{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T17:31:49Z","timestamp":1767720709786,"version":"3.44.0"},"reference-count":68,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["18K10852","22K11497"],"award-info":[{"award-number":["18K10852","22K11497"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.bbr.2025.115718","type":"journal-article","created":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T12:29:33Z","timestamp":1751372973000},"page":"115718","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Effects of acute treadmill running following administration of lipopolysaccharide on subsequent changes in microglial activation and depressive-like behavior in rats"],"prefix":"10.1016","volume":"493","author":[{"given":"Shuntaro","family":"Sugimoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Misaki","family":"Yokoshi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takumi","family":"Maruyama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seiichiro","family":"Amemiya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5381-3775","authenticated-orcid":false,"given":"Ichiro","family":"Kita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.bbr.2025.115718_bib1","first-page":"2723","article-title":"Biomarkers of depression in cancer patients","volume":"107","author":"Jehn","year":"2006","journal-title":"Cancer Interdisciplinary Int. J. Am. Cancer Soc."},{"key":"10.1016\/j.bbr.2025.115718_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11920-014-0530-4","article-title":"Depression in HIV infected patients: a review","volume":"17","author":"Nanni","year":"2015","journal-title":"Curr. Psychiat. Rep."},{"issue":"3","key":"10.1016\/j.bbr.2025.115718_bib3","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0006-3223(03)00413-X","article-title":"Depression in cancer: new developments regarding diagnosis and treatment","volume":"54","author":"Raison","year":"2003","journal-title":"Biol. Psychiat."},{"issue":"1","key":"10.1016\/j.bbr.2025.115718_bib4","doi-asserted-by":"crossref","first-page":"41","DOI":"10.31887\/DCNS.2011.13.1\/rshelton","article-title":"Inflammation in depression: is adiposity a cause?","volume":"13","author":"Shelton","year":"2011","journal-title":"Dialog. Clin. Neurosci."},{"issue":"5 Pt 1","key":"10.1016\/j.bbr.2025.115718_bib5","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/j.1399-0012.1997.tb00842.x","article-title":"Vulnerability to psychologic distress and depression in patients with end-stage liver disease due to hepatitis C virus","volume":"11","author":"Singh","year":"1997","journal-title":"Clin. Transplant."},{"key":"10.1016\/j.bbr.2025.115718_bib6","doi-asserted-by":"crossref","first-page":"476","DOI":"10.3389\/fncel.2015.00476","article-title":"Neuroinflammation and depression: microglia activation, extracellular microvesicles and microRNA dysregulation","volume":"9","author":"Brites","year":"2015","journal-title":"Front. Cell. Neurosci."},{"issue":"1","key":"10.1016\/j.bbr.2025.115718_bib7","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nrn2297","article-title":"From inflammation to sickness and depression: when the immune system subjugates the brain","volume":"9","author":"Dantzer","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"issue":"10","key":"10.1016\/j.bbr.2025.115718_bib8","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1016\/j.tins.2015.08.001","article-title":"Depression as a microglial disease","volume":"38","author":"Yirmiya","year":"2015","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.bbr.2025.115718_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-015-0332-6","article-title":"Systemic inflammation and microglial activation: systematic review of animal experiments","volume":"12","author":"Hoogland","year":"2015","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.bbr.2025.115718_bib10","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.psyneuen.2018.12.233","article-title":"Microglial-driven changes in synaptic plasticity: a possible role in major depressive disorder","volume":"102","author":"Innes","year":"2019","journal-title":"Psychoneuroendocrinology"},{"issue":"9","key":"10.1016\/j.bbr.2025.115718_bib11","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.biopsych.2008.11.029","article-title":"Inflammation and its discontents: the role of cytokines in the pathophysiology of major depression","volume":"65","author":"Miller","year":"2009","journal-title":"Biol. Psychiat."},{"issue":"5","key":"10.1016\/j.bbr.2025.115718_bib12","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.psyneuen.2007.03.005","article-title":"Lipopolysaccharide induces delayed FosB\/DeltaFosB immunostaining within the mouse extended amygdala, hippocampus and hypothalamus, that parallel the expression of depressive-like behavior","volume":"32","author":"Frenois","year":"2007","journal-title":"Psychoneuroendocrinology"},{"issue":"4","key":"10.1016\/j.bbr.2025.115718_bib13","doi-asserted-by":"crossref","first-page":"905","DOI":"10.3233\/JAD-2011-111097","article-title":"The role of indoleamine 2, 3-dioxygenase in a mouse model of neuroinflammation-induced depression","volume":"28","author":"Dobos","year":"2012","journal-title":"J. Alzheimer's Dis."},{"key":"10.1016\/j.bbr.2025.115718_bib14","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.bbi.2014.03.016","article-title":"Neuroinflammation in bipolar disorder \u2013 A[(11)C]-(R)-PK11195 positron emission tomography study","volume":"40","author":"Haarman","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbr.2025.115718_bib15","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/1756-6606-2-8","article-title":"Tryptophan 2,3-dioxygenase is a key modulator of physiological neurogenesis and anxiety-related behavior in mice","volume":"2","author":"Kanai","year":"2009","journal-title":"Mol. Brain"},{"issue":"2","key":"10.1016\/j.bbr.2025.115718_bib16","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1073\/pnas.0708092105","article-title":"IL-1\u03b2 is an essential mediator of the antineurogenic and anhedonic effects of stress","volume":"105","author":"Koo","year":"2008","journal-title":"Proc. Nat. Acad. Sci."},{"key":"10.1016\/j.bbr.2025.115718_bib17","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0896-6273(02)00653-0","article-title":"Neurobiology of depression","volume":"34","author":"Nestler","year":"2002","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2025.115718_bib18","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s00441-018-2978-8","article-title":"Monoaminergic system and depression","volume":"377","author":"Perez-Caballero","year":"2019","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.bbr.2025.115718_bib19","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/nature10287","article-title":"Adult hippocampal neurogenesis buffers stress responses and depressive behaviour","volume":"476","author":"Snyder","year":"2011","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.bbr.2025.115718_bib20","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.amepre.2005.06.009","article-title":"Prospective study of physical activity and depressive symptoms in middle-aged women","volume":"29","author":"Brown","year":"2005","journal-title":"Am. J. Prev. Med."},{"issue":"2","key":"10.1016\/j.bbr.2025.115718_bib21","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1136\/bjsm.35.2.114","article-title":"Benefits from aerobic exercise in patients with major depression: a pilot study","volume":"35","author":"Dimeo","year":"2001","journal-title":"Br. J. Sports Med."},{"issue":"5","key":"10.1016\/j.bbr.2025.115718_bib22","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.ypmed.2010.07.019","article-title":"A prospective study of leisure-time physical activity and mental health in Swedish health care workers and social insurance officers","volume":"51","author":"Jonsdottir","year":"2010","journal-title":"Prev. Med."},{"issue":"7","key":"10.1016\/j.bbr.2025.115718_bib23","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1210\/en.2003-0097","article-title":"Effects of long-term voluntary exercise on the mouse hypothalamic-pituitary-adrenocortical axis","volume":"144","author":"Droste","year":"2003","journal-title":"Endocrinology"},{"issue":"6","key":"10.1016\/j.bbr.2025.115718_bib24","doi-asserted-by":"crossref","first-page":"1867","DOI":"10.1152\/japplphysiol.01416.2005","article-title":"Effect of voluntary wheel running on circadian corticosterone release and on HPA axis responsiveness to restraint stress in Sprague-Dawley rats","volume":"100","author":"Fediuc","year":"2006","journal-title":"J. Appl. Physiol."},{"issue":"4","key":"10.1016\/j.bbr.2025.115718_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0035901","article-title":"Neurogenomic evidence for a shared mechanism of the antidepressant effects of exercise and chronic fluoxetine in mice","volume":"7","author":"Huang","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.bbr.2025.115718_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12576-020-00788-5","article-title":"Interaction between intensity and duration of acute exercise on neuronal activity associated with depression-related behavior in rats","volume":"71","author":"Morikawa","year":"2021","journal-title":"J. Physiol. Sci."},{"key":"10.1016\/j.bbr.2025.115718_bib27","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.bbr.2015.10.055","article-title":"Effects of acute treadmill running at different intensities on activities of serotonin and corticotropin-releasing factor neurons, and anxiety-and depressive-like behaviors in rats","volume":"298","author":"Otsuka","year":"2016","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2025.115718_bib28","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1007\/s12017-008-8027-0","article-title":"Central mechanisms of HPA axis regulation by voluntary exercise","volume":"10","author":"Stranahan","year":"2008","journal-title":"Neuromol. Med."},{"key":"10.1016\/j.bbr.2025.115718_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.brainresbull.2019.04.001","article-title":"The effects of running exercise on oligodendrocytes in the hippocampus of rats with depression induced by chronic unpredictable stress","volume":"149","author":"Tang","year":"2019","journal-title":"Brain Res. Bull."},{"issue":"1","key":"10.1016\/j.bbr.2025.115718_bib30","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.bbr.2005.10.007","article-title":"Beneficial effects of exercise and its molecular mechanisms on depression in rats","volume":"168","author":"Zheng","year":"2006","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2025.115718_bib31","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3389\/fnbeh.2017.00235","article-title":"Adaptive changes in the sensitivity of the dorsal raphe and hypothalamic paraventricular nuclei to acute exercise, and hippocampal neurogenesis may contribute to the antidepressant effect of regular treadmill running in rats","volume":"11","author":"Nishii","year":"2017","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.bbr.2025.115718_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2024.1420322","article-title":"Physical exercise regulates microglia in health and disease","volume":"18","author":"Strohm","year":"2024","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.bbr.2025.115718_bib33","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/908901","article-title":"Total adiponectin is inversely associated with platelet activation and CHA\u2082DS\u2082-VASc score in anticoagulated patients with atrial fibrillation","volume":"2014","author":"Carnevale","year":"2014","journal-title":"Mediat. Inflamm."},{"issue":"4","key":"10.1016\/j.bbr.2025.115718_bib34","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1111\/j.1365-2362.2008.01937.x","article-title":"Metabolic and anti-inflammatory benefits of eccentric endurance exercise\u2013a pilot study","volume":"38","author":"Drexel","year":"2008","journal-title":"Eur. J. Clin. Invest"},{"issue":"1","key":"10.1016\/j.bbr.2025.115718_bib35","doi-asserted-by":"crossref","first-page":"38","DOI":"10.4103\/ijpvm.IJPVM_315_20","article-title":"Studying the effect of garlic consumption and endurance training on serum levels of some pro-and anti-inflammatory cytokines in female mice with breast cancer-a randomized trial","volume":"13","author":"Enayatjazi","year":"2022","journal-title":"Int. J. Prev. Med."},{"issue":"1","key":"10.1016\/j.bbr.2025.115718_bib36","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1111\/j.1365-2796.2010.02321.x","article-title":"The pulse of inflammation: heart rate variability, the cholinergic anti-inflammatory pathway and implications for therapy","volume":"269","author":"Huston","year":"2011","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.bbr.2025.115718_bib37","doi-asserted-by":"crossref","first-page":"404","DOI":"10.3389\/fncel.2017.00404","article-title":"Physical exercise improves cognitive function together with microglia phenotype modulation and remyelination in chronic cerebral hypoperfusion","volume":"11","author":"Jiang","year":"2017","journal-title":"Front. Cell. Neurosci."},{"issue":"4","key":"10.1016\/j.bbr.2025.115718_bib38","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1152\/japplphysiol.00164.2004","article-title":"The anti-inflammatory effect of exercise","volume":"98","author":"Petersen","year":"2005","journal-title":"J. Appl. Physiol."},{"issue":"4","key":"10.1016\/j.bbr.2025.115718_bib39","doi-asserted-by":"crossref","first-page":"295","DOI":"10.5604\/20831862.1163692","article-title":"Long-term treadmill exercise improves spatial memory of male APPswe\/PS1dE9 mice by regulation of BDNF expression and microglia activation","volume":"32","author":"Xiong","year":"2015","journal-title":"Biol. Sport"},{"issue":"9","key":"10.1016\/j.bbr.2025.115718_bib40","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1038\/npp.2013.71","article-title":"NMDA receptor blockade by ketamine abrogates lipopolysaccharide-induced depressive-like behavior in C57BL\/6J mice","volume":"38","author":"Walker","year":"2013","journal-title":"Neuropsychopharmacology"},{"issue":"3","key":"10.1016\/j.bbr.2025.115718_bib41","doi-asserted-by":"crossref","first-page":"R484","DOI":"10.1152\/ajpregu.00453.2003","article-title":"Delineation of responsive AVP-containing neurons to running stress in the hypothalamus","volume":"286","author":"Saito","year":"2004","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"4","key":"10.1016\/j.bbr.2025.115718_bib42","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1016\/j.neures.2007.04.004","article-title":"Threshold-like pattern of neuronal activation in the hypothalamus during treadmill running: establishment of a minimum running stress (MRS) rat model","volume":"58","author":"Soya","year":"2007","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.bbr.2025.115718_bib43","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.brainres.2007.12.047","article-title":"Voluntary exercise produces antidepressant and anxiolytic behavioral effects in mice","volume":"1199","author":"Duman","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2025.115718_bib44","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1002\/glia.10149","article-title":"Intracellular signaling in M-CSF-induced microglia activation: role of Iba1","volume":"40","author":"Imai","year":"2002","journal-title":"Glia"},{"issue":"7","key":"10.1016\/j.bbr.2025.115718_bib45","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.bbi.2010.02.001","article-title":"Chronic stress alters the density and morphology of microglia in a subset of stress-responsive brain regions","volume":"24","author":"Tynan","year":"2010","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbr.2025.115718_bib46","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.ijdevneu.2013.12.008","article-title":"Spreading depression features and Iba1 immunoreactivity in the cerebral cortex of developing rats submitted to treadmill exercise after treatment with monosodium glutamate","volume":"33","author":"Lima","year":"2014","journal-title":"Int. J. Dev. Neurosci."},{"year":"2017","series-title":"The rat brain in stereotaxic coordinates: compact","author":"Paxinos","key":"10.1016\/j.bbr.2025.115718_bib47"},{"key":"10.1016\/j.bbr.2025.115718_bib48","unstructured":"W.S. Rasband, ImageJ, U. S. National Institutes of Health, Bethesda, Maryland, USA, 1997\u20132018. \u3008https:\/\/imagej.net\/ij\/\u3009."},{"key":"10.1016\/j.bbr.2025.115718_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.exger.2023.112141","article-title":"A systematic review of exercise modalities that reduce pro-inflammatory cytokines in humans and animals' models with mild cognitive impairment or dementia","volume":"175","author":"Ayari","year":"2023","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.bbr.2025.115718_bib50","article-title":"Exercise-induced immune system response: anti-inflammatory status on peripheral and central organs","volume":"1866","author":"da","year":"2020","journal-title":"BBA Mol. Basis Dis."},{"issue":"6","key":"10.1016\/j.bbr.2025.115718_bib51","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1177\/1545968314562108","article-title":"Effects of physical exercise on neuroinflammation, neuroplasticity, neurodegeneration, and behavior","volume":"29","author":"Svensson","year":"2015","journal-title":"Neurorehabil. Neural Repair"},{"key":"10.1016\/j.bbr.2025.115718_bib52","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.brainres.2016.10.029","article-title":"Neuroprotective effects of endurance exercise against neuroinflammation in MPTP-induced Parkinson\u2019s disease mice","volume":"1655","author":"Jang","year":"2017","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2025.115718_bib53","doi-asserted-by":"crossref","first-page":"691","DOI":"10.3390\/cells8070691","article-title":"Physical exercise inhibits inflammation and microglial activation","volume":"8","author":"Mee-inta","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.bbr.2025.115718_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2022.113820","article-title":"Treadmill exercise improve recognition memory by TREM2 pathway to inhibit hippocampal microglial activation and neuroinflammation in Alzheimer\u2019s disease model","volume":"251","author":"Zhang","year":"2022","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbr.2025.115718_bib55","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1159\/000356144","article-title":"Voluntary wheel running does not affect lipopolysaccharide-induced depressive-like behavior in young adult and aged mice","volume":"21","author":"Martin","year":"2014","journal-title":"Neuroimmunomodulation"},{"issue":"9","key":"10.1016\/j.bbr.2025.115718_bib56","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1038\/nri3041","article-title":"The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease","volume":"11","author":"Gleeson","year":"2011","journal-title":"Nat. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.bbr.2025.115718_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.berh.2020.101504","article-title":"Exercise and inflammation","volume":"34","author":"Metsios","year":"2020","journal-title":"Best. Pract. Res. Clin. Rheumatol."},{"key":"10.1016\/j.bbr.2025.115718_bib58","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/j.metabol.2008.02.017","article-title":"Endurance exercise increases the SIRT1 and peroxisome proliferator-activated receptor gamma coactivator-1alpha protein expressions in rat skeletal muscle","volume":"57","author":"Suwa","year":"2008","journal-title":"Metabolism"},{"key":"10.1016\/j.bbr.2025.115718_bib59","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/bs.pmbts.2015.07.003","article-title":"Exercise and the regulation of inflammatory responses","volume":"135","author":"Allen","year":"2015","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10.1016\/j.bbr.2025.115718_bib60","doi-asserted-by":"crossref","first-page":"1550","DOI":"10.3389\/fphys.2019.01550","article-title":"Inflammatory effects of high and moderate intensity exercise\u2014a systematic review","volume":"10","author":"Cerqueira","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbr.2025.115718_bib61","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/1083596","article-title":"The critical role of IL-10 in the antineuroinflammatory and antioxidative effects of Rheum tanguticum on activated microglia","volume":"2018","author":"Meng","year":"2018","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.bbr.2025.115718_bib62","doi-asserted-by":"crossref","first-page":"115","DOI":"10.2165\/00007256-200131020-00004","article-title":"The cytokine response to physical activity and training","volume":"31","author":"Moldoveanu","year":"2001","journal-title":"Sport. Med."},{"key":"10.1016\/j.bbr.2025.115718_bib63","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/S0893-133X(00)00226-8","article-title":"J. Weidenfeld, Effects of antidepressant drugs on the behavioral and physiological responses to lipopolysaccharide (LPS) in rodents","volume":"24","author":"Yirmiya","year":"2001","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2025.115718_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2020.135000","article-title":"Regulation of microglia by neuromodulators: modulations in major and minor modes","volume":"733","author":"Albertini","year":"2020","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbr.2025.115718_bib65","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3233\/BPL-180069","article-title":"The neuroprotective effects of exercise: maintaining a healthy brain throughout aging","volume":"4","author":"Vecchio","year":"2018","journal-title":"Brain Plast."},{"key":"10.1016\/j.bbr.2025.115718_bib66","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1186\/s12974-015-0362-0","article-title":"Voluntary exercise attenuates LPS-induced reductions in neurogenesis and increases microglia expression of a proneurogenic phenotype in aged mice","volume":"12","author":"Littlefield","year":"2015","journal-title":"J. Neuroinflamm."},{"key":"10.1016\/j.bbr.2025.115718_bib67","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.jshs.2024.02.002","article-title":"The anti-inflammatory effects of exercise on autoimmune diseases: a 20-year systematic review","volume":"13","author":"Luo","year":"2024","journal-title":"J. Sport Health Sci."},{"key":"10.1016\/j.bbr.2025.115718_bib68","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.cyto.2017.10.001","article-title":"T-cells and their cytokine production: the anti-inflammatory and immunosuppressive effects of strenuous exercise","volume":"104","author":"Shaw","year":"2017","journal-title":"Cytokine"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432825003055?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432825003055?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,18]],"date-time":"2025-08-18T06:14:58Z","timestamp":1755497698000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432825003055"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":68,"alternative-id":["S0166432825003055"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2025.115718","relation":{},"ISSN":["0166-4328"],"issn-type":[{"type":"print","value":"0166-4328"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effects of acute treadmill running following administration of lipopolysaccharide on subsequent changes in microglial activation and depressive-like behavior in rats","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2025.115718","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"115718"}}