{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T22:31:22Z","timestamp":1768343482154,"version":"3.49.0"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100019018","name":"Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021193","name":"Xinjiang Production and Construction Corps Xinjiang Production and Construction Corps","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021193","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.bbr.2025.115506","type":"journal-article","created":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T15:08:33Z","timestamp":1740323313000},"page":"115506","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Chronic unpredictable mild stress-induced anxiety is linked to inflammatory responses and disruptions in tryptophan metabolism in male C57BL\/6N mice"],"prefix":"10.1016","volume":"484","author":[{"given":"Yanqin","family":"Luo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiwen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yongzhi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueyan","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinmin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Muhammad Zulqarnain","family":"Shakir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1534-0177","authenticated-orcid":false,"given":"Chunhui","family":"Shan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10277","key":"10.1016\/j.bbr.2025.115506_bib1","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/S0140-6736(21)00359-7","article-title":"Anxiety disorders","volume":"397","author":"Penninx","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.bbr.2025.115506_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2020.110207","article-title":"Prevalence of anxiety in the COVID-19 pandemic: an updated meta-analysis of community-based studies","volume":"109","author":"Santab\u00e1rbara","year":"2021","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"3","key":"10.1016\/j.bbr.2025.115506_bib3","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1002\/da.22711","article-title":"Treatment gap for anxiety disorders is global: results of the World Mental Health Surveys in 21 countries","volume":"35","author":"Alonso","year":"2018","journal-title":"Depress Anxiety"},{"issue":"10312","key":"10.1016\/j.bbr.2025.115506_bib4","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1016\/S0140-6736(21)02143-7","article-title":"Global prevalence and burden of depressive and anxiety disorders in 204 countries and territories in 2020 due to the COVID-19 pandemic","volume":"398","author":"Santomauro","year":"2021","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.bbr.2025.115506_bib5","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1038\/s41467-020-15920-7","article-title":"Identification of a prefrontal cortex-to-amygdala pathway for chronic stress-induced anxiety","volume":"11","author":"Liu","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbr.2025.115506_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.670500","article-title":"Chronic stress-induced depression and anxiety priming modulated by gut-brain-axis immunity","volume":"12","author":"Westfall","year":"2021","journal-title":"Front Immunol."},{"issue":"3","key":"10.1016\/j.bbr.2025.115506_bib7","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.biopsych.2022.11.004","article-title":"Preclinical models of chronic stress: adaptation or pathology?","volume":"94","author":"Radley","year":"2023","journal-title":"Biol. Psychiatry"},{"issue":"4","key":"10.1016\/j.bbr.2025.115506_bib8","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s002130050471","article-title":"Chronic mild stress and depressive disorder: a useful new model?","volume":"134","author":"Reid","year":"1997","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2025.115506_bib9","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.neubiorev.2018.12.002","article-title":"Chronic unpredictable mild stress for modeling depression in rodents: meta-analysis of model reliability","volume":"99","author":"Antoniuk","year":"2019","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"2","key":"10.1016\/j.bbr.2025.115506_bib10","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/0149-7634(81)90008-7","article-title":"Amitriptyline and scopolamine in an animal model of depression","volume":"5","author":"Katz","year":"1981","journal-title":"Neurosci. Biobehav Rev."},{"issue":"S6","key":"10.1016\/j.bbr.2025.115506_bib11","doi-asserted-by":"crossref","DOI":"10.5694\/mja12.10628","article-title":"Depression and anxiety","volume":"199","author":"Tiller","year":"2013","journal-title":"Med J. Aust."},{"issue":"5","key":"10.1016\/j.bbr.2025.115506_bib12","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1080\/10253890701821081","article-title":"Hypothalamic-pituitary-adrenal axis dysregulation and behavioral analysis of mouse mutants with altered glucocorticoid or mineralocorticoid receptor function","volume":"11","author":"Kolber","year":"2008","journal-title":"Stress"},{"issue":"14","key":"10.1016\/j.bbr.2025.115506_bib13","first-page":"1464","article-title":"Hyperactivity of hypothalamus-pituitary-adrenalaxis is associated with reduced expression of glucocorticoid steroid receptor in a rat model of anxiety","volume":"39","author":"Yu Qing","year":"2017","journal-title":"J. Third Mil. Med. Univ. 2017"},{"issue":"6","key":"10.1016\/j.bbr.2025.115506_bib14","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1002\/ame2.12360","article-title":"Recent advances in anxiety disorders: Focus on animal models and pathological mechanisms","volume":"6","author":"Zhao","year":"2023","journal-title":"Anim. Model Exp. Med"},{"issue":"3","key":"10.1016\/j.bbr.2025.115506_bib15","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/nri1571","article-title":"Stress-induced immune dysfunction: implications for health","volume":"5","author":"Glaser","year":"2005","journal-title":"Nat. Rev. Immunol."},{"issue":"11","key":"10.1016\/j.bbr.2025.115506_bib16","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1038\/s41590-022-01321-z","article-title":"The neuroimmunology of social-stress-induced sensitization","volume":"23","author":"Biltz","year":"2022","journal-title":"Nat. Immunol."},{"issue":"3","key":"10.1016\/j.bbr.2025.115506_bib17","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/j.immuni.2024.01.018","article-title":"Disruption of the Na(+)\/K(+)-ATPase-purinergic P2X7 receptor complex in microglia promotes stress-induced anxiety","volume":"57","author":"Huang","year":"2024","journal-title":"Immunity"},{"issue":"9","key":"10.1016\/j.bbr.2025.115506_bib18","doi-asserted-by":"crossref","first-page":"1637","DOI":"10.1007\/s00213-016-4218-9","article-title":"Stress and neuroinflammation: a systematic review of the effects of stress on microglia and the implications for mental illness","volume":"233","author":"Calcia","year":"2016","journal-title":"Psychopharmacology"},{"issue":"1","key":"10.1016\/j.bbr.2025.115506_bib19","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/s42255-019-0161-5","article-title":"NAD(+) homeostasis in health and disease","volume":"2","author":"Katsyuba","year":"2020","journal-title":"Nat. Metab."},{"issue":"2","key":"10.1016\/j.bbr.2025.115506_bib20","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0955-0674(03)00006-1","article-title":"Nicotinamide adenine dinucleotide, a metabolic regulator of transcription, longevity and disease","volume":"15","author":"Lin","year":"2003","journal-title":"Curr. Opin. Cell Biol."},{"issue":"8","key":"10.1016\/j.bbr.2025.115506_bib21","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1111\/j.1742-4658.2012.08487.x","article-title":"Kynurenine pathway inhibition as a therapeutic strategy for neuroprotection","volume":"279","author":"Stone","year":"2012","journal-title":"Febs J."},{"key":"10.1016\/j.bbr.2025.115506_bib22","doi-asserted-by":"crossref","DOI":"10.1177\/1178646919852996","article-title":"Microorganisms, tryptophan metabolism, and kynurenine pathway: a complex interconnected loop influencing human health status","volume":"12","author":"Dehhaghi","year":"2019","journal-title":"Int J. Tryptophan Res"},{"issue":"6","key":"10.1016\/j.bbr.2025.115506_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/cells10061548","article-title":"Neuroinflammation and the kynurenine pathway in CNS disease: molecular mechanisms and therapeutic implications","volume":"10","author":"Mithaiwala","year":"2021","journal-title":"Cells"},{"issue":"7","key":"10.1016\/j.bbr.2025.115506_bib24","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/nrn3257","article-title":"Kynurenines in the mammalian brain: when physiology meets pathology","volume":"13","author":"Schwarcz","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"issue":"3","key":"10.1016\/j.bbr.2025.115506_bib25","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1111\/j.1742-4658.2007.05635.x","article-title":"Tissue expression and biochemical characterization of human 2-amino 3-carboxymuconate 6-semialdehyde decarboxylase, a key enzyme in tryptophan catabolism","volume":"274","author":"Pucci","year":"2007","journal-title":"Febs J."},{"issue":"2","key":"10.1016\/j.bbr.2025.115506_bib26","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/s41580-020-00313-x","article-title":"NAD(+) metabolism and its roles in cellular processes during ageing","volume":"22","author":"Covarrubias","year":"2021","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.bbr.2025.115506_bib27","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1111\/j.1471-4159.1985.tb05435.x","article-title":"Quinolinic acid phosphoribosyltransferase in rat brain","volume":"44","author":"Foster","year":"1985","journal-title":"J. Neurochem."},{"issue":"1","key":"10.1016\/j.bbr.2025.115506_bib28","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1471-4159.1986.tb02826.x","article-title":"Synthesis of quinolinic acid by 3-hydroxyanthranilic acid oxygenase in rat brain tissue in vitro","volume":"47","author":"Foster","year":"1986","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbr.2025.115506_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.868833","article-title":"Ginsenosides Rb1 attenuates chronic social defeat stress-induced depressive behavior via regulation of SIRT1-NLRP3\/Nrf2 pathways","volume":"9","author":"Jiang","year":"2022","journal-title":"Front Nutr."},{"key":"10.1016\/j.bbr.2025.115506_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.176301","article-title":"Effects of different chronic restraint stress periods on anxiety- and depression-like behaviors and tryptophan-kynurenine metabolism along the brain-gut axis in C57BL\/6N mice","volume":"965","author":"Ye","year":"2024","journal-title":"Eur. J. Pharm."},{"key":"10.1016\/j.bbr.2025.115506_bib31","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.ibneur.2022.07.007","article-title":"Chronic clomipramine treatment reverses depressogenic-like effects of a chronic treatment with dexamethasone in rats","volume":"13","author":"Laaziz","year":"2022","journal-title":"IBRO Neurosci. Rep."},{"issue":"1","key":"10.1016\/j.bbr.2025.115506_bib32","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.367","article-title":"Anxiety- and activity-related effects of paracetamol on healthy and neuropathic rats","volume":"6","author":"Chen","year":"2018","journal-title":"Pharm. Res Perspect."},{"key":"10.1016\/j.bbr.2025.115506_bib33","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/j.brainresbull.2019.09.007","article-title":"Dammarane sapogenins alleviates depression-like behaviours induced by chronic social defeat stress in mice through the promotion of the BDNF signalling pathway and neurogenesis in the hippocampus","volume":"153","author":"Jiang","year":"2019","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.bbr.2025.115506_bib34","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jchromb.2019.02.021","article-title":"LC-MS\/MS-based quantification of tryptophan metabolites and neurotransmitters in the serum and brain of mice","volume":"1112","author":"Wang","year":"2019","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"issue":"2","key":"10.1016\/j.bbr.2025.115506_bib35","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1002\/ptr.7627","article-title":"Tenuifolin ameliorates the sleep deprivation-induced cognitive deficits","volume":"37","author":"Jiang","year":"2023","journal-title":"Phytother. Res."},{"issue":"12","key":"10.1016\/j.bbr.2025.115506_bib36","doi-asserted-by":"crossref","first-page":"1748","DOI":"10.1002\/ptr.3130","article-title":"Comparison of ginsenosides Rg1 and Rb1 for their effects on improving scopolamine-induced learning and memory impairment in mice","volume":"24","author":"Wang","year":"2010","journal-title":"Phytother. Res."},{"issue":"1","key":"10.1016\/j.bbr.2025.115506_bib37","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1038\/s41398-021-01468-7","article-title":"Catalpol ameliorates depressive-like behaviors in CUMS mice via oxidative stress-mediated NLRP3 inflammasome and neuroinflammation","volume":"11","author":"Wang","year":"2021","journal-title":"Transl. Psychiatry"},{"issue":"3","key":"10.1016\/j.bbr.2025.115506_bib38","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/0165-0270(85)90031-7","article-title":"Validation of open:closed arm entries in an elevated plus-maze as a measure of anxiety in the rat","volume":"14","author":"Pellow","year":"1985","journal-title":"J. Neurosci. Methods"},{"issue":"3","key":"10.1016\/j.bbr.2025.115506_bib39","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/BF00181937","article-title":"The effects of chronic antidepressant treatment in an animal model of anxiety","volume":"95","author":"Bodnoff","year":"1988","journal-title":"Psychopharmacology"},{"issue":"2","key":"10.1016\/j.bbr.2025.115506_bib40","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/0091-3057(80)90067-2","article-title":"Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines","volume":"13","author":"Crawley","year":"1980","journal-title":"Pharm. Biochem Behav."},{"key":"10.1016\/j.bbr.2025.115506_bib41","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.euroneuro.2023.08.496","article-title":"Sucrose preference test: a systematic review of protocols for the assessment of anhedonia in rodents","volume":"77","author":"Primo","year":"2023","journal-title":"Eur. Neuropsychopharmacol."},{"issue":"10","key":"10.1016\/j.bbr.2025.115506_bib42","doi-asserted-by":"crossref","DOI":"10.3390\/brainsci12101287","article-title":"Sucrose preference test as a measure of anhedonic behavior in a chronic unpredictable mild stress model of depression: outstanding issues","volume":"12","author":"Markov","year":"2022","journal-title":"Brain Sci."},{"issue":"Pt B","key":"10.1016\/j.bbr.2025.115506_bib43","article-title":"The role of EndophilinA1 in chronic unpredicted mild stress-induced depression model mice","volume":"124","author":"Liu","year":"2023","journal-title":"Int Immunopharmacol."},{"key":"10.1016\/j.bbr.2025.115506_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2023.116360","article-title":"SNS alleviates depression-like behaviors in CUMS mice by regluating dendritic spines via NCOA4-mediated ferritinophagy","volume":"312","author":"Zhang","year":"2023","journal-title":"J. Ethnopharmacol."},{"issue":"5","key":"10.1016\/j.bbr.2025.115506_bib45","doi-asserted-by":"crossref","first-page":"453","DOI":"10.4062\/biomolther.2014.058","article-title":"Strain differences in the chronic mild stress animal model of depression and anxiety in mice","volume":"22","author":"Jung","year":"2014","journal-title":"Biomol. Ther."},{"issue":"11","key":"10.1016\/j.bbr.2025.115506_bib46","first-page":"1238","article-title":"Differences in anxiety-related behavior induced by mCPP and responses to diazepam in two strains of mice","volume":"18","author":"Yan","year":"2013","journal-title":"Chin. J. Clin. Pharmacol. Ther."},{"issue":"6","key":"10.1016\/j.bbr.2025.115506_bib47","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1080\/10253890.2020.1859475","article-title":"Brain mechanisms of HPA axis regulation: neurocircuitry and feedback in context Richard Kvetnansky lecture","volume":"23","author":"Herman","year":"2020","journal-title":"Stress"},{"issue":"6","key":"10.1016\/j.bbr.2025.115506_bib48","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1016\/S1734-1140(13)71527-5","article-title":"Cytokines, prostaglandins and nitric oxide in the regulation of stress-response systems","volume":"65","author":"G\u0105dek-Michalska","year":"2013","journal-title":"Pharm. Rep."},{"issue":"2","key":"10.1016\/j.bbr.2025.115506_bib49","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1007\/s00213-003-1640-6","article-title":"Acute psychological and physiological effects of psilocybin in healthy humans: a double-blind, placebo-controlled dose-effect study","volume":"172","author":"Hasler","year":"2004","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2025.115506_bib50","doi-asserted-by":"crossref","first-page":"443","DOI":"10.3389\/fpsyt.2020.00443","article-title":"Pharmacological treatment of anxiety disorders: the role of the HPA axis","volume":"11","author":"Tafet","year":"2020","journal-title":"Front Psychiatry"},{"key":"10.1016\/j.bbr.2025.115506_bib51","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.bbr.2016.12.045","article-title":"Effects of the chronic restraint stress induced depression on reward-related learning in rats","volume":"321","author":"Xu","year":"2017","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2025.115506_bib52","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.pneurobio.2015.05.003","article-title":"Alternatively activated microglia and macrophages in the central nervous system","volume":"131","author":"Franco","year":"2015","journal-title":"Prog. Neurobiol."},{"issue":"3","key":"10.1016\/j.bbr.2025.115506_bib53","first-page":"410","article-title":"Research progress on phenotype and function of microglia","volume":"40","author":"WEI Xiao-tong","year":"2024","journal-title":"Chin. Pharmacol. Bull. 2024"},{"issue":"2","key":"10.1016\/j.bbr.2025.115506_bib54","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1007\/s12035-014-9070-5","article-title":"Differential roles of M1 and M2 microglia in neurodegenerative diseases","volume":"53","author":"Tang","year":"2016","journal-title":"Mol. Neurobiol."},{"issue":"12","key":"10.1016\/j.bbr.2025.115506_bib55","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1002\/glia.23041","article-title":"IL-4 drives microglia and macrophages toward a phenotype conducive for tissue repair and functional recovery after spinal cord injury","volume":"64","author":"Francos-Quijorna","year":"2016","journal-title":"Glia"},{"issue":"2","key":"10.1016\/j.bbr.2025.115506_bib56","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/BF00917743","article-title":"Human tuberculosis sera show prominent antibody responses to particulate fractions of Mycobacterium tuberculosis","volume":"11","author":"Das","year":"1991","journal-title":"J. Clin. Immunol."},{"issue":"11","key":"10.1016\/j.bbr.2025.115506_bib57","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1038\/nn1997","article-title":"Microglia: active sensor and versatile effector cells in the normal and pathologic brain","volume":"10","author":"Hanisch","year":"2007","journal-title":"Nat. Neurosci."},{"issue":"23","key":"10.1016\/j.bbr.2025.115506_bib58","doi-asserted-by":"crossref","first-page":"13632","DOI":"10.1073\/pnas.2234031100","article-title":"Inflammation is detrimental for neurogenesis in adult brain","volume":"100","author":"Ekdahl","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"1","key":"10.1016\/j.bbr.2025.115506_bib59","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1161\/01.STR.0000251791.64910.cd","article-title":"Chronic treatment with minocycline preserves adult new neurons and reduces functional impairment after focal cerebral ischemia","volume":"38","author":"Liu","year":"2007","journal-title":"Stroke"},{"issue":"9","key":"10.1016\/j.bbr.2025.115506_bib60","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1038\/nn.3469","article-title":"M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination","volume":"16","author":"Miron","year":"2013","journal-title":"Nat. Neurosci."},{"issue":"5","key":"10.1016\/j.bbr.2025.115506_bib61","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/s41573-019-0016-5","article-title":"Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond","volume":"18","author":"Platten","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"issue":"5","key":"10.1016\/j.bbr.2025.115506_bib62","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1038\/cmi.2017.143","article-title":"IDO1 in cancer: a Gemini of immune checkpoints","volume":"15","author":"Zhai","year":"2018","journal-title":"Cell Mol. Immunol."},{"key":"10.1016\/j.bbr.2025.115506_bib63","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1756-6606-2-8","article-title":"Tryptophan 2,3-dioxygenase is a key modulator of physiological neurogenesis and anxiety-related behavior in mice","volume":"2","author":"Kanai","year":"2009","journal-title":"Mol. Brain"},{"issue":"3","key":"10.1016\/j.bbr.2025.115506_bib64","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s00018-009-0166-4","article-title":"Structure, expression, and function of kynurenine aminotransferases in human and rodent brains","volume":"67","author":"Han","year":"2010","journal-title":"Cell Mol. Life Sci."},{"issue":"1","key":"10.1016\/j.bbr.2025.115506_bib65","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s12974-016-0590-y","article-title":"Kynurenine metabolic balance is disrupted in the hippocampus following peripheral lipopolysaccharide challenge","volume":"13","author":"Parrott","year":"2016","journal-title":"J. Neuroinflamm."},{"issue":"4582","key":"10.1016\/j.bbr.2025.115506_bib66","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1126\/science.6849138","article-title":"Quinolinic acid: an endogenous metabolite that produces axon-sparing lesions in rat brain","volume":"219","author":"Schwarcz","year":"1983","journal-title":"Science"},{"issue":"12","key":"10.1016\/j.bbr.2025.115506_bib67","doi-asserted-by":"crossref","first-page":"2693","DOI":"10.1097\/00001756-200108280-00020","article-title":"In vivo hydroxyl radical formation after quinolinic acid infusion into rat corpus striatum","volume":"12","author":"Santamar\u00eda","year":"2001","journal-title":"Neuroreport"},{"issue":"6","key":"10.1016\/j.bbr.2025.115506_bib68","doi-asserted-by":"crossref","first-page":"5111","DOI":"10.1007\/s12035-017-0749-2","article-title":"Kynurenic acid prevents cytoskeletal disorganization induced by quinolinic acid in mixed cultures of rat striatum","volume":"55","author":"Pierozan","year":"2018","journal-title":"Mol. Neurobiol."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432825000920?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432825000920?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T05:01:50Z","timestamp":1741669310000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432825000920"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":68,"alternative-id":["S0166432825000920"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2025.115506","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronic unpredictable mild stress-induced anxiety is linked to inflammatory responses and disruptions in tryptophan metabolism in male C57BL\/6N mice","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2025.115506","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115506"}}