{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T14:11:36Z","timestamp":1773324696891,"version":"3.50.1"},"reference-count":142,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","award":["2025SF-YBXM-243"],"award-info":[{"award-number":["2025SF-YBXM-243"]}],"id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017592","name":"Key Science and Technology Program of Shaanxi Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017592","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32360891"],"award-info":[{"award-number":["32360891"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.bbr.2025.115900","type":"journal-article","created":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T00:06:06Z","timestamp":1761696366000},"page":"115900","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Bidirectional regulatory mechanisms and targeted therapeutic strategies of the microbiota in ischemic stroke"],"prefix":"10.1016","volume":"497","author":[{"given":"Bingbing","family":"Wang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yibo","family":"Jia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Can","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shenghao","family":"Qian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caizhen","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Dan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianyu","family":"Zhai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yajuan","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bobo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.bbr.2025.115900_bib1","doi-asserted-by":"crossref","first-page":"466","DOI":"10.4103\/NRR.NRR-D-24-00777","article-title":"Tryptophan metabolism and ischemic stroke: an intricate balance","volume":"21","author":"Yao","year":"2026","journal-title":"Neural Regen. Res"},{"issue":"2","key":"10.1016\/j.bbr.2025.115900_bib2","doi-asserted-by":"crossref","first-page":"443","DOI":"10.4103\/NRR.NRR-D-24-01166","article-title":"Microglial intervention in ischemic stroke: roles and intervention strategies","volume":"21","author":"Ji","year":"2026","journal-title":"Neural Regen. Res."},{"issue":"9","key":"10.1016\/j.bbr.2025.115900_bib3","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.124.038862","article-title":"Host-microbial cometabolite ursodeoxycholic acid protects against poststroke cognitive impairment","volume":"14","author":"Gao","year":"2025","journal-title":"J. Am. Heart Assoc."},{"issue":"1","key":"10.1016\/j.bbr.2025.115900_bib4","doi-asserted-by":"crossref","first-page":"2486518","DOI":"10.1080\/19490976.2025.2486518","article-title":"Microbial diversity and fitness in the gut-brain axis: influences on developmental risk for Alzheimer's disease","volume":"17","author":"Jamerlan","year":"2025","journal-title":"Gut Microbes"},{"issue":"1","key":"10.1016\/j.bbr.2025.115900_bib5","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s40001-022-00691-2","article-title":"Ischemic stroke and intestinal flora: an insight into brain-gut axis","volume":"27","author":"Hu","year":"2022","journal-title":"Eur. J. Med Res"},{"key":"10.1016\/j.bbr.2025.115900_bib6","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.neuroscience.2025.02.004","article-title":"Multidimensional-based exploration of gut microbial and metabolite differences in patients with recurrent stroke","volume":"572","author":"Fang","year":"2025","journal-title":"Neuroscience"},{"issue":"5","key":"10.1016\/j.bbr.2025.115900_bib7","doi-asserted-by":"crossref","DOI":"10.1128\/msystems.01492-24","article-title":"Hypercoagulable state and gut microbiota dysbiosis as predictors of poor functional outcomes in acute ischemic stroke patients","volume":"10","author":"Li","year":"2025","journal-title":"mSystems"},{"key":"10.1016\/j.bbr.2025.115900_bib8","doi-asserted-by":"crossref","first-page":"965","DOI":"10.2147\/NDT.S507156","article-title":"Potential inflammatory biomarkers and differential gut microbiota in cognitive impairment after ischemic stroke","volume":"21","author":"Wu","year":"2025","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.bbr.2025.115900_bib9","doi-asserted-by":"crossref","first-page":"4","DOI":"10.3389\/fcimb.2019.00004","article-title":"Higher risk of stroke is correlated with increased opportunistic pathogen load and reduced levels of butyrate-producing bacteria in the gut","volume":"9","author":"Zeng","year":"2019","journal-title":"Front. Cell Infect. Microbiol"},{"issue":"28","key":"10.1016\/j.bbr.2025.115900_bib10","doi-asserted-by":"crossref","first-page":"7428","DOI":"10.1523\/JNEUROSCI.1114-16.2016","article-title":"Microbiota dysbiosis controls the neuroinflammatory response after stroke","volume":"36","author":"Singh","year":"2016","journal-title":"J. Neurosci."},{"issue":"5","key":"10.1016\/j.bbr.2025.115900_bib11","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.cell.2019.03.036","article-title":"A forward chemical genetic screen reveals gut microbiota metabolites that modulate host physiology","volume":"177","author":"Chen","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.bbr.2025.115900_bib12","doi-asserted-by":"crossref","first-page":"1557746","DOI":"10.3389\/fncel.2025.1557746","article-title":"Intestinal injury and changes of the gut microbiota after ischemic stroke","volume":"19","author":"Shen","year":"2025","journal-title":"Front Cell Neurosci."},{"key":"10.1016\/j.bbr.2025.115900_bib13","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.neulet.2017.08.061","article-title":"Ischemic stroke damages the intestinal mucosa and induces alteration of the intestinal lymphocytes and CCL19 mRNA in rats","volume":"658","author":"Liu","year":"2017","journal-title":"Neurosci. Lett."},{"issue":"11","key":"10.1016\/j.bbr.2025.115900_bib14","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1038\/nm.4194","article-title":"Translocation and dissemination of commensal bacteria in post-stroke infection","volume":"22","author":"Stanley","year":"2016","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbr.2025.115900_bib15","doi-asserted-by":"crossref","first-page":"1315797","DOI":"10.1155\/2021\/1315797","article-title":"Exploratory investigation of intestinal structure and function after stroke in mice","volume":"2021","author":"Ye","year":"2021","journal-title":"Mediat. Inflamm."},{"issue":"1","key":"10.1016\/j.bbr.2025.115900_bib16","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/s41598-017-18904-8","article-title":"An insight into intestinal mucosal microbiota disruption after stroke","volume":"8","author":"Stanley","year":"2018","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.bbr.2025.115900_bib17","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/iep.12263","article-title":"Focal, but not global, cerebral ischaemia causes loss of myenteric neurons and upregulation of vasoactive intestinal peptide in mouse ileum","volume":"99","author":"Cheng","year":"2018","journal-title":"Int. J. Exp. Pathol."},{"key":"10.1016\/j.bbr.2025.115900_bib18","doi-asserted-by":"crossref","first-page":"1081347","DOI":"10.3389\/fnins.2023.1081347","article-title":"Gut-brain axis: mechanisms and potential therapeutic strategies for ischemic stroke through immune functions","volume":"17","author":"Zhou","year":"2023","journal-title":"Front. Neurosci."},{"issue":"6","key":"10.1016\/j.bbr.2025.115900_bib19","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1007\/s10571-019-00687-3","article-title":"Neuroprotection of resveratrol against focal cerebral ischemia\/reperfusion injury in mice through a mechanism targeting gut-brain axis","volume":"39","author":"Dou","year":"2019","journal-title":"Cell Mol. Neurobiol."},{"issue":"1","key":"10.1016\/j.bbr.2025.115900_bib20","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s40200-025-01560-5","article-title":"Diabetic wounds and short-chain fatty acids","volume":"24","author":"Rezaeiasl","year":"2025","journal-title":"J. Diabetes Metab. Disord."},{"issue":"11","key":"10.1016\/j.bbr.2025.115900_bib21","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1136\/thorax-2021-217923","article-title":"Gut microbiota composition and metabolite profiling in smokers: a comparative study between emphysema and asymptomatic individuals with therapeutic implications","volume":"78","author":"Lee","year":"2023","journal-title":"Thorax"},{"issue":"7","key":"10.1016\/j.bbr.2025.115900_bib22","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/j.chom.2021.05.002","article-title":"Gut microbes impact stroke severity via the trimethylamine N-oxide pathway","volume":"29","author":"Zhu","year":"2021","journal-title":"Cell Host Microbe"},{"issue":"2","key":"10.1016\/j.bbr.2025.115900_bib23","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11020431","article-title":"Contribution of trimethylamine N-Oxide (TMAO) to chronic inflammatory and degenerative diseases","volume":"11","author":"Constantino-Jonapa","year":"2023","journal-title":"Biomedicines"},{"issue":"6","key":"10.1016\/j.bbr.2025.115900_bib24","doi-asserted-by":"crossref","first-page":"1741","DOI":"10.1053\/j.gastro.2018.08.022","article-title":"FXR-dependent modulation of the human small intestinal microbiome by the bile acid derivative obeticholic acid","volume":"155","author":"Friedman","year":"2018","journal-title":"Gastroenterology"},{"issue":"5","key":"10.1016\/j.bbr.2025.115900_bib25","doi-asserted-by":"crossref","first-page":"1935","DOI":"10.1210\/jc.2015-2583","article-title":"Increased BIle Acid Synthesis and Impaired Bile Acid Transport in Human Obesity","volume":"101","author":"Haeusler","year":"2016","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1","key":"10.1016\/j.bbr.2025.115900_bib26","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1080\/13880209.2022.2136209","article-title":"Mechanism of Huangqi-Honghua combination regulating the gut microbiota to affect bile acid metabolism towards preventing cerebral ischaemia-reperfusion injury in rats","volume":"60","author":"Wang","year":"2022","journal-title":"Pharm. Biol."},{"issue":"4","key":"10.1016\/j.bbr.2025.115900_bib27","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1038\/s41590-021-00894-5","article-title":"Fibroblastic reticular cell lineage convergence in Peyer's patches governs intestinal immunity","volume":"22","author":"Prados","year":"2021","journal-title":"Nat. Immunol."},{"issue":"49","key":"10.1016\/j.bbr.2025.115900_bib28","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.aat7117","article-title":"Gut T cell-independent IgA responses to commensal bacteria require engagement of the TACI receptor on B cells","volume":"5","author":"Grasset","year":"2020","journal-title":"Sci. Immunol."},{"issue":"4","key":"10.1016\/j.bbr.2025.115900_bib29","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1161\/CIRCRESAHA.119.316448","article-title":"Gut microbiota-derived short-chain fatty acids promote poststroke recovery in aged mice","volume":"127","author":"Lee","year":"2020","journal-title":"Circ. Res."},{"issue":"5","key":"10.1016\/j.bbr.2025.115900_bib30","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/nm.4068","article-title":"Commensal microbiota affects ischemic stroke outcome by regulating intestinal gammadelta T cells","volume":"22","author":"Benakis","year":"2016","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.bbr.2025.115900_bib31","doi-asserted-by":"crossref","first-page":"14046","DOI":"10.1038\/s41598-025-97432-2","article-title":"Association of gut microbiota and immunometabolic profiles with ischemic stroke severity","volume":"15","author":"Pilon","year":"2025","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.bbr.2025.115900_bib32","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1084\/jem.20180794","article-title":"Microbiome-microglia connections via the gut-brain axis","volume":"216","author":"Abdel-Haq","year":"2019","journal-title":"J. Exp. Med."},{"issue":"5","key":"10.1016\/j.bbr.2025.115900_bib33","doi-asserted-by":"crossref","first-page":"1007","DOI":"10.4103\/1673-5374.324839","article-title":"Gut-brain axis in traumatic brain injury: impact on neuroinflammation","volume":"17","author":"Celorrio","year":"2022","journal-title":"Neural Regen. Res."},{"issue":"1","key":"10.1016\/j.bbr.2025.115900_bib34","doi-asserted-by":"crossref","first-page":"2506843","DOI":"10.1080\/19490976.2025.2506843","article-title":"Microbiome signatures of virulence in the oral-gut-brain axis influence Parkinson's disease and cognitive decline pathophysiology","volume":"17","author":"Clasen","year":"2025","journal-title":"Gut Microbes"},{"issue":"1","key":"10.1016\/j.bbr.2025.115900_bib35","doi-asserted-by":"crossref","first-page":"11535","DOI":"10.1038\/s41598-025-95728-x","article-title":"Oral microbiome dysbiosis in cryptogenic ischemic stroke patients with high-risk patent foramen ovale","volume":"15","author":"Manzoor","year":"2025","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.bbr.2025.115900_bib36","doi-asserted-by":"crossref","first-page":"ycae088","DOI":"10.1093\/ismeco\/ycae088","article-title":"Multikingdom oral microbiome interactions in early-onset cryptogenic ischemic stroke","volume":"4","author":"Manzoor","year":"2024","journal-title":"ISME Commun."},{"key":"10.1016\/j.bbr.2025.115900_bib37","doi-asserted-by":"crossref","first-page":"1171898","DOI":"10.3389\/fimmu.2023.1171898","article-title":"The oral microbiome of patients with ischemic stroke predicts their severity and prognosis","volume":"14","author":"Sun","year":"2023","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.bbr.2025.115900_bib38","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/BF00400967","article-title":"The levels and relations of prostaglandins in pregnant and non-pregnant tumor-bearing mice","volume":"115","author":"Mujagic","year":"1989","journal-title":"J. Cancer Res. Clin. Oncol."},{"issue":"1","key":"10.1016\/j.bbr.2025.115900_bib39","doi-asserted-by":"crossref","first-page":"2382620","DOI":"10.1080\/20002297.2024.2382620","article-title":"Association between oral microbial nitrate metabolism and poor prognosis in acute ischemic stroke patients with a history of hypertension","volume":"16","author":"Ren","year":"2024","journal-title":"J. Oral. Microbiol."},{"issue":"11","key":"10.1016\/j.bbr.2025.115900_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms10112288","article-title":"The spouses of stroke patients have a similar oral microbiome to their partners with an elevated risk of stroke","volume":"10","author":"Wang","year":"2022","journal-title":"Microorganisms"},{"issue":"5","key":"10.1016\/j.bbr.2025.115900_bib41","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1002\/JPER.21-0159","article-title":"Association of enhanced circulating trimethylamine N-oxide with vascular endothelial dysfunction in periodontitis patients","volume":"93","author":"Zhou","year":"2022","journal-title":"J. Periodo"},{"issue":"4","key":"10.1016\/j.bbr.2025.115900_bib42","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.cden.2024.07.002","article-title":"Systemic factors affecting prognosis in periodontics: part II","volume":"68","author":"Pitchumani","year":"2024","journal-title":"Dent. Clin. North Am."},{"issue":"1183","key":"10.1016\/j.bbr.2025.115900_bib43","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1093\/postmj\/qgad133","article-title":"Research progress on the association between trimethylamine\/trimethylamine-N-oxide and neurological disorders","volume":"100","author":"Xie","year":"2024","journal-title":"Post. Med. J."},{"issue":"1","key":"10.1016\/j.bbr.2025.115900_bib44","doi-asserted-by":"crossref","first-page":"2213112","DOI":"10.1080\/20002297.2023.2213112","article-title":"The interplay between oral microbiota, gut microbiota and systematic diseases","volume":"15","author":"Tan","year":"2023","journal-title":"J. Oral. Microbiol."},{"key":"10.1016\/j.bbr.2025.115900_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2024.122979","article-title":"Short-chain fatty acid on blood-brain barrier and glial function in ischemic stroke","volume":"354","author":"Mathias","year":"2024","journal-title":"Life Sci."},{"key":"10.1016\/j.bbr.2025.115900_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2020.113176","article-title":"Chronic periodontitis induces microbiota-gut-brain axis disorders and cognitive impairment in mice","volume":"326","author":"Xue","year":"2020","journal-title":"Exp. Neurol."},{"issue":"16","key":"10.1016\/j.bbr.2025.115900_bib47","doi-asserted-by":"crossref","first-page":"4103","DOI":"10.1128\/JB.00275-10","article-title":"The native 67-kilodalton minor fimbria of Porphyromonas gingivalis is a novel glycoprotein with DC-SIGN-targeting motifs","volume":"192","author":"Zeituni","year":"2010","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.bbr.2025.115900_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2024.115200","article-title":"Mechanisms of oral microflora in Parkinson's disease","volume":"474","author":"Wang","year":"2024","journal-title":"Behav. Brain Res."},{"issue":"4","key":"10.1016\/j.bbr.2025.115900_bib49","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.01085-22","article-title":"Bacterial signatures of cerebral thrombi in large vessel occlusion stroke","volume":"13","author":"Liao","year":"2022","journal-title":"mBio"},{"key":"10.1016\/j.bbr.2025.115900_bib50","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105277","article-title":"Dysbiosis is one of the risk factor for stroke and cognitive impairment and potential target for treatment","volume":"164","author":"Koszewicz","year":"2021","journal-title":"Pharm. Res."},{"issue":"1","key":"10.1016\/j.bbr.2025.115900_bib51","doi-asserted-by":"crossref","first-page":"2382620","DOI":"10.1080\/20002297.2024.2382620","article-title":"Association between oral microbial nitrate metabolism and poor prognosis in acute ischemic stroke patients with a history of hypertension","volume":"16","author":"Ren","year":"2024","journal-title":"J. Oral. Microbiol."},{"issue":"6","key":"10.1016\/j.bbr.2025.115900_bib52","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms12061057","article-title":"Oral administration of Lactobacillus acidophilus LA5 prevents alveolar bone loss and alters oral and gut microbiomes in a murine periodontitis experimental model","volume":"12","author":"Cataruci","year":"2024","journal-title":"Microorganisms"},{"key":"10.1016\/j.bbr.2025.115900_bib53","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/704202","article-title":"TLR2 and TLR4 in ischemia reperfusion injury","volume":"2010","author":"Arslan","year":"2010","journal-title":"Mediat. Inflamm."},{"issue":"3","key":"10.1016\/j.bbr.2025.115900_bib54","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1007\/s00018-018-2953-2","article-title":"The regulatory role of Toll-like receptors after ischemic stroke: neurosteroids as TLR modulators with the focus on TLR2\/4","volume":"76","author":"Tajalli-Nezhad","year":"2019","journal-title":"Cell Mol. Life Sci."},{"key":"10.1016\/j.bbr.2025.115900_bib55","doi-asserted-by":"crossref","first-page":"1048","DOI":"10.3389\/fnins.2019.01048","article-title":"Region-specific response of astrocytes to prion infection","volume":"13","author":"Makarava","year":"2019","journal-title":"Front. Neurosci."},{"issue":"1","key":"10.1016\/j.bbr.2025.115900_bib56","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s13024-023-00658-9","article-title":"Astrocytes of the optic nerve exhibit a region-specific and temporally distinct response to elevated intraocular pressure","volume":"18","author":"Mazumder","year":"2023","journal-title":"Mol. Neurodegener."},{"issue":"12","key":"10.1016\/j.bbr.2025.115900_bib57","doi-asserted-by":"crossref","DOI":"10.1111\/cns.70152","article-title":"The oral-gut-brain axis: the influence of microbes as a link of periodontitis with ischemic stroke","volume":"30","author":"Zhong","year":"2024","journal-title":"CNS Neurosci. Ther."},{"issue":"31","key":"10.1016\/j.bbr.2025.115900_bib58","doi-asserted-by":"crossref","first-page":"9839","DOI":"10.1523\/JNEUROSCI.2496-09.2009","article-title":"Systemic lipopolysaccharide protects the brain from ischemic injury by reprogramming the response of the brain to stroke: a critical role for IRF3","volume":"29","author":"Marsh","year":"2009","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2025.115900_bib59","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.2147\/IDR.S491628","article-title":"Association between Porphyromonas gingivalis and Alzheimer's disease: a comprehensive review","volume":"18","author":"Sarmiento-Ordonez","year":"2025","journal-title":"Infect. Drug Resist"},{"issue":"2","key":"10.1016\/j.bbr.2025.115900_bib60","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms11020470","article-title":"Local and systemic effects of porphyromonas gingivalis infection","volume":"11","author":"Chen","year":"2023","journal-title":"Microorganisms"},{"issue":"8","key":"10.1016\/j.bbr.2025.115900_bib61","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.00002-24","article-title":"Mitigation of P. gingivalis-exacerbated intestinal inflammation by paeoniflorin through alteration of the gut microbiota","volume":"13","author":"Qu","year":"2025","journal-title":"Microbiol. Spectr."},{"issue":"1","key":"10.1016\/j.bbr.2025.115900_bib62","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s11626-023-00747-5","article-title":"Cathepsin K degrades osteoprotegerin to promote osteoclastogenesis in vitro","volume":"59","author":"Kawai","year":"2023","journal-title":"Vitr. Cell Dev. Biol. Anim."},{"issue":"3","key":"10.1016\/j.bbr.2025.115900_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.job.2025.100678","article-title":"Proteolytic N-terminal processing of Mfa proteins in the periodontal pathogen Porphyromonas gingivalis","volume":"67","author":"Hirohata","year":"2025","journal-title":"J. Oral. Biosci."},{"issue":"1","key":"10.1016\/j.bbr.2025.115900_bib64","article-title":"Periodontitis in ischemic stroke: impact of Porphyromonas gingivalis on thrombus composition and ischemic stroke outcomes","volume":"8","author":"Freiherr Von Seckendorff","year":"2024","journal-title":"Res Pr. Thromb. Haemost."},{"key":"10.1016\/j.bbr.2025.115900_bib65","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellsig.2025.111770","article-title":"An update on the role and mechanisms of periodontitis in cardiovascular diseases","volume":"132","author":"Lai","year":"2025","journal-title":"Cell Signal"},{"issue":"1","key":"10.1016\/j.bbr.2025.115900_bib66","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1038\/s41392-025-02251-6","article-title":"Porphyromonas gingivalis aggravates atherosclerotic plaque instability by promoting lipid-laden macrophage necroptosis","volume":"10","author":"Huang","year":"2025","journal-title":"Signal Transduct. Target Ther."},{"issue":"1","key":"10.1016\/j.bbr.2025.115900_bib67","doi-asserted-by":"crossref","DOI":"10.3390\/biom11010030","article-title":"Iron dysregulation and inflammagens related to oral and gut health are central to the development of Parkinson's Disease","volume":"11","author":"Vuuren","year":"2020","journal-title":"Biomolecules"},{"issue":"1","key":"10.1016\/j.bbr.2025.115900_bib68","doi-asserted-by":"crossref","first-page":"2445194","DOI":"10.1080\/07853890.2024.2445194","article-title":"Deciphering the role of APOE in cerebral amyloid angiopathy: from genetic insights to therapeutic horizons","volume":"57","author":"Hu","year":"2025","journal-title":"Ann. Med."},{"issue":"4","key":"10.1016\/j.bbr.2025.115900_bib69","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1007\/s00405-020-06370-4","article-title":"The influence of nasal bacterial microbiome diversity on the pathogenesis and prognosis of chronic rhinosinusitis patients with polyps","volume":"278","author":"Gan","year":"2021","journal-title":"Eur. Arch. Otorhinolaryngol."},{"issue":"6","key":"10.1016\/j.bbr.2025.115900_bib70","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1002782","article-title":"Global regulatory functions of the Staphylococcus aureus endoribonuclease III in gene expression","volume":"8","author":"Lioliou","year":"2012","journal-title":"PLoS Genet"},{"issue":"4","key":"10.1016\/j.bbr.2025.115900_bib71","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1007\/s00405-020-06370-4","article-title":"The influence of nasal bacterial microbiome diversity on the pathogenesis and prognosis of chronic rhinosinusitis patients with polyps","volume":"278","author":"Gan","year":"2021","journal-title":"Eur. Arch. Otorhinolaryngol."},{"issue":"2","key":"10.1016\/j.bbr.2025.115900_bib72","doi-asserted-by":"crossref","first-page":"2459","DOI":"10.1007\/s12035-024-04375-2","article-title":"Is nasal dysbiosis a required component for neuroinflammation in major depressive disorder?","volume":"62","author":"Vasquez-Perez","year":"2025","journal-title":"Mol. Neurobiol."},{"issue":"6","key":"10.1016\/j.bbr.2025.115900_bib73","doi-asserted-by":"crossref","first-page":"1545","DOI":"10.1016\/j.cell.2025.01.017","article-title":"Engineered commensals for targeted nose-to-brain drug delivery","volume":"188","author":"Shen","year":"2025","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.bbr.2025.115900_bib74","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/s44161-024-00462-8","article-title":"Stroke and myocardial infarction induce neutrophil extracellular trap release disrupting lymphoid organ structure and immunoglobulin secretion","volume":"3","author":"Tuz","year":"2024","journal-title":"Nat. Cardiovasc Res."},{"key":"10.1016\/j.bbr.2025.115900_bib75","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2025.107768","article-title":"Prevotella histicola suppress olfactory bulb damage caused by LPS-induced rhinitis in mice","volume":"206","author":"Zhuang","year":"2025","journal-title":"Micro Pathog."},{"key":"10.1016\/j.bbr.2025.115900_bib76","article-title":"Analysis of gut microbiota in individuals with distinct types of chronic rhinosinusitis","author":"Bai","year":"2025","journal-title":"Laryngoscope"},{"key":"10.1016\/j.bbr.2025.115900_bib77","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000548918","article-title":"Investigating the impact of the gut microbiota on nasal polyp development: insights from mendelian randomization","author":"Lu","year":"2025","journal-title":"Int Arch. Allergy Immunol."},{"issue":"9","key":"10.1016\/j.bbr.2025.115900_bib78","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1007\/s00106-025-01661-w","article-title":"The microbiome in diseases of the nose and paranasal sinuses","volume":"73","author":"Bartosik","year":"2025","journal-title":"HNO"},{"issue":"7","key":"10.1016\/j.bbr.2025.115900_bib79","doi-asserted-by":"crossref","DOI":"10.3390\/medicina59071259","article-title":"Antimicrobial and defense proteins in chronic rhinosinusitis with nasal polyps","volume":"59","author":"Viksne","year":"2023","journal-title":"Medicina"},{"issue":"1","key":"10.1016\/j.bbr.2025.115900_bib80","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1038\/s41467-024-45518-2","article-title":"Microbes translocation from oral cavity to nasopharyngeal carcinoma in patients","volume":"15","author":"Liao","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbr.2025.115900_bib81","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.placenta.2022.02.018","article-title":"Gardnerella vaginalis infection in pregnancy: Effects on placental development and neonatal outcomes","volume":"120","author":"Wong","year":"2022","journal-title":"Placenta"},{"issue":"8","key":"10.1016\/j.bbr.2025.115900_bib82","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.tem.2021.04.014","article-title":"Gut and vaginal microbiomes on steroids: implications for women's health","volume":"32","author":"Graham","year":"2021","journal-title":"Trends Endocrinol. Metab."},{"issue":"2","key":"10.1016\/j.bbr.2025.115900_bib83","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1007\/s13365-015-0385-4","article-title":"Multiple strokes associated with herpes simplex virus type-2 infection: case report","volume":"22","author":"Joshi","year":"2016","journal-title":"J. Neurovirol"},{"key":"10.1016\/j.bbr.2025.115900_bib84","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.neurobiolaging.2021.04.029","article-title":"Cerebrovascular disease, neurodegeneration, and clinical phenotype in dementia with Lewy bodies","volume":"105","author":"Ferreira","year":"2021","journal-title":"Neurobiol. Aging"},{"issue":"9","key":"10.1016\/j.bbr.2025.115900_bib85","doi-asserted-by":"crossref","DOI":"10.1128\/iai.00057-25","article-title":"Cervicovaginal microbial features predict Chlamydia trachomatis spread to the upper genital tract of infected women","volume":"93","author":"Jeong","year":"2025","journal-title":"Infect. Immun."},{"issue":"1","key":"10.1016\/j.bbr.2025.115900_bib86","doi-asserted-by":"crossref","first-page":"2442070","DOI":"10.1080\/07853890.2024.2442070","article-title":"Maternal group B Streptococcus decreases infant length and alters the early-life microbiome: a prospective cohort study","volume":"57","author":"Li","year":"2025","journal-title":"Ann. Med."},{"issue":"1","key":"10.1016\/j.bbr.2025.115900_bib87","doi-asserted-by":"crossref","first-page":"2496787","DOI":"10.1080\/14767058.2025.2496787","article-title":"Microbial imbalances linked to early pregnancy loss: a comparative analysis of vaginal microbiota","volume":"38","author":"Wang","year":"2025","journal-title":"J. Matern Fetal Neonatal Med."},{"key":"10.1016\/j.bbr.2025.115900_bib88","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1196\/annals.1347.006","article-title":"Estrogen: a neuroprotective or proinflammatory hormone? Emerging evidence from reproductive aging models","volume":"1052","author":"Sohrabji","year":"2005","journal-title":"Ann. N. Y Acad. Sci."},{"issue":"10","key":"10.1016\/j.bbr.2025.115900_bib89","doi-asserted-by":"crossref","DOI":"10.3390\/biom14101325","article-title":"Endometrial dysbiosis: a possible association with estrobolome alteration","volume":"14","author":"Scarfo","year":"2024","journal-title":"Biomolecules"},{"issue":"15","key":"10.1016\/j.bbr.2025.115900_bib90","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202500244RRR","article-title":"Complex interplay between estrogen and aging via lipid metabolism and inflammation forms the novel treatment strategies for atherosclerosis","volume":"39","author":"Xin","year":"2025","journal-title":"FASEB J."},{"key":"10.1016\/j.bbr.2025.115900_bib91","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpba.2025.116841","article-title":"Covalent protein modification by multiple reactive dialdehyde metabolites of catalpol via intestinal bioactivation","volume":"261","author":"Jing","year":"2025","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.bbr.2025.115900_bib92","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156623","article-title":"Shenqi granules enhance recovery from cerebral ischemia-reperfusion injury by modulating tryptophan and tyrosine metabolism and activating NFE2L2\/NRF2","volume":"140","author":"Liu","year":"2025","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bbr.2025.115900_bib93","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2025.115263","article-title":"Edaravone ameliorates inflammation in ischemic stroke mouse by regulating the CYP1A1 pathway through gut microbiota","volume":"390","author":"Zhang","year":"2025","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbr.2025.115900_bib94","doi-asserted-by":"crossref","DOI":"10.1007\/s12035-025-04865-x","article-title":"Rhubarb with different cooking methods restored the gut microbiota dysbiosis and SCFAs in ischemic stroke mice","author":"Xu","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbr.2025.115900_bib95","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119435","article-title":"Multi-omics approaches reveal the therapeutic mechanism of Naoxintong capsule against ischemic stroke","volume":"343","author":"Li","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bbr.2025.115900_bib96","doi-asserted-by":"crossref","first-page":"1498502","DOI":"10.3389\/fnagi.2024.1498502","article-title":"Association between plasma trimethylamine N-oxide and cerebral white matter hyperintensity: a cross-sectional study","volume":"16","author":"Ji","year":"2024","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.bbr.2025.115900_bib97","doi-asserted-by":"crossref","first-page":"1533343","DOI":"10.3389\/fimmu.2025.1533343","article-title":"Advancements in the investigation of gut microbiota-based strategies for stroke prevention and treatment","volume":"16","author":"Wang","year":"2025","journal-title":"Front Immunol."},{"issue":"26","key":"10.1016\/j.bbr.2025.115900_bib98","doi-asserted-by":"crossref","first-page":"8048","DOI":"10.1080\/10408398.2022.2054934","article-title":"Bifidobacterium spp. as functional foods: a review of current status, challenges, and strategies","volume":"63","author":"He","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.bbr.2025.115900_bib99","doi-asserted-by":"crossref","first-page":"1042189","DOI":"10.3389\/fphar.2022.1042189","article-title":"Gut microbiome and human health: exploring how the probiotic genus Lactobacillus modulate immune responses","volume":"13","author":"Rastogi","year":"2022","journal-title":"Front. Pharm."},{"key":"10.1016\/j.bbr.2025.115900_bib100","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106714","article-title":"Gut microbiota-derived melatonin from Puerariae Lobatae Radix-resistant starch supplementation attenuates ischemic stroke injury via a positive microbial co-occurrence pattern","volume":"190","author":"Lian","year":"2023","journal-title":"Pharm. Res."},{"issue":"7975","key":"10.1016\/j.bbr.2025.115900_bib101","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1038\/s41586-023-06409-6","article-title":"Lactate limits CNS autoimmunity by stabilizing HIF-1alpha in dendritic cells","volume":"620","author":"Sanmarco","year":"2023","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.bbr.2025.115900_bib102","doi-asserted-by":"crossref","first-page":"2493901","DOI":"10.1080\/19490976.2025.2493901","article-title":"Fecal microbiota transplantation: a tale of two regulatory pathways","volume":"17","author":"Hoffmann","year":"2025","journal-title":"Gut Microbes"},{"issue":"4","key":"10.1016\/j.bbr.2025.115900_bib103","doi-asserted-by":"crossref","DOI":"10.3892\/ijmm.2025.5505","article-title":"p23 protects against ferroptosis of brain microvascular endothelial cells in ischemic stroke","volume":"55","author":"Zhao","year":"2025","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.bbr.2025.115900_bib104","doi-asserted-by":"crossref","first-page":"1425054","DOI":"10.3389\/fmicb.2025.1425054","article-title":"Microbiota-gut-brain-axis: a new target of acupuncture therapy for post-stroke cognitive impairment","volume":"16","author":"Ba","year":"2025","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.bbr.2025.115900_bib105","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.ibneur.2025.02.007","article-title":"Acupuncture ameliorates inflammation by regulating gut microbiota in acute ischemic stroke","volume":"18","author":"Yan","year":"2025","journal-title":"IBRO Neurosci. Rep."},{"issue":"5","key":"10.1016\/j.bbr.2025.115900_bib106","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0300844","article-title":"Mediterranean diet effects on vascular health and serum levels of adipokines and ceramides","volume":"19","author":"Daidone","year":"2024","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.bbr.2025.115900_bib107","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1038\/nrcardio.2016.183","article-title":"Role of gut microbiota in atherosclerosis","volume":"14","author":"Jonsson","year":"2017","journal-title":"Nat. Rev. Cardiol."},{"issue":"9","key":"10.1016\/j.bbr.2025.115900_bib108","first-page":"1065","article-title":"Longitudinal changes in subgingival biofilm composition following periodontal treatment","volume":"94","author":"Johnston","year":"2023","journal-title":"J. Periodo"},{"issue":"4","key":"10.1016\/j.bbr.2025.115900_bib109","first-page":"62","article-title":"Pilot, open-label, randomized controlled clinical trial evaluating 4 oral hygiene regimens using a manual toothbrush, toothpaste, and mouthwash","volume":"72","author":"Rosu","year":"2024","journal-title":"Gen. Dent."},{"issue":"5","key":"10.1016\/j.bbr.2025.115900_bib110","article-title":"Systemic antibiotics and chlorhexidine associated with periodontal therapy: microbiological effect on intraoral surfaces and saliva","volume":"12","author":"Mendes","year":"2023","journal-title":"Antibiot. (Basel)"},{"issue":"10","key":"10.1016\/j.bbr.2025.115900_bib111","doi-asserted-by":"crossref","first-page":"3577","DOI":"10.1128\/IAI.01288-12","article-title":"LL-37 opsonizes and inhibits biofilm formation of Aggregatibacter actinomycetemcomitans at subbactericidal concentrations","volume":"81","author":"Sol","year":"2013","journal-title":"Infect. Immun."},{"issue":"8","key":"10.1016\/j.bbr.2025.115900_bib112","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.22830","article-title":"Ferroptosis: a potential therapeutic target for neurodegenerative diseases","volume":"35","author":"Vitalakumar","year":"2021","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.bbr.2025.115900_bib113","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.bbi.2024.10.026","article-title":"Prophylactic use of probiotics as an adjunctive treatment for ischemic stroke via the gut-spleen-brain axis","volume":"123","author":"Wang","year":"2025","journal-title":"Brain Behav. Immun."},{"issue":"3","key":"10.1016\/j.bbr.2025.115900_bib114","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0248308","article-title":"A concerted probiotic activity to inhibit periodontitis-associated bacteria","volume":"16","author":"Jansen","year":"2021","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.bbr.2025.115900_bib115","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1186\/s12951-022-01672-7","article-title":"Antibiofilm activity of ultra-small gold nanoclusters against Fusobacterium nucleatum in dental plaque biofilms","volume":"20","author":"Zhang","year":"2022","journal-title":"J. Nanobiotechnol."},{"issue":"1","key":"10.1016\/j.bbr.2025.115900_bib116","doi-asserted-by":"crossref","first-page":"2243067","DOI":"10.1080\/20002297.2023.2243067","article-title":"Trans-cinnamaldehyde loaded chitosan based nanocapsules display antibacterial and antibiofilm effects against cavity-causing Streptococcus mutans","volume":"15","author":"Mu","year":"2023","journal-title":"J. Oral. Microbiol."},{"issue":"3","key":"10.1016\/j.bbr.2025.115900_bib117","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s40204-018-0098-x","article-title":"Development of a PCL\/gelatin\/chitosan\/beta-TCP electrospun composite for guided bone regeneration","volume":"7","author":"Ezati","year":"2018","journal-title":"Prog. Biomater."},{"issue":"3","key":"10.1016\/j.bbr.2025.115900_bib118","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1111\/jre.12403","article-title":"Local wound healing biomarkers for real-time assessment of periodontal regeneration: pilot study","volume":"52","author":"Pellegrini","year":"2017","journal-title":"J. Periodontal Res."},{"issue":"6","key":"10.1016\/j.bbr.2025.115900_bib119","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2025.115854","article-title":"Staphylococci in high resolution: capturing diversity within the human nasal microbiota","volume":"44","author":"Ingham","year":"2025","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.bbr.2025.115900_bib120","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/s11259-024-10596-6","article-title":"Effects of intranasal administration with a symbiotic strain of Bacillus velezensis NSV2 on nasal cavity mucosal barrier in lambs","volume":"49","author":"Zheng","year":"2024","journal-title":"Vet. Res. Commun."},{"issue":"9","key":"10.1016\/j.bbr.2025.115900_bib121","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22094744","article-title":"Association between microbiota and nasal mucosal diseases in terms of immunity","volume":"22","author":"Tai","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"3","key":"10.1016\/j.bbr.2025.115900_bib122","doi-asserted-by":"crossref","DOI":"10.1016\/j.humimm.2025.111259","article-title":"The effect of vitamin D supplementation and vaginal probiotics on fertility in women with recurrent implantation failure: a randomized clinical trial","volume":"86","author":"Badihi","year":"2025","journal-title":"Hum. Immunol."},{"issue":"1","key":"10.1016\/j.bbr.2025.115900_bib123","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/ijgo.16005","article-title":"Roles of probiotics against HPV through the gut-vaginal axis","volume":"169","author":"Xu","year":"2025","journal-title":"Int J. Gynaecol. Obstet."},{"issue":"1","key":"10.1016\/j.bbr.2025.115900_bib124","doi-asserted-by":"crossref","first-page":"2494703","DOI":"10.1080\/19490976.2025.2494703","article-title":"Gut microbiota and associated metabolites: key players in high-fat diet-induced chronic diseases","volume":"17","author":"Du","year":"2025","journal-title":"Gut Microbes"},{"issue":"1","key":"10.1016\/j.bbr.2025.115900_bib125","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1186\/s13024-023-00658-9","article-title":"Astrocytes of the optic nerve exhibit a region-specific and temporally distinct response to elevated intraocular pressure","volume":"18","author":"Mazumder","year":"2023","journal-title":"Mol. Neurodegener."},{"issue":"6","key":"10.1016\/j.bbr.2025.115900_bib126","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.00045-25","article-title":"Gut microbiota modulates lung gene expression and metabolism to aid SD rats in adapting to low-pressure hypoxia","volume":"13","author":"Chen","year":"2025","journal-title":"Microbiol. Spectr."},{"issue":"6","key":"10.1016\/j.bbr.2025.115900_bib127","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1136\/svn-2023-002717","article-title":"Gut microbiome and stroke: a bidirectional mendelian randomisation study in east Asian and European populations","volume":"9","author":"Cheng","year":"2024","journal-title":"Stroke Vasc. Neurol."},{"issue":"1","key":"10.1016\/j.bbr.2025.115900_bib128","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1186\/s12905-025-03789-x","article-title":"Causal association between gut microbiota and endometrial cancer in European and East Asian populations: a two-sample Mendelian randomization study","volume":"25","author":"Chen","year":"2025","journal-title":"BMC Women\u2019s. Health"},{"issue":"1","key":"10.1016\/j.bbr.2025.115900_bib129","doi-asserted-by":"crossref","first-page":"2484385","DOI":"10.1080\/19490976.2025.2484385","article-title":"Genomic and functional co-diversification imprint African Hominidae microbiomes to signal dietary and lifestyle adaptations","volume":"17","author":"Otani","year":"2025","journal-title":"Gut Microbes"},{"issue":"12","key":"10.1016\/j.bbr.2025.115900_bib130","doi-asserted-by":"crossref","first-page":"2276","DOI":"10.1681\/ASN.2022020189","article-title":"Expansion of Escherichia-Shigella in gut is associated with the onset and response to immunosuppressive therapy of IgA nephropathy","volume":"33","author":"Zhao","year":"2022","journal-title":"J. Am. Soc. Nephrol."},{"issue":"12","key":"10.1016\/j.bbr.2025.115900_bib131","doi-asserted-by":"crossref","DOI":"10.3390\/medicina60121969","article-title":"The significance of plant nutrition in the creation of the intestinal microbiota-prevention of chronic diseases: a narrative review","volume":"60","author":"Jovandaric","year":"2024","journal-title":"Medicina"},{"issue":"1","key":"10.1016\/j.bbr.2025.115900_bib132","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/ejcn.2012.158","article-title":"Dietary fiber intake and stroke risk: a meta-analysis of prospective cohort studies","volume":"67","author":"Chen","year":"2013","journal-title":"Eur. J. Clin. Nutr."},{"key":"10.1016\/j.bbr.2025.115900_bib133","first-page":"217","article-title":"The influence of interdental brushes and toothpaste on approximal enamel and dentine abrasion - a laboratory study","volume":"23","author":"Marconi","year":"2025","journal-title":"Oral. Health Prev. Dent."},{"issue":"10","key":"10.1016\/j.bbr.2025.115900_bib134","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s11910-021-01143-w","article-title":"Dietary insights in neurological diseases","volume":"21","author":"Ramirez-Salazar","year":"2021","journal-title":"Curr. Neurol. Neurosci. Rep."},{"issue":"5","key":"10.1016\/j.bbr.2025.115900_bib135","doi-asserted-by":"crossref","DOI":"10.3390\/nu17050778","article-title":"Gene-diet interactions in high-density lipoprotein cholesterol-related polymorphisms and cardiovascular disease risk: insights from the korean genome and epidemiology study","volume":"17","author":"Lee","year":"2025","journal-title":"Nutrients"},{"issue":"1","key":"10.1016\/j.bbr.2025.115900_bib136","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1186\/s12866-025-04184-0","article-title":"An analysis of the vaginal microbiota in women positive for group B Streptococcus during the third trimester of pregnancy","volume":"25","author":"Zhang","year":"2025","journal-title":"BMC Microbiol."},{"issue":"8","key":"10.1016\/j.bbr.2025.115900_bib137","doi-asserted-by":"crossref","first-page":"546","DOI":"10.14423\/SMJ.0000000000000687","article-title":"Predictors of 30-day mortality in hospitalized patients with clostridium difficile infection","volume":"110","author":"Chintanaboina","year":"2017","journal-title":"South Med. J."},{"issue":"1","key":"10.1016\/j.bbr.2025.115900_bib138","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1186\/s12903-024-04365-9","article-title":"Quantitative analysis of the effects of essential oil mouthrinses on clinical plaque microbiome: a parallel-group, randomized trial","volume":"24","author":"Min","year":"2024","journal-title":"BMC Oral. Health"},{"key":"10.1016\/j.bbr.2025.115900_bib139","article-title":"Targeted prevention of radiation-induced oral mucositis by glutathione-modified liposome coated K12 probiotics and clinical study","volume":"34","author":"Li","year":"2025","journal-title":"Mater. Today Bio"},{"issue":"3","key":"10.1016\/j.bbr.2025.115900_bib140","doi-asserted-by":"crossref","DOI":"10.1002\/jcla.23678","article-title":"Levels of nasal exhaled hydrogen sulfide in the general population and allergic rhinitis patients","volume":"35","author":"Li","year":"2021","journal-title":"J. Clin. Lab Anal."},{"issue":"5","key":"10.1016\/j.bbr.2025.115900_bib141","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.bbadis.2016.01.015","article-title":"Stroke injury, cognitive impairment and vascular dementia","volume":"1862","author":"Kalaria","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbr.2025.115900_bib142","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.genhosppsych.2020.06.011","article-title":"Post-stroke depression: a 2020 updated review","volume":"66","author":"Medeiros","year":"2020","journal-title":"Gen. Hosp. Psychiatry"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432825004875?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432825004875?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T23:41:37Z","timestamp":1773272497000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432825004875"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":142,"alternative-id":["S0166432825004875"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2025.115900","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bidirectional regulatory mechanisms and targeted therapeutic strategies of the microbiota in ischemic stroke","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2025.115900","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"115900"}}