{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T17:41:01Z","timestamp":1790012461648,"version":"4.0.1"},"reference-count":100,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T00:00:00Z","timestamp":1776124800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008725","name":"Maj Institute of Pharmacology Polish Academy of Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004382","name":"Polska Akademia Nauk","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004382","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004281","name":"National Science Centre Poland","doi-asserted-by":"publisher","award":["UMO-2016\/21\/B\/NZ4\/00203"],"award-info":[{"award-number":["UMO-2016\/21\/B\/NZ4\/00203"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.bbr.2026.116222","type":"journal-article","created":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T07:14:00Z","timestamp":1776237240000},"page":"116222","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Maternal isocaloric fructose exposure selectively attenuates effort-based cocaine motivation and remodels mesostriatal dopaminergic and melanocortin receptor profiles in male rat offspring"],"prefix":"10.1016","volume":"508","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2905-9183","authenticated-orcid":false,"given":"Kacper","family":"Witek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3773-1707","authenticated-orcid":false,"given":"Karolina","family":"Wydra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata","family":"Suder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4321-7942","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"Filip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbr.2026.116222_bib1","series-title":"Global Report on Cocaine 2023 \u2013 Local Dynamics, Global Challenges","author":"United Nations Office on Drugs and Crime","year":"2023"},{"key":"10.1016\/j.bbr.2026.116222_bib2","unstructured":"Substance Abuse and Mental Health Services Administration (SAMHSA). (2024). Key substance use and mental health indicators in the United States: Results from the 2023 National Survey on Drug Use and Health (HHS Publication No. PEP23-07-01-006, NSDUH Series H-59). Rockville, MD: Center for Behavioral Health Statistics and Quality. Retrieved from \u3008https:\/\/library.samhsa.gov\/product\/2023-nsduh-report\/pep24-07-021\u3009. Accessed January 1, 2026."},{"key":"10.1016\/j.bbr.2026.116222_bib3","unstructured":"European Monitoring Centre for Drugs and Drug Addiction (2024) European Drug Report 2024: Trends and developments. Retrieved from \u3008https:\/\/www.emcdda.europa.eu\/publications\/european-drug-report\/2024_en\u3009. Accessed January 1, 2026."},{"key":"10.1016\/j.bbr.2026.116222_bib4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.2147\/SAR.S337338","article-title":"Cocaine use disorder (CUD): current clinical perspectives","volume":"13","author":"Schwartz","year":"2022","journal-title":"Subst. Abus. Rehabil."},{"key":"10.1016\/j.bbr.2026.116222_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2024.1230626","article-title":"Understanding the patient and supporter journey in cocaine use disorder","volume":"15","author":"Leclair","year":"2024","journal-title":"Front. Psychiatry"},{"key":"10.1016\/j.bbr.2026.116222_bib6","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.3390\/brainsci12111546","article-title":"Pharmacological treatments for cocaine craving: what is the way forward? A systematic review","volume":"12","author":"Lassi","year":"2022","journal-title":"Brain Sci."},{"key":"10.1016\/j.bbr.2026.116222_bib7","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1038\/s41386-018-0008-x","article-title":"Environmental, genetic and epigenetic contributions to cocaine addiction","volume":"43","author":"Pierce","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2026.116222_bib8","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/s41380-021-01256-1","article-title":"Molecular genetics of cocaine use disorders in humans","volume":"27","author":"Fern\u00e0ndez-Castillo","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbr.2026.116222_bib9","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1080\/15504263.2017.1360535","article-title":"Increased depression and anxiety symptoms are associated with more breakdowns in cognitive control to cocaine cues in veterans with cocaine use disorder","volume":"13","author":"DiGirolamo","year":"2017","journal-title":"J. Dual Diagn."},{"key":"10.1016\/j.bbr.2026.116222_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyg.2018.02639","article-title":"Interaction between stress and addiction: contributions from Latin-American neuroscience","volume":"9","author":"Torres-Berrio","year":"2018","journal-title":"Front. Psychol."},{"key":"10.1016\/j.bbr.2026.116222_bib11","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.neubiorev.2017.07.003","article-title":"Prenatal developmental origins of behavior and mental health: the influence of maternal stress in pregnancy","volume":"117","author":"Van den Bergh","year":"2020","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbr.2026.116222_bib12","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1038\/s41380-020-0648-1","article-title":"The importance of a developmental perspective in Psychiatry: what do recent genetic-epidemiological findings show?","volume":"25","author":"Thapar","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbr.2026.116222_bib13","doi-asserted-by":"crossref","first-page":"8206","DOI":"10.3390\/ijerph18158206","article-title":"Biopsychosocial factors during the perinatal period: risks, preventative factors, and implications for healthcare professionals","volume":"18","author":"Blount","year":"2021","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.bbr.2026.116222_bib14","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.clnesp.2024.10.155","article-title":"Nutritional requirements in pregnancy and lactation","volume":"64","author":"Talebi","year":"2024","journal-title":"Clin. Nutr. ESPEN"},{"key":"10.1016\/j.bbr.2026.116222_bib15","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/j.1365-2796.2007.01809.x","article-title":"The origins of the developmental origins theory","volume":"261","author":"Barker","year":"2007","journal-title":"J. Intern. Med."},{"key":"10.1016\/j.bbr.2026.116222_bib16","first-page":"160","article-title":"Dietary fructose consumption among us children and adults: the third National Health and Nutrition Examination Survey","volume":"10","author":"Vos","year":"2008","journal-title":"Medscape J. Med."},{"key":"10.1016\/j.bbr.2026.116222_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2023.148427","article-title":"Can early-life high fructose exposure induce long-term depression and anxiety-like behaviours? \u2013 A preclinical systematic review","volume":"1814","author":"Hyldgaard Andersen","year":"2023","journal-title":"Brain Res."},{"key":"10.1016\/j.bbr.2026.116222_bib18","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.1016\/j.jnutbio.2015.07.018","article-title":"High sucrose consumption during pregnancy induced ADHD-like behavioral phenotypes in mice offspring","volume":"26","author":"Choi","year":"2015","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.bbr.2026.116222_bib19","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.lfs.2018.02.010","article-title":"Maternal high fructose diet and neonatal immune challenge alter offspring anxiety-like behavior and inflammation across the lifespan","volume":"197","author":"Bukhari","year":"2018","journal-title":"Life Sci."},{"key":"10.1016\/j.bbr.2026.116222_bib20","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1002\/dneu.22940","article-title":"Pregestational fructose-induced metabolic syndrome in Wistar rats causes sexually dimorphic behavioral changes in their offspring","volume":"84","author":"Cuervo S\u00e1nchez","year":"2024","journal-title":"Dev. Neurobiol."},{"key":"10.1016\/j.bbr.2026.116222_bib21","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.nlm.2016.02.004","article-title":"Environmental stimulation rescues maternal high fructose intake-impaired learning and memory in female offspring: Its correlation with redistribution of histone deacetylase 4","volume":"130","author":"Wu","year":"2016","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.bbr.2026.116222_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2024.109571","article-title":"Butyrate reduction and HDAC4 increase underlie maternal high fructose-induced metabolic dysfunction in hippocampal astrocytes in female rats","volume":"126","author":"Wu","year":"2024","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.bbr.2026.116222_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.cbi.2023.110518","article-title":"Alternative splicing affects synapses in the hippocampus of offspring after maternal fructose exposure during gestation and lactation","volume":"379","author":"Zou","year":"2023","journal-title":"Chem. Biol. Inter."},{"key":"10.1016\/j.bbr.2026.116222_bib24","doi-asserted-by":"crossref","first-page":"3919","DOI":"10.3390\/ijerph17113919","article-title":"Environmental stimulation counteracts the suppressive effects of maternal high-fructose diet on cell proliferation and neuronal differentiation in the dentate gyrus of adult female offspring via histone deacetylase 4","volume":"17","author":"Liu","year":"2020","journal-title":"Int. J. Environ. Res. Public Health"},{"key":"10.1016\/j.bbr.2026.116222_bib25","article-title":"Learning and memory impairment and transcriptomic profile in hippocampus of offspring after maternal fructose exposure during gestation and lactation","volume":"169","author":"Zou","year":"2022"},{"key":"10.1016\/j.bbr.2026.116222_bib26","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2022.966271","article-title":"Association between maternal sugar-sweetened beverage consumption and the social-emotional development of child before 1 year old: a prospective cohort study","volume":"9","author":"Gao","year":"2022","journal-title":"Front. Nutr."},{"key":"10.1016\/j.bbr.2026.116222_bib27","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.clnu.2013.03.002","article-title":"Maternal dietary patterns during pregnancy and child internalising and externalising problems. The Generation R Study","volume":"33","author":"Steenweg-de Graaff","year":"2014","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.bbr.2026.116222_bib28","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.3390\/nu13072435","article-title":"Association of prenatal sugar consumption with newborn brain tissue organization","volume":"13","author":"Berger","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.bbr.2026.116222_bib29","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1007\/s00394-022-02798-y","article-title":"Association of sweetened carbonated beverage consumption during pregnancy and ADHD symptoms in the offspring: a study from the Norwegian Mother, Father and Child Cohort Study (MoBa)","volume":"61","author":"Kvalvik","year":"2022","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.bbr.2026.116222_bib30","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.amepre.2018.02.020","article-title":"Associations of prenatal and child sugar intake with child cognition","volume":"54","author":"Cohen","year":"2018","journal-title":"Am. J. Prev. Med."},{"key":"10.1016\/j.bbr.2026.116222_bib31","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.jaac.2013.07.002","article-title":"Maternal and early postnatal nutrition and mental health of offspring by age 5 years: a prospective cohort study","volume":"52","author":"Jacka","year":"2013","journal-title":"J. Am. Acad. Child Adolesc. Psychiatry"},{"key":"10.1016\/j.bbr.2026.116222_bib32","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2023.1176213","article-title":"Maternal monosaccharide diets evoke cognitive, locomotor, and emotional disturbances in adolescent and young adult offspring rats","volume":"10","author":"Witek","year":"2023","journal-title":"Front. Nutr."},{"key":"10.1016\/j.bbr.2026.116222_bib33","doi-asserted-by":"crossref","first-page":"1657","DOI":"10.1007\/s43440-025-00785-8","article-title":"Maternal monosaccharide diets modulate melanocortin-4 receptor signaling and metabolic state in rat offspring","volume":"77","author":"Witek","year":"2025","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.bbr.2026.116222_bib34","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/npp.2009.110","article-title":"Neurocircuitry of addiction","volume":"35","author":"Koob","year":"2009","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2026.116222_bib35","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.cell.2015.07.046","article-title":"The brain on drugs: from reward to addiction","volume":"162","author":"Volkow","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.bbr.2026.116222_bib36","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1016\/j.neubiorev.2013.02.010","article-title":"From the ventral to the dorsal striatum: devolving views of their roles in drug addiction","volume":"37","author":"Everitt","year":"2013","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbr.2026.116222_bib37","doi-asserted-by":"crossref","first-page":"11638","DOI":"10.3389\/fnana.2011.00041","article-title":"The striatal balancing act in drug addiction: distinct roles of direct and indirect pathway medium spiny neurons","volume":"5","author":"Lobo","year":"2011","journal-title":"Front. Neuroanat."},{"key":"10.1016\/j.bbr.2026.116222_bib38","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev-neuro-061010-113641","article-title":"Modulation of striatal projection systems by dopamine","volume":"34","author":"Gerfen","year":"2011","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.bbr.2026.116222_bib39","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.conb.2013.01.026","article-title":"Cocaine-induced adaptations in D1 and D2 accumbens projection neurons (a dichotomy not necessarily synonymous with direct and indirect pathways)","volume":"23","author":"Smith","year":"2013","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.bbr.2026.116222_bib40","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1038\/nrn3657","article-title":"Synaptic changes induced by melanocortin signalling","volume":"15","author":"Caruso","year":"2014","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbr.2026.116222_bib41","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1038\/nn.4202","article-title":"Melanocortin-4 receptor\u2013regulated energy homeostasis","volume":"19","author":"Krashes","year":"2016","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbr.2026.116222_bib42","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1016\/j.peptides.2004.11.029","article-title":"Involvement of melanocortin-4 receptor in anxiety and depression","volume":"26","author":"Chaki","year":"2005","journal-title":"Peptides"},{"key":"10.1016\/j.bbr.2026.116222_bib43","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/j.psyneuen.2015.08.025","article-title":"High-fructose diet during periadolescent development increases depressive-like behavior and remodels the hypothalamic transcriptome in male rats","volume":"62","author":"Harrell","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbr.2026.116222_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106521","article-title":"Investigating the role of the central melanocortin system in stress and stress-related disorders","volume":"185","author":"Micioni Di Bonaventura","year":"2022","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bbr.2026.116222_bib45","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1124\/jpet.102.040311","article-title":"Molecular and behavioral interactions between central melanocortins and cocaine","volume":"304","author":"Alvaro","year":"2003","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbr.2026.116222_bib46","doi-asserted-by":"crossref","first-page":"2233","DOI":"10.1111\/j.1460-9568.2005.04038.x","article-title":"Blockade of melanocortin transmission inhibits cocaine reward","volume":"21","author":"Hsu","year":"2005","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bbr.2026.116222_bib47","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1111\/gbb.12057","article-title":"The expression of MC4Rs in D1R neurons regulates food intake and locomotor sensitization to cocaine","volume":"12","author":"Cui","year":"2013","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.bbr.2026.116222_bib48","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.physbeh.2012.01.025","article-title":"Melanocortin 4 receptor signaling in dopamine 1 receptor neurons is required for procedural memory learning","volume":"106","author":"Cui","year":"2012","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbr.2026.116222_bib49","doi-asserted-by":"crossref","first-page":"576","DOI":"10.3803\/EnM.2015.30.4.576","article-title":"Melanocortin 4 receptor and dopamine D2 receptor expression in brain areas involved in food intake","volume":"30","author":"Yoon","year":"2015","journal-title":"Endocrinol. Metab."},{"key":"10.1016\/j.bbr.2026.116222_bib50","doi-asserted-by":"crossref","first-page":"12215","DOI":"10.3390\/ijms232012215","article-title":"Maternal fructose intake, programmed mitochondrial function and predisposition to adult disease","volume":"23","author":"Smith","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbr.2026.116222_bib51","doi-asserted-by":"crossref","first-page":"3278","DOI":"10.3390\/nu13093278","article-title":"Maternal fructose diet-induced developmental programming","volume":"13","author":"Thompson","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.bbr.2026.116222_bib52","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1210\/en.2010-1093","article-title":"Maternal fructose intake during pregnancy and lactation alters placental growth and leads to sex-specific changes in fetal and neonatal endocrine function","volume":"152","author":"Vickers","year":"2011","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbr.2026.116222_bib53","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1515\/nipt-2024-0011","article-title":"Motivational dysregulation with melanocortin 4 receptor haploinsufficiency","volume":"3","author":"Steiner","year":"2024","journal-title":"NeuroImmune Pharm. Ther."},{"key":"10.1016\/j.bbr.2026.116222_bib54","doi-asserted-by":"crossref","first-page":"3160","DOI":"10.1172\/JCI97854","article-title":"Motivational valence is determined by striatal melanocortin 4 receptors","volume":"128","author":"Klawonn","year":"2018","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.bbr.2026.116222_bib55","doi-asserted-by":"crossref","DOI":"10.1186\/s11689-020-09353-y","article-title":"Controlling litter effects to enhance rigor and reproducibility with rodent models of neurodevelopmental disorders","volume":"13","author":"Jim\u00e9nez","year":"2021","journal-title":"J. Neurodev. Disord."},{"key":"10.1016\/j.bbr.2026.116222_bib56","doi-asserted-by":"crossref","first-page":"1411","DOI":"10.3390\/biom13091411","article-title":"Esketamine inhibits cocaine-seeking behaviour subsequent to various abstinence conditions in rats","volume":"13","author":"Wydra","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.bbr.2026.116222_bib57","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0165-0270(95)00153-0","article-title":"Progressive ratio schedules in drug self-administration studies in rats: a method to evaluate reinforcing efficacy","volume":"66","author":"Richardson","year":"1996","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.bbr.2026.116222_bib58","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/S0091-3057(96)00445-5","article-title":"A critique of fixed and progressive ratio schedules used to examine the neural substrates of drug reinforcement","volume":"57","author":"Arnold","year":"1997","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.bbr.2026.116222_bib59","series-title":"The Rat Brain in Stereotaxic Coordinates","first-page":"237","author":"Paxinos","year":"1998"},{"key":"10.1016\/j.bbr.2026.116222_bib60","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1016\/j.mex.2014.08.002","article-title":"Method and validation of synaptosomal preparation for isolation of synaptic membrane proteins from rat brain","volume":"1","author":"Kamat","year":"2014","journal-title":"MethodsX"},{"key":"10.1016\/j.bbr.2026.116222_bib61","doi-asserted-by":"crossref","DOI":"10.1095\/biolreprod.113.109595","article-title":"Maternal fructose and\/or salt intake and reproductive outcome in the rat: Effects on growth, fertility, sex ratio, and birth order","volume":"89","author":"Gray","year":"2013","journal-title":"Biol. Reprod."},{"key":"10.1016\/j.bbr.2026.116222_bib62","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1111\/1440-1681.12162","article-title":"Fructose, pregnancy and later life impacts","volume":"40","author":"Regnault","year":"2013","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.bbr.2026.116222_bib63","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/203474","article-title":"Early life exposure to fructose and offspring phenotype: implications for long term metabolic homeostasis","volume":"2014","author":"Sloboda","year":"2014","journal-title":"J. Obes."},{"key":"10.1016\/j.bbr.2026.116222_bib64","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.3389\/fnut.2022.917880","article-title":"Sex-specific effects of maternal dietary carbohydrate quality on fetal development and offspring metabolic phenotype in mice","volume":"9","author":"Campbell","year":"2022","journal-title":"Front. Nutr."},{"key":"10.1016\/j.bbr.2026.116222_bib65","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2023.1203063","article-title":"Effect of high-fructose consumption in pregnancy on the bone growth of offspring rats","volume":"10","author":"Li","year":"2023","journal-title":"Front. Nutr."},{"key":"10.1016\/j.bbr.2026.116222_bib66","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1016\/j.ajcnut.2023.01.006","article-title":"Fructose consumption from different food sources and cardiometabolic biomarkers: cross-sectional associations in US men and women","volume":"117","author":"Li","year":"2023","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.bbr.2026.116222_bib67","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.ijdevneu.2018.07.001","article-title":"Neurobehavioral effects of long-term maternal fructose intake in rat offspring","volume":"69","author":"Erbas","year":"2018","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.bbr.2026.116222_bib68","doi-asserted-by":"crossref","DOI":"10.1016\/j.jnutbio.2022.109220","article-title":"Early life exposure to high fructose diet induces metabolic dysregulation associated with sex-specific cognitive impairment in adolescent rats","volume":"114","author":"Barrett","year":"2023","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.bbr.2026.116222_bib69","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0165-6147(97)01115-2","article-title":"The role of stress in drug self-administration","volume":"19","author":"Piazza","year":"1998","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.bbr.2026.116222_bib70","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1146\/annurev.psych.59.103006.093548","article-title":"Addiction and the brain antireward system","volume":"59","author":"Koob","year":"2008","journal-title":"Annu. Rev. Psychol."},{"key":"10.1016\/j.bbr.2026.116222_bib71","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1111\/j.1360-0443.2010.02902.x","article-title":"Mental disorders as risk factors for substance use, abuse and dependence: results from the 10-year follow-up of the national comorbidity survey","volume":"105","author":"Swendsen","year":"2010","journal-title":"Addiction"},{"key":"10.1016\/j.bbr.2026.116222_bib72","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s40429-019-00282-y","article-title":"Identifying early risk factors for addiction later in life: a review of prospective longitudinal studies","volume":"7","author":"Morales","year":"2020","journal-title":"Curr. Addict. Rep."},{"key":"10.1016\/j.bbr.2026.116222_bib73","first-page":"1014","article-title":"Evidence for addiction-like behavior in the rat","volume":"305","author":"Deroche-Gamonet","year":"2004","journal-title":"Science (1979)"},{"key":"10.1016\/j.bbr.2026.116222_bib74","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.neubiorev.2010.06.006","article-title":"Reconsidering anhedonia in depression: lessons from translational neuroscience","volume":"35","author":"Treadway","year":"2011","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbr.2026.116222_bib75","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1007\/s40473-015-0044-3","article-title":"Anhedonia and the brain reward circuitry in depression","volume":"2","author":"Heshmati","year":"2015","journal-title":"Curr. Behav. Neurosci. Rep."},{"key":"10.1016\/j.bbr.2026.116222_bib76","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1146\/annurev-clinpsy-050212-185606","article-title":"Depression, stress, and anhedonia: Toward a synthesis and integrated model","volume":"10","author":"Pizzagalli","year":"2014","journal-title":"Annu. Rev. Clin. Psychol."},{"key":"10.1016\/j.bbr.2026.116222_bib77","doi-asserted-by":"crossref","first-page":"2627","DOI":"10.1038\/s41386-018-0025-9","article-title":"Unlimited sucrose consumption during adolescence generates a depressive-like phenotype in adulthood","volume":"43","author":"Gueye","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2026.116222_bib78","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms15527","article-title":"Drug-seeking motivation level in male rats determines offspring susceptibility or resistance to cocaine-seeking behaviour","volume":"8","author":"Le","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbr.2026.116222_bib79","doi-asserted-by":"crossref","first-page":"2905","DOI":"10.1523\/JNEUROSCI.3172-20.2022","article-title":"Cocaine-induced changes in sperm Cdkn1a methylation are associated with cocaine resistance in male offspring","volume":"42","author":"Swinford-Jackson","year":"2022","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2026.116222_bib80","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1038\/nn.3280","article-title":"Epigenetic inheritance of a cocaine-resistance phenotype","volume":"16","author":"Vassoler","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbr.2026.116222_bib81","doi-asserted-by":"crossref","first-page":"9192","DOI":"10.1096\/fj.202000163R","article-title":"Maternal high-sugar diet changes offspring vulnerability to reinstatement of cocaine-seeking behavior: role of melanocortin-4 receptors","volume":"34","author":"Gawli\u0144ski","year":"2020","journal-title":"FASEB J."},{"key":"10.1016\/j.bbr.2026.116222_bib82","doi-asserted-by":"crossref","first-page":"1462","DOI":"10.3390\/nu12051462","article-title":"Maternal diet influences the reinstatement of cocaine-seeking behavior and the expression of melanocortin-4 receptors in female offspring of rats","volume":"12","author":"Gawli\u0144ski","year":"2020","journal-title":"Nutrients"},{"key":"10.1016\/j.bbr.2026.116222_bib83","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.neuroscience.2015.06.015","article-title":"Differences in bingeing behavior and cocaine reward following intermittent access to sucrose, glucose, or fructose solutions","volume":"301","author":"Rorabaugh","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbr.2026.116222_bib84","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.yfrne.2007.07.003","article-title":"Sex differences in drug abuse","volume":"29","author":"Becker","year":"2008","journal-title":"Front. Neuroendocr."},{"key":"10.1016\/j.bbr.2026.116222_bib85","doi-asserted-by":"crossref","first-page":"8477","DOI":"10.1523\/JNEUROSCI.1378-22.2022","article-title":"Neural mechanisms mediating sex differences in motivation for reward: cognitive bias, food, gambling, and drugs of abuse","volume":"42","author":"Orsini","year":"2022","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2026.116222_bib86","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s00213-002-1183-2","article-title":"Biological basis of sex differences in drug abuse: preclinical and clinical studies","volume":"164","author":"Lynch","year":"2002","journal-title":"Psychopharmacol. (Berl. )"},{"key":"10.1016\/j.bbr.2026.116222_bib87","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1038\/s41386-018-0125-6","article-title":"Sex differences in neural mechanisms mediating reward and addiction","volume":"44","author":"Becker","year":"2018","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbr.2026.116222_bib88","doi-asserted-by":"crossref","first-page":"2465","DOI":"10.1073\/pnas.0605569104","article-title":"Menstrual cycle phase modulates reward-related neural function in women","volume":"104","author":"Dreher","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbr.2026.116222_bib89","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.expneurol.2014.01.022","article-title":"Sex differences in the neurobiology of drug addiction","volume":"259","author":"Bobzean","year":"2014","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbr.2026.116222_bib90","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.neubiorev.2015.06.020","article-title":"Regulation of the mesocorticolimbic and mesostriatal dopamine systems by \u03b1-melanocyte stimulating hormone and agouti-related protein","volume":"56","author":"Roseberry","year":"2015","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbr.2026.116222_bib91","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2024.137805","article-title":"Acute manipulation of Drd1 neurons in the prefrontal cortex bidirectionally regulates anxiety and depression-like behaviors","volume":"832","author":"Chen","year":"2024","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbr.2026.116222_bib92","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1002\/syn.890140210","article-title":"Decreased dopamine D2 receptor availability is associated with reduced frontal metabolism in cocaine abusers","volume":"14","author":"Volkow","year":"1993","journal-title":"Synapse"},{"key":"10.1016\/j.bbr.2026.116222_bib93","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1002\/bies.201000042","article-title":"Addiction: decreased reward sensitivity and increased expectation sensitivity conspire to overwhelm the brain\u2019s control circuit","volume":"32","author":"Volkow","year":"2010","journal-title":"BioEssays"},{"key":"10.1016\/j.bbr.2026.116222_bib94","doi-asserted-by":"crossref","first-page":"3125","DOI":"10.1098\/rstb.2008.0089","article-title":"Neural mechanisms underlying the vulnerability to develop compulsive drug-seeking habits and addiction","volume":"363","author":"Everitt","year":"2008","journal-title":"Philos. Trans. R. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.bbr.2026.116222_bib95","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1038\/nn1737","article-title":"PET imaging of dopamine D2 receptors during chronic cocaine self-administration in monkeys","volume":"9","author":"Nader","year":"2006","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbr.2026.116222_bib96","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/gbb.12265","article-title":"search of predictive endophenotypes in addiction: insights from preclinical research","volume":"15","author":"Belin","year":"2016","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.bbr.2026.116222_bib97","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1016\/j.neuropharm.2013.06.031","article-title":"Imaging addiction: D2 receptors and dopamine signaling in the striatum as biomarkers for impulsivity","volume":"76","author":"Trifilieff","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbr.2026.116222_bib98","first-page":"346","article-title":"Neuroscience: processed foods and food reward","volume":"363","author":"Small","year":"2019","journal-title":"Science (1979)"},{"key":"10.1016\/j.bbr.2026.116222_bib99","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1172\/JCI121653","article-title":"Melanocortin 4 receptors switch reward to aversion","volume":"128","author":"DiFeliceantonio","year":"2018","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.bbr.2026.116222_bib100","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1006\/phrs.2001.0913","article-title":"Chronic infusion of a melanocortin receptor agonist modulates dopamine receptor binding in the rat brain","volume":"45","author":"Lindblom","year":"2002","journal-title":"Pharmacol. Res."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432826001981?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432826001981?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T08:29:49Z","timestamp":1776932989000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432826001981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":100,"alternative-id":["S0166432826001981"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2026.116222","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Maternal isocaloric fructose exposure selectively attenuates effort-based cocaine motivation and remodels mesostriatal dopaminergic and melanocortin receptor profiles in male rat offspring","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2026.116222","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"116222"}}