{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,3]],"date-time":"2026-11-03T22:23:21Z","timestamp":1793744601286,"version":"4.6.1"},"reference-count":62,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003093","name":"Ministry of Higher Education, Malaysia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004595","name":"Science University of Malaysia","doi-asserted-by":"publisher","award":["304\/CDADAH\/ 4401009"],"award-info":[{"award-number":["304\/CDADAH\/ 4401009"]}],"id":[{"id":"10.13039\/501100004595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.bbr.2026.116354","type":"journal-article","created":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T06:44:21Z","timestamp":1782888261000},"page":"116354","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Bacopa-enriched formulation enhances memory and synaptic plasticity in a rat model of vascular dementia"],"prefix":"10.1016","volume":"514","author":[{"given":"Suleiman","family":"Yunusa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nur Sabrina","family":"Halimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Hazim","family":"Abdullah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro Espinosa","family":"Sosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farah Wahida","family":"Suhaimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zurina","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bbr.2026.116354_bib1","doi-asserted-by":"crossref","first-page":"2","DOI":"10.2174\/0115672050319219240711103459","article-title":"Alzheimer's disease and vascular dementia, connecting and differentiating features","volume":"22","author":"Hur\u0142a","year":"2025","journal-title":"Curr. Alzheimer Res."},{"issue":"1","key":"10.1016\/j.bbr.2026.116354_bib2","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1186\/s40478-023-01590-1","article-title":"Chronic cerebral hypoperfusion: a critical feature in unravelling the etiology of vascular cognitive impairment","volume":"11","author":"Rajeev","year":"2023","journal-title":"Acta Neuropathol. Commun."},{"issue":"1","key":"10.1016\/j.bbr.2026.116354_bib3","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s11011-021-00796-3","article-title":"Cognitive impairment caused by hypoxia: from clinical evidences to molecular mechanisms","volume":"37","author":"Wang","year":"2022","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.bbr.2026.116354_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2020.593364","article-title":"FTY720 prevents spatial memory impairment in a rat model of chronic cerebral hypoperfusion via a SIRT3-independent pathway","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.bbr.2026.116354_bib5","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1046\/j.1440-1681.2003.03825.x","article-title":"Long-term measurement of cerebral blood flow and metabolism in a rat chronic hypoperfusion model","volume":"30","author":"Otori","year":"2003","journal-title":"Clin. Exp. Pharmacol. Physiol."},{"key":"10.1016\/j.bbr.2026.116354_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2023.1224633","article-title":"Research progress of mitophagy in chronic cerebral ischemia","volume":"15","author":"Yu","year":"2023","journal-title":"Front. Aging Neurosci."},{"issue":"4","key":"10.1016\/j.bbr.2026.116354_bib7","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3390\/antiox13040393","article-title":"Investigating the neuroprotective and cognitive-enhancing effects of Bacopa monnieri: a systematic review focused on inflammation, oxidative stress, mitochondrial dysfunction, and apoptosis","volume":"13","author":"Neto","year":"2024","journal-title":"Antioxidants"},{"key":"10.1016\/j.bbr.2026.116354_bib8","article-title":"Dammarane Triterpene Saponins in Bacopa monnieri (Brahmi): Unraveling their Pharmacological Potential","author":"Tanwar","year":"2026","journal-title":"Pharmacol. Res. Nat. Prod."},{"key":"10.1016\/j.bbr.2026.116354_bib9","first-page":"44","article-title":"Bacopa monnieri extract as a neuroprotective and cognitive enhancement agent","author":"Nishanth","year":"2023","journal-title":"Int. J. Drug. Discov. Pharmacol."},{"key":"10.1016\/j.bbr.2026.116354_bib10","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2026.121690","article-title":"Bacopa monnieri confers neuroprotection against middle cerebral artery occlusion (MCAO)-induced neurobehavioral and biochemical dysregulation in the frontal cortex and hippocampus of male Wistar rats","author":"Khuwaja","year":"2026","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bbr.2026.116354_bib11","article-title":"The antioxidant potential of bacoside and its derivatives in Alzheimer's disease: the molecular mechanistic paths and therapeutic prospects","volume":"14","author":"Karati","year":"2025","journal-title":"Toxicol. Rep."},{"issue":"13","key":"10.1016\/j.bbr.2026.116354_bib12","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202300245","article-title":"Amelioration of Amyloid-\u03b2 Induced Alzheimer's Disease by Bacopa monnieri through Modulation of Mitochondrial Dysfunction and GSK-3\u03b2\/Wnt\/\u03b2-Catenin Signaling","volume":"68","author":"Sushma","year":"2024","journal-title":"Mol. Nutr. Food Res."},{"issue":"6","key":"10.1016\/j.bbr.2026.116354_bib13","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1002\/jdn.10350","article-title":"Restoration of hippocampal adult neurogenesis by CDRI-08 (Bacopa monnieri extract) relates with the recovery of BDNF\u2013TrkB levels in male rats with moderate grade hepatic encephalopathy","volume":"84","author":"Mallick","year":"2024","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.bbr.2026.116354_bib14","doi-asserted-by":"crossref","first-page":"4","DOI":"10.31083\/JIN36128","article-title":"Hippocampal Neuroplasticity and Adult Neurogenesis: Mechanisms and Implications","volume":"24","author":"Jang","year":"2025","journal-title":"J. Integr. Neurosci."},{"issue":"1","key":"10.1016\/j.bbr.2026.116354_bib15","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jep.2009.09.056","article-title":"Cognitive enhancement and neuroprotective effects of Bacopa monnieri in Alzheimer's disease model","volume":"127","author":"Uabundit","year":"2010","journal-title":"J. Ethnopharmacol."},{"issue":"9","key":"10.1016\/j.bbr.2026.116354_bib16","doi-asserted-by":"crossref","first-page":"3365","DOI":"10.3390\/ijms21093365","article-title":"Bacopa monnieri (L.) Wettst. Extract improves memory performance via promotion of neurogenesis in the hippocampal dentate gyrus of adolescent mice","volume":"21","author":"Pham","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.bbr.2026.116354_bib17","doi-asserted-by":"crossref","first-page":"1928","DOI":"10.1007\/s11064-012-0811-4","article-title":"Neuroprotective effects of Bacopa monnieri in experimental model of dementia","volume":"37","author":"Saini","year":"2012","journal-title":"Neurochem. Res."},{"issue":"4","key":"10.1016\/j.bbr.2026.116354_bib18","first-page":"208","article-title":"Evaluation of Bacopa monniera for its synergistic activity with rivastigmine in reversing aluminum-induced memory loss and learning deficit in rats","volume":"6","author":"Thippeswamy","year":"2013","journal-title":"Innov. Acupunct. Med."},{"issue":"4","key":"10.1016\/j.bbr.2026.116354_bib19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.14283\/jpad.2016.110","article-title":"Short-term impact of a combined nutraceutical on cognitive function, perceived stress and depression in young elderly with cognitive impairment: a pilot, double-blind, randomized clinical trial","volume":"3","author":"Cicero","year":"2016","journal-title":"J. Prev. Alzheimers Dis."},{"issue":"4","key":"10.1016\/j.bbr.2026.116354_bib20","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S0091-3057(02)00940-1","article-title":"A comparative study in rodents of standardized extracts of Bacopa monniera and Ginkgo biloba: anticholinesterase and cognitive enhancing activities","volume":"73","author":"Das","year":"2002","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"4","key":"10.1016\/j.bbr.2026.116354_bib21","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.jams.2013.02.004","article-title":"Evaluation of Bacopa monniera for its synergistic activity with rivastigmine in reversing aluminum-induced memory loss and learning deficit in rats","volume":"6","author":"Thippeswamy","year":"2013","journal-title":"J. Acupunct. Meridian Stud."},{"issue":"1","key":"10.1016\/j.bbr.2026.116354_bib22","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s12916-014-0206-2","article-title":"The overlap between vascular disease and Alzheimer\u2019s disease-lessons from pathology","volume":"12","author":"Attems","year":"2014","journal-title":"BMC Med."},{"issue":"4","key":"10.1016\/j.bbr.2026.116354_bib23","doi-asserted-by":"crossref","DOI":"10.1002\/prp2.70131","article-title":"Multi-Target Drug Design in Alzheimer's Disease Treatment: Emerging Technologies, Advantages, Challenges, and Limitations","volume":"13","author":"Hossain","year":"2025","journal-title":"Pharmacol. Res. Perspect."},{"issue":"3","key":"10.1016\/j.bbr.2026.116354_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0265285","article-title":"Study protocol for a phase III randomised controlled trial of Sailuotong (SLT) for vascular dementia and Alzheimer\u2019s disease with cerebrovascular disease","volume":"18","author":"Karamacoska","year":"2023","journal-title":"PLoS. One"},{"issue":"8","key":"10.1016\/j.bbr.2026.116354_bib25","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.3390\/antiox10081325","article-title":"Role of coenzyme Q10 in health and disease: An update on the last 10 years (2010\u20132020)","volume":"10","author":"Cirilli","year":"2021","journal-title":"Antioxidants"},{"issue":"7","key":"10.1016\/j.bbr.2026.116354_bib26","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.2741\/4459","article-title":"The neurobiology of acetyl-L-carnitine","volume":"21","author":"Traina","year":"2016","journal-title":"Front. Biosci."},{"issue":"6","key":"10.1016\/j.bbr.2026.116354_bib27","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/j.nut.2014.10.014","article-title":"Phosphatidylserine and the human brain","volume":"31","author":"Glade","year":"2015","journal-title":"Nutrition"},{"issue":"7","key":"10.1016\/j.bbr.2026.116354_bib28","doi-asserted-by":"crossref","first-page":"8695","DOI":"10.1007\/s12035-025-04811-x","article-title":"Benfotiamine ameliorates Streptozotocin-Induced alzheimer\u2019s disease in rats by modulating Neuroinflammation, oxidative Stress, and microglia","volume":"62","author":"Cardinali","year":"2025","journal-title":"Mol. Neurobiol."},{"issue":"4","key":"10.1016\/j.bbr.2026.116354_bib29","doi-asserted-by":"crossref","first-page":"393","DOI":"10.3233\/JAD-2006-9404","article-title":"Elevated plasma homocysteine levels: risk factor or risk marker for the development of dementia and Alzheimer's disease?","volume":"9","author":"Seshadri","year":"2006","journal-title":"J. Alzheimer\u2019S. Dis."},{"issue":"11","key":"10.1016\/j.bbr.2026.116354_bib30","doi-asserted-by":"crossref","first-page":"1629","DOI":"10.1111\/jphp.13345","article-title":"Xanthone-enriched fraction of Garcinia mangostana and \u03b1-mangostin improve the spatial learning and memory of chronic cerebral hypoperfusion rats","volume":"72","author":"Tiang","year":"2020","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.bbr.2026.116354_bib31","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2023.101990","article-title":"Bio-enhanced fraction from Clitoria ternatea root extract ameliorates cognitive functions and in vivo hippocampal neuroplasticity in chronic cerebral hypoperfusion rat model","volume":"89","author":"Ahad","year":"2023","journal-title":"Ageing Res. Rev."},{"issue":"7","key":"10.1016\/j.bbr.2026.116354_bib32","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1177\/0269881119844186","article-title":"Mitragynine (Kratom) impairs spatial learning and hippocampal synaptic transmission in rats","volume":"33","author":"Hassan","year":"2019","journal-title":"J. Psychopharmacol."},{"key":"10.1016\/j.bbr.2026.116354_bib33","doi-asserted-by":"crossref","first-page":"15709","DOI":"10.1038\/srep15709","article-title":"Rapid alteration of protein phosphorylation during postmortem: implication in the study of protein phosphorylation","volume":"5","author":"Wang","year":"2015","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.bbr.2026.116354_bib34","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/0006-2952(61)90145-9","article-title":"A new and rapid colorimetric determination of acetylcholinesterase activity","volume":"7","author":"Ellman","year":"1961","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbr.2026.116354_bib35","first-page":"1","article-title":"Biological effects of contaminants: cholinesterase inhibition by organophosphate and carbamate compounds","volume":"22","author":"Bocquen\u00e9","year":"1998","journal-title":"ICES Tech. Mar. Environ. Sci."},{"issue":"5259","key":"10.1016\/j.bbr.2026.116354_bib36","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1038\/227680a0","article-title":"Cleavage of structural proteins during the assembly of the head of bacteriophage T4","volume":"227","author":"Laemmli","year":"1970","journal-title":"Nature"},{"issue":"7","key":"10.1016\/j.bbr.2026.116354_bib37","doi-asserted-by":"crossref","first-page":"4169","DOI":"10.1093\/cercor\/bhaa041","article-title":"Inhibition of histone deacetylase reinstates hippocampus-dependent long-term synaptic plasticity and associative memory in sleep-deprived mice","volume":"30","author":"Wong","year":"2020","journal-title":"Cereb. Cortex"},{"issue":"S1","key":"10.1016\/j.bbr.2026.116354_bib38","first-page":"3","article-title":"On brain: chemistry to cognition","volume":"30","author":"Ahlquist","year":"2023","journal-title":"Ann. Neurosci."},{"key":"10.1016\/j.bbr.2026.116354_bib39","series-title":"Doctoral dissertation","article-title":"Investigating associations between electrophysiological and pathological changes in the TgF344-AD rat model for Alzheimer\u2019s disease","author":"Sun","year":"2023"},{"key":"10.1016\/j.bbr.2026.116354_bib40","unstructured":"Purves, D., Augustine, G.J., Fitzpatrick, D., et al. (Eds.), 2001. Neuroscience, 2nd ed. Sinauer Associates, Sunderland, MA. Molecular mechanisms underlying LTP."},{"issue":"11","key":"10.1016\/j.bbr.2026.116354_bib41","doi-asserted-by":"crossref","first-page":"5888","DOI":"10.1073\/pnas.94.11.5888","article-title":"Long-term potentiation involves increases in the probability of neurotransmitter release","volume":"94","author":"Schulz","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"50","key":"10.1016\/j.bbr.2026.116354_bib42","doi-asserted-by":"crossref","first-page":"13706","DOI":"10.1523\/JNEUROSCI.3503-07.2007","article-title":"GluR1 links structural and functional plasticity at excitatory synapses","volume":"27","author":"Kopec","year":"2007","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.bbr.2026.116354_bib43","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.3351","article-title":"Genes PSD-95 and GSK-3\u03b2 expression improved by hair follicular stem cells-conditioned medium enhances synaptic transmission and cognitive abilities in the rat model of vascular dementia","volume":"14","author":"Ghobadi","year":"2024","journal-title":"Brain Behav."},{"issue":"8","key":"10.1016\/j.bbr.2026.116354_bib44","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1017\/S1461145714000133","article-title":"Long-term potentiation at excitatory synaptic inputs to the intercalated cell masses of the amygdala","volume":"17","author":"Huang","year":"2014","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"9","key":"10.1016\/j.bbr.2026.116354_bib45","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0162784","article-title":"CaMKII-mediated CREB phosphorylation is involved in Ca2+-induced BDNF mRNA transcription and neurite outgrowth promoted by electrical stimulation","volume":"11","author":"Yan","year":"2016","journal-title":"PloS. One"},{"issue":"4-5","key":"10.1016\/j.bbr.2026.116354_bib46","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1016\/S0028-3908(98)00035-5","article-title":"A role for BDNF in the late-phase of hippocampal long-term potentiation","volume":"37","author":"Korte","year":"1998","journal-title":"Neuropharmacology"},{"issue":"01","key":"10.1016\/j.bbr.2026.116354_bib47","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1002\/nep3.32","article-title":"Mechanisms of glutamate metabolic function and dysfunction in vascular dementia","volume":"2","author":"Wang","year":"2024","journal-title":"Neuroprotection"},{"key":"10.1016\/j.bbr.2026.116354_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.prostaglandins.2023.106733","article-title":"Docosahexaenoic acid inhibits ischemic stroke to reduce vascular dementia and Alzheimer\u2019s disease","volume":"167","author":"Yamagata","year":"2023","journal-title":"Prostaglandins Other Lipid Mediat."},{"issue":"11","key":"10.1016\/j.bbr.2026.116354_bib49","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1002\/iub.2862","article-title":"Neuroprotection and mechanisms of ginsenosides in nervous system diseases: progress and perspectives","volume":"76","author":"Zhou","year":"2024","journal-title":"IUBMB life"},{"issue":"1","key":"10.1016\/j.bbr.2026.116354_bib50","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s13024-023-00640-5","article-title":"Pathophysiology and probable etiology of cerebral small vessel disease in vascular dementia and Alzheimer\u2019s disease","volume":"18","author":"Inoue","year":"2023","journal-title":"Mol. Neurodegener."},{"issue":"1","key":"10.1016\/j.bbr.2026.116354_bib51","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1038\/s42003-025-08177-7","article-title":"White matter dysfunction in Alzheimer\u2019s disease is associated with disease-related transcriptomic signatures","volume":"8","author":"Li","year":"2025","journal-title":"Commun. Biol."},{"issue":"10","key":"10.1016\/j.bbr.2026.116354_bib52","doi-asserted-by":"crossref","first-page":"9067","DOI":"10.3390\/ijms24109067","article-title":"Role of calcium modulation in the pathophysiology and treatment of Alzheimer\u2019s disease","volume":"24","author":"Baracaldo-Santamar\u00eda","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"5","key":"10.1016\/j.bbr.2026.116354_bib53","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s11940-023-00749-4","article-title":"Parkinson disease dementia management: an update of current evidence and future directions","volume":"25","author":"Phillips","year":"2023","journal-title":"Curr. Treat. Options Neurol."},{"issue":"2","key":"10.1016\/j.bbr.2026.116354_bib54","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.expneurol.2006.02.117","article-title":"The role of NR2B containing NMDA receptor in place preference conditioned with morphine and natural reinforcers in rats","volume":"200","author":"Ma","year":"2006","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbr.2026.116354_bib55","series-title":"Doctoral dissertation","article-title":"Modulation of ligand-gated receptors in the central nervous system","author":"Wu","year":"2010"},{"issue":"10","key":"10.1016\/j.bbr.2026.116354_bib56","doi-asserted-by":"crossref","first-page":"894","DOI":"10.1111\/j.1365-2826.2011.02209.x","article-title":"BDNF-TrkB pathway mediates NMDA receptor NR2B subunit phosphorylation in the supraoptic nuclei following progressive dehydration","volume":"23","author":"Carre\u00f1o","year":"2011","journal-title":"J. Neuroendocrinol."},{"issue":"2","key":"10.1016\/j.bbr.2026.116354_bib57","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1007\/s12035-024-04357-4","article-title":"BDNF-TrkB signaling in mitochondria: implications for neurodegenerative diseases","volume":"62","author":"Soman","year":"2025","journal-title":"Mol. Neurobiol."},{"issue":"2","key":"10.1016\/j.bbr.2026.116354_bib58","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0896-6273(03)00640-8","article-title":"AMPA receptor trafficking at excitatory synapses","volume":"40","author":"Bredt","year":"2003","journal-title":"Neuron"},{"issue":"10","key":"10.1016\/j.bbr.2026.116354_bib59","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.3390\/ph17101265","article-title":"NMDA receptors: distribution, role, and insights into neuropsychiatric disorders","volume":"17","author":"Beaurain","year":"2024","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.bbr.2026.116354_bib60","first-page":"1","article-title":"Exploring the connection between BDNF\/TrkB and AC\/cAMP\/PKA\/CREB signaling pathways: potential for neuroprotection and therapeutic targets for neurological disorders","author":"Gupta","year":"2025","journal-title":"Mol. Neurobiol."},{"issue":"4","key":"10.1016\/j.bbr.2026.116354_bib61","doi-asserted-by":"crossref","first-page":"652","DOI":"10.3390\/jpm13040652","article-title":"The role of BDNF as a biomarker in cognitive and sensory neurodegeneration","volume":"13","author":"Pisani","year":"2023","journal-title":"J. Pers. Med."},{"issue":"3","key":"10.1016\/j.bbr.2026.116354_bib62","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited","volume":"22","author":"Reagan-Shaw","year":"2008","journal-title":"FASEB J."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016643282600330X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S016643282600330X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T16:41:45Z","timestamp":1786552905000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S016643282600330X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":62,"alternative-id":["S016643282600330X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2026.116354","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Bacopa-enriched formulation enhances memory and synaptic plasticity in a rat model of vascular dementia","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2026.116354","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116354"}}