{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T08:19:47Z","timestamp":1771489187502,"version":"3.50.1"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T00:00:00Z","timestamp":1771200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K01 DA055068"],"award-info":[{"award-number":["K01 DA055068"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32GM139807"],"award-info":[{"award-number":["T32GM139807"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DA042057"],"award-info":[{"award-number":["R01DA042057"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000057","name":"National Institute of General Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000057","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.bbr.2026.116055","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:44:26Z","timestamp":1769042666000},"page":"116055","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The role of nucleus accumbens Fos expression in sex-dependent cocaine-induced locomotion, cocaine self-administration, and primed cocaine seeking in rats"],"prefix":"10.1016","volume":"503","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2015-9249","authenticated-orcid":false,"given":"Alixandria T.","family":"Mascarin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Srinivasu","family":"Kallakuri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justin L.","family":"Carthage","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali","family":"Gheidi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alana C.","family":"Conti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shane A.","family":"Perrine","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2026.116055_bib1","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aax1532","article-title":"The treatment of cocaine use disorder","volume":"5","author":"Kampman","year":"2019","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bbr.2026.116055_bib2","first-page":"29","article-title":"The neurocircuitry of illicit psychostimulant addiction: acute and chronic effects in humans","volume":"4","author":"Taylor","year":"2013","journal-title":"Subst. Abus. Rehabil."},{"key":"10.1016\/j.bbr.2026.116055_bib3","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1007\/s13311-017-0525-z","article-title":"Reward circuitry in addiction","volume":"14","author":"Cooper","year":"2017","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.bbr.2026.116055_bib4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1146\/annurev-psych-010213-115159","article-title":"The nucleus accumbens: an interface between cognition, emotion, and action","volume":"66","author":"Floresco","year":"2015","journal-title":"Annu Rev. Psychol."},{"key":"10.1016\/j.bbr.2026.116055_bib5","article-title":"Hope Locomotor sensitization to cocaine is associated with increased Fos expression in the accumbens","author":"Hans","year":"2002","journal-title":"but Not. caudate"},{"key":"10.1016\/j.bbr.2026.116055_bib6","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1111\/j.1460-9568.2007.05984.x","article-title":"Context-specific sensitization of cocaine-induced locomotor activity and associated neuronal ensembles in rat nucleus accumbens","volume":"27","author":"Mattson","year":"2008","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bbr.2026.116055_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11020383","article-title":"Distinctive neuroanatomic regions involved in cocaine-induced behavioral sensitization in mice","volume":"11","author":"Santos-Baldaia","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.bbr.2026.116055_bib8","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1111\/j.1460-9568.2006.04969.x","article-title":"Cocaine-induced locomotor activity and Fos expression in nucleus accumbens are sensitized for 6 months after repeated cocaine administration outside the home cage","volume":"24","author":"Hope","year":"2006","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bbr.2026.116055_bib9","doi-asserted-by":"crossref","first-page":"13287","DOI":"10.1523\/JNEUROSCI.3795-06.2006","article-title":"c-Fos facilitates the acquisition and extinction of cocaine-induced persistent changes","volume":"26","author":"Zhang","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2026.116055_bib10","doi-asserted-by":"crossref","first-page":"3150","DOI":"10.1038\/s41380-020-00888-z","article-title":"Cocaine and sucrose rewards recruit different seeking ensembles in the nucleus accumbens core","volume":"25","author":"Bobadilla","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbr.2026.116055_bib11","doi-asserted-by":"crossref","first-page":"7437","DOI":"10.1523\/JNEUROSCI.0238-14.2014","article-title":"Role of nucleus accumbens shell neuronal ensembles in context-induced reinstatement of cocaine-seeking","volume":"34","author":"Cruz","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2026.116055_bib12","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.yfrne.2007.07.003","article-title":"Sex differences in drug abuse","volume":"29","author":"Becker","year":"2008","journal-title":"Front. Neuroendocr."},{"key":"10.1016\/j.bbr.2026.116055_bib13","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1124\/pr.115.011163","article-title":"Sex differences in animal models: focus on addiction","volume":"68","author":"Becker","year":"2016","journal-title":"Pharm. Rev."},{"key":"10.1016\/j.bbr.2026.116055_bib14","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.1007\/s00221-022-06479-4","article-title":"The influence of sex and reproductive cycle on cocaine-induced behavioral and neurobiological alterations: a review","volume":"240","author":"Dos Anjos Rosario","year":"2022","journal-title":"Exp. Brain Res"},{"key":"10.1016\/j.bbr.2026.116055_bib15","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3389\/fnbeh.2020.00074","article-title":"Sex differences and the role of estradiol in mesolimbic reward circuits and vulnerability to cocaine and opiate addiction","volume":"14","author":"Kokane","year":"2020","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.bbr.2026.116055_bib16","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1124\/pharmrev.121.000367","article-title":"Sex differences in opioid and psychostimulant craving and relapse: a critical review","volume":"74","author":"Nicolas","year":"2022","journal-title":"Pharm. Rev."},{"key":"10.1016\/j.bbr.2026.116055_bib17","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0376-8716(98)00135-5","article-title":"Comparing levels of cocaine cue reactivity in male and female outpatients","volume":"53","author":"Robbins","year":"1999","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.bbr.2026.116055_bib18","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1081\/ADA-100103705","article-title":"Gender differences in cocaine craving among non-treatment-seeking individuals with cocaine dependence","volume":"27","author":"Elman","year":"2001","journal-title":"Am. J. Drug Alcohol Abus."},{"key":"10.1016\/j.bbr.2026.116055_bib19","doi-asserted-by":"crossref","unstructured":"T. Kosten, F. Gawin, T. Kosten, B. Rounsaville, Gender Differences in Cocaine Use and Treatment Response. Journal of Substance Abuse Treatement 10, 63-66.","DOI":"10.1016\/0740-5472(93)90100-G"},{"key":"10.1016\/j.bbr.2026.116055_bib20","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/0091-3057(91)90054-6","article-title":"Sex differences in locomotor activity after acute and chronic cocaine administration","volume":"39","author":"van Haaren","year":"1991","journal-title":"Pharm. Biochem Behav."},{"key":"10.1016\/j.bbr.2026.116055_bib21","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/sj.npp.1300778","article-title":"Sex differences and hormonal influences on acquisition of cocaine self-administration in rats","volume":"31","author":"Jackson","year":"2006","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2026.116055_bib22","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1007\/s00213-004-2080-7","article-title":"Influence of sex and estrous cyclicity on conditioned cue-induced reinstatement of cocaine-seeking behavior in rats","volume":"179","author":"Fuchs","year":"2005","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2026.116055_bib23","doi-asserted-by":"crossref","first-page":"1831","DOI":"10.1007\/s00429-013-0605-8","article-title":"Fos expression induced by cocaine-conditioned cues in male and female rats","volume":"219","author":"Zhou","year":"2014","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.bbr.2026.116055_bib24","unstructured":"Guide for the Care and Use of Laboratory Animals. The National Academies Collection: Reports funded by National Institutes of Health (Washington (DC), ed. 8th, 2011)."},{"key":"10.1016\/j.bbr.2026.116055_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.pacs.2021.100297","article-title":"Direct measurement of neuronal ensemble activity using photoacoustic imaging in the stimulated Fos-LacZ transgenic rat brain: a proof-of-principle study","volume":"24","author":"Matchynski","year":"2021","journal-title":"Photoacoustics"},{"key":"10.1016\/j.bbr.2026.116055_bib26","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.bbr.2015.02.027","article-title":"Single prolonged stress effects on sensitization to cocaine and cocaine self-administration in rats","volume":"284","author":"Eagle","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2026.116055_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.addicn.2022.100046","article-title":"Low- and high-cocaine intake affects the spatial and temporal dynamics of class IIa HDAC expression-activity in the nucleus accumbens and hippocampus of male rats as measured by [18F]TFAHA PET\/CT neuroimaging","volume":"4","author":"Perrine","year":"2022","journal-title":"Addict. Neurosci."},{"key":"10.1016\/j.bbr.2026.116055_bib28","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.brainres.2014.11.005","article-title":"Using c-fos to study neuronal ensembles in corticostriatal circuitry of addiction","volume":"1628","author":"Cruz","year":"2015","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2026.116055_bib29","unstructured":"G. Paxinos, C. Watson, The Rat Brain in Stereotaxic Coordinates 7th Edition. (elsevier), pp. 456."},{"key":"10.1016\/j.bbr.2026.116055_bib30","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1177\/1359105320937055","article-title":"Cumulative lifetime stress exposure predicts greater impulsivity and addictive behaviors","volume":"26","author":"McMullin","year":"2021","journal-title":"J. Health Psychol."},{"key":"10.1016\/j.bbr.2026.116055_bib31","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1523\/JNEUROSCI.23-02-00693.2003","article-title":"Effects of sex and estrogen on behavioral sensitization to cocaine in rats","volume":"23","author":"Hu","year":"2003","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2026.116055_bib32","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1124\/jpet.108.141051","article-title":"Alterations in fos-related antigen 2 and sigma1 receptor gene and protein expression are associated with the development of cocaine-induced behavioral sensitization: time course and regional distribution studies","volume":"327","author":"Liu","year":"2008","journal-title":"J. Pharm. Exp. Ther."},{"key":"10.1016\/j.bbr.2026.116055_bib33","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S0006-8993(01)03040-2","article-title":"Environmental context modulates the ability of cocaine and amphetamine to induce c-fos mRNA expression in the neocortex, caudate nucleus, and nucleus accumbens","volume":"920","author":"Uslaner","year":"2001","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2026.116055_bib34","doi-asserted-by":"crossref","first-page":"5303","DOI":"10.1523\/JNEUROSCI.3086-20.2021","article-title":"Estradiol regulation of the prelimbic cortex and the reinstatement of cocaine seeking in female rats","volume":"41","author":"Doncheck","year":"2021","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2026.116055_bib35","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00213-005-0071-y","article-title":"Potentiation of cocaine-primed reinstatement of drug seeking in female rats during estrus","volume":"182","author":"Kippin","year":"2005","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2026.116055_bib36","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1007\/s002130050042","article-title":"Reinstatement of cocaine self-administration in rats: sex differences","volume":"148","author":"Lynch","year":"1999","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2026.116055_bib37","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.pnpbp.2018.01.002","article-title":"Modeling cocaine relapse in rodents: Behavioral considerations and circuit mechanisms","volume":"87","author":"Farrell","year":"2018","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2026.116055_bib38","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s00213-003-1393-2","article-title":"Brain circuitry and the reinstatement of cocaine-seeking behavior","volume":"168","author":"Kalivas","year":"2003","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2026.116055_bib39","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1002\/syn.20666","article-title":"c-Fos expression associated with reinstatement of cocaine-seeking behavior by response-contingent conditioned cues","volume":"63","author":"Kufahl","year":"2009","journal-title":"Synapse"},{"key":"10.1016\/j.bbr.2026.116055_bib40","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/s41386-018-0125-6","article-title":"Sex differences in neural mechanisms mediating reward and addiction","volume":"44","author":"Becker","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2026.116055_bib41","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1002\/1098-1063(2000)10:3<274::AID-HIPO8>3.0.CO;2-Q","article-title":"Estradiol induces a phasic Fos response in the hippocampal CA1 and CA3 regions of adult female rats","volume":"10","author":"Rudick","year":"2000","journal-title":"Hippocampus"},{"key":"10.1016\/j.bbr.2026.116055_bib42","doi-asserted-by":"crossref","DOI":"10.1016\/j.yhbeh.2022.105296","article-title":"The medial preoptic area and acute cocaine's stimulant effects in rats: potential influences of estradiol and biological sex","volume":"148","author":"Martz","year":"2023","journal-title":"Horm. Behav."},{"key":"10.1016\/j.bbr.2026.116055_bib43","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s00213-017-4800-9","article-title":"Influence of preoptic estradiol on behavioral and neural response to cocaine in female Sprague-Dawley rats","volume":"235","author":"Robison","year":"2018","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbr.2026.116055_bib44","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/0149-7634(94)00021-R","article-title":"Conditioned place preference using opiate and stimulant drugs: a meta-analysis","volume":"19","author":"Bardo","year":"1995","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbr.2026.116055_bib45","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0006-8993(02)04240-3","article-title":"Strain differences in the behavioral responses of male rats to chronically administered methylphenidate","volume":"971","author":"Yang","year":"2003","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2026.116055_bib46","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms13877","article-title":"Dopaminergic dynamics underlying sex-specific cocaine reward","volume":"8","author":"Calipari","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbr.2026.116055_bib47","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.neuroscience.2016.05.049","article-title":"17beta-Estradiol infusions into the dorsal striatum rapidly increase dorsal striatal dopamine release in vivo","volume":"330","author":"Shams","year":"2016","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2026.116055_bib48","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1038\/s42003-021-02358-w","article-title":"Cocaine self-administration induces sex-dependent protein expression in the nucleus accumbens","volume":"4","author":"Lopez","year":"2021","journal-title":"Commun. Biol."},{"key":"10.1016\/j.bbr.2026.116055_bib49","doi-asserted-by":"crossref","first-page":"9525","DOI":"10.1523\/JNEUROSCI.2637-08.2008","article-title":"Region and sex differences in constituent dopamine neurons and immunoreactivity for intracellular estrogen and androgen receptors in mesocortical projections in rats","volume":"28","author":"Kritzer","year":"2008","journal-title":"J. Neurosci."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432826000318?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432826000318?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T07:24:16Z","timestamp":1771485856000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432826000318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":49,"alternative-id":["S0166432826000318"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2026.116055","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of nucleus accumbens Fos expression in sex-dependent cocaine-induced locomotion, cocaine self-administration, and primed cocaine seeking in rats","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2026.116055","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"116055"}}