{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T17:33:21Z","timestamp":1786556001031,"version":"build-2736575974"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274620"],"award-info":[{"award-number":["82274620"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.bbr.2026.116376","type":"journal-article","created":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T23:20:44Z","timestamp":1783639244000},"page":"116376","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Alisol A attenuates hypothalamic inflammation and metabolic dysfunction in high-fat diet mice"],"prefix":"10.1016","volume":"514","author":[{"given":"Guihua","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinhui","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linlin","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoqing","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiehua","family":"Xue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taotao","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10481","key":"10.1016\/j.bbr.2026.116376_bib1","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S0140-6736(25)00355-1","article-title":"Global, regional, and national prevalence of adult overweight and obesity, 1990-2021, with forecasts to 2050: a forecasting study for the Global Burden of Disease Study 2021","volume":"405","author":"GBD 2021 Adult BMI Collaborators","year":"2025","journal-title":"Lancet"},{"issue":"11","key":"10.1016\/j.bbr.2026.116376_bib2","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1161\/CIRCRESAHA.120.316101","article-title":"Obesity Phenotypes, Diabetes, and Cardiovascular Diseases","volume":"126","author":"Pich\u00e9","year":"2020","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbr.2026.116376_bib3","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.bbi.2024.01.216","article-title":"Dietary fatty acid composition drives neuroinflammation and impaired behavior in obesity","volume":"117","author":"Sanchez","year":"2024","journal-title":"Brain Behav. Immun."},{"issue":"1","key":"10.1016\/j.bbr.2026.116376_bib4","doi-asserted-by":"crossref","DOI":"10.1530\/JOE-22-0271","article-title":"Immunology of chronic low-grade inflammation: relationship with metabolic function","volume":"257","author":"van de Vyver","year":"2023","journal-title":"J. Endocrinol."},{"issue":"1","key":"10.1016\/j.bbr.2026.116376_bib5","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/ijo.2016.183","article-title":"High fat induces acute and chronic inflammation in the hypothalamus: effect of high-fat diet, palmitate and TNF-\u03b1 on appetite-regulating NPY neurons","volume":"41","author":"Dalvi","year":"2017","journal-title":"Int. J. Obes. (Lond. )"},{"issue":"1","key":"10.1016\/j.bbr.2026.116376_bib6","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/s13679-024-00595-8","article-title":"Update on Hypothalamic Inflammation and Gliosis: Expanding Evidence of Relevance Beyond Obesity","volume":"14","author":"Huang","year":"2025","journal-title":"Curr. Obes. Rep."},{"issue":"1","key":"10.1016\/j.bbr.2026.116376_bib7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1172\/JCI92035","article-title":"Inflammatory mechanisms linking obesity and metabolic disease","volume":"127","author":"Saltiel","year":"2017","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.bbr.2026.116376_bib8","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1210\/endrev\/bnac023","article-title":"The Significance of Hypothalamic Inflammation and Gliosis for the Pathogenesis of Obesity in Humans","volume":"44","author":"Sewaybricker","year":"2023","journal-title":"Endocr. Rev."},{"issue":"3","key":"10.1016\/j.bbr.2026.116376_bib9","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1093\/nutrit\/nuab033","article-title":"High-fat diet promotes hypothalamic inflammation in animal models: a systematic review","volume":"80","author":"Santos","year":"2022","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.bbr.2026.116376_bib10","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.80388","article-title":"Obesogenic diet induces circuit-specific memory deficits in mice","volume":"13","author":"Bakoyiannis","year":"2024","journal-title":"Elife"},{"issue":"2","key":"10.1016\/j.bbr.2026.116376_bib11","doi-asserted-by":"crossref","first-page":"498","DOI":"10.3390\/nu13020498","article-title":"The Role of Hypothalamic Inflammation in Diet-Induced Obesity and Its Association with Cognitive and Mood Disorders","volume":"13","author":"Dionysopoulou","year":"2021","journal-title":"Nutrients"},{"key":"10.1016\/j.bbr.2026.116376_bib12","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/B978-0-12-819975-6.00005-4","article-title":"Kullmann S, Veit R. Resting-state functional connectivity of the human hypothalamus","volume":"179","year":"2021","journal-title":"Handb. Clin. Neurol."},{"issue":"3","key":"10.1016\/j.bbr.2026.116376_bib13","doi-asserted-by":"crossref","first-page":"R37","DOI":"10.1093\/ejendo\/lvad030","article-title":"Is human obesity an inflammatory disease of the hypothalamus?","volume":"188","author":"Sonnefeld","year":"2023","journal-title":"Eur. J. Endocrinol."},{"issue":"10","key":"10.1016\/j.bbr.2026.116376_bib14","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1016\/j.cmet.2022.09.002","article-title":"Hypothalamic astrocytes control systemic glucose metabolism and energy balance","volume":"34","author":"Herrera Moro Chao","year":"2022","journal-title":"Cell. Metab."},{"issue":"20","key":"10.1016\/j.bbr.2026.116376_bib15","doi-asserted-by":"crossref","first-page":"2000","DOI":"10.1001\/jama.2023.19897","article-title":"Obesity Management in Adults: A Review","volume":"330","author":"Elmaleh-Sachs","year":"2023","journal-title":"JAMA"},{"issue":"5","key":"10.1016\/j.bbr.2026.116376_bib16","doi-asserted-by":"crossref","DOI":"10.1002\/iid3.848","article-title":"Alisol A 24-acetate ameliorates osteoarthritis progression by inhibiting reactive oxygen species and inflammatory response through the AMPK\/mTOR pathway","volume":"11","author":"Xu","year":"2023","journal-title":"Immun. Inflamm. Dis."},{"key":"10.1016\/j.bbr.2026.116376_bib17","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/8857687","article-title":"Alismatis Rhizoma Triterpenes Alleviate High-Fat Diet-Induced Insulin Resistance in Skeletal Muscle of Mice","volume":"2021","author":"Jia","year":"2021","journal-title":"Evid. Based Complement. Altern. Med."},{"issue":"8","key":"10.1016\/j.bbr.2026.116376_bib18","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.3390\/biomedicines10081945","article-title":"Pharmacological Properties and Molecular Targets of Alisol Triterpenoids from Alismatis Rhizoma","volume":"10","author":"Bailly","year":"2022","journal-title":"Biomedicines"},{"issue":"8","key":"10.1016\/j.bbr.2026.116376_bib19","doi-asserted-by":"crossref","first-page":"5108","DOI":"10.1111\/jcmm.14380","article-title":"Alisol A attenuates high-fat-diet-induced obesity and metabolic disorders via the AMPK\/ACC\/SREBP-1c pathway","volume":"23","author":"Ho","year":"2019","journal-title":"J. Cell. Mol. Med."},{"issue":"2","key":"10.1016\/j.bbr.2026.116376_bib20","doi-asserted-by":"crossref","first-page":"753","DOI":"10.1007\/s12035-023-03592-5","article-title":"Alisol A Exerts Neuroprotective Effects Against HFD-Induced Pathological Brain Aging via the SIRT3-NF-\u03baB\/MAPK Pathway","volume":"61","author":"Lu","year":"2024","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbr.2026.116376_bib21","doi-asserted-by":"crossref","DOI":"10.1002\/0471142727.mb1415s102","article-title":"Basic image analysis and manipulation in ImageJ","author":"Hartig","year":"2013","journal-title":"Curr. Protoc. Mol. Biol."},{"issue":"7","key":"10.1016\/j.bbr.2026.116376_bib22","doi-asserted-by":"crossref","first-page":"e805","DOI":"10.1212\/WNL.0000000000010003","article-title":"Metabolites of neuroinflammation relate to neuropathic pain after spinal cord injury","volume":"95","author":"Pfyffer","year":"2020","journal-title":"Neurology"},{"key":"10.1016\/j.bbr.2026.116376_bib23","doi-asserted-by":"crossref","DOI":"10.1038\/srep19880","article-title":"Magnetic Resonance Spectroscopy discriminates the response to microglial stimulation of wild type and Alzheimer's disease models","volume":"6","author":"Pardon","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbr.2026.116376_bib24","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.617308","article-title":"Brain Metabolite, N-Acetylaspartate Is a Potent Protein Aggregation Inhibitor","volume":"15","author":"Warepam","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.bbr.2026.116376_bib25","doi-asserted-by":"crossref","first-page":"39","DOI":"10.3389\/fnhum.2014.00039","article-title":"Moderate relationships between NAA and cognitive ability in healthy adults: implications for cognitive spectroscopy","volume":"8","author":"Patel","year":"2014","journal-title":"Front. Hum. Neurosci."},{"issue":"3","key":"10.1016\/j.bbr.2026.116376_bib26","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1016\/j.cmet.2024.12.009","article-title":"Lactate homeostasis is maintained through regulation of glycolysis and lipolysis","volume":"37","author":"Lee","year":"2025","journal-title":"Cell. Metab."},{"issue":"3","key":"10.1016\/j.bbr.2026.116376_bib27","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1038\/nrendo.2017.161","article-title":"Animal models of obesity and diabetes mellitus","volume":"14","author":"Kleinert","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"issue":"2","key":"10.1016\/j.bbr.2026.116376_bib28","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1177\/0023677216653984","article-title":"Does age matter? The impact of rodent age on study outcomes","volume":"51","author":"Jackson","year":"2017","journal-title":"Lab. Anim."},{"issue":"5","key":"10.1016\/j.bbr.2026.116376_bib29","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1007\/s12272-019-01138-9","article-title":"Hypothalamic inflammation and obesity: a mechanistic review","volume":"42","author":"Seong","year":"2019","journal-title":"Arch. Pharm. Res."},{"issue":"2","key":"10.1016\/j.bbr.2026.116376_bib30","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1210\/endrev\/bnab025","article-title":"Arcuate Nucleus-Dependent Regulation of Metabolism-Pathways to Obesity and Diabetes Mellitus","volume":"43","author":"Jais","year":"2022","journal-title":"Endocr. Rev."},{"issue":"10","key":"10.1016\/j.bbr.2026.116376_bib31","doi-asserted-by":"crossref","first-page":"4192","DOI":"10.1210\/en.2004-1520","article-title":"Consumption of a fat-rich diet activates a proinflammatory response and induces insulin resistance in the hypothalamus","volume":"146","author":"De Souza","year":"2005","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbr.2026.116376_bib32","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.mce.2016.05.015","article-title":"Diet-induced cellular neuroinflammation in the hypothalamus: Mechanistic insights from investigation of neurons and microglia","volume":"438","author":"Tran","year":"2016","journal-title":"Mol. Cell. Endocrinol."},{"issue":"7","key":"10.1016\/j.bbr.2026.116376_bib33","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.1038\/s42255-024-01079-8","article-title":"Obesity-induced inflammation: connecting the periphery to the brain","volume":"6","author":"Le Thuc","year":"2024","journal-title":"Nat. Metab."},{"issue":"5","key":"10.1016\/j.bbr.2026.116376_bib34","first-page":"431","article-title":"Cellular Contributors to Hypothalamic Inflammation in Obesity","volume":"43","author":"Lee","year":"2020","journal-title":"Mol. Cells"},{"issue":"6","key":"10.1016\/j.bbr.2026.116376_bib35","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/j.neuron.2020.03.022","article-title":"PNOCARC Neurons Promote Hyperphagia and Obesity upon High-Fat-Diet Feeding","volume":"106","author":"Jais","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2026.116376_bib36","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jchromb.2015.11.011","article-title":"Simultaneous determination of three triterpenes in rat plasma by LC-MS\/MS and its application to a pharmacokinetic study of Rhizoma Alismatis extract","volume":"1008","author":"Cheng","year":"2016","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.bbr.2026.116376_bib37","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.jpba.2017.09.009","article-title":"Pharmacokinetics and tissue distribution of five major triterpenoids after oral administration of Rhizoma Alismatis extract to rats using ultra high-performance liquid chromatography-tandem mass spectrometry","volume":"146","author":"Xu","year":"2017","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"1","key":"10.1016\/j.bbr.2026.116376_bib38","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/s00018-021-04019-x","article-title":"Hypothalamic inflammation in metabolic disorders and aging","volume":"79","author":"Bhusal","year":"2021","journal-title":"Cell. Mol. Life Sci."},{"issue":"3","key":"10.1016\/j.bbr.2026.116376_bib39","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s11154-025-09992-3","article-title":"Redefining the timeline: a three-phase framework of hypothalamic microinflammation in metabolic disease","volume":"27","author":"Zagmutt","year":"2026","journal-title":"Rev. Endocr. Metab. Disord."},{"key":"10.1016\/j.bbr.2026.116376_bib40","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.95044","article-title":"CXCR3-expressing myeloid cells recruited to the hypothalamus protect against diet-induced body mass gain and metabolic dysfunction","volume":"13","author":"Mendes","year":"2024","journal-title":"Elife"},{"key":"10.1016\/j.bbr.2026.116376_bib41","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2023.1197432","article-title":"Serum amyloid A and metabolic disease: evidence for a critical role in chronic inflammatory conditions","volume":"10","author":"den Hartigh","year":"2023","journal-title":"Front. Cardiovasc. Med."},{"issue":"4","key":"10.1016\/j.bbr.2026.116376_bib42","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1038\/ijo.2017.266","article-title":"Obesity-induced changes in lipid mediators persist after weight loss","volume":"42","author":"Hernandez-Carretero","year":"2018","journal-title":"Int. J. Obes. (Lond. )"},{"issue":"9","key":"10.1016\/j.bbr.2026.116376_bib43","doi-asserted-by":"crossref","DOI":"10.1097\/HC9.0000000000000802","article-title":"Arachidonic acid metabolism in metabolic dysfunction-associated steatotic liver disease and liver fibrosis","volume":"9","author":"Ma","year":"2025","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.bbr.2026.116376_bib44","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.87120","article-title":"An acute microglial metabolic response controls metabolism and improves memory","volume":"12","author":"Drougard","year":"2024","journal-title":"Elife"},{"issue":"3","key":"10.1016\/j.bbr.2026.116376_bib45","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0116587","article-title":"Metabolic and tissue-specific regulation of acyl-CoA metabolism","volume":"10","author":"Ellis","year":"2015","journal-title":"PLoS. One"},{"issue":"44","key":"10.1016\/j.bbr.2026.116376_bib46","doi-asserted-by":"crossref","first-page":"18108","DOI":"10.1073\/pnas.1114863108","article-title":"Hypothalamic mitochondrial dysfunction associated with anorexia in the anx\/anx mouse","volume":"108","author":"Lindfors","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"18","key":"10.1016\/j.bbr.2026.116376_bib47","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.160987","article-title":"ACOT1 deficiency attenuates high-fat diet-induced fat mass gain by increasing energy expenditure","volume":"8","author":"Heden","year":"2023","journal-title":"JCI Insight"},{"issue":"8","key":"10.1016\/j.bbr.2026.116376_bib48","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1016\/j.celrep.2018.07.065","article-title":"Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial Metabolism","volume":"24","author":"Koenis","year":"2018","journal-title":"Cell. Rep."},{"issue":"4","key":"10.1016\/j.bbr.2026.116376_bib49","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1038\/s41380-023-02025-y","article-title":"Brain functional and structural magnetic resonance imaging of obesity and weight loss interventions","volume":"28","author":"Li","year":"2023","journal-title":"Mol. Psychiatry"},{"issue":"9","key":"10.1016\/j.bbr.2026.116376_bib50","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.biopsych.2015.09.011","article-title":"Hippocampus Contributions to Food Intake Control: Mnemonic, Neuroanatomical, and Endocrine Mechanisms","volume":"81","author":"Kanoski","year":"2017","journal-title":"Biol. Psychiatry"},{"issue":"7978","key":"10.1016\/j.bbr.2026.116376_bib51","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/s41586-023-06459-w","article-title":"An orexigenic subnetwork within the human hippocampus","volume":"621","author":"Barbosa","year":"2023","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.bbr.2026.116376_bib52","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1016\/j.neuron.2013.02.018","article-title":"Hypothalamic survival circuits: blueprints for purposive behaviors","volume":"77","author":"Sternson","year":"2013","journal-title":"Neuron"}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432826003529?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432826003529?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T16:39:51Z","timestamp":1786552791000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432826003529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":52,"alternative-id":["S0166432826003529"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2026.116376","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Alisol A attenuates hypothalamic inflammation and metabolic dysfunction in high-fat diet mice","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2026.116376","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"116376"}}