{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T16:58:41Z","timestamp":1793293121392,"version":"4.5.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016045","name":"University of Central Punjab","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016045","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001427","name":"All India Council for Technical Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001427","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013644","name":"Indian Council for Cultural Relations","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013644","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002862","name":"China University of Petroleum, Beijing","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002862","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.bbr.2025.115475","type":"journal-article","created":{"date-parts":[[2025,2,8]],"date-time":"2025-02-08T16:02:08Z","timestamp":1739030528000},"page":"115475","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Elucidating the neuroprotective potential of arbutin in 3-NPA induced HD-like pathology: Insights from in silico, in vitro, and in vivo models"],"prefix":"10.1016","volume":"483","author":[{"given":"Pooja","family":"Temgire","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richmond","family":"Arthur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shubham","family":"Upadhayay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahil","family":"Arora","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gargi","family":"Kapatia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raj","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uma shanker","family":"Navik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Puneet","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2025.115475_bib1","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/B978-0-12-801893-4.00001-8","article-title":"Genetics of Huntington disease","volume":"144","author":"Nance","year":"2017","journal-title":"Handb. Clin. Neurol."},{"issue":"12","key":"10.1016\/j.bbr.2025.115475_bib2","doi-asserted-by":"crossref","first-page":"2327","DOI":"10.1002\/mds.29228","article-title":"Prevalence and Incidence of Huntington\u2019s Disease: An Updated Systematic Review and Meta-Analysis","volume":"37","author":"Medina","year":"2022","journal-title":"Mov Disord"},{"issue":"3","key":"10.1016\/j.bbr.2025.115475_bib3","doi-asserted-by":"crossref","first-page":"217","DOI":"10.3233\/JHD-200394","article-title":"The neurodevelopmental hypothesis of Huntington's disease","volume":"9","author":"van der Plas","year":"2020","journal-title":"J. Huntingt. Dis."},{"key":"10.1016\/j.bbr.2025.115475_bib4","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/978-3-319-19285-7_1","article-title":"The Neuropathology of Huntington\u00b4s disease: classical findings, recent developments and correlation to functional neuroanatomy","volume":"217","author":"R\u00fcb","year":"2015","journal-title":"Adv. Anat. Embryol. Cell Biol."},{"issue":"3","key":"10.1016\/j.bbr.2025.115475_bib5","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1159\/000449184","article-title":"Tetrabenazine: spotlight on drug review","volume":"23","author":"Kaur","year":"2016","journal-title":"Ann. Neurosci."},{"issue":"3","key":"10.1016\/j.bbr.2025.115475_bib6","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1021\/acschemneuro.0c00824","article-title":"Protective effect of natural products against Huntington's disease: an overview of scientific evidence and understanding their mechanism of action","volume":"12","author":"Lum","year":"2021","journal-title":"ACS Chem. Neurosci."},{"issue":"7","key":"10.1016\/j.bbr.2025.115475_bib7","doi-asserted-by":"crossref","first-page":"6076","DOI":"10.1007\/s12035-017-0798-6","article-title":"Natural dietary supplementation of anthocyanins via PI3K\/Akt\/Nrf2\/HO-1 pathways mitigate oxidative stress, neurodegeneration, and memory impairment in a mouse model of alzheimer's disease","volume":"55","author":"Ali","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbr.2025.115475_bib8","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.freeradbiomed.2022.12.002","article-title":"TrkB agonist N-acetyl serotonin promotes functional recovery after traumatic brain injury by suppressing ferroptosis via the PI3K\/Akt\/Nrf2\/Ferritin H pathway","volume":"194","author":"Cheng","year":"2023","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbr.2025.115475_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.120480","article-title":"Telmisartan neuroprotective effects in 3-nitropropionic acid Huntington's disease model in rats: cross talk between PPAR-\u03b3 and PI3K\/Akt\/GSK-3\u03b2 pathway","volume":"297","author":"Abdel Rasheed","year":"2022","journal-title":"Life Sci."},{"issue":"1","key":"10.1016\/j.bbr.2025.115475_bib10","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1007\/s13311-019-00805-5","article-title":"Vildagliptin attenuates Huntington's disease through activation of GLP-1 receptor\/PI3K\/Akt\/BDNF pathway in 3-nitropropionic acid rat model","volume":"17","author":"Sayed","year":"2020","journal-title":"Neurotherapeutics"},{"issue":"6","key":"10.1016\/j.bbr.2025.115475_bib11","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1021\/acschemneuro.1c00523","article-title":"Erythropoietin and Bacillus Calmette-Gu\u00e9rin vaccination mitigate 3-nitropropionic acid-induced huntington-like disease in rats by modulating the PI3K\/Akt\/mTOR\/P70S6K pathway and enhancing the autophagy","volume":"13","author":"Senousy","year":"2022","journal-title":"ACS Chem. Neurosci."},{"issue":"5","key":"10.1016\/j.bbr.2025.115475_bib12","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.bbamcr.2018.02.010","article-title":"Nrf2-Keap1 signaling in oxidative and reductive stress","volume":"1865","author":"Bellezza","year":"2018","journal-title":"Biochim. Biophys. Acta Mol. Cell Res."},{"key":"10.1016\/j.bbr.2025.115475_bib13","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.cotox.2016.10.002","article-title":"The multifaceted role of Nrf2 in mitochondrial function","volume":"1","author":"Holmstr\u00f6m","year":"2016","journal-title":"Curr. Opin. Toxicol."},{"issue":"17","key":"10.1016\/j.bbr.2025.115475_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22179592","article-title":"An overview of the Nrf2\/ARE pathway and its role in neurodegenerative diseases","volume":"22","author":"Zgorzynska","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.bbr.2025.115475_bib15","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1007\/s11064-023-03868-1","article-title":"An overview of the pathophysiological mechanisms of 3-nitropropionic acid (3-NPA) as a neurotoxin in a Huntington's disease model and its relevance to drug discovery and development","volume":"48","author":"Upadhayay","year":"2023","journal-title":"Neurochem. Res"},{"issue":"8","key":"10.1016\/j.bbr.2025.115475_bib16","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/s00011-012-0474-2","article-title":"Anti-inflammatory effects of arbutin in lipopolysaccharide-stimulated BV2 microglial cells","volume":"61","author":"Lee","year":"2012","journal-title":"Inflamm. Res."},{"issue":"5","key":"10.1016\/j.bbr.2025.115475_bib17","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18050969","article-title":"Study of hydroquinone mediated cytotoxicity and hypopigmentation effects from UVB-irradiated arbutin and deoxyarbutin","volume":"18","author":"Chang","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.bbr.2025.115475_bib18","first-page":"533","article-title":"Arbutin attenuates behavioral impairment and oxidative stress in an animal model of Parkinson's disease","volume":"8","author":"Dadgar","year":"2018","journal-title":"Avicenna J. Phytomed."},{"key":"10.1016\/j.bbr.2025.115475_bib19","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.neuropharm.2018.11.038","article-title":"Arbutin attenuates cognitive impairment and inflammatory response in pentylenetetrazol-induced kindling model of epilepsy","volume":"146","author":"Ahmadian","year":"2019","journal-title":"Neuropharmacology"},{"issue":"10","key":"10.1016\/j.bbr.2025.115475_bib20","doi-asserted-by":"crossref","first-page":"2030","DOI":"10.4103\/1673-5374.308102","article-title":"Arbutin effectively ameliorates the symptoms of Parkinson's disease: the role of adenosine receptors and cyclic adenosine monophosphate","volume":"16","author":"Zhao","year":"2021","journal-title":"Neural Regen. Res."},{"issue":"1","key":"10.1016\/j.bbr.2025.115475_bib21","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s12539-016-0171-x","article-title":"Exploration of novel human tyrosinase inhibitors by molecular modeling, docking and simulation studies","volume":"10","author":"Hassan","year":"2018","journal-title":"Interdiscip. Sci."},{"issue":"1","key":"10.1016\/j.bbr.2025.115475_bib22","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1186\/1471-2164-15-1154","article-title":"Systems genomics evaluation of the SH-SY5Y neuroblastoma cell line as a model for Parkinson's disease","volume":"15","author":"Krishna","year":"2014","journal-title":"BMC Genom."},{"issue":"6","key":"10.1016\/j.bbr.2025.115475_bib23","article-title":"Analysis of Cell Viability by the MTT Assay","volume":"2018","author":"Kumar","year":"2018","journal-title":"Cold Spring Harb. Protoc."},{"issue":"1-2","key":"10.1016\/j.bbr.2025.115475_bib24","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"issue":"2","key":"10.1016\/j.bbr.2025.115475_bib25","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.tiv.2013.01.016","article-title":"Dichloro-dihydro-fluorescein diacetate (DCFH-DA) assay: a quantitative method for oxidative stress assessment of nanoparticle-treated cells","volume":"27","author":"Aranda","year":"2013","journal-title":"Toxicol. Vitr."},{"issue":"9","key":"10.1016\/j.bbr.2025.115475_bib26","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1007\/s00210-021-02106-1","article-title":"Ellagic acid prevents 3-nitropropionic acid induced symptoms of Huntington's disease","volume":"394","author":"Sharma","year":"2021","journal-title":"Naunyn Schmiede Arch. Pharmacol."},{"issue":"11","key":"10.1016\/j.bbr.2025.115475_bib27","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1080\/00207454.2019.1638376","article-title":"Arbutin reduces cognitive deficit and oxidative stress in animal model of Alzheimer's disease","volume":"129","author":"Dastan","year":"2019","journal-title":"Int. J. Neurosci."},{"key":"10.1016\/j.bbr.2025.115475_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2021.105217","article-title":"Arbutin attenuates monosodium L-glutamate induced neurotoxicity and cognitive dysfunction in rats","volume":"151","author":"Kumar","year":"2021","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.bbr.2025.115475_bib29","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.physbeh.2015.12.015","article-title":"Spermidine ameliorates 3-nitropropionic acid (3-NP)-induced striatal toxicity: possible role of oxidative stress, neuroinflammation, and neurotransmitters","volume":"155","author":"Jamwal","year":"2016","journal-title":"Physiol. Behav."},{"issue":"6","key":"10.1016\/j.bbr.2025.115475_bib30","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1007\/s12640-022-00604-5","article-title":"Filgrastim, a recombinant form of granulocyte colony-stimulating factor, ameliorates 3-nitropropionic acid and haloperidol-induced striatal neurotoxicity in rats","volume":"40","author":"Rahi","year":"2022","journal-title":"Neurotox. Res."},{"issue":"11","key":"10.1016\/j.bbr.2025.115475_bib31","doi-asserted-by":"crossref","first-page":"3285","DOI":"10.1007\/s11064-022-03677-y","article-title":"Berberine ameliorate haloperidol and 3-nitropropionic acid-induced neurotoxicity in rats","volume":"47","author":"Kadir","year":"2022","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.bbr.2025.115475_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2022.120569","article-title":"Inosine attenuates 3-nitropropionic acid-induced Huntington's disease-like symptoms in rats via the activation of the A2AR\/BDNF\/TrKB\/ERK\/CREB signaling pathway","volume":"300","author":"El-Shamarka","year":"2022","journal-title":"Life Sci."},{"issue":"1-3","key":"10.1016\/j.bbr.2025.115475_bib33","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1016\/j.ejphar.2009.04.058","article-title":"Protective effect of rivastigmine against 3-nitropropionic acid-induced Huntington's disease like symptoms: possible behavioural, biochemical and cellular alterations","volume":"615","author":"Kumar","year":"2009","journal-title":"Eur. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.bbr.2025.115475_bib34","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","article-title":"Protein measurement with the Folin phenol reagent","volume":"193","author":"Lowry","year":"1951","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.bbr.2025.115475_bib35","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1042\/bj0990667","article-title":"Mechanisms of lipid peroxide formation in animal tissues","volume":"99","author":"Wills","year":"1966","journal-title":"Biochem. J."},{"issue":"1","key":"10.1016\/j.bbr.2025.115475_bib36","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/0003-9861(90)90230-V","article-title":"A study of the kinetic mechanism followed by glutathione reductase from mycelium of phycomyces blakesleeanus","volume":"278","author":"Montero","year":"1990","journal-title":"Arch. Biochem. Biophys."},{"issue":"1","key":"10.1016\/j.bbr.2025.115475_bib37","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0003-2697(82)90118-X","article-title":"Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids","volume":"126","author":"Green","year":"1982","journal-title":"Anal. Biochem."},{"issue":"1-2","key":"10.1016\/j.bbr.2025.115475_bib38","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.jchromb.2006.07.054","article-title":"Analysis of nitrite and nitrate in biological fluids by assays based on the Griess reaction: appraisal of the Griess reaction in the L-arginine\/nitric oxide area of research","volume":"851","author":"Tsikas","year":"2007","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"issue":"2","key":"10.1016\/j.bbr.2025.115475_bib39","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/0003-9861(86)90004-4","article-title":"Analysis of the peroxidatic mode of action of catalase","volume":"249","author":"Sichak","year":"1986","journal-title":"Arch. Biochem. Biophys."},{"issue":"1","key":"10.1016\/j.bbr.2025.115475_bib40","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0003-9861(78)90479-4","article-title":"Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase","volume":"186","author":"Kono","year":"1978","journal-title":"Arch. Biochem. Biophys."},{"key":"10.1016\/j.bbr.2025.115475_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.abb.2021.109115","article-title":"On 'Generation of superoxide radical during autoxidation of hydroxylamine and an assay for superoxide dismutase' by Yasuhisa Kono","volume":"726","author":"Taniguchi","year":"2022","journal-title":"Arch. Biochem. Biophys."},{"issue":"2","key":"10.1016\/j.bbr.2025.115475_bib42","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/s12640-015-9535-y","article-title":"Protective effect of spermidine against excitotoxic neuronal death induced by quinolinic acid in rats: possible neurotransmitters and neuroinflammatory mechanism","volume":"28","author":"Jamwal","year":"2015","journal-title":"Neurotox. Res."},{"issue":"18","key":"10.1016\/j.bbr.2025.115475_bib43","doi-asserted-by":"crossref","first-page":"3139","DOI":"10.1002\/jssc.200800316","article-title":"Development and validation of an RP-HPLC method for the estimation of adenosine and related purines in brain tissues of rats","volume":"31","author":"Akula","year":"2008","journal-title":"J. Sep. Sci."},{"issue":"1","key":"10.1016\/j.bbr.2025.115475_bib44","doi-asserted-by":"crossref","first-page":"4461","DOI":"10.1038\/s41598-023-31716-3","article-title":"Neuromodulatory effect of 4-(methylthio)butyl isothiocyanate against 3-nitropropionic acid induced oxidative impairments in human dopaminergic SH-SY5Y cells via BDNF\/CREB\/TrkB pathway","volume":"13","author":"Kaur","year":"2023","journal-title":"Sci. Rep."},{"issue":"1-2","key":"10.1016\/j.bbr.2025.115475_bib45","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1007\/s10495-020-01645-x","article-title":"Potential role of TrkB agonist in neuronal survival by promoting CREB\/BDNF and PI3K\/Akt signaling in vitro and in vivo model of 3-nitropropionic acid (3-NP)-induced neuronal death","volume":"26","author":"Ahmed","year":"2021","journal-title":"Apoptosis"},{"key":"10.1016\/j.bbr.2025.115475_bib46","article-title":"Artemisinin ameliorates the neurotoxic effect of 3-nitropropionic acid: a possible involvement of the ERK\/BDNF\/Nrf2\/HO-1 signaling pathway","author":"Arthur","year":"2024","journal-title":"Mol. Neurobiol."},{"issue":"1","key":"10.1016\/j.bbr.2025.115475_bib47","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1007\/s12017-019-08562-6","article-title":"\u03b1-arbutin protects against parkinson's disease-associated mitochondrial dysfunction in vitro and in vivo","volume":"22","author":"Ding","year":"2020","journal-title":"Neuromol. Med."},{"issue":"6","key":"10.1016\/j.bbr.2025.115475_bib48","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1038\/cdd.2009.22","article-title":"Complex II inhibition by 3-NP causes mitochondrial fragmentation and neuronal cell death via an NMDA- and ROS-dependent pathway","volume":"16","author":"Liot","year":"2009","journal-title":"Cell Death Differ."},{"issue":"11","key":"10.1016\/j.bbr.2025.115475_bib49","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10112866","article-title":"Beta-Boswellic acid reverses 3-nitropropionic acid-induced molecular, mitochondrial, and histopathological defects in experimental rat model of Huntington's disease","volume":"10","author":"Albekairi","year":"2022","journal-title":"Biomedicines"},{"issue":"6","key":"10.1016\/j.bbr.2025.115475_bib50","doi-asserted-by":"crossref","first-page":"309","DOI":"10.4103\/ijp.IJP_11_18","article-title":"Neuroprotective effect of solanesol against 3-nitropropionic acid-induced Huntington's disease-like behavioral, biochemical, and cellular alterations: restoration of coenzyme-Q10-mediated mitochondrial dysfunction","volume":"50","author":"Mehan","year":"2018","journal-title":"Indian J. Pharmacol."},{"issue":"8","key":"10.1016\/j.bbr.2025.115475_bib51","doi-asserted-by":"crossref","first-page":"8051","DOI":"10.1007\/s11033-022-07345-w","article-title":"The neuroprotective roles of Dietary Micronutrients on Parkinson's disease: a review","volume":"49","author":"Rahimmi","year":"2022","journal-title":"Mol. Biol. Rep."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432825000610?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432825000610?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T16:40:32Z","timestamp":1740501632000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432825000610"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":51,"alternative-id":["S0166432825000610"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2025.115475","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Elucidating the neuroprotective potential of arbutin in 3-NPA induced HD-like pathology: Insights from in silico, in vitro, and in vivo models","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2025.115475","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115475"}}