{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T09:00:58Z","timestamp":1776934858932,"version":"3.51.2"},"reference-count":12,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100024990","name":"National Yang Ming Chiao Tung University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100024990","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.bbr.2026.116202","type":"journal-article","created":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T13:07:57Z","timestamp":1775135277000},"page":"116202","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Transcriptomic dissociation between synaptic plasticity suppression and structure-related maintenance signaling in the Alzheimer\u2019s frontal cortex: A molecular analysis"],"prefix":"10.1016","volume":"508","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-8545-9076","authenticated-orcid":false,"given":"Chen","family":"Juanlu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pin-Syuan","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bbr.2026.116202_bib1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1001\/jamaneurol.2021.4417","article-title":"Research criteria for the behavioral variant of Alzheimer disease: a systematic review and meta-analysis","volume":"79","author":"Ossenkoppele","year":"2022","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.bbr.2026.116202_bib2","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/nrneurol.2017.96","article-title":"A clinicopathological approach to the diagnosis of dementia","volume":"13","author":"Elahi","year":"2017","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.bbr.2026.116202_bib3","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.neuron.2009.03.024","article-title":"Neurodegenerative diseases target large-scale human brain networks","volume":"62","author":"Seeley","year":"2009","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2026.116202_bib4","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/s41467-019-14159-1","article-title":"Functional brain architecture is associated with the rate of tau accumulation in Alzheimer\u2019s disease","volume":"11","author":"Franzmeier","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbr.2026.116202_bib5","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1001\/jamaneurol.2018.1836","article-title":"Assessing synaptic density in Alzheimer disease with synaptic vesicle glycoprotein 2A positron emission tomographic imaging","volume":"75","author":"Chen","year":"2018","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.bbr.2026.116202_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2025.103764","article-title":"Detection of structural-functional coupling abnormalities using multimodal brain networks in Alzheimer\u2019s disease: a comparison of three computational models","volume":"46","author":"Lu","year":"2025","journal-title":"NeuroImage Clin."},{"key":"10.1016\/j.bbr.2026.116202_bib7","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1038\/s41467-024-54715-y","article-title":"Stereo-seq of the prefrontal cortex in aging and Alzheimer\u2019s disease","volume":"16","author":"Gong","year":"2025","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbr.2026.116202_bib8","doi-asserted-by":"crossref","first-page":"2704","DOI":"10.1038\/s41588-024-01961-x","article-title":"Spatial and single-nucleus transcriptomic analysis of genetic and sporadic forms of Alzheimer\u2019s disease","volume":"56","author":"Miyoshi","year":"2024","journal-title":"Nat. Genet"},{"key":"10.1016\/j.bbr.2026.116202_bib9","doi-asserted-by":"crossref","first-page":"4365","DOI":"10.1016\/j.cell.2023.08.039","article-title":"Single-cell atlas reveals correlates of high cognitive function, dementia, and resilience to Alzheimer\u2019s disease pathology","volume":"186","author":"Mathys","year":"2023","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.bbr.2026.116202_bib10","doi-asserted-by":"crossref","first-page":"436","DOI":"10.1093\/jnen\/nlz023","article-title":"Peri-infarct upregulation of the oxytocin receptor in vascular dementia","volume":"78","author":"McKay","year":"2019","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.bbr.2026.116202_bib11","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.jalz.2016.10.007","article-title":"The vascular impairment of cognition classification consensus study","volume":"13","author":"Skrobot","year":"2017","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.bbr.2026.116202_bib12","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc. Natl. Acad. Sci."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432826001786?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432826001786?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T08:28:43Z","timestamp":1776932923000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432826001786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":12,"alternative-id":["S0166432826001786"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2026.116202","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Transcriptomic dissociation between synaptic plasticity suppression and structure-related maintenance signaling in the Alzheimer\u2019s frontal cortex: A molecular analysis","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2026.116202","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116202"}}