{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T17:06:35Z","timestamp":1779815195199,"version":"3.53.1"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:00:00Z","timestamp":1769040000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100032579","name":"Beijing Medical Award Foundation","doi-asserted-by":"publisher","award":["YXJL-2022\\u20130351\\u20130177"],"award-info":[{"award-number":["YXJL-2022\\u20130351\\u20130177"]}],"id":[{"id":"10.13039\/100032579","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.bbr.2026.116058","type":"journal-article","created":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T00:44:43Z","timestamp":1769042683000},"page":"116058","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Sleep deprivation-induced TLR4\/MyD88\/NF-\u03baB pathway dysregulation worsens cognitive impairment in Parkinson\u2019s Disease"],"prefix":"10.1016","volume":"504","author":[{"given":"Tianhao","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinjia","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siyu","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoran","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhong","family":"Ren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rundong","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kechun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuna","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuhua","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9996","key":"10.1016\/j.bbr.2026.116058_bib1","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/S0140-6736(14)61393-3","article-title":"Parkinson's disease","volume":"386","author":"Kalia","year":"2015","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.bbr.2026.116058_bib2","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1002\/mds.24996","article-title":"Identifying prodromal Parkinson's disease: pre-motor disorders in Parkinson's disease","volume":"27","author":"Postuma","year":"2012","journal-title":"Mov. Disord. Off. J. Mov. Disord. Soc."},{"issue":"3","key":"10.1016\/j.bbr.2026.116058_bib3","doi-asserted-by":"crossref","first-page":"ITC33","DOI":"10.7326\/AITC202103160","article-title":"Insomnia","volume":"174","author":"Sutton","year":"2021","journal-title":"Ann. Intern. Med."},{"issue":"10","key":"10.1016\/j.bbr.2026.116058_bib4","article-title":"Insomnia: risk factor for neurodegenerative diseases","volume":"11","author":"Shamim","year":"2019","journal-title":"Cureus"},{"key":"10.1016\/j.bbr.2026.116058_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2022.853096","article-title":"Neuroinflammation, sleep, and circadian rhythms","volume":"12","author":"Zielinski","year":"2022","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.bbr.2026.116058_bib6","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.brainresbull.2021.11.011","article-title":"Asparagine endopeptidase deletion ameliorates cognitive impairments by inhibiting proinflammatory microglial activation in MPTP mouse model of Parkinson disease","volume":"178","author":"Gao","year":"2022","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.bbr.2026.116058_bib7","article-title":"Gastrodin regulates the TLR4\/TRAF6\/NF-\u03baB pathway to reduce neuroinflammation and microglial activation in an AD model","volume":"128","author":"Wang","year":"2024","journal-title":"Phytomedicine Int. J. Phytother. Phytopharm."},{"key":"10.1016\/j.bbr.2026.116058_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.etap.2021.103750","article-title":"Anti-inflammatory\/anti-apoptotic impact of betulin attenuates experimentally induced ulcerative colitis: an insight into TLR4\/NF-kB\/caspase signalling modulation","volume":"88","author":"El-Sherbiny","year":"2021","journal-title":"Environ. Toxicol. Pharmacol."},{"issue":"10","key":"10.1016\/j.bbr.2026.116058_bib9","doi-asserted-by":"crossref","first-page":"1610","DOI":"10.1038\/s41401-020-00597-x","article-title":"Deletion of TLR4 attenuates lipopolysaccharide-induced acute liver injury by inhibiting inflammation and apoptosis","volume":"42","author":"Chen","year":"2021","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.bbr.2026.116058_bib10","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1016\/j.ebiom.2018.08.035","article-title":"Boosting mTOR-dependent autophagy via upstream TLR4-MyD88-MAPK signalling and downstream NF-\u03baB pathway quenches intestinal inflammation and oxidative stress injury","volume":"35","author":"Zhou","year":"2018","journal-title":"EBioMedicine"},{"issue":"12","key":"10.1016\/j.bbr.2026.116058_bib11","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1080\/15548627.2020.1719723","article-title":"Microglial autophagy defect causes parkinson disease-like symptoms by accelerating inflammasome activation in mice","volume":"16","author":"Cheng","year":"2020","journal-title":"Autophagy"},{"issue":"3","key":"10.1016\/j.bbr.2026.116058_bib12","doi-asserted-by":"crossref","first-page":"540","DOI":"10.2174\/1570159X19666210712141041","article-title":"Zebrafish as a tool in the study of sleep and memory-related disorders","volume":"20","author":"Altenhofen","year":"2022","journal-title":"Curr. Neuropharmacol."},{"issue":"2","key":"10.1016\/j.bbr.2026.116058_bib13","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.tips.2013.12.002","article-title":"Zebrafish as an emerging model for studying complex brain disorders","volume":"35","author":"Kalueff","year":"2014","journal-title":"Trends Pharmacol. Sci."},{"issue":"2","key":"10.1016\/j.bbr.2026.116058_bib14","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s10071-016-1034-x","article-title":"Sleep deprivation effects on object discrimination task in zebrafish (Danio rerio)","volume":"20","author":"Pinheiro-da-Silva","year":"2017","journal-title":"Anim. Cogn."},{"key":"10.1016\/j.bbr.2026.116058_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2024.114861","article-title":"Sleep deprivation effects on EGFR signaling in a zebrafish exposed to rotenone","volume":"462","author":"Kniazkina","year":"2024","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2026.116058_bib16","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.neubiorev.2017.09.002","article-title":"The zebrafish as a promising tool for modeling human brain disorders: a review based upon an IBNS Symposium","volume":"85","author":"Shams","year":"2018","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"6","key":"10.1016\/j.bbr.2026.116058_bib17","first-page":"1099","article-title":"Modeling and evaluation of zebrafish insomnia by continuous illumination [In Chinese","volume":"57","author":"Simiao","year":"2022","journal-title":"Acta Univ. Med. Anhui"},{"key":"10.1016\/j.bbr.2026.116058_bib18","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/B978-0-12-384892-5.00011-6","article-title":"Monitoring sleep and arousal in zebrafish","volume":"100","author":"Rihel","year":"2010","journal-title":"Methods Cell Biol."},{"key":"10.1016\/j.bbr.2026.116058_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.175950","article-title":"Neuroprotective effect of chlorogenic acid on Parkinson's disease like symptoms through boosting the autophagy in zebrafish","volume":"956","author":"Gao","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbr.2026.116058_bib20","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/978-1-0716-2213-1_11","article-title":"Zebrafish behavioral assays in toxicology","volume":"2474","author":"Dasgupta","year":"2022","journal-title":"Methods Mol. Biol."},{"issue":"7","key":"10.1016\/j.bbr.2026.116058_bib21","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1002\/jat.4294","article-title":"Neurodevelopmental toxicity of pyrazinamide to larval zebrafish and the restoration after intoxication withdrawal","volume":"42","author":"Wang","year":"2022","journal-title":"J. Appl. Toxicol."},{"issue":"8","key":"10.1016\/j.bbr.2026.116058_bib22","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1136\/jnnp-2019-322338","article-title":"Parkinson's disease: etiopathogenesis and treatment","volume":"91","author":"Jankovic","year":"2020","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"8","key":"10.1016\/j.bbr.2026.116058_bib23","doi-asserted-by":"crossref","first-page":"1261","DOI":"10.3390\/cells11081261","article-title":"GBA variants and Parkinson disease: mechanisms and treatments","volume":"11","author":"Smith","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.bbr.2026.116058_bib24","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/5764017","article-title":"Sleep deprivation and neurological disorders","volume":"2020","author":"Bishir","year":"2020","journal-title":"BioMed. Res. Int."},{"issue":"8","key":"10.1016\/j.bbr.2026.116058_bib25","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.3390\/brainsci13081202","article-title":"Neurological insights into sleep disorders in Parkinson's Disease","volume":"13","author":"Thangaleela","year":"2023","journal-title":"Brain Sci."},{"issue":"9","key":"10.1016\/j.bbr.2026.116058_bib26","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1016\/S1474-4422(24)00170-4","article-title":"Sleep and sleep disorders in people with Parkinson's disease","volume":"23","author":"Iranzo","year":"2024","journal-title":"Lancet Neurol."},{"issue":"2","key":"10.1016\/j.bbr.2026.116058_bib27","doi-asserted-by":"crossref","first-page":"1425","DOI":"10.1039\/C9FO02288K","article-title":"Anti-Parkinson's disease activity of phenolic acids from Eucommia ulmoides Oliver leaf extracts and their autophagy activation mechanism","volume":"11","author":"Zhang","year":"2020","journal-title":"Food Funct."},{"issue":"1","key":"10.1016\/j.bbr.2026.116058_bib28","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ydbio.2007.11.012","article-title":"Visualization of monoaminergic neurons and neurotoxicity of MPTP in live transgenic zebrafish","volume":"314","author":"Wen","year":"2008","journal-title":"Dev. Biol."},{"key":"10.1016\/j.bbr.2026.116058_bib29","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1016\/j.freeradbiomed.2015.08.013","article-title":"Discovery of a novel neuroprotectant, BHDPC, that protects against MPP+\/MPTP-induced neuronal death in multiple experimental models","volume":"89","author":"Chong","year":"2015","journal-title":"Free Radic. Biol. Med."},{"issue":"2","key":"10.1016\/j.bbr.2026.116058_bib30","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1006\/dbio.2002.0711","article-title":"In vivo imaging of embryonic vascular development using transgenic zebrafish","volume":"248","author":"Lawson","year":"2002","journal-title":"Dev. Biol."},{"issue":"5","key":"10.1016\/j.bbr.2026.116058_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.bj.2024.100826","article-title":"Sleep deprivation affects pain sensitivity by increasing oxidative stress and apoptosis in the medial prefrontal cortex of rats via the HDAC2-NRF2 pathway","volume":"48","author":"Chen","year":"2025","journal-title":"Biomed. J."},{"key":"10.1016\/j.bbr.2026.116058_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1430599","article-title":"Melatonin modulates TLR4\/MyD88\/NF-\u03baB signaling pathway to ameliorate cognitive impairment in sleep-deprived rats","volume":"15","author":"Yin","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbr.2026.116058_bib33","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.brainresbull.2021.06.010","article-title":"Melatonin ameliorates anxiety-like behaviors induced by sleep deprivation in mice: role of oxidative stress, neuroinflammation, autophagy and apoptosis","volume":"174","author":"Wang","year":"2021","journal-title":"Brain Res. Bull."},{"issue":"2","key":"10.1016\/j.bbr.2026.116058_bib34","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3390\/brainsci13020179","article-title":"Gastrodin improves cognitive dysfunction in REM sleep-deprived rats by regulating TLR4\/NF-\u03baB and Wnt\/\u03b2-catenin signaling pathways","volume":"13","author":"Liu","year":"2023","journal-title":"Brain Sci."},{"issue":"2","key":"10.1016\/j.bbr.2026.116058_bib35","doi-asserted-by":"crossref","first-page":"3101","DOI":"10.18632\/aging.202503","article-title":"Sleep deprivation aggravates brain injury after experimental subarachnoid hemorrhage via TLR4-MyD88 pathway","volume":"13","author":"Xu","year":"2021","journal-title":"Aging"},{"issue":"1","key":"10.1016\/j.bbr.2026.116058_bib36","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s12035-025-05610-0","article-title":"Sleep deprivation induces anxiety-like behaviors in mice by impairing ApoE\/AMPK\/mTOR-mediated autophagy","volume":"63","author":"Bai","year":"2025","journal-title":"Mol. Neurobiol."},{"issue":"3","key":"10.1016\/j.bbr.2026.116058_bib37","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/s11910-015-0525-5","article-title":"Parkinson's disease and sleep\/wake disturbances","volume":"15","author":"Suzuki","year":"2015","journal-title":"Curr. Neurol. Neurosci. Rep."},{"issue":"1","key":"10.1016\/j.bbr.2026.116058_bib38","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsae251","article-title":"Glymphatic system, sleep, and Parkinson's disease: interconnections, research opportunities, and potential for disease modification","volume":"48","author":"Nepozitek","year":"2025","journal-title":"Sleep"},{"issue":"1","key":"10.1016\/j.bbr.2026.116058_bib39","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s12035-025-05545-6","article-title":"Bidirectional effects of sleep deprivation associated with Parkinson's disease on behavior, oxidative stress, and energy metabolism in male and female rats","volume":"63","author":"Mathia","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbr.2026.116058_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2022.927994","article-title":"Bidirectional relationship between sleep disturbances and Parkinson's Disease","volume":"13","author":"Minakawa","year":"2022","journal-title":"Front. Neurol."},{"key":"10.1016\/j.bbr.2026.116058_bib41","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2020.592989","article-title":"Molecular mechanisms underlying reciprocal interactions between sleep disorders and Parkinson's Disease","volume":"14","author":"Yang","year":"2021","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.bbr.2026.116058_bib42","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.neuroscience.2024.08.008","article-title":"Alzheimer's disease and sleep disorders: a bidirectional relationship","volume":"557","author":"Chen","year":"2024","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2026.116058_bib43","article-title":"Pathophysiology and pharmacological management for sleep problems in Parkinson's disease","author":"Falup-Pecurariu","year":"2025","journal-title":"J. Park. Dis."},{"issue":"4","key":"10.1016\/j.bbr.2026.116058_bib44","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1111\/cns.14060","article-title":"Ferulic acid alleviates sciatica by inhibiting neuroinflammation and promoting nerve repair via the TLR4\/NF-\u03baB pathway","volume":"29","author":"Zhang","year":"2023","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.bbr.2026.116058_bib45","article-title":"Neurodegenerative diseases and immune system: from pathogenic mechanism to therapy","author":"Chen","year":"2025","journal-title":"Neural Regen. Res."},{"issue":"1","key":"10.1016\/j.bbr.2026.116058_bib46","article-title":"Specificity in the commonalities of inhibition control: using meta-analysis and regression analysis to identify the key brain regions in psychiatric disorders","volume":"67","author":"Wan","year":"2024","journal-title":"Eur. Psychiatry. J. Assoc. Eur. Psychiatr."},{"key":"10.1016\/j.bbr.2026.116058_bib47","article-title":"Ginsenoside Rd: a promising natural neuroprotective agent","volume":"95","author":"Chen","year":"2022","journal-title":"Phytomedicine Int. J. Phytother. Phytopharm."},{"key":"10.1016\/j.bbr.2026.116058_bib48","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.freeradbiomed.2024.08.031","article-title":"Icariin targets p53 to protect against ceramide-induced neuronal senescence: implication in Alzheimer's disease","volume":"224","author":"Wu","year":"2024","journal-title":"Free Radic. Biol. Med."},{"issue":"1","key":"10.1016\/j.bbr.2026.116058_bib49","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12974-020-02065-z","article-title":"Microglial activation contributes to cognitive impairments in rotenone-induced mouse Parkinson's disease model","volume":"18","author":"Zhang","year":"2021","journal-title":"J. Neuroinflamm."},{"issue":"8","key":"10.1016\/j.bbr.2026.116058_bib50","doi-asserted-by":"crossref","first-page":"2651","DOI":"10.1016\/j.jmb.2020.01.037","article-title":"Autophagy in Parkinson's Disease","volume":"432","author":"Hou","year":"2020","journal-title":"J. Mol. Biol."},{"issue":"8","key":"10.1016\/j.bbr.2026.116058_bib51","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.3390\/biom15081188","article-title":"Apelin-13-mediated upregulation of METTL3 Ameliorates Alzheimer's disease via inhibiting neuroinflammation through m6A-dependent regulation of lncRNA BDNF-AS","volume":"15","author":"Han","year":"2025","journal-title":"Biomolecules"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432826000343?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432826000343?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T16:45:55Z","timestamp":1779813955000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432826000343"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":51,"alternative-id":["S0166432826000343"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2026.116058","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sleep deprivation-induced TLR4\/MyD88\/NF-\u03baB pathway dysregulation worsens cognitive impairment in Parkinson\u2019s Disease","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2026.116058","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"116058"}}