{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:13:36Z","timestamp":1787724816778,"version":"build-2784847793"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100019264","name":"University of Colima","doi-asserted-by":"publisher","award":["CGIC-BAN-1\/22"],"award-info":[{"award-number":["CGIC-BAN-1\/22"]}],"id":[{"id":"10.13039\/100019264","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Humanidades, Ciencias y Tecnolog\u00edas","doi-asserted-by":"publisher","award":["939505"],"award-info":[{"award-number":["939505"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Humanidades, Ciencias y Tecnolog\u00edas","doi-asserted-by":"publisher","award":["CF-2023-G-893"],"award-info":[{"award-number":["CF-2023-G-893"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004485","name":"Iran Nanotechnology Initiative Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004485","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.bbr.2025.115456","type":"journal-article","created":{"date-parts":[[2025,1,27]],"date-time":"2025-01-27T11:53:59Z","timestamp":1737978839000},"page":"115456","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Permanent tactile sensory loss reduces neuronal activity in the amygdala and ventral hippocampus and alters anxiety-like behaviors"],"prefix":"10.1016","volume":"482","author":[{"given":"Nereida","family":"Ibarra-Castaneda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Veronica","family":"Lopez-Virgen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma","family":"Moy-Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6527-485X","authenticated-orcid":false,"given":"Oscar","family":"Gonzalez-Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.bbr.2025.115456_bib1","first-page":"205","article-title":"The structural organization of layer IV in the somatosensory region (SI) of mouse cerebral cortex","volume":"17","author":"Woolsey","year":"1970","journal-title":"Descr. a cortical Field Compos. Discret. cytoarchitectonic units. Brain Res"},{"key":"10.1016\/j.bbr.2025.115456_bib2","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1038\/nn.3191","article-title":"Shaping barrels: activity moves NG2+\u2009glia","volume":"15","author":"Dimou","year":"2012","journal-title":"Nat. Neurosci."},{"issue":"8","key":"10.1016\/j.bbr.2025.115456_bib3","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1038\/nrn2411","article-title":"Where' and 'what' in the whisker sensorimotor system","volume":"9","author":"Diamond","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbr.2025.115456_bib4","doi-asserted-by":"crossref","first-page":"40","DOI":"10.3389\/fnsys.2019.00040","article-title":"Whisker-mediated touch system in rodents: from neuron to behavior","volume":"13","author":"Adibi","year":"2019","journal-title":"Front Syst. Neurosci."},{"key":"10.1016\/j.bbr.2025.115456_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.crneur.2022.100034","article-title":"Tactile information from the vibrissal system modulates hippocampal functioning","volume":"3","author":"Ibarra-Casta\u00f1eda","year":"2022","journal-title":"Curr. Res Neurobiol."},{"issue":"1","key":"10.1016\/j.bbr.2025.115456_bib6","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.infbeh.2008.10.004","article-title":"Seeing and touching: the role of sensory-motor experience on the development of infant reaching","volume":"32","author":"Corbetta","year":"2009","journal-title":"Infant Behav. Dev."},{"issue":"6","key":"10.1016\/j.bbr.2025.115456_bib7","doi-asserted-by":"crossref","first-page":"3457","DOI":"10.1093\/cercor\/bhx084","article-title":"Sensory deprivation triggers synaptic and intrinsic plasticity in the hippocampus","volume":"27","author":"Milshtein-Parush","year":"2017","journal-title":"Cereb. Cortex"},{"issue":"1","key":"10.1016\/j.bbr.2025.115456_bib8","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.neuron.2017.11.031","article-title":"Reward-based learning drives rapid sensory signals in medial prefrontal cortex and dorsal hippocampus necessary for goal-directed behavior","volume":"97","author":"Le Merre","year":"2018","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2025.115456_bib9","doi-asserted-by":"crossref","first-page":"132","DOI":"10.3389\/fncel.2018.00132","article-title":"Permanent whisker removal reduces the density of c-Fos+\u2009cells and the expression of calbindin protein, disrupts hippocampal neurogenesis and affects spatial-memory-related tasks","volume":"12","author":"Gonzalez-Perez","year":"2018","journal-title":"Front Cell Neurosci."},{"issue":"6","key":"10.1016\/j.bbr.2025.115456_bib10","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1002\/(SICI)1098-1063(1998)8:6<608::AID-HIPO3>3.0.CO;2-7","article-title":"Functional differentiation in the hippocampus","volume":"8","author":"Moser","year":"1998","journal-title":"Hippocampus"},{"issue":"1","key":"10.1016\/j.bbr.2025.115456_bib11","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.neuron.2009.11.031","article-title":"Are the dorsal and ventral hippocampus functionally distinct structures?","volume":"65","author":"Fanselow","year":"2010","journal-title":"Neuron"},{"issue":"5","key":"10.1016\/j.bbr.2025.115456_bib12","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/0361-9230(90)90044-Z","article-title":"Hippocampal pathway to the amygdala and stress ulcer development","volume":"25","author":"Henke","year":"1990","journal-title":"Brain Res Bull."},{"key":"10.1016\/j.bbr.2025.115456_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2022.894886","article-title":"The basolateral amygdala to ventral hippocampus circuit controls anxiety-like behaviors induced by morphine withdrawal","volume":"16","author":"Deji","year":"2022","journal-title":"Front Cell Neurosci."},{"issue":"16","key":"10.1016\/j.bbr.2025.115456_bib14","doi-asserted-by":"crossref","first-page":"4805","DOI":"10.1002\/hbm.26005","article-title":"Amygdala subnuclei volumes and anxiety behaviors in children and adolescents with autism spectrum disorder, attention deficit hyperactivity disorder, and obsessive-compulsive disorder","volume":"43","author":"Seguin","year":"2022","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.bbr.2025.115456_bib15","first-page":"1","article-title":"Functional neuroanatomy of the basolateral amygdala: neurons, neurotransmitters, and circuits","volume":"26","author":"McDonald","year":"2020","journal-title":"Handb. Behav. Neurosci."},{"key":"10.1016\/j.bbr.2025.115456_bib16","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.psychres.2016.09.011","article-title":"Affective touch awareness in mental health and disease relates to autistic traits - an explorative neurophysiological investigation","volume":"245","author":"Croy","year":"2016","journal-title":"Psychiatry Res"},{"issue":"4","key":"10.1016\/j.bbr.2025.115456_bib17","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1037\/emo0001320","article-title":"Touch me or touch me not: emotion regulation by affective touch in human adults","volume":"24","author":"Silvestri","year":"2024","journal-title":"Emotion"},{"issue":"1","key":"10.1016\/j.bbr.2025.115456_bib18","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1111\/nyas.15056","article-title":"Characterizing affiliative touch in humans and its role in advancing haptic design","volume":"1528","author":"Kryklywy","year":"2023","journal-title":"Ann. N. Y Acad. Sci."},{"issue":"1","key":"10.1016\/j.bbr.2025.115456_bib19","doi-asserted-by":"crossref","first-page":"6045","DOI":"10.1038\/s41467-020-19874-8","article-title":"Tactile modulation of memory and anxiety requires dentate granule cells along the dorsoventral axis","volume":"11","author":"Wang","year":"2020","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.bbr.2025.115456_bib20","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1016\/j.neuron.2012.12.038","article-title":"Differential control of learning and anxiety along the dorsoventral axis of the dentate gyrus","volume":"77","author":"Kheirbek","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2025.115456_bib21","doi-asserted-by":"crossref","first-page":"112","DOI":"10.3389\/fnbeh.2014.00112","article-title":"Distributed circuits underlying anxiety","volume":"8","author":"Adhikari","year":"2014","journal-title":"Front Behav. Neurosci."},{"issue":"96","key":"10.1016\/j.bbr.2025.115456_bib22","doi-asserted-by":"crossref","DOI":"10.3791\/52434-v","article-title":"Use of the open field maze to measure locomotor and anxiety-like behavior in mice","author":"Seibenhener","year":"2015","journal-title":"J. Vis. Exp."},{"issue":"22","key":"10.1016\/j.bbr.2025.115456_bib23","doi-asserted-by":"crossref","DOI":"10.3791\/1088","article-title":"Elevated plus maze for mice","author":"Komada","year":"2008","journal-title":"J. Vis. Exp."},{"issue":"2-3","key":"10.1016\/j.bbr.2025.115456_bib24","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0301-0082(96)00021-4","article-title":"Activation of c-fos in the brain","volume":"50","author":"Herrera","year":"1996","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.bbr.2025.115456_bib25","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.conb.2013.08.019","article-title":"Microcircuit dynamics of map plasticity in barrel cortex","volume":"24","author":"Margolis","year":"2014","journal-title":"Curr. Opin. Neurobiol."},{"issue":"7338","key":"10.1016\/j.bbr.2025.115456_bib26","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/nature09820","article-title":"Amygdala circuitry mediating reversible and bidirectional control of anxiety","volume":"471","author":"Tye","year":"2011","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.bbr.2025.115456_bib27","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.neuron.2009.11.031","article-title":"Are the dorsal and ventral hippocampus functionally distinct structures?","volume":"65","author":"Fanselow","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2025.115456_bib28","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1196\/annals.1410.012","article-title":"Limbic regulation of hypothalamo-pituitary-adrenocortical function during acute and chronic stress","volume":"1148","author":"Jankord","year":"2008","journal-title":"Ann. N. Y Acad. Sci."},{"key":"10.1016\/j.bbr.2025.115456_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroimage.2014.08.038","article-title":"The fine line between \u2018brave\u2019 and \u2018reckless\u2019: Amygdala reactivity and regulation predict recognition of risk","volume":"103","author":"Mujica-Parodi","year":"2014","journal-title":"NeuroImage"},{"issue":"1","key":"10.1016\/j.bbr.2025.115456_bib30","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-023-44360-8","article-title":"The influence of sex difference on behavior and adult hippocampal neurogenesis in C57BL\/6 mice","volume":"13","author":"Tsao","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbr.2025.115456_bib31","doi-asserted-by":"crossref","unstructured":"Pinaud R., Filipkowski R.K., Fortes A., Tremere L. Immediate Early Gene Expression in the Primary Somatosensory Cortex: Focus on the Barrel Cortex. 2006. p. 73-92.","DOI":"10.1007\/978-0-387-33604-6_5"},{"issue":"1","key":"10.1016\/j.bbr.2025.115456_bib32","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1152\/physrev.00019.2019","article-title":"Neuronal circuits in barrel cortex for whisker sensory perception","volume":"101","author":"Staiger","year":"2021","journal-title":"Physiol. Rev."},{"issue":"12","key":"10.1016\/j.bbr.2025.115456_bib33","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.18632\/aging.100862","article-title":"c-Fos importance for brain development","volume":"7","author":"Velazquez","year":"2015","journal-title":"Aging (Albany NY)"},{"issue":"9","key":"10.1016\/j.bbr.2025.115456_bib34","doi-asserted-by":"crossref","first-page":"2160","DOI":"10.1093\/cercor\/bhr303","article-title":"Experience-dependent plasticity of the barrel cortex in mice observed with 2-DG brain mapping and c-Fos: effects of MMP-9 KO","volume":"22","author":"Kaliszewska","year":"2012","journal-title":"Cereb. Cortex"},{"issue":"4","key":"10.1016\/j.bbr.2025.115456_bib35","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/S0306-4522(01)00310-4","article-title":"Expression of c-Fos, Fos B, Jun B, and Zif268 transcription factor proteins in rat barrel cortex following apomorphine-evoked whisking behavior","volume":"106","author":"Filipkowski","year":"2001","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.bbr.2025.115456_bib36","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1471-2202-7-42","article-title":"Texture discrimination and multi-unit recording in the rat vibrissal nerve","volume":"7","author":"Albarrac\u00edn","year":"2006","journal-title":"BMC Neurosci."},{"issue":"5","key":"10.1016\/j.bbr.2025.115456_bib37","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/0168-5597(90)90059-M","article-title":"Modulation of vibrissa-evoked cortical potentials after infraorbital nerve crush in rats","volume":"77","author":"Shiraki","year":"1990","journal-title":"Electroencephalogr. Clin. Neurophysiol. \/Evoked Potentials Sect."},{"issue":"46","key":"10.1016\/j.bbr.2025.115456_bib38","doi-asserted-by":"crossref","first-page":"18286","DOI":"10.1073\/pnas.0708611104","article-title":"Processing of tactile information by the hippocampus","volume":"104","author":"Pereira","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"3","key":"10.1016\/j.bbr.2025.115456_bib39","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.neuroimage.2009.05.074","article-title":"The brain and the stress axis: the neural correlates of cortisol regulation in response to stress","volume":"47","author":"Dedovic","year":"2009","journal-title":"Neuroimage"},{"key":"10.1016\/j.bbr.2025.115456_bib40","doi-asserted-by":"crossref","first-page":"86","DOI":"10.3389\/fncir.2017.00086","article-title":"From structure to behavior in basolateral amygdala-hippocampus circuits","volume":"11","author":"Yang","year":"2017","journal-title":"Front Neural Circuits"},{"issue":"2","key":"10.1016\/j.bbr.2025.115456_bib41","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1101\/lm.039909.115","article-title":"Basolateral amygdala projections to ventral hippocampus modulate the consolidation of footshock, but not contextual, learning in rats","volume":"23","author":"Huff","year":"2016","journal-title":"Learn Mem."},{"issue":"8","key":"10.1016\/j.bbr.2025.115456_bib42","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2017.161","article-title":"Basolateral amygdala and stress-induced hyperexcitability affect motivated behaviors and addiction","volume":"7","author":"Sharp","year":"2017","journal-title":"Transl. Psychiatry"},{"issue":"3","key":"10.1016\/j.bbr.2025.115456_bib43","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.cell.2018.09.028","article-title":"The basolateral amygdala is essential for rapid escape: a human and rodent study","volume":"175","author":"Terburg","year":"2018","journal-title":"Cell"},{"issue":"31","key":"10.1016\/j.bbr.2025.115456_bib44","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2119072119","article-title":"Breakdown of utilitarian moral judgement after basolateral amygdala damage","volume":"119","author":"van Honk","year":"2022","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"12","key":"10.1016\/j.bbr.2025.115456_bib45","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1016\/j.biopsych.2010.04.027","article-title":"Amygdala activity, fear, and anxiety: modulation by stress","volume":"67","author":"Ressler","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2025.115456_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2022.104901","article-title":"How stress hormones shape memories of fear and anxiety in humans","volume":"142","author":"Merz","year":"2022","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"3","key":"10.1016\/j.bbr.2025.115456_bib47","doi-asserted-by":"crossref","first-page":"431","DOI":"10.3758\/s13415-021-00973-y","article-title":"Anxiety and hippocampal neuronal activity: relationship and potential mechanisms","volume":"22","author":"Ghasemi","year":"2022","journal-title":"Cogn., Affect., Behav. Neurosci."},{"issue":"10","key":"10.1016\/j.bbr.2025.115456_bib48","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1001\/archgenpsychiatry.2012.73","article-title":"Amygdala volume in combat-exposed veterans with and without posttraumatic stress disorder: a cross-sectional study","volume":"69","author":"Kuo","year":"2012","journal-title":"Arch. Gen. Psychiatry"},{"issue":"8","key":"10.1016\/j.bbr.2025.115456_bib49","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.jpsychires.2008.10.014","article-title":"The role of trauma-related distractors on neural systems for working memory and emotion processing in posttraumatic stress disorder","volume":"43","author":"Morey","year":"2009","journal-title":"J. Psychiatr. Res"},{"issue":"2","key":"10.1016\/j.bbr.2025.115456_bib50","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.neuron.2005.09.025","article-title":"Contributions of the amygdala to emotion processing: from animal models to human behavior","volume":"48","author":"Phelps","year":"2005","journal-title":"Neuron"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432825000427?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432825000427?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T11:24:23Z","timestamp":1778671463000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432825000427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":50,"alternative-id":["S0166432825000427"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2025.115456","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Permanent tactile sensory loss reduces neuronal activity in the amygdala and ventral hippocampus and alters anxiety-like behaviors","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2025.115456","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115456"}}