{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T17:06:41Z","timestamp":1779815201960,"version":"3.53.1"},"reference-count":165,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2025ZNSFSC0710"],"award-info":[{"award-number":["2025ZNSFSC0710"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.bbr.2026.116088","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T07:37:24Z","timestamp":1770449844000},"page":"116088","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Natural synergistic interventions for depression: Voluntary wheel running and flavonoids"],"prefix":"10.1016","volume":"504","author":[{"given":"DeXia","family":"Kong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"DongLing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"YunFei","family":"Duan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2026.116088_bib1","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2023.1320304","article-title":"Industry influence on mental health research: depression as a case example","volume":"10","author":"Cosgrove","year":"2024","journal-title":"Front. Med."},{"key":"10.1016\/j.bbr.2026.116088_bib2","unstructured":"WHO, Depressive disorder (depression), (2023). \u3008https:\/\/www.who.int\/news-room\/fact-sheets\/detail\/depression\u3009 (Accessed April 28, 2025)."},{"key":"10.1016\/j.bbr.2026.116088_bib3","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1176\/appi.focus.16407","article-title":"Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis","volume":"16","author":"Cipriani","year":"2018","journal-title":"Focus"},{"key":"10.1016\/j.bbr.2026.116088_bib4","article-title":"Prevention and management of physical health conditions in adults with severe mental disorders: WHO recommendations","volume":"15","author":"Pc","year":"2021","journal-title":"Int. J. Ment. Health Syst."},{"key":"10.1016\/j.bbr.2026.116088_bib5","unstructured":"Depression in adults: treatment and management, PubMed (2022). \u3008https:\/\/pubmed.ncbi.nlm.nih.gov\/35977056\/\u3009 (Accessed December 23, 2025)."},{"key":"10.1016\/j.bbr.2026.116088_bib6","article-title":"Clinical guidelines for the use of lifestyle-based mental health care in major depressive disorder: world federation of societies for biological psychiatry (WFSBP) and australasian society of lifestyle medicine (ASLM) taskforce","volume":"24","author":"M","year":"2023","journal-title":"World J. Biol. Psychiatry Off. J. World Fed. Soc. Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2026.116088_bib7","article-title":"New trends in personalized treatment of depression","volume":"37","author":"S","year":"2024","journal-title":"Curr. Opin. Psychiatry"},{"key":"10.1016\/j.bbr.2026.116088_bib8","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1037\/a0021769","article-title":"Lifestyle and mental health","volume":"66","author":"Walsh","year":"2011","journal-title":"Am. Psychol."},{"key":"10.1016\/j.bbr.2026.116088_bib9","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/1471-244X-14-107","article-title":"Lifestyle medicine for depression","volume":"14","author":"Sarris","year":"2014","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.bbr.2026.116088_bib10","article-title":"Exercise and the brain: something to chew on","volume":"32","author":"van","year":"2009","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.bbr.2026.116088_bib11","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/3589271","article-title":"Lifestyle modulators of neuroplasticity: how physical activity, mental engagement, and diet promote cognitive health during aging","volume":"2017","author":"Phillips","year":"2017","journal-title":"Neural Plast."},{"key":"10.1016\/j.bbr.2026.116088_bib12","article-title":"Effects of aerobic exercise and dietary flavonoids on cognition: a systematic review and meta-analysis","volume":"14","author":"Joseph","year":"2023","journal-title":"Front Physiol."},{"key":"10.1016\/j.bbr.2026.116088_bib13","article-title":"Docosahexaenoic acid dietary supplementation enhances the effects of exercise on synaptic plasticity and cognition","volume":"155","author":"A","year":"2008","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2026.116088_bib14","article-title":"Plant-derived flavanol (-)epicatechin enhances angiogenesis and retention of spatial memory in mice","volume":"27","author":"van P","year":"2007","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.bbr.2026.116088_bib15","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.3390\/ijerph18041645","article-title":"Skeletal muscle metabolomic responses to endurance and resistance training in rats under chronic unpredictable mild stress","volume":"18","author":"Liu","year":"2021","journal-title":"Int J. Environ. Res Public Health"},{"key":"10.1016\/j.bbr.2026.116088_bib16","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1007\/s00441-018-2973-0","article-title":"Animal models of depression: pros and cons","volume":"377","author":"Harro","year":"2019","journal-title":"Cell Tissue Res."},{"key":"10.1016\/j.bbr.2026.116088_bib17","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2023-075847","article-title":"Effect of exercise for depression: systematic review and network meta-analysis of randomised controlled trials","volume":"384","author":"Noetel","year":"2024","journal-title":"BMJ"},{"key":"10.1016\/j.bbr.2026.116088_bib18","doi-asserted-by":"crossref","first-page":"4965","DOI":"10.1007\/s11033-022-07156-z","article-title":"An overview of the molecular and physiological antidepressant mechanisms of physical exercise in animal models of depression","volume":"49","author":"de Oliveira","year":"2022","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.bbr.2026.116088_bib19","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1249\/MSS.0000000000001627","article-title":"Exercise reduces dopamine D1R and Increases D2R in rats: implications for addiction","volume":"50","author":"Robison","year":"2018","journal-title":"Med. Sci. Sports Exerc"},{"key":"10.1016\/j.bbr.2026.116088_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fnint.2024.1426219","article-title":"Voluntary wheel running access produces opposite effects in male and female rats on both palatable diet consumption and associated ventral striatal opioid- and dopamine-related gene expression","volume":"18","author":"Kocum","year":"2024","journal-title":"Front. Integr. Neurosci."},{"key":"10.1016\/j.bbr.2026.116088_bib21","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jsams.2013.03.010","article-title":"Exercise and the treatment of depression: a review of the exercise program variables","volume":"17","author":"Stanton","year":"2014","journal-title":"J. Sci. Med Sport"},{"key":"10.1016\/j.bbr.2026.116088_bib22","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.3390\/ph16121691","article-title":"Procognitive, anxiolytic, and antidepressant-like properties of hyperoside and protocatechuic acid corresponding with the increase in serum serotonin level after prolonged treatment in mice","volume":"16","author":"Orzelska-G\u00f3rka","year":"2023","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.bbr.2026.116088_bib23","doi-asserted-by":"crossref","first-page":"3069","DOI":"10.1519\/JSC.0000000000003282","article-title":"Comparison of the affective responses to continuous training and high-intensity interval training protocols: application of the dual-mode model","volume":"35","author":"Alicea","year":"2021","journal-title":"J. Strength Cond. Res."},{"key":"10.1016\/j.bbr.2026.116088_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2023.1259711","article-title":"Exercise as an antidepressant: exploring its therapeutic potential","volume":"14","author":"Hwang","year":"2023","journal-title":"Front Psychiatry"},{"key":"10.1016\/j.bbr.2026.116088_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0299481","article-title":"Exercise induced hypoalgesia during different intensities of a dynamic resistance exercise: a randomized controlled trial","volume":"19","author":"Wilson","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.bbr.2026.116088_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyg.2020.568331","article-title":"Affective determinants of physical activity: a conceptual framework and narrative review","volume":"11","author":"Stevens","year":"2020","journal-title":"Front. Psychol."},{"key":"10.1016\/j.bbr.2026.116088_bib27","doi-asserted-by":"crossref","first-page":"641","DOI":"10.2165\/11590680-000000000-00000","article-title":"The pleasure and displeasure people feel when they exercise at different intensities: decennial update and progress towards a tripartite rationale for exercise intensity prescription","volume":"41","author":"Ekkekakis","year":"2011","journal-title":"Sports Med."},{"key":"10.1016\/j.bbr.2026.116088_bib28","doi-asserted-by":"crossref","first-page":"R926","DOI":"10.1152\/ajpregu.00694.2005","article-title":"Novel quantitative phenotypes of exercise training in mouse models","volume":"290","author":"De Bono","year":"2006","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.bbr.2026.116088_bib29","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1006\/anbe.1998.0836","article-title":"Voluntary wheel running: a review and novel interpretation","volume":"56","author":"Sherwin","year":"1998","journal-title":"Anim. Behav."},{"key":"10.1016\/j.bbr.2026.116088_bib30","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.physbeh.2015.05.025","article-title":"Effects of voluntary exercise on spontaneous physical activity and food consumption in mice: results from an artificial selection experiment","volume":"149","author":"Copes","year":"2015","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbr.2026.116088_bib31","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.cub.2016.12.009","article-title":"Increases in physical activity result in diminishing increments in daily energy expenditure in mice","volume":"27","author":"O\u2019Neal","year":"2017","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bbr.2026.116088_bib32","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1258\/002367700780384681","article-title":"Preferences of mice, Mus musculus, for different types of running wheel","volume":"34","author":"Banjanin","year":"2000","journal-title":"Lab Anim."},{"key":"10.1016\/j.bbr.2026.116088_bib33","article-title":"Wheel running in the wild","volume":"281","author":"Meijer","year":"2014","journal-title":"Proc. Biol. Sci."},{"key":"10.1016\/j.bbr.2026.116088_bib34","doi-asserted-by":"crossref","first-page":"R77","DOI":"10.1530\/JME-17-0165","article-title":"Voluntary exercise and depression-like behavior in rodents: are we running in the right direction?","volume":"60","author":"Mul","year":"2018","journal-title":"J. Mol. Endocrinol."},{"key":"10.1016\/j.bbr.2026.116088_bib35","doi-asserted-by":"crossref","first-page":"e476","DOI":"10.1097\/j.pain.0000000000002392","article-title":"Voluntary exercise blocks ongoing pain and diminishes bone remodeling while sparing protective mechanical pain in a rat model of advanced osteoarthritis pain","volume":"163","author":"Townsend","year":"2022","journal-title":"Pain"},{"key":"10.1016\/j.bbr.2026.116088_bib36","article-title":"Voluntary wheel running: patterns and physiological effects in mice","volume":"52","author":"Manzanares","year":"2018","journal-title":"Braz. J. Med Biol. Res."},{"key":"10.1016\/j.bbr.2026.116088_bib37","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1523\/JNEUROSCI.23-07-02889.2003","article-title":"Freewheel running prevents learned helplessness\/behavioral depression: role of dorsal raphe serotonergic neurons","volume":"23","author":"Greenwood","year":"2003","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.bbr.2026.116088_bib38","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.brainres.2007.12.047","article-title":"Voluntary exercise produces antidepressant and anxiolytic behavioral effects in mice","volume":"1199","author":"Duman","year":"2008","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2026.116088_bib39","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1111\/ejn.14630","article-title":"Role of BDNF in the pathophysiology and treatment of depression: activity-dependent effects distinguish rapid-acting antidepressants","volume":"53","author":"Duman","year":"2021","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bbr.2026.116088_bib40","doi-asserted-by":"crossref","first-page":"3724","DOI":"10.1007\/s12011-024-04433-9","article-title":"Effect of voluntary wheel running on anxiety- and depression-like behaviors in fluoride-exposed mice","volume":"203","author":"Qi","year":"2025","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.bbr.2026.116088_bib41","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2024.137872","article-title":"Long-term voluntary running improves cognitive ability in developing mice by modulating the cholinergic system, antioxidant ability, and BDNF\/PI3K\/Akt\/CREB pathway","volume":"836","author":"Wan","year":"2024","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbr.2026.116088_bib42","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jpsychires.2014.10.003","article-title":"A meta-analytic review of the effects of exercise on brain-derived neurotrophic factor","volume":"60","author":"Szuhany","year":"2015","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.bbr.2026.116088_bib43","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1177\/1073858420975712","article-title":"Does the brain-derived neurotrophic factor Val66Met polymorphism modulate the effects of physical activity and exercise on cognition?","volume":"28","author":"de Las Heras","year":"2022","journal-title":"Neuroscientist"},{"key":"10.1016\/j.bbr.2026.116088_bib44","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.jad.2023.01.086","article-title":"Effects of exercise training on inflammatory, neurotrophic and immunological markers and neurotransmitters in people with depression: a systematic review and meta-analysis","volume":"326","author":"da Cunha","year":"2023","journal-title":"J. Affect Disord."},{"key":"10.1016\/j.bbr.2026.116088_bib45","doi-asserted-by":"crossref","DOI":"10.1155\/da\/5716755","article-title":"The optimal type and dose of exercise for elevating brain-derived neurotrophic factor levels in patients with depression: a systematic review with pairwise, network, and dose-response meta-analyses","volume":"2024","author":"Yuping","year":"2024","journal-title":"Depress Anxiety"},{"key":"10.1016\/j.bbr.2026.116088_bib46","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1249\/MSS.0000000000003394","article-title":"Simple and complex wheel running effect on depression, memory, neuroinflammation, and neurogenesis in Alzheimer\u2019s Rat Model","volume":"56","author":"Talebi","year":"2024","journal-title":"Med. Sci. Sports Exerc"},{"key":"10.1016\/j.bbr.2026.116088_bib47","doi-asserted-by":"crossref","DOI":"10.1177\/03000605241261986","article-title":"The improvement effect of exercise on rats with chronic stress-induced depression-like behavior: a discussion based on the kynurenine pathway","volume":"52","author":"Zhao","year":"2024","journal-title":"J. Int. Med. Res."},{"key":"10.1016\/j.bbr.2026.116088_bib48","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1038\/s41380-024-02464-1","article-title":"Running exercise alleviates hippocampal neuroinflammation and shifts the balance of microglial M1\/M2 polarization through adiponectin\/AdipoR1 pathway activation in mice exposed to chronic unpredictable stress","volume":"29","author":"Liu","year":"2024","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbr.2026.116088_bib49","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1016\/j.neuropharm.2011.10.006","article-title":"Anxiety- and depression-like behaviors are accompanied by an increase in oxidative stress in a rat model of fetal alcohol spectrum disorders: protective effects of voluntary physical exercise","volume":"62","author":"Brocardo","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2026.116088_bib50","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3389\/fpsyt.2013.00003","article-title":"Treating depression and depression-like behavior with physical activity: an immune perspective","volume":"4","author":"Eyre","year":"2013","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.bbr.2026.116088_bib51","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1186\/s12877-023-04544-3","volume":"23","author":"Pleguezuelos","year":"2023","journal-title":"BMC Geriatr."},{"key":"10.1016\/j.bbr.2026.116088_bib52","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.700055","article-title":"A Mixed Comparisons of different intensities and types of physical exercise in patients with diseases related to oxidative stress: a systematic review and network meta-analysis","volume":"12","author":"Lu","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbr.2026.116088_bib53","doi-asserted-by":"crossref","first-page":"256","DOI":"10.3389\/fnins.2019.00256","article-title":"Voluntary wheel running reverses deficits in social behavior induced by chronic social defeat stress in mice: involvement of the dopamine system","volume":"13","author":"Zhang","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.bbr.2026.116088_bib54","doi-asserted-by":"crossref","DOI":"10.1080\/10253890.2023.2245492","article-title":"Female rats are more responsive than are males to the protective effects of voluntary physical activity against the behavioral consequences of inescapable stress","volume":"26","author":"Tanner","year":"2023","journal-title":"Stress"},{"key":"10.1016\/j.bbr.2026.116088_bib55","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1016\/j.neubiorev.2019.09.040","article-title":"Physical activity and depression: towards understanding the antidepressant mechanisms of physical activity","volume":"107","author":"Kandola","year":"2019","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbr.2026.116088_bib56","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1002\/wps.21314","article-title":"The efficacy, mechanisms and implementation of physical activity as an adjunctive treatment in mental disorders: a meta-review of outcomes, neurobiology and key determinants","volume":"24","author":"Vancampfort","year":"2025","journal-title":"World Psychiatry"},{"key":"10.1016\/j.bbr.2026.116088_bib57","article-title":"Sex-specific effects of voluntary wheel running on behavior and the gut microbiota-immune-brain axis in mice","volume":"30","author":"Williams","year":"2023","journal-title":"Brain Behav. Immun. Health"},{"key":"10.1016\/j.bbr.2026.116088_bib58","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2021.113675","article-title":"Effects of selective breeding, voluntary exercise, and sex on endocannabinoid levels in the mouse small-intestinal epithelium","volume":"245","author":"Schmill","year":"2022","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbr.2026.116088_bib59","article-title":"Exercise-induced oxidative-nitrosative stress is associated with impaired dynamic cerebral autoregulation and blood-brain barrier leakage","volume":"96","author":"Dm","year":"2011","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.bbr.2026.116088_bib60","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.70219","article-title":"Eight weeks of resistance exercise improves mood state and intestinal permeability in healthy adults: a randomized controlled trial","volume":"13","author":"Dow","year":"2025","journal-title":"Physiol. Rep."},{"key":"10.1016\/j.bbr.2026.116088_bib61","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1002\/hipo.20579","article-title":"Running exercise-induced up-regulation of hippocampal brain-derived neurotrophic factor is CREB-dependent","volume":"19","author":"Chen","year":"2009","journal-title":"Hippocampus"},{"key":"10.1016\/j.bbr.2026.116088_bib62","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2024.137872","article-title":"Long-term voluntary running improves cognitive ability in developing mice by modulating the cholinergic system, antioxidant ability, and BDNF\/PI3K\/Akt\/CREB pathway","volume":"836","author":"Wan","year":"2024","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbr.2026.116088_bib63","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1139\/apnm-2024-0024","article-title":"Reduced-exertion high-intensity interval training (REHIT): a feasible approach for improving health and fitness?","volume":"49","author":"Metcalfe","year":"2024","journal-title":"Appl. Physiol. Nutr. Metab."},{"key":"10.1016\/j.bbr.2026.116088_bib64","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1186\/s12966-024-01636-0","article-title":"Individualized pleasure-oriented exercise sessions, exercise frequency, and affective outcomes: a pragmatic randomized controlled trial","volume":"21","author":"Teixeira","year":"2024","journal-title":"Int. J. Behav. Nutr. Phys. Act."},{"key":"10.1016\/j.bbr.2026.116088_bib65","doi-asserted-by":"crossref","first-page":"351","DOI":"10.3949\/ccjm.73.4.351","article-title":"Side effects of antidepressants: an overview","volume":"73","author":"Khawam","year":"2006","journal-title":"Cleve Clin. J. Med."},{"key":"10.1016\/j.bbr.2026.116088_bib66","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1097\/JCP.0000000000001928","article-title":"Differentiating depressive symptoms from side effects in individuals with major depressive disorder with postpartum onset","volume":"45","author":"Pulido","year":"2025","journal-title":"J. Clin. Psychopharmacol."},{"key":"10.1016\/j.bbr.2026.116088_bib67","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.gerinurse.2012.08.004","article-title":"Antidepressant adverse drug reactions in older adults: implications for RNs and APNs","volume":"34","author":"Mitsch","year":"2013","journal-title":"Geriatr. Nurs."},{"key":"10.1016\/j.bbr.2026.116088_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2023.114431","article-title":"A comprehensive review and meta-analysis of neurological side effects related to second-generation antidepressants in individuals with major depressive disorder","volume":"447","author":"Zhou","year":"2023","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbr.2026.116088_bib69","doi-asserted-by":"crossref","first-page":"4982","DOI":"10.3390\/molecules28134982","article-title":"A review of classification, biosynthesis, biological activities and potential applications of flavonoids","volume":"28","author":"Chen","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.bbr.2026.116088_bib70","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2025.111489","article-title":"Flavonoids and their role in oxidative stress, inflammation, and human diseases","volume":"413","author":"Jomova","year":"2025","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.bbr.2026.116088_bib71","doi-asserted-by":"crossref","first-page":"3750","DOI":"10.1080\/10408398.2021.1993128","article-title":"LC-Q-TOF-MS\/MS detection of food flavonoids: principle, methodology, and applications","volume":"63","author":"Yang","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.bbr.2026.116088_bib72","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.2174\/1381612826666200127093701","article-title":"Anthocyanins: plant pigments, food ingredients or therapeutic agents for the CNS? A mini-review focused on clinical trials","volume":"26","author":"C\u00e1sedas","year":"2020","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bbr.2026.116088_bib73","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2022.101146","article-title":"Revisiting the bioavailability of flavan-3-ols in humans: a systematic review and comprehensive data analysis","volume":"89","author":"Di Pede","year":"2023","journal-title":"Mol. Asp. Med."},{"key":"10.1016\/j.bbr.2026.116088_bib74","article-title":"Flavonols and flavones as potential anti-inflammatory, antioxidant, and antibacterial compounds","volume":"2022","author":"do S.S. Chagas","year":"2022","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.bbr.2026.116088_bib75","doi-asserted-by":"crossref","first-page":"423","DOI":"10.3945\/an.116.012948","article-title":"Flavones: food sources, bioavailability, metabolism, and bioactivity","volume":"8","author":"Hostetler","year":"2017","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.bbr.2026.116088_bib76","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s13318-021-00731-y","article-title":"Pharmacology of diosmin, a citrus flavone glycoside: an updated review","volume":"47","author":"Gerges","year":"2022","journal-title":"Eur. J. Drug Metab. Pharm."},{"key":"10.1016\/j.bbr.2026.116088_bib77","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.3390\/molecules24061076","article-title":"Isoflavones","volume":"24","author":"K\u0159\u00ed\u017eov\u00e1","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.bbr.2026.116088_bib78","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0031-9422(00)00235-1","article-title":"Advances in flavonoid research since 1992","volume":"55","author":"Harborne","year":"2000","journal-title":"Phytochemistry"},{"key":"10.1016\/j.bbr.2026.116088_bib79","doi-asserted-by":"crossref","first-page":"8839","DOI":"10.1080\/10408398.2022.2057914","article-title":"Flavonoids for depression and anxiety: a systematic review and meta-analysis","volume":"63","author":"Jia","year":"2023","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.bbr.2026.116088_bib80","doi-asserted-by":"crossref","first-page":"1644","DOI":"10.3390\/antiox10111644","article-title":"Exploring the impact of flavonoids on symptoms of depression: a systematic review and meta-analysis","volume":"10","author":"Ali","year":"2021","journal-title":"Antioxidants"},{"key":"10.1016\/j.bbr.2026.116088_bib81","doi-asserted-by":"crossref","DOI":"10.1155\/2018\/2963565","article-title":"Advances in the preclinical study of some flavonoids as potential antidepressant agents","volume":"2018","author":"German-Ponciano","year":"2018","journal-title":"Scientifica"},{"key":"10.1016\/j.bbr.2026.116088_bib82","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1211\/0022357991772790","article-title":"Flavonoids and the central nervous system: from forgotten factors to potent anxiolytic compounds","volume":"51","author":"Paladini","year":"1999","journal-title":"J. Pharm. Pharm."},{"key":"10.1016\/j.bbr.2026.116088_bib83","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1016\/j.biopha.2017.06.010","article-title":"Protective effects of flavonoids against Alzheimer\u2019s disease-related neural dysfunctions","volume":"93","author":"Bakhtiari","year":"2017","journal-title":"Biomed. Pharm."},{"key":"10.1016\/j.bbr.2026.116088_bib84","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/S0031-6997(24)01472-8","article-title":"The effects of plant flavonoids on mammalian cells: implications for inflammation, heart disease, and cancer","volume":"52","author":"Middleton","year":"2000","journal-title":"Pharm. Rev."},{"key":"10.1016\/j.bbr.2026.116088_bib85","doi-asserted-by":"crossref","first-page":"1493","DOI":"10.1002\/ptr.5651","article-title":"Brain-derived neurotrophic factor signaling mediates the antidepressant-like effect of the total flavonoids of alpiniae oxyphyllae fructus in chronic unpredictable mild stress mice","volume":"30","author":"Yan","year":"2016","journal-title":"Phytother. Res"},{"key":"10.1016\/j.bbr.2026.116088_bib86","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/s41380-020-00925-x","article-title":"Diet and depression: exploring the biological mechanisms of action","volume":"26","author":"Marx","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbr.2026.116088_bib87","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1002\/mnfr.201400753","article-title":"Orientin improves depression-like behavior and BDNF in chronic stressed mice","volume":"59","author":"Liu","year":"2015","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.bbr.2026.116088_bib88","doi-asserted-by":"crossref","first-page":"3387","DOI":"10.1021\/acschemneuro.1c00371","article-title":"Quercitrin rapidly alleviated depression-like behaviors in lipopolysaccharide-treated mice: the involvement of PI3K\/AKT\/NF-\u03baB signaling suppression and CREB\/BDNF signaling restoration in the hippocampus","volume":"12","author":"Sun","year":"2021","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.bbr.2026.116088_bib89","doi-asserted-by":"crossref","first-page":"381","DOI":"10.3389\/fpsyt.2020.00381","article-title":"Associations among monoamine neurotransmitter pathways, personality traits, and major depressive disorder","volume":"11","author":"Shao","year":"2020","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.bbr.2026.116088_bib90","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.physbeh.2010.10.008","article-title":"Involvement of monoaminergic systems in the antidepressant-like effect of nobiletin","volume":"102","author":"Yi","year":"2011","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbr.2026.116088_bib91","article-title":"Quercetin alleviates chronic unpredictable mild stress-induced depression-like behavior by inhibiting NMDAR1 with \u03b12\u03b4-1 in rats","volume":"30","author":"Wang","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.bbr.2026.116088_bib92","first-page":"670","volume":"44","author":"Tongtong","year":"2024","journal-title":"J. Tradit. Chin. Med."},{"key":"10.1016\/j.bbr.2026.116088_bib93","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/j.pnpbp.2010.06.024","article-title":"Involvement of monoaminergic system in the antidepressant-like effect of the flavonoid naringenin in mice","volume":"34","author":"Yi","year":"2010","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2026.116088_bib94","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.brainresbull.2020.12.003","article-title":"Naringenin improves depressive- and anxiety-like behaviors in mice exposed to repeated hypoxic stress through modulation of oxido-inflammatory mediators and NF-kB\/BDNF expressions","volume":"169","author":"Olugbemide","year":"2021","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.bbr.2026.116088_bib95","doi-asserted-by":"crossref","first-page":"904","DOI":"10.2174\/1570159X21666230811141557","article-title":"The HPA axis as target for depression","volume":"22","author":"Menke","year":"2024","journal-title":"Curr. Neuropharmacol."},{"key":"10.1016\/j.bbr.2026.116088_bib96","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.2174\/1381612826666200127093701","article-title":"Anthocyanins: plant pigments, food ingredients or therapeutic agents for the CNS? A mini-review focused on clinical trials","volume":"26","author":"C\u00e1sedas","year":"2020","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bbr.2026.116088_bib97","doi-asserted-by":"crossref","first-page":"11076","DOI":"10.3390\/ijms222011076","article-title":"An insight into anti-inflammatory activities and inflammation related diseases of anthocyanins: a review of both in vivo and in vitro investigations","volume":"22","author":"Ma","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbr.2026.116088_bib98","doi-asserted-by":"crossref","unstructured":"L. Li, W. Zhang, C. Sun, Z. Chai, K. Wang, Q. Zhou, X. Wang, Scutellariae radix Ameliorates Prenatal Stress-Induced Anxiety-Like and Depression-Like Behavior in the Offspring via Reversing HPA Axis Hyperfunction and Ameliorating Neurodevelopmental Dysfunction, Dev Neurosci (n.d.). https:\/\/doi.org\/10.1159\/000543152.","DOI":"10.1159\/000543152"},{"key":"10.1016\/j.bbr.2026.116088_bib99","doi-asserted-by":"crossref","first-page":"1749","DOI":"10.3390\/medicina58121749","article-title":"The role and mechanism of hyperoside against depression-like behavior in mice via the NLRP1 inflammasome","volume":"58","author":"Song","year":"2022","journal-title":"Medicina"},{"key":"10.1016\/j.bbr.2026.116088_bib100","article-title":"Quercetin alleviates chronic unpredictable mild stress-induced depression-like behavior by inhibiting NMDAR1 with \u03b12\u03b4-1 in rats","volume":"30","author":"Wang","year":"2024","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.bbr.2026.116088_bib101","doi-asserted-by":"crossref","first-page":"ES60","DOI":"10.1017\/S0007114508965776","article-title":"Flavonoids: modulators of brain function?","volume":"99","author":"Spencer","year":"2008","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.bbr.2026.116088_bib102","doi-asserted-by":"crossref","first-page":"273","DOI":"10.3390\/nu13010273","article-title":"Polyphenols and human health: the role of bioavailability","volume":"13","author":"Di Lorenzo","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.bbr.2026.116088_bib103","doi-asserted-by":"crossref","first-page":"234","DOI":"10.3390\/antiox9030234","article-title":"Potential Antidepressant effects of Scutellaria baicalensis, Hericium erinaceus and Rhodiola rosea","volume":"9","author":"Limanaqi","year":"2020","journal-title":"Antioxidants"},{"key":"10.1016\/j.bbr.2026.116088_bib104","doi-asserted-by":"crossref","first-page":"326","DOI":"10.3390\/molecules24020326","article-title":"Anti-depressive effectiveness of baicalin in vitro and in vivo","volume":"24","author":"Liu","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.bbr.2026.116088_bib105","doi-asserted-by":"crossref","first-page":"180","DOI":"10.3390\/foods10010180","article-title":"Combined extract of Leonurus japonicus Houtt, Eclipta prostrata L., and Pueraria lobata Ohwi improved hot flashes and depression in an ovariectomized rat model of menopause","volume":"10","author":"Kang","year":"2021","journal-title":"Foods"},{"key":"10.1016\/j.bbr.2026.116088_bib106","article-title":"Therapeutic potential of rutin in premenstrual depression: evidence from in vivo and in vitro studies","volume":"15","author":"Wang","year":"2024","journal-title":"Front Pharm."},{"key":"10.1016\/j.bbr.2026.116088_bib107","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.3390\/biom11121825","article-title":"Emerging role of flavonoids as the treatment of depression","volume":"11","author":"Pannu","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.bbr.2026.116088_bib108","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1093\/advances\/nmz117","article-title":"Effects of polyphenols in a mediterranean diet on symptoms of depression: a systematic literature review","volume":"11","author":"Bayes","year":"2020","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.bbr.2026.116088_bib109","article-title":"Effect of 4 weeks daily wild blueberry supplementation on symptoms of depression in adolescents","volume":"124","author":"F","year":"2020","journal-title":"Br. J. Nutr."},{"key":"10.1016\/j.bbr.2026.116088_bib110","article-title":"Mental health in new mothers: a randomised controlled study into the effects of dietary flavonoids on mood and perceived quality of life","volume":"13","author":"Kl","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.bbr.2026.116088_bib111","doi-asserted-by":"crossref","first-page":"145","DOI":"10.3390\/nu15010145","article-title":"Effects of flavonoid-rich orange juice intervention on major depressive disorder in young adults: a randomized controlled trial","volume":"15","author":"Choi","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.bbr.2026.116088_bib112","unstructured":"Modification of flavonoids: methods and influences on biological activities: Critical Reviews in Food Science and Nutrition: Vol 63, No 31 - Get Access, (n.d.). \u3008https:\/\/www.tandfonline.com\/doi\/full\/10.1080\/10408398.2022.2083572?src=recsys\u3009 (Accessed May 13, 2025)."},{"key":"10.1016\/j.bbr.2026.116088_bib113","doi-asserted-by":"crossref","first-page":"6169","DOI":"10.1080\/10408398.2021.1898333","article-title":"The fate of flavonoids after oral administration: a comprehensive overview of its bioavailability","volume":"62","author":"Naeem","year":"2022","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.bbr.2026.116088_bib114","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.foodres.2017.09.073","article-title":"Chilean berry Ugni molinae Turcz. fruit and leaves extracts with interesting antioxidant, antimicrobial and tyrosinase inhibitory properties","volume":"102","author":"L\u00f3pez de Dicastillo","year":"2017","journal-title":"Food Res. Int."},{"key":"10.1016\/j.bbr.2026.116088_bib115","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1016\/j.carbpol.2015.10.013","article-title":"Antioxidant films based on cross-linked methyl cellulose and native Chilean berry for food packaging applications","volume":"136","author":"L\u00f3pez de Dicastillo","year":"2016","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.bbr.2026.116088_bib116","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1080\/14786419.2018.1493588","article-title":"Flavonoids: biological activities and therapeutic potential","volume":"34","author":"Juc\u00e1","year":"2020","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.bbr.2026.116088_bib117","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1080\/14786419.2019.1607333","article-title":"Chemical composition and antiproliferative, antioxidant and trypanocidal activities of the fruits from Campomanesia xanthocarpa (Mart.) O. Berg (Myrtaceae)","volume":"35","author":"Salmazzo","year":"2021","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.bbr.2026.116088_bib118","doi-asserted-by":"crossref","first-page":"383","DOI":"10.3390\/pharmaceutics12040383","article-title":"In vivo antidepressant effect of Passiflora edulis f. flavicarpa into cationic nanoparticles: improving bioactivity and safety","volume":"12","author":"Alves","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bbr.2026.116088_bib119","doi-asserted-by":"crossref","first-page":"998","DOI":"10.3390\/pharmaceutics15030998","article-title":"Nanosystems, drug molecule functionalization and intranasal delivery: an update on the most promising strategies for increasing the therapeutic efficacy of antidepressant and anxiolytic drugs","volume":"15","author":"Antunes","year":"2023","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bbr.2026.116088_bib120","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1186\/s12951-023-02150-4","article-title":"Enhanced antidepressant effects of BDNF-quercetin alginate nanogels for depression therapy","volume":"21","author":"Xu","year":"2023","journal-title":"J. Nanobiotech."},{"key":"10.1016\/j.bbr.2026.116088_bib121","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.119550","article-title":"Intranasal delivery of icariin via a nanogel-thermoresponsive hydrogel compound system to improve its antidepressant-like activity","volume":"586","author":"Xu","year":"2020","journal-title":"Int J. Pharm."},{"key":"10.1016\/j.bbr.2026.116088_bib122","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2023.1120683","article-title":"The clinical application of chinese herbal medication to depression: a narrative review","volume":"11","author":"Kang","year":"2023","journal-title":"Front. Public Health"},{"key":"10.1016\/j.bbr.2026.116088_bib123","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1176\/ajp.137.5.535","article-title":"The clinical application of the biopsychosocial model","volume":"137","author":"Engel","year":"1980","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.bbr.2026.116088_bib124","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1089\/cap.2023.0018","article-title":"What is the added benefit of combining cognitive behavioral therapy and selective serotonin reuptake inhibitors in youth with obsessive compulsive disorder? A Bayesian hierarchical modeling meta-analysis","volume":"33","author":"Mendez","year":"2023","journal-title":"J. Child Adolesc. Psychopharmacol."},{"key":"10.1016\/j.bbr.2026.116088_bib125","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.jad.2021.10.047","article-title":"Combining selective serotonin reuptake inhibitors and cognitive behavioral therapy in youth with depression and anxiety","volume":"298","author":"Strawn","year":"2022","journal-title":"J. Affect Disord."},{"key":"10.1016\/j.bbr.2026.116088_bib126","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s12993-025-00273-2","article-title":"A comprehensive review on the impact of polyphenol supplementation and exercise on depression and brain function parameters","volume":"21","author":"Jie","year":"2025","journal-title":"Behav. Brain Funct."},{"key":"10.1016\/j.bbr.2026.116088_bib127","doi-asserted-by":"crossref","first-page":"208","DOI":"10.3390\/bioengineering12020208","article-title":"Neuro-nutrition and exercise synergy: exploring the bioengineering of cognitive enhancement and mental health optimization","volume":"12","author":"Clemente-Su\u00e1rez","year":"2025","journal-title":"Bioengineering"},{"key":"10.1016\/j.bbr.2026.116088_bib128","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1016\/j.foodchem.2012.07.080","article-title":"Physical activity increases the bioavailability of flavanones after dietary aronia-citrus juice intake in triathletes","volume":"135","author":"Medina","year":"2012","journal-title":"Food Chem."},{"key":"10.1016\/j.bbr.2026.116088_bib129","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1113\/expphysiol.2011.060178","article-title":"Exercise-induced oxidative\u2013nitrosative stress is associated with impaired dynamic cerebral autoregulation and blood\u2013brain barrier leakage","volume":"96","author":"Bailey","year":"2011","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.bbr.2026.116088_bib130","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2022.132531","article-title":"Plant flavonoids: classification, distribution, biosynthesis, and antioxidant activity","volume":"383","author":"Shen","year":"2022","journal-title":"Food Chem."},{"key":"10.1016\/j.bbr.2026.116088_bib131","doi-asserted-by":"crossref","first-page":"96","DOI":"10.5213\/inj.2040432.216","article-title":"Voluntary wheel running improves spatial learning memory by suppressing inflammation and apoptosis via inactivation of nuclear factor kappa B in brain inflammation rats","volume":"24","author":"Ko","year":"2020","journal-title":"Int Neurourol. J."},{"key":"10.1016\/j.bbr.2026.116088_bib132","article-title":"Combination of quercetin and exercise training attenuates depression in rats with 1,2-dimethylhydrazine-induced colorectal cancer: possible involvement of inflammation and BDNF signalling","volume":"105","author":"S","year":"2020","journal-title":"Exp. Physiol."},{"key":"10.1016\/j.bbr.2026.116088_bib133","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1016\/j.ibneur.2022.03.001","article-title":"Blueberry juice augments exercise-induced neuroprotection in a Parkinson\u2019s disease model through modulation of GDNF levels","volume":"12","author":"Castro","year":"2022","journal-title":"IBRO Neurosci. Rep."},{"key":"10.1016\/j.bbr.2026.116088_bib134","doi-asserted-by":"crossref","DOI":"10.1002\/fsn3.70219","article-title":"Highly bioavailable curcumin, but not native curcumin, combined with exercise improves cognitive function in mice","volume":"13","author":"Suzuki","year":"2025","journal-title":"Food Sci. Nutr."},{"key":"10.1016\/j.bbr.2026.116088_bib135","article-title":"The independent and combined associations between the intake of ultra-processed foods, sedentary behavior, and depressive symptoms in young adults","volume":"12","author":"J","year":"2025","journal-title":"Front. Nutr."},{"key":"10.1016\/j.bbr.2026.116088_bib136","doi-asserted-by":"crossref","unstructured":"Domain dependent associations between cognitive functioning and regular voluntary exercise behavior, Brain and Cognition 97 (2015) 32\u201339. https:\/\/doi.org\/10.1016\/j.bandc.2015.04.001.","DOI":"10.1016\/j.bandc.2015.04.001"},{"key":"10.1016\/j.bbr.2026.116088_bib137","doi-asserted-by":"crossref","first-page":"5415","DOI":"10.3390\/molecules28145415","article-title":"Polyphenols and neurodegenerative diseases: potential effects and mechanisms of neuroprotection","volume":"28","author":"Arias-S\u00e1nchez","year":"2023","journal-title":"Molecules"},{"key":"10.1016\/j.bbr.2026.116088_bib138","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.phymed.2017.07.008","article-title":"Green tea effects on cognition, mood and human brain function: a systematic review","volume":"34","author":"Mancini","year":"2017","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bbr.2026.116088_bib139","article-title":"Exercise, tea consumption, and depression among breast cancer survivors","volume":"28","author":"C","year":"2010","journal-title":"J. Clin. Oncol. Off. J. Am. Soc. Clin. Oncol."},{"key":"10.1016\/j.bbr.2026.116088_bib140","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1411168","article-title":"Flavonoids against depression: a comprehensive review of literature","volume":"15","author":"Alizadeh","year":"2024","journal-title":"Front. Pharm."},{"key":"10.1016\/j.bbr.2026.116088_bib141","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.fct.2018.04.052","article-title":"Current standing of plant derived flavonoids as an antidepressant","volume":"119","author":"Khan","year":"2018","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.bbr.2026.116088_bib142","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2024.1435891","article-title":"Voluntary wheel-running exercise improvement of anxiety or depressive symptoms in different models of depression","volume":"18","author":"Shen","year":"2024","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.bbr.2026.116088_bib143","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.neuroscience.2019.12.037","article-title":"Therapeutic and preventive effect of voluntary running wheel exercise on social defeat stress (SDS)-induced depressive-like behavior and chronic pain in mice","volume":"428","author":"Pagliusi","year":"2020","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2026.116088_bib144","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/pcn.13551","article-title":"Depression and lifestyle: focusing on nutrition, exercise, and their possible relevance to molecular mechanisms","volume":"77","author":"Kunugi","year":"2023","journal-title":"Psychiatry Clin. Neurosci."},{"key":"10.1016\/j.bbr.2026.116088_bib145","doi-asserted-by":"crossref","first-page":"309","DOI":"10.17219\/acem\/202674","article-title":"Non-pharmacological approaches for stress-related neuropsychiatric disorders: focus on physical activity and natural compounds","volume":"34","author":"Moradikor","year":"2025","journal-title":"Adv. Clin. Exp. Med"},{"key":"10.1016\/j.bbr.2026.116088_bib146","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1136\/bjsports-2020-102955","article-title":"World Health Organization 2020 guidelines on physical activity and sedentary behaviour","volume":"54","author":"Bull","year":"2020","journal-title":"Br. J. Sports Med"},{"key":"10.1016\/j.bbr.2026.116088_bib147","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1001\/jamapsychiatry.2022.0609","article-title":"association between physical activity and risk of depression: a systematic review and meta-analysis","volume":"79","author":"Pearce","year":"2022","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.bbr.2026.116088_bib148","doi-asserted-by":"crossref","first-page":"999","DOI":"10.3390\/molecules23050999","article-title":"Dietary polyphenol intake and depression: results from the mediterranean healthy eating, lifestyle and aging (MEAL) Study","volume":"23","author":"Godos","year":"2018","journal-title":"Molecules"},{"key":"10.1016\/j.bbr.2026.116088_bib149","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.jpsychires.2016.02.023","article-title":"Exercise as a treatment for depression: a meta-analysis adjusting for publication bias","volume":"77","author":"Schuch","year":"2016","journal-title":"J. Psychiatr. Res"},{"key":"10.1016\/j.bbr.2026.116088_bib150","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/5762172","article-title":"Antidepressant flavonoids and their relationship with oxidative stress","volume":"2017","author":"Hritcu","year":"2017","journal-title":"Oxid. Med. Cell Longev."},{"key":"10.1016\/j.bbr.2026.116088_bib151","doi-asserted-by":"crossref","DOI":"10.2196\/45776","article-title":"Association between joint physical activity and dietary quality and lower risk of depression symptoms in US adults: cross-sectional NHANES study","volume":"9","author":"Liang","year":"2023","journal-title":"JMIR Public Health Surveill."},{"key":"10.1016\/j.bbr.2026.116088_bib152","doi-asserted-by":"crossref","DOI":"10.1038\/s41380-020-00925-x","article-title":"Diet and depression: exploring the biological mechanisms of action","volume":"26","author":"Marx","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbr.2026.116088_bib153","article-title":"A meta-review of \u201clifestyle psychiatry\u201d: the role of exercise, smoking, diet and sleep in the prevention and treatment of mental disorders","volume":"19","author":"Firth","year":"2020","journal-title":"World Psychiatry. Off. J. World Psychiatr. Assoc."},{"key":"10.1016\/j.bbr.2026.116088_bib154","doi-asserted-by":"crossref","DOI":"10.1186\/1471-244X-14-107","article-title":"Lifestyle medicine for depression","volume":"14","author":"Sarris","year":"2014","journal-title":"BMC Psychiatry"},{"key":"10.1016\/j.bbr.2026.116088_bib155","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2023.1163800","article-title":"A personalized intervention to prevent depression in primary care based on risk predictive algorithms and decision support systems: protocol of the e-predictD study","volume":"14","author":"Bell\u00f3n","year":"2023","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.bbr.2026.116088_bib156","article-title":"Natural health product interactions with medication","volume":"20","author":"J","year":"2005","journal-title":"Nutr. Clin. Pract. Off. Publ. Am. Soc. Parenter. Enter. Nutr."},{"key":"10.1016\/j.bbr.2026.116088_bib157","article-title":"J.F. Cryan, The lancet psychiatry commission: a blueprint for protecting physical health in people with mental illness","volume":"6","author":"Wiley","year":"2019","journal-title":"Lancet Psychiatry"},{"key":"10.1016\/j.bbr.2026.116088_bib158","article-title":"The microbiota-gut-brain axis as a key regulator of neural function and the stress response: implications for human and animal health","volume":"95","author":"Nc","year":"2017","journal-title":"J. Anim. Sci."},{"key":"10.1016\/j.bbr.2026.116088_bib159","article-title":"Machine learning for precision psychiatry: opportunities and challenges","volume":"3","author":"D","year":"2018","journal-title":"Biol. Psychiatry Cogn. Neurosci. Neuroimaging"},{"key":"10.1016\/j.bbr.2026.116088_bib160","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1007\/s13311-019-00749-w","article-title":"Exercise for brain health: an investigation into the underlying mechanisms guided by dose","volume":"16","author":"Cabral","year":"2019","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.bbr.2026.116088_bib161","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.2165\/00007256-200535120-00004","article-title":"Exercise-induced oxidative stress:myths, realities and physiological relevance","volume":"35","author":"Vollaard","year":"2005","journal-title":"Sports Med."},{"key":"10.1016\/j.bbr.2026.116088_bib162","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.freeradbiomed.2004.04.034","article-title":"Potential toxicity of flavonoids and other dietary phenolics: significance for their chemopreventive and anticancer properties","volume":"37","author":"Galati","year":"2004","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbr.2026.116088_bib163","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.jad.2015.10.019","article-title":"Dropout from exercise randomized controlled trials among people with depression: a meta-analysis and meta regression","volume":"190","author":"Stubbs","year":"2016","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.bbr.2026.116088_bib164","first-page":"287","article-title":"The efficacy of smartphone-based mental health interventions for depressive symptoms: a meta-analysis of randomized controlled trials","volume":"16","author":"Firth","year":"2017","journal-title":"World Psychiatry. Off. J. World Psychiatr. Assoc. (WPA"},{"key":"10.1016\/j.bbr.2026.116088_bib165","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s11920-018-0969-9","article-title":"Social determinants of mental health: where we are and where we need to go","volume":"20","author":"Alegr\u00eda","year":"2018","journal-title":"Curr. Psychiatry Rep."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432826000641?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432826000641?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T16:45:41Z","timestamp":1779813941000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432826000641"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":165,"alternative-id":["S0166432826000641"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2026.116088","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Natural synergistic interventions for depression: Voluntary wheel running and flavonoids","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2026.116088","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116088"}}