{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T21:05:40Z","timestamp":1779311140272,"version":"3.51.4"},"reference-count":84,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003810","name":"Hospital de Cl\u00ednicas de Porto Alegre","doi-asserted-by":"publisher","award":["13-0047"],"award-info":[{"award-number":["13-0047"]}],"id":[{"id":"10.13039\/501100003810","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018824","name":"Instituto Nacional de Ci\u00eancia e Tecnologia em Neuroimunomodula\u00e7\u00e3o","doi-asserted-by":"publisher","award":["465489\/2014-1"],"award-info":[{"award-number":["465489\/2014-1"]}],"id":[{"id":"10.13039\/501100018824","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.bbr.2025.115721","type":"journal-article","created":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T02:59:28Z","timestamp":1751684368000},"page":"115721","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Placental alterations related to neurodevelopmental and associated disorders"],"prefix":"10.1016","volume":"494","author":[{"given":"Isabela","family":"Drehmer","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brayan","family":"Braz-Barbosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmem","family":"Gottfried","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00falio","family":"Santos-Terra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iohanna","family":"Deckmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2025.115721_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ejogrb.2013.05.005","article-title":"Global and regional estimates of preeclampsia and eclampsia: a systematic review","volume":"170","author":"Abalos","year":"2013","journal-title":"Eur. J. Obstet. Gynecol. Reprod. Biol."},{"key":"10.1016\/j.bbr.2025.115721_bib2","doi-asserted-by":"crossref","first-page":"528","DOI":"10.3109\/15622975.2011.639803","article-title":"Amniotic fluid inflammatory cytokines: potential markers of immunologic dysfunction in autism spectrum disorders","volume":"14","author":"Abdallah","year":"2013","journal-title":"World J. Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2025.115721_bib3","doi-asserted-by":"crossref","DOI":"10.1002\/jcla.22834","article-title":"Association of pro- and anti-inflammatory cytokines in preeclampsia","volume":"33","author":"Aggarwal","year":"2019","journal-title":"J. Clin. Lab. Anal."},{"key":"10.1016\/j.bbr.2025.115721_bib4","series-title":"Diagnostic and statistical manual of mental disorders: DSM-5\u2122. 5th ed. Washington","author":"American Psychiatric Association","year":"2013"},{"key":"10.1016\/j.bbr.2025.115721_bib5","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1038\/s41574-020-0372-6","article-title":"Tracking placental development in health and disease","volume":"16","author":"Aplin","year":"2020","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.bbr.2025.115721_bib6","doi-asserted-by":"crossref","first-page":"2307","DOI":"10.1042\/CS20190070","article-title":"Epigenetic processes during preeclampsia and effects on fetal development and chronic health","volume":"135","author":"Ashraf","year":"2021","journal-title":"Clin. Sci."},{"key":"10.1016\/j.bbr.2025.115721_bib7","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1186\/s12916-022-02699-1","article-title":"Chromatin modifier developmental pluripotency associated factor 4 (DPPA4) is a candidate gene for alcohol-induced developmental disorders","volume":"20","author":"Auvinen","year":"2022","journal-title":"BMC Med"},{"key":"10.1016\/j.bbr.2025.115721_bib8","first-page":"8150","article-title":"Artificial intelligence and placental DNA methylation: newborn prediction and molecular mechanisms of autism in preterm children","volume":"35","author":"Bahado-Singh","year":"2022","journal-title":"J. Matern. Fetal Neonatal Med. Off. J. Eur. Assoc. Perinat. Med. Fed. Asia Ocean. Perinat. Soc. Int. Soc. Perinat. Obstet."},{"key":"10.1016\/j.bbr.2025.115721_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2021.775390","article-title":"Autism-associated DNA Methylation at birth from multiple tissues is enriched for autism genes in the early autism risk longitudinal investigation","volume":"14","author":"Bakulski","year":"2021","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.bbr.2025.115721_bib10","series-title":"Comprehensive Guide to Autism","first-page":"1779","article-title":"Prenatal Exposure to Valproate in Animals and Autism","author":"Bambini-Junior","year":"2014"},{"key":"10.1016\/j.bbr.2025.115721_bib11","article-title":"Immunologic aspects of preeclampsia","volume":"4","author":"Boulanger","year":"2024","journal-title":"AJOG Glob. Rep."},{"key":"10.1016\/j.bbr.2025.115721_bib12","first-page":"24","article-title":"on behalf of the international society for the study of hypertension in pregnancy (ISSHP)","volume":"72","author":"Brown","year":"2018","journal-title":"Hypertens. Disord. Pregnancy Hypertens."},{"issue":"4","key":"10.1016\/j.bbr.2025.115721_bib13","article-title":"A narrative review on the effect of valproic acid on the placenta","volume":"117","author":"Brown","year":"2025","journal-title":"Birth Defects Res. Apr"},{"key":"10.1016\/j.bbr.2025.115721_bib14","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1080\/14767050701298365","article-title":"Ethanol and the placenta: a review","volume":"20","author":"Burd","year":"2007","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"10.1016\/j.bbr.2025.115721_bib15","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1111\/acer.13808","article-title":"Alcohol-related alterations in placental imprinted gene expression in humans mediate effects of prenatal alcohol exposure on postnatal growth","volume":"42","author":"Carter","year":"2018","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.bbr.2025.115721_bib16","unstructured":"Centers for Disease Control and Prevention (CDC), 2024. Data and Statistics on ADHD. Available in: https:\/\/www.cdc.gov\/ncbddd\/adhd\/data\/diagnosis-treatment-data.html."},{"key":"10.1016\/j.bbr.2025.115721_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.jmb.2024.168454","article-title":"Serotonin transporter-dependent histone serotonylation in placenta contributes to the neurodevelopmental transcriptome","volume":"436","author":"Chan","year":"2024","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bbr.2025.115721_bib18","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/s12911-017-0564-8","article-title":"Autism risk classification using placental chorionic surface vascular network features","volume":"17","author":"Chang","year":"2017","journal-title":"BMC Med. Inform. Decis. Mak."},{"key":"10.1016\/j.bbr.2025.115721_bib19","doi-asserted-by":"crossref","DOI":"10.1093\/bfgp\/elw018","article-title":"Methods for identifying differentially methylated regions for sequence- and array-based data","author":"Chen","year":"2016","journal-title":"Brief. Funct. Genom. 15 485490."},{"key":"10.1016\/j.bbr.2025.115721_bib20","first-page":"1179545","article-title":"Preeclampsia: from inflammation to immunoregulation","volume":"11","author":"Cornelius","year":"2018","journal-title":"Clin. Med. Insights Blood Disord."},{"key":"10.1016\/j.bbr.2025.115721_bib21","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1111\/acer.13448","article-title":"Placental proteomics reveal insights into fetal alcohol spectrum disorders","volume":"41","author":"Davis-Anderson","year":"2017","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.bbr.2025.115721_bib22","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/s41581-022-00670-0","article-title":"The role of immune cells and mediators in preeclampsia","volume":"19","author":"Deer","year":"2023","journal-title":"Nat. Rev. Nephrol."},{"key":"10.1016\/j.bbr.2025.115721_bib23","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1111\/j.1530-0277.2012.01757.x","article-title":"Gene expression changes in C57BL\/6J and DBA\/2J mice following prenatal alcohol exposure","volume":"36","author":"Downing","year":"2012","journal-title":"Alcohol. Clin. Exp. Res"},{"key":"10.1016\/j.bbr.2025.115721_bib24","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.alcohol.2010.07.006","article-title":"Subtle decreases in DNA methylation and gene expression at the mouse Igf2 locus following prenatal alcohol exposure: effects of a methyl-supplemented diet","volume":"45","author":"Downing","year":"2011","journal-title":"Alcohol Fayettev. N."},{"issue":"20","key":"10.1016\/j.bbr.2025.115721_bib25","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1002\/bdr2.2119","article-title":"Prenatal epigenetic factors are predisposing for neurodevelopmental disorders-considering placenta as a model","volume":"114","author":"Durbagula","year":"2022","journal-title":"Birth Defects Res"},{"key":"10.1016\/j.bbr.2025.115721_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2022.842755","article-title":"Neuronal cell adhesion molecules may mediate neuroinflammation in autism spectrum disorder","volume":"13","author":"Eve","year":"2022","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.bbr.2025.115721_bib27","doi-asserted-by":"crossref","first-page":"677","DOI":"10.3390\/genes14030677","article-title":"The autism spectrum: behavioral, psychiatric and genetic associations","volume":"14","author":"Genovese","year":"2023","journal-title":"Genes"},{"key":"10.1016\/j.bbr.2025.115721_bib28","doi-asserted-by":"crossref","first-page":"121","DOI":"10.3389\/fpsyt.2015.00121","article-title":"The impact of neuroimmune alterations in autism spectrum disorder","volume":"6","author":"Gottfried","year":"2015","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.bbr.2025.115721_bib29","first-page":"4418","article-title":"Elevated maternal IL-16 Levels, enhanced IL-16 expressions in endothelium and leukocytes, and increased IL-16 production by placental trophoblasts in women with preeclampsia","volume":"181","author":"Gu","year":"2008","journal-title":"J. Immunol. Baltim. Md 1950"},{"key":"10.1016\/j.bbr.2025.115721_bib30","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.placenta.2007.10.002","article-title":"Impaired placentation in fetal alcohol syndrome","volume":"29","author":"Gundogan","year":"2008","journal-title":"Placenta"},{"key":"10.1016\/j.bbr.2025.115721_bib31","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1016\/j.placenta.2015.02.010","article-title":"Dose effect of gestational ethanol exposure on placentation and fetal growth","volume":"36","author":"Gundogan","year":"2015","journal-title":"Placenta"},{"key":"10.1016\/j.bbr.2025.115721_bib32","doi-asserted-by":"crossref","first-page":"1594","DOI":"10.1111\/acer.13135","article-title":"An update on fetal alcohol syndrome-pathogenesis, risks, and treatment","volume":"40","author":"Gupta","year":"2016","journal-title":"Alcohol Clin. Exp. Res"},{"key":"10.1016\/j.bbr.2025.115721_bib33","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.bbi.2020.07.019","article-title":"Evaluation of maternal inflammation as a marker of future offspring ADHD symptoms: a prospective investigation","volume":"89","author":"Gustafsson","year":"2020","journal-title":"Brain. Behav. Immun."},{"key":"10.1016\/j.bbr.2025.115721_bib34","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1095\/biolreprod.109.082412","article-title":"Human pregnancy specific beta-1-glycoprotein 1 (PSG1) has a potential role in placental vascular morphogenesis1","volume":"83","author":"Ha","year":"2010","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.bbr.2025.115721_bib35","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/0002-9378(86)90286-3","article-title":"\u03b1-Fetoprotein, human placental lactogen, and pregnancy-specific \u03b21-glycoprotein in pregnant women who drink: relation to fetal alcohol syndrome","volume":"155","author":"Halmesm\u00e4ki","year":"1986","journal-title":"Am J. Obstet. Gynecol."},{"key":"10.1016\/j.bbr.2025.115721_bib36","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1038\/s41582-021-00530-8","article-title":"Maternal immune activation and neuroinflammation in human neurodevelopmental disorders","volume":"17","author":"Han","year":"2021","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.bbr.2025.115721_bib37","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41576-019-0169-4","article-title":"Mechanisms of early placental development in mouse and humans","volume":"21","author":"Hemberger","year":"2020","journal-title":"Nat. Rev. Genet"},{"key":"10.1016\/j.bbr.2025.115721_bib38","series-title":"In: StatPearls. StatPearls Publishing","article-title":"Embryology, Placenta","author":"Herrick","year":"2024"},{"key":"10.1016\/j.bbr.2025.115721_bib39","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1002\/bdr2.1488","article-title":"The association between prenatal alcohol exposure and protein expression in human placenta","volume":"111","author":"Holbrook","year":"2019","journal-title":"Birth Defects Res"},{"key":"10.1016\/j.bbr.2025.115721_bib40","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.molmed.2018.06.008","article-title":"The impact of systemic inflammation on neurodevelopment","volume":"24","author":"Jiang","year":"2018","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.bbr.2025.115721_bib41","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.placenta.2015.05.011","article-title":"Prenatal ethanol exposure and placental hCG and IGF2 expression","volume":"36","author":"Joya","year":"2015","journal-title":"Placenta"},{"key":"10.1016\/j.bbr.2025.115721_bib42","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1007\/s12519-022-00524-6","article-title":"Prenatal risk factors and genetic causes of ADHD in children","volume":"18","author":"Kian","year":"2022","journal-title":"World J. Pediatr. WJP"},{"key":"10.1016\/j.bbr.2025.115721_bib43","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.placenta.2020.10.014","article-title":"Trophoblast inclusions in the human placenta: identification, characterization, quantification, and interrelations of subtypes","volume":"103","author":"Kliman","year":"2021","journal-title":"Placenta"},{"key":"10.1016\/j.bbr.2025.115721_bib44","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.alcohol.2019.11.003","article-title":"Maternal iron nutriture modulates placental development in a rat model of fetal alcohol spectrum disorder","volume":"84","author":"Kwan","year":"2020","journal-title":"Alcohol Fayettev. N."},{"issue":"1","key":"10.1016\/j.bbr.2025.115721_bib45","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s40478-017-0444-6","article-title":"PLGF, a placental marker of fetal brain defects after in utero alcohol exposure","volume":"5","author":"Lecuyer","year":"2017","journal-title":"Acta Neuropathol. Commun."},{"key":"10.1016\/j.bbr.2025.115721_bib46","doi-asserted-by":"crossref","first-page":"5","DOI":"10.3390\/v12010005","article-title":"Recent updates on research models and tools to study virus\u2013host interactions at the placenta","volume":"12","author":"Lee","year":"2020","journal-title":"Viruses"},{"key":"10.1016\/j.bbr.2025.115721_bib47","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.ymeth.2020.10.002","article-title":"DNA methylation methods: global DNA methylation and methylomic analyses","volume":"187","author":"Li","year":"2021","journal-title":"Methods San. Diego Calif."},{"key":"10.1016\/j.bbr.2025.115721_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2021.152848","article-title":"Prenatal ethanol exposure increases maternal bile acids through placental transport pathway","volume":"458","author":"Liu","year":"2021","journal-title":"Toxicology"},{"key":"10.1016\/j.bbr.2025.115721_bib49","doi-asserted-by":"crossref","first-page":"291","DOI":"10.2217\/epi-2016-0163","article-title":"Epigenetics studies of fetal alcohol spectrum disorder: where are we now?","volume":"9","author":"Lussier","year":"2017","journal-title":"Epigenomics"},{"key":"10.1016\/j.bbr.2025.115721_bib50","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2024.1385154","article-title":"Unveiling immune tolerance pathways in preeclampsia placenta: implications for molecular targets and discovery of potential biomarkers","volume":"15","author":"Ma","year":"2024","journal-title":"Front Endocrinol."},{"key":"10.1016\/j.bbr.2025.115721_bib51","doi-asserted-by":"crossref","first-page":"1","DOI":"10.15585\/mmwr.ss7202a1","article-title":"Prevalence and characteristics of autism spectrum disorder among children aged 8 years \u2014 autism and developmental disabilities monitoring network, 11 sites, United States, 2020","volume":"72","author":"Maenner","year":"2023","journal-title":"MMWR Surveill. Summ."},{"key":"10.1016\/j.bbr.2025.115721_bib52","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1001\/jamapsychiatry.2018.0854","article-title":"Association of hypertensive disorders of pregnancy with risk of neurodevelopmental disorders in offspring","volume":"75","author":"Maher","year":"2018","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.bbr.2025.115721_bib53","doi-asserted-by":"crossref","DOI":"10.1093\/hropen\/hox014","article-title":"rs10732516 polymorphism at the IGF2\/H19 locus associates with a genotype-specific trend in placental DNA methylation and head circumference of prenatally alcohol-exposed newborns","volume":"2017","author":"Marjonen","year":"2017","journal-title":"Hum. Reprod. Open"},{"key":"10.1016\/j.bbr.2025.115721_bib54","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0197461","article-title":"Early prenatal alcohol exposure alters imprinted gene expression in placenta and embryo in a mouse model","volume":"13","author":"Marjonen","year":"2018","journal-title":"PloS One"},{"key":"10.1016\/j.bbr.2025.115721_bib55","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2016-0517","article-title":"Objective measures of prenatal alcohol exposure: a systematic review","volume":"138","author":"McQuire","year":"2016","journal-title":"Pediatrics"},{"key":"10.1016\/j.bbr.2025.115721_bib56","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1387\/ijdb.130329gd","article-title":"Pregnancy-specific glycoproteins: complex gene families regulating maternal-fetal interactions","volume":"58","author":"Moore","year":"2014","journal-title":"Int. J. Dev. Biol."},{"key":"10.1016\/j.bbr.2025.115721_bib57","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.ab.2011.06.038","article-title":"Ethyl-glucuronide and ethyl-sulfate in placental and fetal tissues by liquid chromatography coupled with tandem mass spectrometry","volume":"418","author":"Morini","year":"2011","journal-title":"Anal. Biochem"},{"key":"10.1016\/j.bbr.2025.115721_bib58","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1038\/npp.2016.166","article-title":"Impact of maternal serotonin transporter genotype on placental serotonin, fetal forebrain serotonin, and neurodevelopment","volume":"42","author":"Muller","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2025.115721_bib59","unstructured":"National Center for Biotechnology Information (NCBI), 2024. DLL1 delta like canonical Notch ligand 1 [ Homo sapiens (human)]. Available in: https:\/\/www.ncbi.nlm.nih.gov\/gene\/28514."},{"key":"10.1016\/j.bbr.2025.115721_bib60","doi-asserted-by":"crossref","first-page":"4092","DOI":"10.3390\/ijms21114092","article-title":"Endometrial decidualization: the primary driver of pregnancy health","volume":"21","author":"Ng","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbr.2025.115721_bib61","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.749026","article-title":"From neurodevelopmental to neurodegenerative disorders: the vascular continuum","volume":"13","author":"Ouellette","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.bbr.2025.115721_bib62","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1111\/acer.14846","article-title":"Prenatal alcohol exposure contributes to negative pregnancy outcomes by altering fetal vascular dynamics and the placental transcriptome","volume":"46","author":"Pinson","year":"2022","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.bbr.2025.115721_bib63","first-page":"1","article-title":"Fetal alcohol spectrum disorders","volume":"9","author":"Popova","year":"2023","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.bbr.2025.115721_bib64","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.placenta.2019.06.374","article-title":"Preterm birth subtypes, placental pathology findings, and risk of neurodevelopmental disabilities during childhood","volume":"83","author":"Raghavan","year":"2019","journal-title":"Placenta"},{"key":"10.1016\/j.bbr.2025.115721_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2023.106119","article-title":"Placenta DNA methylation levels of the promoter region of the leptin receptor gene are associated with infant cortisol","volume":"153","author":"Reid","year":"2023","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbr.2025.115721_bib66","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.alcohol.2009.10.002","article-title":"Effects of moderate drinking during pregnancy on placental gene expression","volume":"44","author":"Rosenberg","year":"2010","journal-title":"Alcohol Fayettev. N."},{"key":"10.1016\/j.bbr.2025.115721_bib67","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1002\/jnr.24603","article-title":"The placenta-brain-axis","volume":"99","author":"Rosenfeld","year":"2021","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bbr.2025.115721_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2022.114057","article-title":"Effects of prenatal opioid and alcohol exposures on immune and serotonin factors in human placenta","volume":"353","author":"Ruyak","year":"2022","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbr.2025.115721_bib69","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1001\/jama.2017.12141","article-title":"The heritability of autism spectrum disorder","volume":"318","author":"Sandin","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.bbr.2025.115721_bib70","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/s13229-020-00402-w","article-title":"Evidence for the placenta-brain axis: multi-omic kernel aggregation predicts intellectual and social impairment in children born extremely preterm","volume":"11","author":"Santos Jr","year":"2020","journal-title":"Mol. Autism"},{"key":"10.1016\/j.bbr.2025.115721_bib71","doi-asserted-by":"crossref","first-page":"519","DOI":"10.3389\/fnins.2020.00519","article-title":"Ethanol-induced alterations in placental and fetal cerebrocortical annexin-A4 and cerebral cavernous malformation protein 3 are associated with reductions in fetal cortical VEGF receptor binding and microvascular density","volume":"14","author":"Savage","year":"2020","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.bbr.2025.115721_bib72","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/s13229-016-0114-8","article-title":"Placental methylome analysis from a prospective autism study","volume":"7","author":"Schroeder","year":"2016","journal-title":"Mol. Autism"},{"key":"10.1016\/j.bbr.2025.115721_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2020.104797","article-title":"Prenatal pregnancy-related anxiety predicts boys\u2019 ADHD symptoms via placental C-reactive protein","volume":"120","author":"Shao","year":"2020","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbr.2025.115721_bib74","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1111\/j.1530-0277.2010.01373.x","article-title":"Candidate placental biomarkers for intrauterine alcohol exposure","volume":"35","author":"Shukla","year":"2011","journal-title":"Alcohol. Clin. Exp. Res."},{"key":"10.1016\/j.bbr.2025.115721_bib75","doi-asserted-by":"crossref","first-page":"2877","DOI":"10.1523\/JNEUROSCI.2272-17.2018","article-title":"Maternal immune activation during the third trimester is associated with neonatal functional connectivity of the salience network and fetal to toddler behavior","volume":"38","author":"Spann","year":"2018","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2025.115721_bib76","doi-asserted-by":"crossref","first-page":"607.e1","DOI":"10.1016\/j.ajog.2021.06.078","article-title":"Prenatal alcohol consumption and placental outcomes: a systematic review and meta-analysis of clinical studies","volume":"225","author":"Steane","year":"2021","journal-title":"Am. J. Obstet. Gynecol."},{"key":"10.1016\/j.bbr.2025.115721_bib77","article-title":"Placental morphology in fetal alcohol spectrum disorders","author":"Tai","year":"2017","journal-title":"Alcohol Alcohol 52 138144"},{"key":"10.1016\/j.bbr.2025.115721_bib78","doi-asserted-by":"crossref","first-page":"20150123","DOI":"10.1098\/rstb.2015.0123","article-title":"An examination of sex differences in the effects of early-life opiate and alcohol exposure","volume":"371","author":"Terasaki","year":"2016","journal-title":"Philos. Trans. R. Soc. B Biol. Sci."},{"key":"10.1016\/j.bbr.2025.115721_bib79","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.biopsych.2013.03.006","article-title":"Trophoblast inclusions are significantly increased in the placentas of children in families at risk for autism","volume":"74","author":"Walker","year":"2013","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2025.115721_bib80","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1007\/s43032-020-00413-1","article-title":"Alterations to placental glucocorticoid receptor expression with alcohol consumption","volume":"28","author":"Young","year":"2021","journal-title":"Reprod. Sci. Thousand Oaks Calif."},{"key":"10.1016\/j.bbr.2025.115721_bib81","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.taap.2018.05.029","article-title":"cAMP\/PKA\/EGR1 signaling mediates the molecular mechanism of ethanol-induced inhibition of placental 11\u03b2-HSD2 expression","volume":"352","author":"Yu","year":"2018","journal-title":"Toxicol. Appl. Pharm."},{"key":"10.1016\/j.bbr.2025.115721_bib82","doi-asserted-by":"crossref","DOI":"10.1016\/j.tox.2019.152237","article-title":"Prenatal ethanol exposure-induced a low level of foetal blood cholesterol and its mechanism of IGF1-related placental cholesterol transport dysfunction","volume":"424","author":"Zhang","year":"2019","journal-title":"Toxicology"},{"key":"10.1016\/j.bbr.2025.115721_bib83","article-title":"Regulators involved in trophoblast syncytialization in the placenta of intrauterine growth restriction","volume":"14","author":"Zhou","year":"2023","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.bbr.2025.115721_bib84","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1093\/hmg\/ddz084","article-title":"Placental DNA methylation levels at CYP2E1 and IRS2 are associated with child outcome in a prospective autism study","volume":"28","author":"Zhu","year":"2019","journal-title":"Hum. Mol. Genet"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432825003080?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432825003080?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,27]],"date-time":"2026-04-27T04:33:21Z","timestamp":1777264401000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432825003080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":84,"alternative-id":["S0166432825003080"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2025.115721","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Placental alterations related to neurodevelopmental and associated disorders","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2025.115721","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115721"}}