{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T17:45:22Z","timestamp":1791827122121,"version":"4.3.4"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T00:00:00Z","timestamp":1791417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010285","name":"University of San Diego","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010285","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Behavioural Brain Research"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.bbr.2026.116526","type":"journal-article","created":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T15:06:03Z","timestamp":1791558363000},"page":"116526","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Contribution of the medial prefrontal cortex to performance on the Traveling Salesperson Problem in rats"],"prefix":"10.1016","volume":"517","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-1033-6790","authenticated-orcid":false,"given":"Luka","family":"Kazanjian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avery","family":"Ehrlich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Spaulding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3690-818X","authenticated-orcid":false,"given":"Anahi","family":"Salazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Tavares","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel","family":"E. Blaser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8260-3777","authenticated-orcid":false,"given":"Jena B.","family":"Hales","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"24","key":"10.1016\/j.bbr.2026.116526_bib1","doi-asserted-by":"crossref","first-page":"3628","DOI":"10.3390\/ani15243628","article-title":"The Map\u2019s design: evolution\u2019s impact on navigation and spatial cognition","volume":"15","author":"Olynik-McLaughlin","year":"2025","journal-title":"Animals"},{"issue":"1","key":"10.1016\/j.bbr.2026.116526_bib2","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.bbr.2010.01.012","article-title":"Age effects on wayfinding and route learning skills","volume":"209","author":"Head","year":"2010","journal-title":"Behav. Brain Res."},{"issue":"3","key":"10.1016\/j.bbr.2026.116526_bib3","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1037\/0278-7393.15.3.507","article-title":"Effects of adult age and working memory on reasoning and spatial abilities","volume":"15","author":"Salthouse","year":"1989","journal-title":"J. Exp. Psychol. Learn. Mem. Cogn."},{"issue":"1\u20133","key":"10.1016\/j.bbr.2026.116526_bib4","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.schres.2016.02.033","article-title":"Examining hippocampal function in schizophrenia using a virtual reality spatial navigation task","volume":"172","author":"Salgado-Pineda","year":"2016","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.bbr.2026.116526_bib5","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.parkreldis.2016.12.020","article-title":"Spatial learning deficits in Parkinson\u2019s disease with and without mild cognitive impairment","volume":"36","author":"Schneider","year":"2017","journal-title":"Park. & Relat. Disord."},{"issue":"1","key":"10.1016\/j.bbr.2026.116526_bib6","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/s43856-026-01484-y","article-title":"Spatial navigation as a digital marker for clinically differentiating cognitive impairment severity","volume":"6","author":"Colombo","year":"2026","journal-title":"Commun. Med."},{"key":"10.1016\/j.bbr.2026.116526_bib7","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s10071-011-0449-7","article-title":"Route selection by rats and humans in a navigational traveling salesman problem","volume":"15","author":"Blaser","year":"2012","journal-title":"Anim. Cogn."},{"issue":"4","key":"10.1016\/j.bbr.2026.116526_bib8","doi-asserted-by":"crossref","first-page":"527","DOI":"10.3758\/BF03213088","article-title":"Human performance on the traveling salesman problem","volume":"58","author":"MacGregor","year":"1996","journal-title":"Percept. & Psychophys."},{"issue":"1","key":"10.1016\/j.bbr.2026.116526_bib9","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1007\/s004260000031","article-title":"Human performance on visually presented Traveling Salesman problems","volume":"65","author":"Vickers","year":"2001","journal-title":"Psychol. Res."},{"issue":"2","key":"10.1016\/j.bbr.2026.116526_bib10","article-title":"Human Performance on the Traveling Salesman and Related Problems: A Review","volume":"3","author":"MacGregor","year":"2011","journal-title":"J. Probl. Solving"},{"issue":"2","key":"10.1016\/j.bbr.2026.116526_bib11","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1080\/13875860902906496","article-title":"Taxonomy of Human Wayfinding Tasks: A Knowledge-Based Approach","volume":"9","author":"Wiener","year":"2009","journal-title":"Spat. Cogn. & Comput."},{"key":"10.1016\/j.bbr.2026.116526_bib12","unstructured":"Sohn, S.S., Mavros, P., Kapadia, M., & H\u00f6lscher, C. (2022). A Computational Method for the Classification of Mental Representations of Objects in 3D Space (Short Paper) [Application\/pdf]. LIPIcs, Volume 240, COSIT 2022, 240, 20:1-20:8. https:\/\/doi.org\/10.4230\/LIPICS.COSIT.2022.20."},{"issue":"4","key":"10.1016\/j.bbr.2026.116526_bib13","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/S0272-4944(89)80009-X","article-title":"The role of cognitive maps in spatial decisions","volume":"9","author":"G\u00e4rling","year":"1989","journal-title":"J. Environ. Psychol."},{"key":"10.1016\/j.bbr.2026.116526_bib14","author":"Bellmore","year":"1986","journal-title":"Travel. Salesm. Probl. A Surv."},{"issue":"2","key":"10.1016\/j.bbr.2026.116526_bib15","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/0040-5809(83)90038-2","article-title":"Optimal foraging and the traveling salesman","volume":"24","author":"Anderson","year":"1983","journal-title":"Theor. Popul. Biol."},{"issue":"7","key":"10.1016\/j.bbr.2026.116526_bib16","doi-asserted-by":"crossref","first-page":"1183","DOI":"10.3758\/BF03211819","article-title":"A model of human performance on the traveling salesperson problem","volume":"28","author":"Macgregor","year":"2000","journal-title":"Mem. & Cogn."},{"issue":"7","key":"10.1016\/j.bbr.2026.116526_bib17","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.3758\/BF03211820","article-title":"The traveling salesman problem: A hierarchical model","volume":"28","author":"Graham","year":"2000","journal-title":"Mem. & Cogn."},{"key":"10.1016\/j.bbr.2026.116526_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2021.113177","article-title":"Contribution of the hippocampus to performance on the traveling salesperson problem in rats","volume":"405","author":"Hales","year":"2021","journal-title":"Behav. brain Res."},{"key":"10.1016\/j.bbr.2026.116526_bib19","first-page":"11","article-title":"Cognitive Approaches to the Traveling Salesperson Problem: Perceptual Complexity that Produces Computational Simplicity","author":"Best","year":"2006","journal-title":"AAAI Spring Symposium a Rock a Hard Place Cognitive Science Principles Meet AI-Hard Problems"},{"issue":"4","key":"10.1016\/j.bbr.2026.116526_bib20","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1037\/com0000358","article-title":"Target number influences strategy use by rats (Rattus norvegicus) in the traveling salesperson problem","volume":"137","author":"Paez","year":"2023","journal-title":"J. Comp. Psychol."},{"key":"10.1016\/j.bbr.2026.116526_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2024.114883","article-title":"Contribution of the medial entorhinal cortex to performance on the Traveling Salesperson Problem in rats","volume":"463","author":"Hales","year":"2024","journal-title":"Behav. brain Res."},{"key":"10.1016\/j.bbr.2026.116526_bib22","first-page":"101","article-title":"Executive control and decision-making in the prefrontal cortex","volume":"1","author":"Domenech","year":"2015","journal-title":"Cogn. Control."},{"issue":"5695","key":"10.1016\/j.bbr.2026.116526_bib23","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1126\/science.1100301","article-title":"The Role of the Medial Frontal Cortex in Cognitive Control","volume":"306","author":"Ridderinkhof","year":"2004","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.bbr.2026.116526_bib24","first-page":"336","article-title":"The somatic marker hypothesis: A neural theory of economic decision","volume":"52","author":"Bechara","year":"2005","journal-title":"Spec. Issue Neuroeconomics"},{"issue":"5573","key":"10.1016\/j.bbr.2026.116526_bib25","doi-asserted-by":"crossref","first-page":"1709","DOI":"10.1126\/science.1069504","article-title":"Anterior Cingulate: Single Neuronal Signals Related to Degree of Reward Expectancy","volume":"296","author":"Shidara","year":"2002","journal-title":"Science"},{"issue":"6333","key":"10.1016\/j.bbr.2026.116526_bib26","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1126\/science.aam6808","article-title":"Engrams and circuits crucial for systems consolidation of a memory","volume":"356","author":"Kitamura","year":"2017","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.bbr.2026.116526_bib27","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/0304-3940(90)90069-L","article-title":"Long-term potentiation in the prefrontal cortex following stimulation of the hippocampal CA1\/subicular region","volume":"114","author":"Laroche","year":"1990","journal-title":"Neurosci. Lett."},{"issue":"17","key":"10.1016\/j.bbr.2026.116526_bib28","doi-asserted-by":"crossref","first-page":"R764","DOI":"10.1016\/j.cub.2013.05.041","article-title":"Interplay of Hippocampus and Prefrontal Cortex in Memory","volume":"23","author":"Preston","year":"2013","journal-title":"Curr. Biol."},{"issue":"13","key":"10.1016\/j.bbr.2026.116526_bib29","doi-asserted-by":"crossref","first-page":"5086","DOI":"10.1073\/pnas.1114415109","article-title":"Contextual encoding by ensembles of medial prefrontal cortex neurons","volume":"109","author":"Hyman","year":"2012","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.bbr.2026.116526_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neuroscience.2006.06.027","article-title":"Interactions among the medial prefrontal cortex, hippocampus and midline thalamus in emotional and cognitive processing in the rat","volume":"142","author":"Vertes","year":"2006","journal-title":"Neuroscience"},{"issue":"6","key":"10.1016\/j.bbr.2026.116526_bib31","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/j.neubiorev.2003.09.003","article-title":"The medial prefrontal cortex in the rat: evidence for a dorso-ventral distinction based upon functional and anatomical characteristics","volume":"27","author":"Heidbreder","year":"2003","journal-title":"Neurosci. & Biobehav. Rev."},{"issue":"12","key":"10.1016\/j.bbr.2026.116526_bib32","doi-asserted-by":"crossref","first-page":"4602","DOI":"10.1073\/pnas.0407332102","article-title":"Coding for spatial goals in the prelimbic\/infralimbic area of the rat frontal cortex","volume":"102","author":"Hok","year":"2005","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"3","key":"10.1016\/j.bbr.2026.116526_bib33","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s00221-007-0939-7","article-title":"The contribution of prefrontal cortex to global perception","volume":"181","author":"Ciaramelli","year":"2007","journal-title":"Exp. Brain Res."},{"issue":"6208","key":"10.1016\/j.bbr.2026.116526_bib34","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1126\/science.1256573","article-title":"Medial prefrontal activity during delay period contributes to learning of a working memory task","volume":"346","author":"Liu","year":"2014","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.bbr.2026.116526_bib35","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.tics.2021.02.010","article-title":"The Versatile Wayfinder: Prefrontal Contributions to Spatial Navigation","volume":"25","author":"Patai","year":"2021","journal-title":"Trends Cogn. Sci."},{"issue":"2","key":"10.1016\/j.bbr.2026.116526_bib36","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.bbr.2008.05.017","article-title":"Sex differences in a virtual water maze: An eye tracking and pupillometry study","volume":"193","author":"Mueller","year":"2008","journal-title":"Behav. Brain Res."},{"issue":"1-2","key":"10.1016\/j.bbr.2026.116526_bib37","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0166-4328(98)00019-9","article-title":"A characterization of performance by men and women in a virtual Morris water task:: A large and reliable sex difference","volume":"93","author":"Astur","year":"1998","journal-title":"Behav. brain Res."},{"issue":"1-2","key":"10.1016\/j.bbr.2026.116526_bib38","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0031-9384(99)00162-6","article-title":"Gender differences in Morris water maze performance depend on task parameters","volume":"68","author":"Roof","year":"1999","journal-title":"Physiol. & Behav."},{"issue":"4","key":"10.1016\/j.bbr.2026.116526_bib39","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0926-6410(98)00002-0","article-title":"Males and females use different distal cues in a virtual environment navigation task","volume":"6","author":"Sandstrom","year":"1998","journal-title":"Cogn. brain Res."},{"issue":"3","key":"10.1016\/j.bbr.2026.116526_bib40","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1037\/a0027992","article-title":"Direct measurement of spontaneous strategy selection in a virtual morris water maze shows females choose an allocentric strategy at least as often as males do","volume":"126","author":"van Gerven","year":"2012","journal-title":"Behav. Neurosci."},{"issue":"3","key":"10.1016\/j.bbr.2026.116526_bib41","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.neubiorev.2010.07.002","article-title":"Sex bias in neuroscience and biomedical research","volume":"35","author":"Beery","year":"2011","journal-title":"Neurosci. & Biobehav. Rev."},{"issue":"1","key":"10.1016\/j.bbr.2026.116526_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pain.2005.06.020","article-title":"The case for the inclusion of female subjects in basic science studies of pain","volume":"117","author":"Mogil","year":"2005","journal-title":"Pain"},{"issue":"1","key":"10.1016\/j.bbr.2026.116526_bib43","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1186\/s13293-016-0087-5","article-title":"Female rats are not more variable than male rats: A meta-analysis of neuroscience studies","volume":"7","author":"Becker","year":"2016","journal-title":"Biol. Sex. Differ."},{"key":"10.1016\/j.bbr.2026.116526_bib44","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.jsbmb.2015.09.039","article-title":"Sex differences in neurodevelopmental and neurodegenerative disorders: Focus on microglial function and neuroinflammation during development","volume":"160","author":"Hanamsagar","year":"2016","journal-title":"J. Steroid Biochem. Mol. Biol."},{"issue":"1","key":"10.1016\/j.bbr.2026.116526_bib45","doi-asserted-by":"crossref","first-page":"6952","DOI":"10.1038\/s41598-020-63965-x","article-title":"An MRI-Derived Neuroanatomical Atlas of the Fischer 344 Rat Brain","volume":"10","author":"Goerzen","year":"2020","journal-title":"Sci. Rep."},{"issue":"31","key":"10.1016\/j.bbr.2026.116526_bib46","doi-asserted-by":"crossref","first-page":"18788","DOI":"10.1073\/pnas.1919091117","article-title":"Integrative structural, functional, and transcriptomic analyses of sex-biased brain organization in humans","volume":"117","author":"Liu","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"11","key":"10.1016\/j.bbr.2026.116526_bib47","doi-asserted-by":"crossref","DOI":"10.21769\/BioProtoc.2870","article-title":"The Traveling Salesman Problem (TSP): A Spatial Navigation Task for Rats","volume":"8","author":"Blaser","year":"2018","journal-title":"Bio-Protoc."},{"issue":"12","key":"10.1016\/j.bbr.2026.116526_bib48","doi-asserted-by":"crossref","first-page":"1515","DOI":"10.1002\/hipo.22652","article-title":"Distinct roles of hippocampus and medial prefrontal cortex in spatial and nonspatial memory","volume":"26","author":"Sapiurka","year":"2016","journal-title":"Hippocampus"},{"issue":"12","key":"10.1016\/j.bbr.2026.116526_bib49","doi-asserted-by":"crossref","first-page":"4732","DOI":"10.1073\/pnas.1300869110","article-title":"Contrasting effects on path integration after hippocampal damage in humans and rats","volume":"110","author":"Kim","year":"2013","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"1","key":"10.1016\/j.bbr.2026.116526_bib50","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1101\/lm.024018.111","article-title":"Working memory, long-term memory, and medial temporal lobe function","volume":"19","author":"Jeneson","year":"2012","journal-title":"Learn. & Mem."},{"issue":"18","key":"10.1016\/j.bbr.2026.116526_bib51","doi-asserted-by":"crossref","first-page":"4818","DOI":"10.1523\/JNEUROSCI.0710-08.2008","article-title":"Working Memory and the Organization of Brain Systems","volume":"28","author":"Shrager","year":"2008","journal-title":"J. Neurosci."},{"issue":"7","key":"10.1016\/j.bbr.2026.116526_bib52","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1002\/hipo.23306","article-title":"A selective role for the mPFC during choice and deliberation, but not spatial memory retention over short delays","volume":"31","author":"Kidder","year":"2021","journal-title":"Hippocampus"},{"issue":"24","key":"10.1016\/j.bbr.2026.116526_bib53","doi-asserted-by":"crossref","first-page":"10996","DOI":"10.1523\/JNEUROSCI.22-24-10996.2002","article-title":"The role of rat medial frontal cortex in effort-based decision making","volume":"22","author":"Walton","year":"2002","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbr.2026.116526_bib54","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2024.109867","article-title":"Sex differences in the rodent medial prefrontal cortex \u2013 What Do and Don\u2019t we know?","volume":"248","author":"Laine","year":"2024","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/j.bbr.2026.116526_bib55","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s13293-022-00468-6","article-title":"Sex differences in the medial prefrontal cortical glutamate system","volume":"13","author":"Knouse","year":"2022","journal-title":"Biol. Sex. Differ."},{"issue":"1","key":"10.1016\/j.bbr.2026.116526_bib56","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.neuron.2015.11.028","article-title":"Relationships between Pupil Diameter and Neuronal Activity in the Locus Coeruleus, Colliculi, and Cingulate Cortex","volume":"89","author":"Joshi","year":"2016","journal-title":"Neuron"},{"issue":"7","key":"10.1016\/j.bbr.2026.116526_bib57","article-title":"The role of medial prefrontal cortex projections to locus ceruleus in mediating the sex differences in behavior in mice with inflammatory pain","volume":"35","author":"Cardenas","year":"2021","journal-title":"FASEB J. Off. Publ. Fed. Am. Soc. Exp. Biol."},{"issue":"2","key":"10.1016\/j.bbr.2026.116526_bib58","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1159\/000145006","article-title":"Strain and sex differences in the rat brain","volume":"103","author":"Yanai","year":"2008","journal-title":"Acta Anat."},{"issue":"2","key":"10.1016\/j.bbr.2026.116526_bib59","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/0006-8993(78)90723-0","article-title":"Evidence for a morphological sex difference within the medial preoptic area of the rat brain","volume":"148","author":"Gorski","year":"1978","journal-title":"Brain Res."},{"issue":"1-2","key":"10.1016\/j.bbr.2026.116526_bib60","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.bbr.2003.09.024","article-title":"The role of the prefrontal cortex in object\u2013place learning: a test of the attribute specificity model","volume":"146","author":"Kesner","year":"2003","journal-title":"Behav. brain Res."},{"issue":"1","key":"10.1016\/j.bbr.2026.116526_bib61","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.neures.2009.05.001","article-title":"Spatial working memory learning in young male and female rats: involvement of different limbic system regions revealed by cytochrome oxidase activity","volume":"65","author":"M\u00e9ndez-L\u00f3pez","year":"2009","journal-title":"Neurosci. Res."},{"issue":"2","key":"10.1016\/j.bbr.2026.116526_bib62","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0166-4328(01)00204-2","article-title":"Neurons in rat medial prefrontal cortex show anticipatory rate changes to predictable differential rewards in a spatial memory task","volume":"123","author":"Pratt","year":"2001","journal-title":"Behav. brain Res."},{"issue":"2","key":"10.1016\/j.bbr.2026.116526_bib63","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/s00429-007-0150-4","article-title":"Anatomical analysis of afferent projections to the medial prefrontal cortex in the rat","volume":"212","author":"Hoover","year":"2007","journal-title":"Brain Struct. Funct."},{"issue":"1","key":"10.1016\/j.bbr.2026.116526_bib64","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.neuron.2015.09.021","article-title":"The cognitive architecture of spatial navigation: hippocampal and striatal contributions","volume":"88","author":"Chersi","year":"2015","journal-title":"Neuron"},{"key":"10.1016\/j.bbr.2026.116526_bib65","doi-asserted-by":"crossref","first-page":"298","DOI":"10.3389\/fnbeh.2015.00298","article-title":"The role of the medial prefrontal cortex in the conditioning and extinction of fear","volume":"9","author":"Giustino","year":"2015","journal-title":"Front. Behav. Neurosci."},{"issue":"12","key":"10.1016\/j.bbr.2026.116526_bib66","doi-asserted-by":"crossref","first-page":"2483","DOI":"10.1007\/s00213-013-3414-0","article-title":"Opposing roles of prelimbic and infralimbic dopamine in conditioned cue and place preference","volume":"231","author":"Hayen","year":"2014","journal-title":"Psychopharmacology"},{"issue":"7","key":"10.1016\/j.bbr.2026.116526_bib67","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.neubiorev.2004.09.006","article-title":"Prefrontal executive and cognitive functions in rodents: neural and neurochemical substrates","volume":"28","author":"Dalley","year":"2004","journal-title":"Neurosci. & Biobehav. Rev."},{"key":"10.1016\/j.bbr.2026.116526_bib68","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3389\/fnbeh.2014.00063","article-title":"Excitotoxic lesions of the infralimbic, but not prelimbic cortex facilitate reversal of appetitive discriminative context conditioning: the role of the infralimbic cortex in context generalization","volume":"8","author":"Ashwell","year":"2014","journal-title":"Front. Behav. Neurosci."},{"issue":"3","key":"10.1016\/j.bbr.2026.116526_bib69","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1016\/j.neuroimage.2009.10.031","article-title":"Specific metabolites in the medial prefrontal cortex are associated with the neurocognitive deficits in schizophrenia: A preliminary study","volume":"49","author":"Shirayama","year":"2010","journal-title":"NeuroImage"},{"issue":"2","key":"10.1016\/j.bbr.2026.116526_bib70","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.archger.2014.07.003","article-title":"Depressive symptoms in older adults are associated with decreased cerebral oxygenation of the prefrontal cortex during a trail-making test","volume":"59","author":"Uemura","year":"2014","journal-title":"Arch. Gerontol. Geriatr."},{"issue":"3","key":"10.1016\/j.bbr.2026.116526_bib71","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcab125","article-title":"The role of the medial prefrontal cortex in cognition, ageing and dementia","volume":"3","author":"Jobson","year":"2021","journal-title":"Brain Commun."},{"key":"10.1016\/j.bbr.2026.116526_bib72","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1002\/hbm.20226","article-title":"Prefrontal modulation of working memory performance in brain injury and disease","volume":"27","author":"Hillary","year":"2006","journal-title":"Hum. Brain Mapp."},{"issue":"4","key":"10.1016\/j.bbr.2026.116526_bib73","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.jaac.2012.01.008","article-title":"Neurobiological Circuits Regulating Attention, Cognitive Control, Motivation, and Emotion: Disruptions in Neurodevelopmental Psychiatric Disorders","volume":"51","author":"Arnsten","year":"2012","journal-title":"J. Am. Acad. Child. Adolesc. Psychiatry"},{"key":"10.1016\/j.bbr.2026.116526_bib74","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.3389\/fneur.2015.00240","article-title":"Brain Injury Impairs Working Memory and Prefrontal Circuit Function","volume":"6","author":"Smith","year":"2015","journal-title":"Front. Neurol."},{"key":"10.1016\/j.bbr.2026.116526_bib75","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2026.1797607","article-title":"Route selection impairment and microglia activation in a rodent model of attention-deficit hyperactivity disorder","volume":"20","author":"Skubic","year":"2026","journal-title":"Front. Cell. Neurosci."}],"container-title":["Behavioural Brain Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432826005024?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0166432826005024?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:52:13Z","timestamp":1791823933000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0166432826005024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":75,"alternative-id":["S0166432826005024"],"URL":"https:\/\/doi.org\/10.1016\/j.bbr.2026.116526","relation":{},"ISSN":["0166-4328"],"issn-type":[{"value":"0166-4328","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Contribution of the medial prefrontal cortex to performance on the Traveling Salesperson Problem in rats","name":"articletitle","label":"Article Title"},{"value":"Behavioural Brain Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbr.2026.116526","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"116526"}}