{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:33:28Z","timestamp":1789173208296,"version":"build-2803163510"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003399","name":"Shanghai Municipality Science and Technology Commission","doi-asserted-by":"publisher","award":["23QA1408300"],"award-info":[{"award-number":["23QA1408300"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Shanghai Municipality Science and Technology Commission","doi-asserted-by":"publisher","award":["25Y22800100"],"award-info":[{"award-number":["25Y22800100"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471532"],"award-info":[{"award-number":["82471532"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32271066"],"award-info":[{"award-number":["32271066"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82230045"],"award-info":[{"award-number":["82230045"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003395","name":"Shanghai Municipal Education Commission","doi-asserted-by":"publisher","award":["2021-01-07-00-02-E0086"],"award-info":[{"award-number":["2021-01-07-00-02-E0086"]}],"id":[{"id":"10.13039\/501100003395","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.bbr.2026.116166","type":"journal-article","created":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T07:27:29Z","timestamp":1773646049000},"page":"116166","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Left hippocampal subiculum-hypothalamus hyperconnectivity as a neural correlate of stress vulnerability"],"prefix":"10.1016","volume":"507","author":[{"given":"Yaqiu","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bei-Bei","family":"Huo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Jia","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong-dong","family":"Shi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2026.116166_bib1","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.neubiorev.2021.10.041","article-title":"The global prevalence of major depressive disorder (MDD) among the elderly: a systematic review and meta-analysis","volume":"132","author":"Abdoli","year":"2022","journal-title":"Neurosci. Biobehav Rev."},{"key":"10.1016\/j.bbr.2026.116166_bib2","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.jad.2018.07.061","article-title":"Prevalence of major depressive disorder in older adults in China: a systematic review and meta-analysis","volume":"241","author":"Wang","year":"2018","journal-title":"J. Affect Disord."},{"key":"10.1016\/j.bbr.2026.116166_bib3","series-title":"Handbook of the Behavior and Psychology of Disease","first-page":"1","article-title":"The Impact of Stressful Life Events in Alzheimer\u2019s Disease","author":"Giannouli","year":"2025"},{"issue":"24","key":"10.1016\/j.bbr.2026.116166_bib4","doi-asserted-by":"crossref","DOI":"10.3390\/ijerph16245123","article-title":"Neurocognitive mechanism of human resilience: a conceptual framework and empirical review","volume":"16","author":"Yao","year":"2019","journal-title":"Int. J. Environ. Res. Public Health"},{"issue":"6","key":"10.1016\/j.bbr.2026.116166_bib5","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.3171\/2016.10.JNS161936","article-title":"Prospective analysis of neuropsychological deficits following resection of benign skull base meningiomas","volume":"127","author":"Zweckberger","year":"2017","journal-title":"J. Neurosurg."},{"issue":"3","key":"10.1016\/j.bbr.2026.116166_bib6","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1111\/jnp.12417","article-title":"Facial emotion recognition, affective empathy and psychosocial functioning in euthymic BD-I","volume":"19","author":"Zyto","year":"2025","journal-title":"J. Neuropsychol."},{"issue":"49","key":"10.1016\/j.bbr.2026.116166_bib7","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2312662120","article-title":"The neurobiology of stress: vulnerability, resilience, and major depression","volume":"120","author":"Akil","year":"2023","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.bbr.2026.116166_bib8","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1111\/ejn.14547","article-title":"Neurobiology of resilience in depression: immune and vascular insights from human and animal studies","volume":"53","author":"Dudek","year":"2021","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bbr.2026.116166_bib9","doi-asserted-by":"crossref","DOI":"10.1155\/2024\/9294268","article-title":"A longitudinal correlational study of psychological resilience, depression disorder, and brain functional-structural hybrid connectome in breast cancer","volume":"2024","author":"Liang","year":"2024","journal-title":"Depress Anxiety"},{"issue":"6","key":"10.1016\/j.bbr.2026.116166_bib10","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.biopsych.2019.06.030","article-title":"Multidimensional predictors of susceptibility and resilience to social defeat stress","volume":"86","author":"Nasca","year":"2019","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2026.116166_bib11","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.jad.2024.02.076","article-title":"Resting-state activity and functional connectivity of insula and postcentral gyrus related to psychological resilience in female depressed patients: a preliminary study","volume":"352","author":"Wang","year":"2024","journal-title":"J. Affect Disord."},{"issue":"12","key":"10.1016\/j.bbr.2026.116166_bib12","doi-asserted-by":"crossref","first-page":"936","DOI":"10.1016\/j.biopsych.2023.05.021","article-title":"Mapping neurophysiological subtypes of major depressive disorder using normative models of the functional connectome","volume":"94","author":"Sun","year":"2023","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2026.116166_bib13","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.jad.2023.03.073","article-title":"Abnormal compositions of gut microbiota and metabolites are associated with susceptibility versus resilience in rats to inescapable electric stress","volume":"331","author":"Wang","year":"2023","journal-title":"J. Affect Disord."},{"issue":"7","key":"10.1016\/j.bbr.2026.116166_bib14","doi-asserted-by":"crossref","first-page":"2943","DOI":"10.1038\/s41380-025-02897-2","article-title":"Resting-state fMRI reveals altered functional connectivity associated with resilience and susceptibility to chronic social defeat stress in mouse brain","volume":"30","author":"Lupinsky","year":"2025","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbr.2026.116166_bib15","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2022.110601","article-title":"The hippocampus in stress susceptibility and resilience: Reviewing molecular and functional markers","volume":"119","author":"Larosa","year":"2022","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.bbr.2026.116166_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajp.2023.103861","article-title":"Decoding the role of the gut microbiome in gut-brain axis, stress-resilience, or stress-susceptibility: a review","volume":"91","author":"Sah","year":"2024","journal-title":"Asian J. Psychiatr."},{"key":"10.1016\/j.bbr.2026.116166_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2021.118503","article-title":"Advances in resting state fMRI acquisitions for functional connectomics","volume":"243","author":"Raimondo","year":"2021","journal-title":"Neuroimage"},{"issue":"2","key":"10.1016\/j.bbr.2026.116166_bib18","doi-asserted-by":"crossref","first-page":"107","DOI":"10.4149\/gpb_2023001","article-title":"Stress, depression, and hippocampus: from biochemistry to electrophysiology","volume":"42","author":"Idunkova","year":"2023","journal-title":"Gen. Physiol. Biophys."},{"key":"10.1016\/j.bbr.2026.116166_bib19","doi-asserted-by":"crossref","DOI":"10.1155\/2017\/6871089","article-title":"The role of neural plasticity in depression: from hippocampus to prefrontal cortex","volume":"2017","author":"Liu","year":"2017","journal-title":"Neural Plast."},{"key":"10.1016\/j.bbr.2026.116166_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neures.2018.08.002","article-title":"The subiculum: Unique hippocampal hub and more","volume":"143","author":"Matsumoto","year":"2019","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.bbr.2026.116166_bib21","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0079-6123(08)61240-6","article-title":"The subiculum: cytoarchitectonically a simple structure, but hodologically complex","volume":"83","author":"Witter","year":"1990","journal-title":"Prog. Brain Res."},{"issue":"11","key":"10.1016\/j.bbr.2026.116166_bib22","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1038\/s41593-018-0241-y","article-title":"Integration of gene expression and brain-wide connectivity reveals the multiscale organization of mouse hippocampal networks","volume":"21","author":"Bienkowski","year":"2018","journal-title":"Nat. Neurosci."},{"issue":"5","key":"10.1016\/j.bbr.2026.116166_bib23","doi-asserted-by":"crossref","first-page":"1280","DOI":"10.1016\/j.cell.2018.03.031","article-title":"Dissociable structural and functional hippocampal outputs via distinct subiculum cell classes","volume":"173","author":"Cembrowski","year":"2018","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.bbr.2026.116166_bib24","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1016\/j.neuron.2019.09.005","article-title":"Chronic stress induces activity, synaptic, and transcriptional remodeling of the lateral habenula associated with deficits in motivated behaviors","volume":"104","author":"Cerniauskas","year":"2019","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2026.116166_bib25","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.neuroimage.2014.10.037","article-title":"Stress-induced alterations in large-scale functional networks of the rodent brain","volume":"105","author":"Henckens","year":"2015","journal-title":"Neuroimage"},{"issue":"9","key":"10.1016\/j.bbr.2026.116166_bib26","doi-asserted-by":"crossref","first-page":"4039","DOI":"10.1038\/s41380-025-02982-6","article-title":"Temporal interactions between neural proxies for memory recall, negative affect, and emotion regulation in major depression","volume":"30","author":"Michel","year":"2025","journal-title":"Mol. Psychiatry"},{"issue":"1","key":"10.1016\/j.bbr.2026.116166_bib27","first-page":"50","article-title":"Altered dentate gyrus microstructure in individuals at high familial risk for depression predicts future symptoms","volume":"6","author":"van Dijk","year":"2021","journal-title":"Biol. Psychiatry Cogn. Neurosci. Neuroimaging"},{"issue":"7","key":"10.1016\/j.bbr.2026.116166_bib28","doi-asserted-by":"crossref","first-page":"562","DOI":"10.30773\/pi.2021.0386","article-title":"Abnormal dynamic functional connectivity of the left rostral hippocampus in predicting antidepressant efficacy in major depressive disorder","volume":"19","author":"Xue","year":"2022","journal-title":"Psychiatry Invest."},{"key":"10.1016\/j.bbr.2026.116166_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2021.105625","article-title":"Cortisol and development of depression in adolescence and young adulthood - a systematic review and meta-analysis","volume":"136","author":"Zajkowska","year":"2022","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbr.2026.116166_bib30","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/bs.pbr.2015.03.003","article-title":"The subiculum: the heart of the extended hippocampal system","volume":"219","author":"Aggleton","year":"2015","journal-title":"Prog. Brain Res."},{"issue":"6","key":"10.1016\/j.bbr.2026.116166_bib31","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2019409118","article-title":"Amygdala-hippocampal innervation modulates stress-induced depressive-like behaviors through AMPA receptors","volume":"118","author":"Ma","year":"2021","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"6","key":"10.1016\/j.bbr.2026.116166_bib32","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1111\/j.1365-2826.1995.tb00784.x","article-title":"Contribution of the ventral subiculum to inhibitory regulation of the hypothalamo-pituitary-adrenocortical axis","volume":"7","author":"Herman","year":"1995","journal-title":"J. Neuroendocr."},{"issue":"2","key":"10.1016\/j.bbr.2026.116166_bib33","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.bbr.2006.05.035","article-title":"Role of the ventral subiculum in stress integration","volume":"174","author":"Herman","year":"2006","journal-title":"Behav. Brain Res."},{"issue":"26","key":"10.1016\/j.bbr.2026.116166_bib34","doi-asserted-by":"crossref","first-page":"9683","DOI":"10.1523\/JNEUROSCI.6040-10.2011","article-title":"A common substrate for prefrontal and hippocampal inhibition of the neuroendocrine stress response","volume":"31","author":"Radley","year":"2011","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.bbr.2026.116166_bib35","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1016\/j.brainresrev.2007.04.005","article-title":"The stress system in depression and neurodegeneration: focus on the human hypothalamus","volume":"57","author":"Bao","year":"2008","journal-title":"Brain Res. Rev."},{"issue":"1","key":"10.1016\/j.bbr.2026.116166_bib36","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1162\/jocn_a_00313","article-title":"Spatial cognition and the hippocampus: the anterior-posterior axis","volume":"25","author":"Nadel","year":"2013","journal-title":"J. Cogn. Neurosci."},{"issue":"11","key":"10.1016\/j.bbr.2026.116166_bib37","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.tins.2023.08.003","article-title":"The role of the hippocampus in the consolidation of emotional memories during sleep","volume":"46","author":"Pronier","year":"2023","journal-title":"Trends Neurosci."},{"issue":"2","key":"10.1016\/j.bbr.2026.116166_bib38","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1007\/s00422-019-00812-x","article-title":"A computational model for spatial cognition combining dorsal and ventral hippocampal place field maps: multiscale navigation","volume":"114","author":"Scleidorovich","year":"2020","journal-title":"Biol. Cyber"},{"issue":"1","key":"10.1016\/j.bbr.2026.116166_bib39","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.neuron.2009.11.031","article-title":"Are the dorsal and ventral hippocampus functionally distinct structures?","volume":"65","author":"Fanselow","year":"2010","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.bbr.2026.116166_bib40","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1038\/s41398-024-02846-7","article-title":"Down-regulation of MKP-1 in hippocampus protects against stress-induced depression-like behaviors and neuroinflammation","volume":"14","author":"Geng","year":"2024","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.bbr.2026.116166_bib41","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.brainresbull.2018.03.004","article-title":"Electroacupuncture restores hippocampal synaptic plasticity via modulation of 5-HT receptors in a rat model of depression","volume":"139","author":"Han","year":"2018","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.bbr.2026.116166_bib42","first-page":"34","article-title":"Cross-cultural cognitive and affective differences in aging: can culture shape the expression and perception of psychopathology in old age?","volume":"59","author":"Makri","year":"2022","journal-title":"Encephalos"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432826001427?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432826001427?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T21:20:43Z","timestamp":1777497643000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432826001427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":42,"alternative-id":["S0166432826001427"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2026.116166","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Left hippocampal subiculum-hypothalamus hyperconnectivity as a neural correlate of stress vulnerability","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2026.116166","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116166"}}