Z","timestamp":1784401320945,"version":"3.55.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81960342"],"award-info":[{"award-number":["81960342"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.bbr.2025.115426","type":"journal-article","created":{"date-parts":[[2025,1,8]],"date-time":"2025-01-08T18:56:26Z","timestamp":1736362586000},"page":"115426","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Causal association between cerebrospinal fluid metabolites and Parkinson's disease: A two-sample bidirectional mendelian randomization study"],"prefix":"10.1016","volume":"482","author":[{"given":"Jing","family":"Liao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangyan","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiliu","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juntao","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanhong","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2025.115426_bib1","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","article-title":"Parkinson\u2019s disease","volume":"386","author":"Kalia","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.bbr.2025.115426_bib2","doi-asserted-by":"crossref","first-page":"754","DOI":"10.2174\/1389557519666191104110908","article-title":"Parkinson\u2019s disease: a review from pathophysiology to treatment","volume":"20","author":"Marino","year":"2020","journal-title":"Mini Rev. Med Chem."},{"key":"10.1016\/j.bbr.2025.115426_bib3","article-title":"Proteome profiling of cerebrospinal fluid reveals biomarker candidates for Parkinson\u2019s disease","volume":"3","author":"Karayel","year":"2022","journal-title":"Cell Rep. Med"},{"key":"10.1016\/j.bbr.2025.115426_bib4","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.conb.2019.11.019","article-title":"An update on fluid biomarkers for neurodegenerative diseases: recent success and challenges ahead","volume":"61","author":"Simr\u00e9n","year":"2020","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.bbr.2025.115426_bib5","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.mcn.2018.12.005","article-title":"Cerebrospinal fluid biomarker for Parkinson\u2019s disease: An overview","volume":"97","author":"Maass","year":"2019","journal-title":"Mol. Cell Neurosci."},{"key":"10.1016\/j.bbr.2025.115426_bib6","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/s42003-020-01583-z","article-title":"Cerebrospinal fluid metabolomics identifies 19 brain-related phenotype associations","volume":"4","author":"Panyard","year":"2021","journal-title":"Commun. Biol."},{"key":"10.1016\/j.bbr.2025.115426_bib7","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S1474-4422(19)30024-9","article-title":"CSF and blood biomarkers for Parkinson\u2019s disease","volume":"18","author":"Parnetti","year":"2019","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.bbr.2025.115426_bib8","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/S1474-4422(21)00030-2","article-title":"Challenges in the diagnosis of Parkinson\u2019s disease","volume":"20","author":"Tolosa","year":"2021","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.bbr.2025.115426_bib9","first-page":"S183","article-title":"Blood and cerebrospinal fluid biomarkers of inflammation in Parkinson\u2019s disease","volume":"12","author":"Zimmermann","year":"2022","journal-title":"J. Park. Dis."},{"key":"10.1016\/j.bbr.2025.115426_bib10","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1002\/mds.26635","article-title":"Protein biomarkers in Parkinson\u2019s disease: Focus on cerebrospinal fluid markers and synaptic proteins","volume":"31","author":"Halbgebauer","year":"2016","journal-title":"Mov. Disord."},{"key":"10.1016\/j.bbr.2025.115426_bib11","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.3390\/ijms23031879","article-title":"Cerebrospinal fluid metabolome in Parkinson\u2019s disease and multiple system atrophy","volume":"23","author":"Kwon","year":"2022","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.bbr.2025.115426_bib12","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1007\/s12264-017-0183-5","article-title":"Biomarkers for Parkinson\u2019s disease: recent advancement","volume":"33","author":"Lotankar","year":"2017","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.bbr.2025.115426_bib13","first-page":"a041302","article-title":"Mendelian randomization","volume":"12","author":"Birney","year":"2022","journal-title":"Cold Spring Harb. Perspect. Med"},{"key":"10.1016\/j.bbr.2025.115426_bib14","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1002\/jrsm.1346","article-title":"Meta-analysis and Mendelian randomization: a review","volume":"10","author":"Bowden","year":"2019","journal-title":"Res Synth. Methods"},{"key":"10.1016\/j.bbr.2025.115426_bib15","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.1681\/ASN.2016010098","article-title":"Mendelian randomization as an approach to assess causality using observational data","volume":"27","author":"Sekula","year":"2016","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbr.2025.115426_bib16","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/S1474-4422(19)30320-5","volume":"18","author":"Nalls","year":"2019","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.bbr.2025.115426_bib17","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1038\/s41588-021-00931-x","article-title":"A cross-population atlas of genetic associations for 220 human phenotypes","volume":"53","author":"Sakaue","year":"2021","journal-title":"Nat. Genet"},{"key":"10.1016\/j.bbr.2025.115426_bib18","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1093\/ije\/dyq151","article-title":"Power and instrument strength requirements for Mendelian randomization studies using multiple genetic variants","volume":"40","author":"Pierce","year":"2011","journal-title":"Int J. Epidemiol."},{"key":"10.1016\/j.bbr.2025.115426_bib19","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.jclinepi.2014.09.005","article-title":"Cochran\u2019s Q test was useful to assess heterogeneity in likelihood ratios in studies of diagnostic accuracy","volume":"68","author":"Cohen","year":"2015","journal-title":"J. Clin. Epidemiol."},{"key":"10.1016\/j.bbr.2025.115426_bib20","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1007\/s10654-017-0255-x","article-title":"Interpreting findings from Mendelian randomization using the MR-Egger method","volume":"32","author":"Burgess","year":"2017","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/j.bbr.2025.115426_bib21","doi-asserted-by":"crossref","first-page":"7182","DOI":"10.3390\/ijms21197182","article-title":"Imbalance of lysine acetylation contributes to the pathogenesis of Parkinson\u2019s disease","volume":"21","author":"Wang","year":"2020","journal-title":"Int J. Mol. Sci."},{"key":"10.1016\/j.bbr.2025.115426_bib22","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3390\/cells9010233","article-title":"Dysregulated interorganellar crosstalk of mitochondria in the pathogenesis of Parkinson\u2019s disease","volume":"9","author":"Sironi","year":"2020","journal-title":"Cells"},{"key":"10.1016\/j.bbr.2025.115426_bib23","article-title":"Parkinson disease","volume":"3","author":"Poewe","year":"2017","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.bbr.2025.115426_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0278711","article-title":"Ribitol alters multiple metabolic pathways of central carbon metabolism with enhanced glycolysis: A metabolomics and transcriptomics profiling of breast cancer","volume":"17","author":"Tucker","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.bbr.2025.115426_bib25","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.mito.2016.07.012","article-title":"Lysine acetylation in mitochondria: From inventory to function","volume":"33","author":"Hosp","year":"2017","journal-title":"Mitochondrion"},{"key":"10.1016\/j.bbr.2025.115426_bib26","doi-asserted-by":"crossref","first-page":"5739","DOI":"10.1021\/acsomega.0c06168","article-title":"Computational Analysis Indicates That PARP1 Acts as a Histone Deacetylases Interactor Sharing Common Lysine Residues for Acetylation, Ubiquitination, and SUMOylation in Alzheimer\u2019s and Parkinson\u2019s Disease","volume":"6","author":"Gupta","year":"2021","journal-title":"ACS Omega"},{"key":"10.1016\/j.bbr.2025.115426_bib27","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01894-17","article-title":"Ancient regulatory role of lysine acetylation in central metabolism","volume":"8","author":"Nakayasu","year":"2017","journal-title":"mBio"},{"key":"10.1016\/j.bbr.2025.115426_bib28","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/s41581-022-00643-3","article-title":"Oxalate homeostasis","volume":"19","author":"Ermer","year":"2023","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.bbr.2025.115426_bib29","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1093\/clinchem\/36.10.1717","article-title":"The relation of clinical catastrophes, endogenous oxalate production, and urolithiasis","volume":"36","author":"Conyers","year":"1990","journal-title":"Clin. Chem."},{"key":"10.1016\/j.bbr.2025.115426_bib30","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/428010","article-title":"Mechanism of oxidative stress in neurodegeneration","volume":"2012","author":"Gandhi","year":"2012","journal-title":"Oxid. Med Cell Longev."},{"key":"10.1016\/j.bbr.2025.115426_bib31","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.lfs.2019.03.057","article-title":"Parkinson\u2019s disease: Mechanisms, translational models and management strategies","volume":"226","author":"Raza","year":"2019","journal-title":"Life Sci."},{"key":"10.1016\/j.bbr.2025.115426_bib32","doi-asserted-by":"crossref","first-page":"597","DOI":"10.3390\/antiox9070597","article-title":"The role of oxidative stress in Parkinson\u2019s disease","volume":"9","author":"Chang","year":"2020","journal-title":"Antioxid. (Basel)"},{"key":"10.1016\/j.bbr.2025.115426_bib33","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1093\/jn\/134.3.489","article-title":"Glutathione metabolism and its implications for health","volume":"134","author":"Wu","year":"2004","journal-title":"J. Nutr."},{"key":"10.1016\/j.bbr.2025.115426_bib34","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1089\/152091503765691839","article-title":"Serum 1,5-anhydroglucitol (GlycoMark): a short-term glycemic marker","volume":"5","author":"Buse","year":"2003","journal-title":"Diabetes Technol. Ther."},{"key":"10.1016\/j.bbr.2025.115426_bib35","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1900\/RDS.2022.18.68","article-title":"1,5-Anhydroglucitol as a marker of acute hyperglycemia in cardiovascular events","volume":"18","author":"Miga\u0142a","year":"2022","journal-title":"Rev. Diabet. Stud."},{"key":"10.1016\/j.bbr.2025.115426_bib36","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.315","article-title":"Association of cerebral white matter lesions with cognitive function and mood in Japanese elderly people: a population-based study","volume":"5","author":"Yamawaki","year":"2015","journal-title":"Brain Behav."},{"key":"10.1016\/j.bbr.2025.115426_bib37","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s12020-012-9760-6","article-title":"1,5-Anhydroglucitol in diabetes mellitus","volume":"43","author":"Kim","year":"2013","journal-title":"Endocrine"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432825000129?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432825000129?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T04:22:53Z","timestamp":1777350173000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432825000129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":37,"alternative-id":["S0166432825000129"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2025.115426","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Causal association between cerebrospinal fluid metabolites and Parkinson's disease: A two-sample bidirectional mendelian randomization study","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2025.115426","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"115426"}}