{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T09:32:54Z","timestamp":1789464774831,"version":"build-2803163510"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003141","name":"Secretariat of Science Humanities Technology and Innovation","doi-asserted-by":"publisher","award":["CBF-2023\\u20132024\\u20133517"],"award-info":[{"award-number":["CBF-2023\\u20132024\\u20133517"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.bbr.2026.116050","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T07:43:27Z","timestamp":1768981407000},"page":"116050","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Combined administration of intracerebroventricular CB1 agonist ACEA and systemic TRPV1 agonist capsaicin induces synergistic antidepressant-like effects in rats"],"prefix":"10.1016","volume":"503","author":[{"given":"Daniela A.","family":"Avalos-Moreno","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio G.","family":"Cuevas-Carbonell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Metzli E.","family":"Ram\u00edrez-Vargas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Castro-S\u00e1nchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo","family":"Virgen-Ortiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique","family":"S\u00e1nchez-Pastor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 L.","family":"G\u00f3ngora-Alfaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo A.","family":"Navarro-Polanco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eloy G.","family":"Moreno-Galindo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Alamilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2026.116050_bib1","unstructured":"Organization W.H. Depressive disorder (depression) 2025 [2025, November 7]. Available from: \u3008https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/depression\u3009."},{"issue":"6","key":"10.1016\/j.bbr.2026.116050_bib2","doi-asserted-by":"crossref","first-page":"946","DOI":"10.4088\/JCP.v69n0610","article-title":"Rapid onset of antidepressant action: a new paradigm in the research and treatment of major depressive disorder","volume":"69","author":"Machado-Vieira","year":"2008","journal-title":"J. Clin. Psychiatry"},{"issue":"3","key":"10.1016\/j.bbr.2026.116050_bib3","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1002\/wps.21120","article-title":"Treatment-resistant depression: definition, prevalence, detection, management, and investigational interventions","volume":"22","author":"McIntyre","year":"2023","journal-title":"World Psychiatry"},{"key":"10.1016\/j.bbr.2026.116050_bib4","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.physbeh.2018.08.006","article-title":"Capsaicin produces antidepressant-like effects in the forced swimming test and enhances the response of a sub-effective dose of amitriptyline in rats","volume":"195","author":"Reyes-Mendez","year":"2018","journal-title":"Physiol. Behav."},{"issue":"7","key":"10.1016\/j.bbr.2026.116050_bib5","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1007\/s00213-020-05528-6","article-title":"Synergistic antidepressant-like effect of capsaicin and citalopram reduces the side effects of citalopram on anxiety and working memory in rats","volume":"237","author":"Aguilar-Martinez","year":"2020","journal-title":"Psychopharmacol. (Berl. )"},{"key":"10.1016\/j.bbr.2026.116050_bib6","article-title":"Synergistic effects of capsaicin and ketamine on the depression-like behaviors of animals subjected to the chronic unpredictable mild stress protocol","volume":"303","author":"Aguilar-Martinez","year":"2025","journal-title":"Physiol. Behav."},{"issue":"1","key":"10.1016\/j.bbr.2026.116050_bib7","first-page":"67","article-title":"A molecular perspective on identifying TRPV1 thermosensitive regions and disentangling polymodal activation","volume":"10","author":"Luu","year":"2023","journal-title":"Temp. (Austin)"},{"key":"10.1016\/j.bbr.2026.116050_bib8","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2024.1400118","article-title":"The dual role of TRPV1 in peripheral neuropathic pain: pain switches caused by its sensitization or desensitization","volume":"17","author":"Gao","year":"2024","journal-title":"Front Mol. Neurosci."},{"issue":"7","key":"10.1016\/j.bbr.2026.116050_bib9","doi-asserted-by":"crossref","first-page":"3655","DOI":"10.1073\/pnas.97.7.3655","article-title":"Distribution of mRNA for vanilloid receptor subtype 1 (VR1), and VR1-like immunoreactivity, in the central nervous system of the rat and human","volume":"97","author":"Mezey","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbr.2026.116050_bib10","article-title":"Spatial distribution of the cannabinoid type 1 and capsaicin receptors may contribute to the complexity of their crosstalk","volume":"6","author":"Chen","year":"2016","journal-title":"Sci. Rep."},{"issue":"1607","key":"10.1016\/j.bbr.2026.116050_bib11","doi-asserted-by":"crossref","first-page":"3216","DOI":"10.1098\/rstb.2011.0382","article-title":"Why do cannabinoid receptors have more than one endogenous ligand?","volume":"367","author":"Di Marzo","year":"2012","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"issue":"17","key":"10.1016\/j.bbr.2026.116050_bib12","doi-asserted-by":"crossref","DOI":"10.3390\/molecules25173957","article-title":"Capsaicin causes vasorelaxation of rat aorta through blocking of L-type Ca(2+) channels and activation of CB(1) receptors","volume":"25","author":"Andrade","year":"2020","journal-title":"Molecules"},{"issue":"43","key":"10.1016\/j.bbr.2026.116050_bib13","doi-asserted-by":"crossref","first-page":"11700","DOI":"10.1523\/JNEUROSCI.1636-07.2007","article-title":"Cannabinoids elicit antidepressant-like behavior and activate serotonergic neurons through the medial prefrontal cortex","volume":"27","author":"Bambico","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2026.116050_bib14","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.phrs.2014.04.014","article-title":"The dual blocker of FAAH\/TRPV1 N-arachidonoylserotonin reverses the behavioral despair induced by stress in rats and modulates the HPA-axis","volume":"87","author":"Navarria","year":"2014","journal-title":"Pharm. Res"},{"issue":"4","key":"10.1016\/j.bbr.2026.116050_bib15","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1007\/s00213-001-0946-5","article-title":"Involvement of CB1 cannabinoid receptors in emotional behaviour","volume":"159","author":"Martin","year":"2002","journal-title":"Psychopharmacol. (Berl. )"},{"issue":"29","key":"10.1016\/j.bbr.2026.116050_bib16","doi-asserted-by":"crossref","first-page":"10506","DOI":"10.1523\/JNEUROSCI.0496-11.2011","article-title":"Recruitment of prefrontal cortical endocannabinoid signaling by glucocorticoids contributes to termination of the stress response","volume":"31","author":"Hill","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2026.116050_bib17","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.neuroscience.2011.09.031","article-title":"CB1 receptor-deficient mice as a model for depression","volume":"204","author":"Valverde","year":"2012","journal-title":"Neuroscience"},{"issue":"9600","key":"10.1016\/j.bbr.2026.116050_bib18","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1016\/S0140-6736(07)61705-X","article-title":"Depression and anxiety with rimonabant","volume":"370","author":"Mitchell","year":"2007","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.bbr.2026.116050_bib19","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.nbd.2010.03.020","article-title":"Depression-like phenotype following chronic CB1 receptor antagonism","volume":"39","author":"Beyer","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbr.2026.116050_bib20","series-title":"The Rat Brain in Stereotaxic Coordinates","author":"Paxinos","year":"1986"},{"issue":"2","key":"10.1016\/j.bbr.2026.116050_bib21","first-page":"165","article-title":"Antidepressant--like properties of ACEA (arachidonyl-2-chloroethylamide), the selective agonist of CB1 receptors","volume":"61","author":"Rutkowska","year":"2004","journal-title":"Acta Pol. Pharm."},{"issue":"2","key":"10.1016\/j.bbr.2026.116050_bib22","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.pharmthera.2010.04.011","article-title":"The application of drug dose equivalence in the quantitative analysis of receptor occupation and drug combinations","volume":"127","author":"Tallarida","year":"2010","journal-title":"Pharm. Ther."},{"issue":"4","key":"10.1016\/j.bbr.2026.116050_bib23","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1093\/ilar.43.4.207","article-title":"Sample size determination","volume":"43","author":"Dell","year":"2002","journal-title":"ILAR J."},{"issue":"3","key":"10.1016\/j.bbr.2026.116050_bib24","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.physbeh.2008.03.004","article-title":"Differential effects of caffeine on the antidepressant-like effect of amitriptyline in female rat subpopulations with low and high immobility in the forced swimming test","volume":"94","author":"Enriquez-Castillo","year":"2008","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbr.2026.116050_bib25","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.physbeh.2013.05.012","article-title":"Factors influencing behavior in the forced swim test","volume":"118","author":"Bogdanova","year":"2013","journal-title":"Physiol. Behav."},{"issue":"10","key":"10.1016\/j.bbr.2026.116050_bib26","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.biopsych.2006.12.001","article-title":"Antidepressant-like activity of the fatty acid amide hydrolase inhibitor URB597 in a rat model of chronic mild stress","volume":"62","author":"Bortolato","year":"2007","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2026.116050_bib27","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2021.762738","article-title":"Reviewing the role of the endocannabinoid system in the pathophysiology of depression","volume":"12","author":"Gallego-Landin","year":"2021","journal-title":"Front Pharm."},{"issue":"6","key":"10.1016\/j.bbr.2026.116050_bib28","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1093\/cercor\/bhm161","article-title":"Role in anxiety behavior of the endocannabinoid system in the prefrontal cortex","volume":"18","author":"Rubino","year":"2008","journal-title":"Cereb. Cortex"},{"issue":"24","key":"10.1016\/j.bbr.2026.116050_bib29","doi-asserted-by":"crossref","first-page":"2959","DOI":"10.1016\/j.lfs.2004.06.006","article-title":"The role of endogenous cannabinoids in the hypothalamo-pituitary-adrenal axis regulation: in vivo and in vitro studies in CB1 receptor knockout mice","volume":"75","author":"Barna","year":"2004","journal-title":"Life Sci."},{"issue":"9","key":"10.1016\/j.bbr.2026.116050_bib30","doi-asserted-by":"crossref","first-page":"3879","DOI":"10.1523\/JNEUROSCI.2737-14.2015","article-title":"Corticotropin-releasing hormone drives anandamide hydrolysis in the amygdala to promote anxiety","volume":"35","author":"Gray","year":"2015","journal-title":"J. Neurosci."},{"issue":"33","key":"10.1016\/j.bbr.2026.116050_bib31","doi-asserted-by":"crossref","first-page":"11188","DOI":"10.1523\/JNEUROSCI.1046-10.2010","article-title":"Repeated stress impairs endocannabinoid signaling in the paraventricular nucleus of the hypothalamus","volume":"30","author":"Wamsteeker","year":"2010","journal-title":"J. Neurosci."},{"issue":"8","key":"10.1016\/j.bbr.2026.116050_bib32","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1016\/j.celrep.2019.04.096","article-title":"An atlas of vagal sensory neurons and their molecular specialization","volume":"27","author":"Kupari","year":"2019","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.bbr.2026.116050_bib33","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1186\/s12974-021-02341-6","article-title":"Mechanisms underlying antidepressant effect of transcutaneous auricular vagus nerve stimulation on CUMS model rats based on hippocampal alpha7nAchR\/NF-kappaB signal pathway","volume":"18","author":"Wang","year":"2021","journal-title":"J. Neuroinflamm."},{"issue":"5","key":"10.1016\/j.bbr.2026.116050_bib34","first-page":"54","article-title":"Vagus nerve stimulation (VNS) and treatment of depression: to the brainstem and beyond","volume":"3","author":"O'Reardon","year":"2006","journal-title":"Psychiatry (Edgmont)"},{"issue":"6785","key":"10.1016\/j.bbr.2026.116050_bib35","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/35013070","article-title":"Vagus nerve stimulation attenuates the systemic inflammatory response to endotoxin","volume":"405","author":"Borovikova","year":"2000","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.bbr.2026.116050_bib36","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2021758118","article-title":"Vagus nerve stimulation activates two distinct neuroimmune circuits converging in the spleen to protect mice from kidney injury","volume":"118","author":"Tanaka","year":"2021","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"2","key":"10.1016\/j.bbr.2026.116050_bib37","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2025.111831","article-title":"Stimulation of TRPV1+ peripheral somatosensory nerves suppress inflammation via the somato-autonomic reflex","volume":"28","author":"Song","year":"2025","journal-title":"iScience"},{"issue":"5","key":"10.1016\/j.bbr.2026.116050_bib38","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1136\/jnnp-2011-301779","article-title":"Depression: an inflammatory illness?","volume":"83","author":"Krishnadas","year":"2012","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"12","key":"10.1016\/j.bbr.2026.116050_bib39","doi-asserted-by":"crossref","first-page":"7393","DOI":"10.1038\/s41380-021-01188-w","article-title":"Association of inflammation with depression and anxiety: evidence for symptom-specificity and potential causality from UK Biobank and NESDA cohorts","volume":"26","author":"Milaneschi","year":"2021","journal-title":"Mol. Psychiatry"},{"issue":"4","key":"10.1016\/j.bbr.2026.116050_bib40","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1503\/jpn.150205","article-title":"Why is depression more prevalent in women?","volume":"40","author":"Albert","year":"2015","journal-title":"J. Psychiatry Neurosci."},{"issue":"2","key":"10.1016\/j.bbr.2026.116050_bib41","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/S2215-0366(16)30263-2","article-title":"Why is depression more common among women than among men?","volume":"4","author":"Kuehner","year":"2017","journal-title":"Lancet Psychiatry"},{"issue":"2","key":"10.1016\/j.bbr.2026.116050_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0316389","article-title":"Nanoencapsulation of amitriptyline enhances the potency of antidepressant-like effects and exhibits anxiolytic-like effects in Wistar rats","volume":"20","author":"Valadez-Lemus","year":"2025","journal-title":"PLoS One"},{"issue":"11","key":"10.1016\/j.bbr.2026.116050_bib43","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1176\/appi.ajp.159.11.1848","article-title":"Are there differences between women's and men's antidepressant responses?","volume":"159","author":"Quitkin","year":"2002","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.bbr.2026.116050_bib44","doi-asserted-by":"crossref","DOI":"10.1007\/s00210-025-04611-z","article-title":"Do sex and gender matter in the pharmacological treatment of depression?","author":"Seifert","year":"2025","journal-title":"Naunyn Schmiede Arch. Pharm."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432826000264?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432826000264?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,17]],"date-time":"2026-02-17T01:20:26Z","timestamp":1771291226000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432826000264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":44,"alternative-id":["S0166432826000264"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2026.116050","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combined administration of intracerebroventricular CB1 agonist ACEA and systemic TRPV1 agonist capsaicin induces synergistic antidepressant-like effects in rats","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2026.116050","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116050"}}