{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T09:01:05Z","timestamp":1776934865625,"version":"3.51.2"},"reference-count":131,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100016350","name":"Sichuan Provincial Administration of Traditional Chinese Medicine","doi-asserted-by":"publisher","award":["2024zd032"],"award-info":[{"award-number":["2024zd032"]}],"id":[{"id":"10.13039\/501100016350","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014895","name":"Southwest Medical University","doi-asserted-by":"publisher","award":["2025LZXNYDJC52"],"award-info":[{"award-number":["2025LZXNYDJC52"]}],"id":[{"id":"10.13039\/501100014895","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014895","name":"Southwest Medical University","doi-asserted-by":"publisher","award":["2023PZXNYD09"],"award-info":[{"award-number":["2023PZXNYD09"]}],"id":[{"id":"10.13039\/501100014895","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.bbr.2026.116200","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T23:49:54Z","timestamp":1775260194000},"page":"116200","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["The ventral tegmental area as a key hub for sleep\u2013wake regulation: A systematic review of cell-type-specific circuits and functional heterogeneity"],"prefix":"10.1016","volume":"508","author":[{"given":"Yulong","family":"Xia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenwen","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiping","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3733-8924","authenticated-orcid":false,"given":"Houping","family":"Xu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.bbr.2026.116200_bib1","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1055\/a-2566-4073","article-title":"Sleep as the foundation of brain health","volume":"45","author":"Ibrahim","year":"2025","journal-title":"Semin Neurol."},{"key":"10.1016\/j.bbr.2026.116200_bib2","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.cophys.2019.12.012","article-title":"The neuroanatomy and neurochemistry of sleep-wake control","volume":"15","author":"Gompf","year":"2020","journal-title":"Curr. Opin. Physiol."},{"key":"10.1016\/j.bbr.2026.116200_bib3","doi-asserted-by":"crossref","first-page":"s1074","DOI":"10.2741\/1159","article-title":"R. Szymusiak, Hypothalamic regulation of sleep and arousal","volume":"8","author":"McGinty","year":"2003","journal-title":"Front Biosci."},{"issue":"15","key":"10.1016\/j.bbr.2026.116200_bib4","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aaz4232","article-title":"Locus coeruleus norepinephrine activity mediates sensory-evoked awakenings from sleep","volume":"6","author":"Hayat","year":"2020","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bbr.2026.116200_bib5","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3389\/fncir.2019.00078","article-title":"VTA GABA neurons at the interface of stress and reward","volume":"13","author":"Bouarab","year":"2019","journal-title":"Front Neural Circuits"},{"key":"10.1016\/j.bbr.2026.116200_bib6","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.neuropharm.2013.03.019","article-title":"Reward and aversion in a heterogeneous midbrain dopamine system","volume":"76","author":"Lammel","year":"2014","journal-title":"Neuropharmacology"},{"issue":"7423","key":"10.1016\/j.bbr.2026.116200_bib7","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1038\/nature11527","article-title":"Input-specific control of reward and aversion in the ventral tegmental area","volume":"491","author":"Lammel","year":"2012","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.bbr.2026.116200_bib8","doi-asserted-by":"crossref","first-page":"1346","DOI":"10.1016\/j.neuron.2014.04.030","article-title":"Separate GABA afferents to dopamine neurons mediate acute action of opioids, development of tolerance, and expression of withdrawal","volume":"82","author":"Matsui","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2026.116200_bib9","doi-asserted-by":"crossref","DOI":"10.3389\/fncir.2025.1516839","article-title":"Optogenetics and chemogenetics: key tools for modulating neural circuits in rodent models of depression","volume":"19","author":"Li","year":"2025","journal-title":"Front Neural Circuits"},{"issue":"10","key":"10.1016\/j.bbr.2026.116200_bib10","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1038\/nn.4377","article-title":"VTA dopaminergic neurons regulate ethologically relevant sleep-wake behaviors","volume":"19","author":"Eban-Rothschild","year":"2016","journal-title":"Nat. Neurosci."},{"issue":"1","key":"10.1016\/j.bbr.2026.116200_bib11","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1038\/s41593-018-0288-9","article-title":"GABA and glutamate neurons in the VTA regulate sleep and wakefulness","volume":"22","author":"Yu","year":"2019","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbr.2026.116200_bib12","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1016\/j.neures.2017.04.008","article-title":"The control of sleep and wakefulness by mesolimbic dopamine systems","volume":"118","author":"Oishi","year":"2017","journal-title":"Neurosci. Res."},{"issue":"2","key":"10.1016\/j.bbr.2026.116200_bib13","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/0165-0173(87)90011-7","article-title":"Ventral tegmental (A10) system: neurobiology. 1. Anatomy and connectivity","volume":"434","author":"Oades","year":"1987","journal-title":"Brain Res."},{"issue":"1-6","key":"10.1016\/j.bbr.2026.116200_bib14","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/0361-9230(82)90145-9","article-title":"The projections of the ventral tegmental area and adjacent regions: a combined fluorescent retrograde tracer and immunofluorescence study in the rat","volume":"9","author":"Swanson","year":"1982","journal-title":"Brain Res. Bull."},{"issue":"2","key":"10.1016\/j.bbr.2026.116200_bib15","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/nrn.2016.165","article-title":"Ventral tegmental area: cellular heterogeneity, connectivity and behaviour","volume":"18","author":"Morales","year":"2017","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbr.2026.116200_bib16","doi-asserted-by":"crossref","DOI":"10.1038\/srep30615","article-title":"Glutamate neurons are intermixed with midbrain dopamine neurons in nonhuman primates and humans","volume":"6","author":"Root","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbr.2026.116200_bib17","article-title":"Untangling dopamine and glutamate in the ventral tegmental area","author":"Pr\u00e9vost","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.bbr.2026.116200_bib18","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.90158","article-title":"Stimulation of VTA dopamine inputs to LH upregulates orexin neuronal activity in a DRD2-dependent manner","volume":"12","author":"Harada","year":"2024","journal-title":"Elife"},{"issue":"1","key":"10.1016\/j.bbr.2026.116200_bib19","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-019-55007-y","article-title":"Ventral Tegmental area projection regulates glutamatergic transmission in nucleus accumbens","volume":"9","author":"Yu","year":"2019","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.bbr.2026.116200_bib20","doi-asserted-by":"crossref","first-page":"2915","DOI":"10.1111\/ejn.14665","article-title":"Electrical stimulation of the ventral tegmental area evokes sleep-like state transitions under urethane anaesthesia in the rat medial prefrontal cortex via dopamine D(1) -like receptors","volume":"52","author":"Gretenkord","year":"2020","journal-title":"Eur. J. Neurosci."},{"issue":"3","key":"10.1016\/j.bbr.2026.116200_bib21","first-page":"402","article-title":"Research progress in the role of the ventral tegmental area-medial prefrontal cortex neural circuit in the regulation of arousal]","volume":"46","author":"Hao","year":"2024","journal-title":"Zhongguo Yi Xue Ke Xue Yuan Xue Bao"},{"issue":"9","key":"10.1016\/j.bbr.2026.116200_bib22","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/nrn3381","article-title":"The brain reward circuitry in mood disorders","volume":"14","author":"Russo","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbr.2026.116200_bib23","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1146\/annurev-neuro-070815-013920","article-title":"The Emergence of a Circuit Model for Addiction","volume":"39","author":"L\u00fcscher","year":"2016","journal-title":"Annu Rev. Neurosci."},{"issue":"7","key":"10.1016\/j.bbr.2026.116200_bib24","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1016\/j.cell.2014.05.017","article-title":"Natural neural projection dynamics underlying social behavior","volume":"157","author":"Gunaydin","year":"2014","journal-title":"Cell"},{"issue":"6358","key":"10.1016\/j.bbr.2026.116200_bib25","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1126\/science.aan4994","article-title":"Gating of social reward by oxytocin in the ventral tegmental area","volume":"357","author":"Hung","year":"2017","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.bbr.2026.116200_bib26","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/0006-8993(83)91101-0","article-title":"Activity of mesencephalic dopamine and non-dopamine neurons across stages of sleep and walking in the rat","volume":"273","author":"Miller","year":"1983","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.bbr.2026.116200_bib27","doi-asserted-by":"crossref","first-page":"7765","DOI":"10.1038\/s41598-018-25770-5","article-title":"Circadian and homeostatic modulation of multi-unit activity in midbrain dopaminergic structures","volume":"8","author":"Fifel","year":"2018","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.bbr.2026.116200_bib28","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1007\/s41105-017-0094-x","article-title":"Activation of the ventral tegmental area increased wakefulness in mice","volume":"15","author":"Sun","year":"2017","journal-title":"Sleep. Biol. Rhythms"},{"issue":"4","key":"10.1016\/j.bbr.2026.116200_bib29","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.neuroscience.2008.01.046","article-title":"Stereological estimates of dopaminergic, GABAergic and glutamatergic neurons in the ventral tegmental area, substantia nigra and retrorubral field in the rat","volume":"152","author":"Nair-Roberts","year":"2008","journal-title":"Neuroscience"},{"issue":"6","key":"10.1016\/j.bbr.2026.116200_bib30","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1111\/ejn.12818","article-title":"Glutamatergic and dopaminergic neurons in the mouse ventral tegmental area","volume":"41","author":"Yamaguchi","year":"2015","journal-title":"Eur. J. Neurosci."},{"issue":"6","key":"10.1016\/j.bbr.2026.116200_bib31","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1007\/s12031-023-02121-2","article-title":"Spatial distribution of neurons expressing single, double, and triple molecular characteristics of glutamatergic, dopaminergic, or gabaergic neurons in the mouse ventral tegmental area","volume":"73","author":"Ma","year":"2023","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.bbr.2026.116200_bib32","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2023.109621","article-title":"Modulation of dopamine from ventral tegmental area neurons by the LC-REM-OFF and PPT-REM-ON neurons in REMS regulation in freely moving rats","volume":"237","author":"Ratna","year":"2023","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2026.116200_bib33","article-title":"Ventral tegmental area interneurons revisited: GABA and glutamate projection neurons make local synapses","author":"Oriol","year":"2025","journal-title":"bioRxiv"},{"issue":"6","key":"10.1016\/j.bbr.2026.116200_bib34","first-page":"H2549","article-title":"Cardiovascular depressor responses to stimulation of substantia nigra and ventral tegmental area","volume":"273","author":"Kirouac","year":"1997","journal-title":"Am. J. Physiol."},{"issue":"1","key":"10.1016\/j.bbr.2026.116200_bib35","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110616","article-title":"An atlas of transcriptionally defined cell populations in the rat ventral tegmental area","volume":"39","author":"Phillips","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbr.2026.116200_bib36","article-title":"Proportion and distribution of neurotransmitter-defined cell types in the ventral tegmental area and substantia nigra pars compacta","author":"Conrad","year":"2024","journal-title":"bioRxiv"},{"issue":"1","key":"10.1016\/j.bbr.2026.116200_bib37","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1460-9568.2006.05263.x","article-title":"Glutamatergic neurons are present in the rat ventral tegmental area","volume":"25","author":"Yamaguchi","year":"2007","journal-title":"Eur. J. Neurosci."},{"issue":"11","key":"10.1016\/j.bbr.2026.116200_bib38","doi-asserted-by":"crossref","first-page":"3602","DOI":"10.1111\/ejn.12359","article-title":"Glutamate neurons in the substantia nigra compacta and retrorubral field","volume":"38","author":"Yamaguchi","year":"2013","journal-title":"Eur. J. Neurosci."},{"issue":"42","key":"10.1016\/j.bbr.2026.116200_bib39","doi-asserted-by":"crossref","first-page":"13906","DOI":"10.1523\/JNEUROSCI.2029-14.2014","article-title":"Role of glutamatergic projections from ventral tegmental area to lateral habenula in aversive conditioning","volume":"34","author":"Root","year":"2014","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.bbr.2026.116200_bib40","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/0006-8993(91)90285-4","article-title":"GABA-labeled terminals form proportionally more synapses with dopaminergic neurons containing low densities of tyrosine hydroxylase-immunoreactivity in rat ventral tegmental area","volume":"559","author":"Bayer","year":"1991","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2026.116200_bib41","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.59328","article-title":"Heterogeneous somatostatin-expressing neuron population in mouse ventral tegmental area","volume":"9","author":"Nagaeva","year":"2020","journal-title":"Elife"},{"issue":"2","key":"10.1016\/j.bbr.2026.116200_bib42","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1002\/syn.20345","article-title":"Topographical organization of GABAergic neurons within the ventral tegmental area of the rat","volume":"61","author":"Olson","year":"2007","journal-title":"Synapse"},{"issue":"43","key":"10.1016\/j.bbr.2026.116200_bib43","doi-asserted-by":"crossref","first-page":"15076","DOI":"10.1523\/JNEUROSCI.3128-12.2012","article-title":"Ventral tegmental area glutamate neurons: electrophysiological properties and projections","volume":"32","author":"Hnasko","year":"2012","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.bbr.2026.116200_bib44","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.neuron.2023.11.002","article-title":"Mesoaccumbal glutamate neurons drive reward via glutamate release but aversion via dopamine co-release","volume":"112","author":"Warlow","year":"2024","journal-title":"Neuron"},{"issue":"5","key":"10.1016\/j.bbr.2026.116200_bib45","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.neuron.2020.06.011","article-title":"VTA Glutamate Neuron Activity Drives Positive Reinforcement Absent Dopamine Co-release","volume":"107","author":"Zell","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2026.116200_bib46","doi-asserted-by":"crossref","DOI":"10.1111\/ejn.15156","article-title":"Ventral tegmental area GABA, glutamate, and glutamate-GABA neurons are heterogeneous in their electrophysiological and pharmacological properties","author":"Miranda-Barrientos","year":"2021","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bbr.2026.116200_bib47","article-title":"GABA-glutamate corelease is a mechanism for state-dependent neurotransmission","author":"Warlow","year":"2025","journal-title":"bioRxiv"},{"key":"10.1016\/j.bbr.2026.116200_bib48","article-title":"Basolateral amygdala dopamine transmits a nonassociative emotional salience signal","author":"Brickner","year":"2025","journal-title":"bioRxiv"},{"issue":"6","key":"10.1016\/j.bbr.2026.116200_bib49","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1038\/sj.npp.1301251","article-title":"Prominent burst firing of dopaminergic neurons in the ventral tegmental area during paradoxical sleep","volume":"32","author":"Dahan","year":"2007","journal-title":"Neuropsychopharmacology"},{"issue":"6","key":"10.1016\/j.bbr.2026.116200_bib50","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1002\/jnr.20602","article-title":"Variations in extracellular levels of dopamine, noradrenaline, glutamate, and aspartate across the sleep--wake cycle in the medial prefrontal cortex and nucleus accumbens of freely moving rats","volume":"81","author":"L\u00e9na","year":"2005","journal-title":"J. Neurosci. Res"},{"issue":"36","key":"10.1016\/j.bbr.2026.116200_bib51","doi-asserted-by":"crossref","first-page":"8908","DOI":"10.1523\/JNEUROSCI.1526-08.2008","article-title":"Midbrain dopamine neurons: projection target determines action potential duration and dopamine D(2) receptor inhibition","volume":"28","author":"Margolis","year":"2008","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.bbr.2026.116200_bib52","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.cell.2015.07.015","article-title":"Circuit architecture of vta dopamine neurons revealed by systematic input-output mapping","volume":"162","author":"Beier","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.bbr.2026.116200_bib53","article-title":"Uncovering the connectivity logic of the ventral tegmental area","volume":"15","author":"Derdeyn","year":"2021","journal-title":"Front Neural Circuits"},{"issue":"10","key":"10.1016\/j.bbr.2026.116200_bib54","doi-asserted-by":"crossref","first-page":"2788","DOI":"10.1523\/JNEUROSCI.4331-05.2006","article-title":"Properties and opioid inhibition of mesolimbic dopamine neurons vary according to target location","volume":"26","author":"Ford","year":"2006","journal-title":"J. Neurosci."},{"issue":"8","key":"10.1016\/j.bbr.2026.116200_bib55","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1073\/pnas.0511159103","article-title":"Kappa opioids selectively control dopaminergic neurons projecting to the prefrontal cortex","volume":"103","author":"Margolis","year":"2006","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"5","key":"10.1016\/j.bbr.2026.116200_bib56","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.neuron.2008.01.022","article-title":"Unique properties of mesoprefrontal neurons within a dual mesocorticolimbic dopamine system","volume":"57","author":"Lammel","year":"2008","journal-title":"Neuron"},{"issue":"18","key":"10.1016\/j.bbr.2026.116200_bib57","doi-asserted-by":"crossref","first-page":"7295","DOI":"10.1523\/JNEUROSCI.4385-14.2015","article-title":"Orexin signaling in the VTA gates morphine-induced synaptic plasticity","volume":"35","author":"Baimel","year":"2015","journal-title":"J. Neurosci."},{"issue":"6584","key":"10.1016\/j.bbr.2026.116200_bib58","doi-asserted-by":"crossref","first-page":"994","DOI":"10.1126\/science.abl6618","article-title":"Rapid eye movement sleep is initiated by basolateral amygdala dopamine signaling in mice","volume":"375","author":"Hasegawa","year":"2022","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.bbr.2026.116200_bib59","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.1038\/npp.2011.33","article-title":"Specific role of VTA dopamine neuronal firing rates and morphology in the reversal of anxiety-related, but not depression-related behavior in the Clock\u039419 mouse model of mania","volume":"36","author":"Coque","year":"2011","journal-title":"Neuropsychopharmacology"},{"issue":"6","key":"10.1016\/j.bbr.2026.116200_bib60","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.biopsych.2010.04.031","article-title":"Knockdown of Clock in the ventral tegmental area through RNA interference results in a mixed state of mania and depression-like behavior","volume":"68","author":"Mukherjee","year":"2010","journal-title":"Biol. Psychiatry"},{"issue":"Pt 2","key":"10.1016\/j.bbr.2026.116200_bib61","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1113\/jphysiol.2006.112599","article-title":"Gene expression profiles of brain dopamine neurons and relevance to neuropsychiatric disease","volume":"575","author":"Greene","year":"2006","journal-title":"J. Physiol."},{"issue":"5","key":"10.1016\/j.bbr.2026.116200_bib62","doi-asserted-by":"crossref","first-page":"1239","DOI":"10.1093\/schbul\/sbz121","article-title":"Differences in functional connectivity networks related to the midbrain dopaminergic system-related area in various psychiatric disorders","volume":"46","author":"Nakamura","year":"2020","journal-title":"Schizophr. Bull."},{"issue":"43","key":"10.1016\/j.bbr.2026.116200_bib63","doi-asserted-by":"crossref","first-page":"16865","DOI":"10.1523\/JNEUROSCI.2449-13.2013","article-title":"The infralimbic cortex bidirectionally modulates mesolimbic dopamine neuron activity via distinct neural pathways","volume":"33","author":"Patton","year":"2013","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.bbr.2026.116200_bib64","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.brainresrev.2007.05.004","article-title":"Dopamine reward circuitry: two projection systems from the ventral midbrain to the nucleus accumbens-olfactory tubercle complex","volume":"56","author":"Ikemoto","year":"2007","journal-title":"Brain Res. Rev."},{"key":"10.1016\/j.bbr.2026.116200_bib65","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/j.neubiorev.2020.10.015","article-title":"Opioid-induced structural and functional plasticity of medium-spiny neurons in the nucleus accumbens","volume":"120","author":"Thompson","year":"2021","journal-title":"Neurosci. Biobehav Rev."},{"key":"10.1016\/j.bbr.2026.116200_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2025.156634","article-title":"Ginsenoside Rc maintains sleep rhythm homeostasis by alleviating oxidative stress","volume":"141","author":"Chen","year":"2025","journal-title":"Phytomedicine"},{"issue":"12","key":"10.1016\/j.bbr.2026.116200_bib67","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.biopsych.2005.09.018","article-title":"Jr., The mesolimbic dopamine reward circuit in depression","volume":"59","author":"Nestler","year":"2006","journal-title":"Biol. Psychiatry"},{"issue":"1","key":"10.1016\/j.bbr.2026.116200_bib68","doi-asserted-by":"crossref","first-page":"6196","DOI":"10.1038\/s41467-025-61180-8","article-title":"Nicotine engages a VTA-NAc feedback loop to inhibit amygdala-projecting dopamine neurons and induce anxiety-like behaviors","volume":"16","author":"Le Borgne","year":"2025","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.bbr.2026.116200_bib69","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1007\/s11011-017-0023-3","article-title":"Role of dopamine projections from ventral tegmental area to nucleus accumbens and medial prefrontal cortex in reinforcement behaviors assessed using optogenetic manipulation","volume":"32","author":"Han","year":"2017","journal-title":"Metab. Brain Dis."},{"issue":"6","key":"10.1016\/j.bbr.2026.116200_bib70","doi-asserted-by":"crossref","first-page":"2907","DOI":"10.1007\/s00429-017-1365-7","article-title":"Activation of ventral tegmental area dopamine neurons produces wakefulness through dopamine D(2)-like receptors in mice","volume":"222","author":"Oishi","year":"2017","journal-title":"Brain Struct. Funct."},{"issue":"12","key":"10.1016\/j.bbr.2026.116200_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.107812","article-title":"Dopamine inputs from the ventral tegmental area into the medial prefrontal cortex modulate neuropathic pain-associated behaviors in mice","volume":"31","author":"Huang","year":"2020","journal-title":"Cell Rep."},{"issue":"4","key":"10.1016\/j.bbr.2026.116200_bib72","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1007\/s12264-021-00809-2","article-title":"Dopaminergic neurons in the ventral tegmental-prelimbic pathway promote the emergence of rats from sevoflurane anesthesia","volume":"38","author":"Song","year":"2022","journal-title":"Neurosci. Bull."},{"issue":"4","key":"10.1016\/j.bbr.2026.116200_bib73","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.bja.2019.07.005","article-title":"Orexin activated emergence from isoflurane anaesthesia involves excitation of ventral tegmental area dopaminergic neurones in rats","volume":"123","author":"Li","year":"2019","journal-title":"Br. J. Anaesth."},{"issue":"1","key":"10.1016\/j.bbr.2026.116200_bib74","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.neuron.2012.09.011","article-title":"Orienting and reorienting: the locus coeruleus mediates cognition through arousal","volume":"76","author":"Sara","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2026.116200_bib75","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.pbb.2017.05.001","article-title":"Organization of dopamine and serotonin system: Anatomical and functional mapping of monosynaptic inputs using rabies virus","volume":"174","author":"Ogawa","year":"2018","journal-title":"Pharm. Biochem. Behav."},{"issue":"39","key":"10.1016\/j.bbr.2026.116200_bib76","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.1202526109","article-title":"Mechanism for Hypocretin-mediated sleep-to-wake transitions","volume":"109","author":"Carter","year":"2012","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbr.2026.116200_bib77","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/1756-6606-6-59","article-title":"Analysis of sleep disorders under pain using an optogenetic tool: possible involvement of the activation of dorsal raphe nucleus-serotonergic neurons","volume":"6","author":"Ito","year":"2013","journal-title":"Mol. Brain"},{"key":"10.1016\/j.bbr.2026.116200_bib78","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1016\/S0079-6123(08)00929-1","article-title":"The roles of dopamine and serotonin, and of their receptors, in regulating sleep and waking","author":"Monti","year":"2008","journal-title":"Prog. Brain Res."},{"key":"10.1016\/j.bbr.2026.116200_bib79","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.bbr.2017.11.006","article-title":"The effects of local microinjection of selective dopamine D1 and D2 receptor agonists and antagonists into the dorsal raphe nucleus on sleep and wakefulness in the rat","volume":"339","author":"Monti","year":"2018","journal-title":"Behav. Brain Res."},{"issue":"3","key":"10.1016\/j.bbr.2026.116200_bib80","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1038\/nrn2573","article-title":"The locus coeruleus and noradrenergic modulation of cognition","volume":"10","author":"Sara","year":"2009","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbr.2026.116200_bib81","doi-asserted-by":"crossref","first-page":"334","DOI":"10.3389\/fnmol.2019.00334","article-title":"Dopamine and Noradrenaline in the Brain; Overlapping or Dissociate Functions?","volume":"12","author":"Ranjbar-Slamloo","year":"2019","journal-title":"Front Mol. Neurosci."},{"issue":"2","key":"10.1016\/j.bbr.2026.116200_bib82","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/0006-8993(86)91016-4","article-title":"Activation of the locus coeruleus induced by selective stimulation of the ventral tegmental area","volume":"363","author":"Deutch","year":"1986","journal-title":"Brain Res."},{"issue":"Pt 3","key":"10.1016\/j.bbr.2026.116200_bib83","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1113\/jphysiol.2006.117069","article-title":"The ventral tegmental area revisited: is there an electrophysiological marker for dopaminergic neurons?","volume":"577","author":"Margolis","year":"2006","journal-title":"J. Physiol."},{"issue":"Pt 15","key":"10.1016\/j.bbr.2026.116200_bib84","doi-asserted-by":"crossref","first-page":"3775","DOI":"10.1113\/jphysiol.2011.210807","article-title":"Distinct cellular properties of identified dopaminergic and GABAergic neurons in the mouse ventral tegmental area","volume":"589","author":"Chieng","year":"2011","journal-title":"J. Physiol."},{"issue":"7","key":"10.1016\/j.bbr.2026.116200_bib85","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0042365","article-title":"Identification of rat ventral tegmental area GABAergic neurons","volume":"7","author":"Margolis","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbr.2026.116200_bib86","doi-asserted-by":"crossref","DOI":"10.3389\/fncir.2022.867053","article-title":"Anatomy and function of ventral tegmental area glutamate neurons","volume":"16","author":"Cai","year":"2022","journal-title":"Front Neural Circuits"},{"issue":"12","key":"10.1016\/j.bbr.2026.116200_bib87","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1038\/sj.npp.1300495","article-title":"Rapid synaptic plasticity of glutamatergic synapses on dopamine neurons in the ventral tegmental area in response to acute amphetamine injection","volume":"29","author":"Faleiro","year":"2004","journal-title":"Neuropsychopharmacology"},{"issue":"4","key":"10.1016\/j.bbr.2026.116200_bib88","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0156-19.2019","article-title":"Defensive behaviors driven by a hypothalamic-ventral midbrain circuit","volume":"6","author":"Mangieri","year":"2019","journal-title":"eNeuro"},{"issue":"2","key":"10.1016\/j.bbr.2026.116200_bib89","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.neuron.2020.04.024","article-title":"VTA glutamatergic neurons mediate innate defensive behaviors","volume":"107","author":"Barbano","year":"2020","journal-title":"Neuron"},{"issue":"23","key":"10.1016\/j.bbr.2026.116200_bib90","doi-asserted-by":"crossref","first-page":"8476","DOI":"10.1523\/JNEUROSCI.1598-11.2011","article-title":"Mesocorticolimbic glutamatergic pathway","volume":"31","author":"Yamaguchi","year":"2011","journal-title":"J. Neurosci."},{"issue":"4","key":"10.1016\/j.bbr.2026.116200_bib91","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1523\/JNEUROSCI.4317-03.2004","article-title":"Dopamine neurons mediate a fast excitatory signal via their glutamatergic synapses","volume":"24","author":"Chuhma","year":"2004","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2026.116200_bib92","article-title":"Control of behavioral arousal and defense by a glutamatergic midbrain-amygdala pathway in mice","volume":"16","author":"Chen","year":"2022","journal-title":"Front Neurosci."},{"issue":"1","key":"10.1016\/j.bbr.2026.116200_bib93","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1038\/s41380-021-01112-2","article-title":"Cocaine-induced projection-specific and cell type-specific adaptations in the nucleus accumbens","volume":"27","author":"Zinsmaier","year":"2022","journal-title":"Mol. Psychiatry"},{"issue":"5","key":"10.1016\/j.bbr.2026.116200_bib94","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nn.4281","article-title":"VTA glutamatergic inputs to nucleus accumbens drive aversion by acting on GABAergic interneurons","volume":"19","author":"Qi","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbr.2026.116200_bib95","doi-asserted-by":"crossref","DOI":"10.1016\/j.physbeh.2020.112850","article-title":"Homeostatic regulation of reward via synaptic insertion of calcium-permeable AMPA receptors in nucleus accumbens","volume":"219","author":"Carr","year":"2020","journal-title":"Physiol. Behav."},{"issue":"2","key":"10.1016\/j.bbr.2026.116200_bib96","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1213\/ANE.0000000000006739","article-title":"Ventral tegmental area glutamatergic neurons facilitated emergence from isoflurane anesthesia involves excitation of lateral septum gaba-ergic neurons in mice","volume":"139","author":"Zhang","year":"2024","journal-title":"Anesth. Analg."},{"issue":"1","key":"10.1016\/j.bbr.2026.116200_bib97","doi-asserted-by":"crossref","first-page":"4163","DOI":"10.1038\/s41467-022-31591-y","article-title":"Orexin neurons inhibit sleep to promote arousal","volume":"13","author":"De Luca","year":"2022","journal-title":"Nat. Commun."},{"issue":"14","key":"10.1016\/j.bbr.2026.116200_bib98","doi-asserted-by":"crossref","first-page":"3308","DOI":"10.1002\/cne.23603","article-title":"GABAergic and glutamatergic efferents of the mouse ventral tegmental area","volume":"522","author":"Taylor","year":"2014","journal-title":"J. Comp. Neurol."},{"issue":"4","key":"10.1016\/j.bbr.2026.116200_bib99","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.physbeh.2005.06.033","article-title":"Sleep-related neurons in the central nucleus of the amygdala of rats and their modulation by the dorsal raphe nucleus","volume":"86","author":"Jha","year":"2005","journal-title":"Physiol. Behav."},{"issue":"8","key":"10.1016\/j.bbr.2026.116200_bib100","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/sleep\/28.8.923","article-title":"Influence of tetrodotoxin inactivation of the central nucleus of the amygdala on sleep and arousal","volume":"28","author":"Tang","year":"2005","journal-title":"Sleep"},{"issue":"2","key":"10.1016\/j.bbr.2026.116200_bib101","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.neuron.2019.05.015","article-title":"Sleep regulation by neurotensinergic neurons in a thalamo-amygdala circuit","volume":"103","author":"Ma","year":"2019","journal-title":"Neuron"},{"issue":"48","key":"10.1016\/j.bbr.2026.116200_bib102","doi-asserted-by":"crossref","first-page":"15948","DOI":"10.1523\/JNEUROSCI.3428-15.2015","article-title":"Rewarding effects of optical stimulation of ventral tegmental area glutamatergic neurons","volume":"35","author":"Wang","year":"2015","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.bbr.2026.116200_bib103","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1523\/JNEUROSCI.3884-09.2010","article-title":"Glutamatergic and nonglutamatergic neurons of the ventral tegmental area establish local synaptic contacts with dopaminergic and nondopaminergic neurons","volume":"30","author":"Dobi","year":"2010","journal-title":"J. Neurosci."},{"issue":"10","key":"10.1016\/j.bbr.2026.116200_bib104","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1002\/syn.20668","article-title":"Ultrastructural analysis of local collaterals of rat ventral tegmental area neurons: GABA phenotype and synapses onto dopamine and GABA cells","volume":"63","author":"Omelchenko","year":"2009","journal-title":"Synapse"},{"key":"10.1016\/j.bbr.2026.116200_bib105","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.conb.2017.03.018","article-title":"Principal cell types of sleep-wake regulatory circuits","volume":"44","author":"Jones","year":"2017","journal-title":"Curr. Opin. Neurobiol."},{"issue":"5","key":"10.1016\/j.bbr.2026.116200_bib106","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0381-18.2018","article-title":"nNOS-expressing neurons in the ventral tegmental area and substantia nigra pars compacta","volume":"5","author":"Paul","year":"2018","journal-title":"eNeuro"},{"issue":"2","key":"10.1016\/j.bbr.2026.116200_bib107","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0356-19.2020","article-title":"Arousal state-dependent alterations in VTA-GABAergic neuronal activity","volume":"7","author":"Eban-Rothschild","year":"2020","journal-title":"eNeuro"},{"key":"10.1016\/j.bbr.2026.116200_bib108","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.44928","article-title":"GABA neurons in the ventral tegmental area regulate non-rapid eye movement sleep in mice","volume":"8","author":"Chowdhury","year":"2019","journal-title":"Elife"},{"issue":"6","key":"10.1016\/j.bbr.2026.116200_bib109","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2020.101240","article-title":"Ablation of ventral midbrain\/Pons GABA neurons induces mania-like behaviors with altered sleep homeostasis and dopamine D(2)R-mediated sleep reduction","volume":"23","author":"Honda","year":"2020","journal-title":"iScience"},{"issue":"6601","key":"10.1016\/j.bbr.2026.116200_bib110","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1126\/science.abn0853","article-title":"A specific circuit in the midbrain detects stress and induces restorative sleep","volume":"377","author":"Yu","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.bbr.2026.116200_bib111","doi-asserted-by":"crossref","first-page":"73","DOI":"10.3389\/fncir.2019.00073","article-title":"Optogenetic\/chemogenetic activation of GABAergic neurons in the ventral tegmental area facilitates general anesthesia via projections to the lateral hypothalamus in mice","volume":"13","author":"Yin","year":"2019","journal-title":"Front Neural Circuits"},{"issue":"9","key":"10.1016\/j.bbr.2026.116200_bib112","doi-asserted-by":"crossref","first-page":"5213","DOI":"10.1038\/s41380-020-0810-9","article-title":"Dysfunction of ventral tegmental area GABA neurons causes mania-like behavior","volume":"26","author":"Yu","year":"2021","journal-title":"Mol. Psychiatry"},{"issue":"12","key":"10.1016\/j.bbr.2026.116200_bib113","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1038\/nn2006","article-title":"RGS2 modulates coupling between GABAB receptors and GIRK channels in dopamine neurons of the ventral tegmental area","volume":"10","author":"Labou\u00e8be","year":"2007","journal-title":"Nat. Neurosci."},{"issue":"2","key":"10.1016\/j.bbr.2026.116200_bib114","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1523\/JNEUROSCI.12-02-00483.1992","article-title":"Opioids excite dopamine neurons by hyperpolarization of local interneurons","volume":"12","author":"Johnson","year":"1992","journal-title":"J. Neurosci."},{"issue":"2","key":"10.1016\/j.bbr.2026.116200_bib115","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1038\/nn1181","article-title":"Bi-directional effects of GABA(B) receptor agonists on the mesolimbic dopamine system","volume":"7","author":"Cruz","year":"2004","journal-title":"Nat. Neurosci."},{"issue":"6","key":"10.1016\/j.bbr.2026.116200_bib116","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1016\/j.neuron.2012.02.016","article-title":"Activation of VTA GABA neurons disrupts reward consumption","volume":"73","author":"van Zessen","year":"2012","journal-title":"Neuron"},{"issue":"46","key":"10.1016\/j.bbr.2026.116200_bib117","doi-asserted-by":"crossref","first-page":"8853","DOI":"10.1523\/JNEUROSCI.0988-20.2020","article-title":"Dissecting the Role of GABA Neurons in the VTA versus SNr in Opioid Reward","volume":"40","author":"Galaj","year":"2020","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.bbr.2026.116200_bib118","doi-asserted-by":"crossref","first-page":"8500","DOI":"10.1038\/s41467-025-63396-0","article-title":"VTA monosynaptic connections by local glutamate and GABA neurons and their distinct roles in behavior","volume":"16","author":"Barbano","year":"2025","journal-title":"Nat. Commun."},{"issue":"10","key":"10.1016\/j.bbr.2026.116200_bib119","doi-asserted-by":"crossref","first-page":"1208","DOI":"10.1111\/ejn.13879","article-title":"Synaptic function and plasticity in identified inhibitory inputs onto VTA dopamine neurons","volume":"47","author":"Polter","year":"2018","journal-title":"Eur. J. Neurosci."},{"issue":"6","key":"10.1016\/j.bbr.2026.116200_bib120","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/j.neuron.2012.02.015","article-title":"GABA neurons of the VTA drive conditioned place aversion","volume":"73","author":"Tan","year":"2012","journal-title":"Neuron"},{"issue":"6153","key":"10.1016\/j.bbr.2026.116200_bib121","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1126\/science.1237059","article-title":"Cocaine disinhibits dopamine neurons by potentiation of GABA transmission in the ventral tegmental area","volume":"341","author":"Bocklisch","year":"2013","journal-title":"Science"},{"issue":"12","key":"10.1016\/j.bbr.2026.116200_bib122","doi-asserted-by":"crossref","DOI":"10.1093\/sleep\/zsac235","article-title":"Regulation of wakefulness by GABAergic dorsal raphe nucleus-ventral tegmental area pathway","volume":"45","author":"Cai","year":"2022","journal-title":"Sleep"},{"issue":"4","key":"10.1016\/j.bbr.2026.116200_bib123","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.neuron.2018.12.012","article-title":"Rostral and caudal ventral tegmental area GABAergic inputs to different dorsal raphe neurons participate in opioid dependence","volume":"101","author":"Li","year":"2019","journal-title":"Neuron"},{"issue":"6","key":"10.1016\/j.bbr.2026.116200_bib124","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1016\/j.neuron.2017.05.020","article-title":"Dorsal raphe dopamine neurons modulate arousal and promote wakefulness by salient stimuli","volume":"94","author":"Cho","year":"2017","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2026.116200_bib125","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.877054","article-title":"Functional interaction between GABAergic neurons in the ventral tegmental area and serotonergic neurons in the dorsal raphe nucleus","volume":"16","author":"Rahaman","year":"2022","journal-title":"Front Neurosci."},{"issue":"3","key":"10.1016\/j.bbr.2026.116200_bib126","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1038\/nrg.2016.150","article-title":"Transcriptional architecture of the mammalian circadian clock","volume":"18","author":"Takahashi","year":"2017","journal-title":"Nat. Rev. Genet"},{"issue":"1","key":"10.1016\/j.bbr.2026.116200_bib127","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41576-022-00519-z","article-title":"Genetics of circadian rhythms and sleep in human health and disease","volume":"24","author":"Lane","year":"2023","journal-title":"Nat. Rev. Genet"},{"key":"10.1016\/j.bbr.2026.116200_bib128","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1007\/978-3-030-81147-1_4","article-title":"The brain's reward system in health and disease","volume":"1344","author":"Lewis","year":"2021","journal-title":"Adv. Exp. Med. Biol."},{"issue":"1","key":"10.1016\/j.bbr.2026.116200_bib129","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.neuron.2023.09.023","article-title":"Circadian rhythms and mood disorders: Time to see the light","volume":"112","author":"Dollish","year":"2024","journal-title":"Neuron"},{"issue":"8","key":"10.1016\/j.bbr.2026.116200_bib130","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1038\/nrn2868","article-title":"Sleep and circadian rhythm disruption in psychiatric and neurodegenerative disease","volume":"11","author":"Wulff","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbr.2026.116200_bib131","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/978-3-030-81147-1_5","article-title":"Brain clocks, sleep, and mood","volume":"1344","author":"Yu","year":"2021","journal-title":"Adv. Exp. Med. Biol."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432826001762?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432826001762?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T08:29:07Z","timestamp":1776932947000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432826001762"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":131,"alternative-id":["S0166432826001762"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2026.116200","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The ventral tegmental area as a key hub for sleep\u2013wake regulation: A systematic review of cell-type-specific circuits and functional heterogeneity","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2026.116200","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116200"}}