{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T03:49:02Z","timestamp":1791258542263,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2004,1]]},"DOI":"10.1016\/j.bbrc.2003.07.018","type":"journal-article","created":{"date-parts":[[2003,12,4]],"date-time":"2003-12-04T06:59:03Z","timestamp":1070521143000},"page":"437-441","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":69,"title":["Raptor, a binding partner of target of rapamycin"],"prefix":"10.1016","volume":"313","author":[{"given":"Kazuyoshi","family":"Yonezawa","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiharu","family":"Tokunaga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriko","family":"Oshiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken-ichi","family":"Yoshino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2003.07.018_BIB1","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/0092-8674(93)90144-F","article-title":"Target of rapamycin in yeast, TOR2, is an essential phosphatidylinositol kinase homolog required for G1 progression","volume":"73","author":"Kunz","year":"1993","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2003.07.018_BIB2","first-page":"6012","article-title":"Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity","volume":"13","author":"Cafferkey","year":"1993","journal-title":"Mol. Cell Biol"},{"key":"10.1016\/j.bbrc.2003.07.018_BIB3","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/S0092-8674(00)00117-3","article-title":"TOR, a central controller of cell growth","volume":"103","author":"Schmelzle","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2003.07.018_BIB4","doi-asserted-by":"crossref","first-page":"18531","DOI":"10.1074\/jbc.270.31.18531","article-title":"Control of PHAS-I by insulin in 3T3-L1 adipocytes. Synthesis, degradation, and phosphorylation by a rapamycin-sensitive and mitogen-activated protein kinase-independent pathway","volume":"270","author":"Lin","year":"1995","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.bbrc.2003.07.018_BIB5","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1126\/science.1380182","article-title":"Rapamycin-induced inhibition of the 70-kilodalton S6 protein kinase","volume":"257","author":"Price","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2003.07.018_BIB6","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/377441a0","article-title":"Control of p70 s6 kinase by kinase activity of FRAP in vivo","volume":"377","author":"Brown","year":"1995","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2003.07.018_BIB7","doi-asserted-by":"crossref","first-page":"26457","DOI":"10.1074\/jbc.272.42.26457","article-title":"Regulation of eIF-4E BP1 phosphorylation by mTOR","volume":"272","author":"Hara","year":"1997","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.bbrc.2003.07.018_BIB8","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1126\/science.270.5233.50","article-title":"PIK-related kinases: DNA repair, recombination, and cell cycle checkpoints","volume":"270","author":"Keith","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2003.07.018_BIB9","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/978-3-642-56688-2_5","article-title":"The p70 S6 kinase integrates nutrient and growth signals to control translational capacity","volume":"26","author":"Avruch","year":"2001","journal-title":"Prog. Mol. Subcell. Biol"},{"key":"10.1016\/j.bbrc.2003.07.018_BIB10","doi-asserted-by":"crossref","first-page":"3693","DOI":"10.1093\/emboj\/16.12.3693","article-title":"Rapamycin suppresses 5\u2032TOP mRNA translation through inhibition of p70s6k","volume":"16","author":"Jefferies","year":"1997","journal-title":"EMBO J"},{"key":"10.1016\/j.bbrc.2003.07.018_BIB11","series-title":"Translational Control","first-page":"245","article-title":"mRNA 5\u2032 Cap-binding protein eIF4E and control of cell growth","author":"Sonenberg","year":"1996"},{"key":"10.1016\/j.bbrc.2003.07.018_BIB12","doi-asserted-by":"crossref","first-page":"14484","DOI":"10.1074\/jbc.273.23.14484","article-title":"Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism","volume":"273","author":"Hara","year":"1998","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.bbrc.2003.07.018_BIB13","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1172\/JCI1326","article-title":"Bidirectional modulation of insulin action by amino acids","volume":"101","author":"Patti","year":"1998","journal-title":"J. Clin. Invest"},{"key":"10.1016\/j.bbrc.2003.07.018_BIB14","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1042\/bj3340261","article-title":"Amino acid availability regulates p70 S6 kinase and multiple translation factors","volume":"334","author":"Wang","year":"1998","journal-title":"Biochem. J"},{"key":"10.1016\/j.bbrc.2003.07.018_BIB15","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.1101\/gad.845700","article-title":"Genetic and biochemical characterization of dTOR, the Drosophila homolog of the target of rapamycin","volume":"14","author":"Oldham","year":"2000","journal-title":"Genes Dev"},{"key":"10.1016\/j.bbrc.2003.07.018_BIB16","doi-asserted-by":"crossref","first-page":"2712","DOI":"10.1101\/gad.835000","article-title":"Regulation of cellular growth by the Drosophila target of rapamycin dTOR","volume":"14","author":"Zhang","year":"2000","journal-title":"Genes Dev"},{"key":"10.1016\/j.bbrc.2003.07.018_BIB17","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.1126\/science.285.5436.2126","article-title":"Drosophila S6 kinase: a regulator of cell size","volume":"285","author":"Montagne","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2003.07.018_BIB18","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1126\/science.277.5322.99","article-title":"Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin","volume":"277","author":"Brunn","year":"1997","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2003.07.018_BIB19","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1073\/pnas.95.4.1432","article-title":"RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4E-BP1","volume":"95","author":"Burnett","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2003.07.018_BIB20","doi-asserted-by":"crossref","first-page":"30061","DOI":"10.1074\/jbc.273.46.30061","article-title":"Molecular cloning and characterization of a novel p70 S6 kinase, p70 S6 kinase beta containing a proline-rich region","volume":"273","author":"Gout","year":"1998","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.bbrc.2003.07.018_BIB21","doi-asserted-by":"crossref","first-page":"34493","DOI":"10.1074\/jbc.274.48.34493","article-title":"Immunopurified mammalian target of rapamycin phosphorylates and activates p70 S6 kinase alpha in vitro","volume":"274","author":"Isotani","year":"1999","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.bbrc.2003.07.018_BIB22","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1046\/j.1365-2443.2001.00479.x","article-title":"Distinct regulatory mechanism for p70 S6 kinase beta from that for p70 S6 kinase alpha","volume":"6","author":"Minami","year":"2001","journal-title":"Genes Cells"},{"key":"10.1016\/j.bbrc.2003.07.018_BIB23","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1128\/MCB.20.4.1234-1242.2000","article-title":"Novel WD-repeat protein Mip1p facilitates function of the meiotic regulator Mei2p in fission yeast","volume":"20","author":"Shinozaki-Yabana","year":"2000","journal-title":"Mol. Cell. Biol"},{"key":"10.1016\/j.bbrc.2003.07.018_BIB24","article-title":"Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action","volume":"177\u2013189","author":"Hara","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2003.07.018_BIB25","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/S0092-8674(02)00808-5","article-title":"mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery","volume":"110","author":"Kim","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2003.07.018_BIB26","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/S1097-2765(02)00636-6","article-title":"Two TOR complexes, only one of which is rapamycin sensitive, have distinct roles in cell growth control","volume":"10","author":"Loewith","year":"2002","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbrc.2003.07.018_BIB27","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/S1097-2765(03)00114-X","article-title":"GbetaL, a positive regulator of the rapamycin-sensitive pathway required for the nutrient-sensitive interaction between raptor and mTOR","volume":"11","author":"Kim","year":"2003","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbrc.2003.07.018_BIB28","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1016\/S0960-9822(02)00762-5","article-title":"Identification of a conserved motif required for mTOR signaling","volume":"12","author":"Schalm","year":"2002","journal-title":"Curr. Biol"},{"key":"10.1016\/j.bbrc.2003.07.018_BIB29","doi-asserted-by":"crossref","first-page":"15461","DOI":"10.1074\/jbc.C200665200","article-title":"The mammalian target of rapamycin (mTOR) partner, raptor, binds the mTOR substrates p70 S6 kinase and 4E-BP1 through their TOR signaling (TOS) motif","volume":"278","author":"Nojima","year":"2003","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.bbrc.2003.07.018_BIB30","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1016\/S0960-9822(03)00329-4","article-title":"TOS motif-mediated raptor binding regulates 4E-BP1 multisite phosphorylation and function","volume":"13","author":"Schalm","year":"2003","journal-title":"Curr. Biol"},{"key":"10.1016\/j.bbrc.2003.07.018_BIB31","doi-asserted-by":"crossref","first-page":"19667","DOI":"10.1074\/jbc.M301142200","article-title":"Two motifs in the translational repressor PHAS-I required for efficient phosphorylation by mammalian target of rapamycin and for recognition by raptor","volume":"278","author":"Choi","year":"2003","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.bbrc.2003.07.018_BIB32","doi-asserted-by":"crossref","first-page":"40717","DOI":"10.1074\/jbc.M308573200","article-title":"Target of rapamycin (TOR)-signaling and RAIP motifs play distinct roles in the mammalian TOR-dependent phosphorylation of initiation factor 4E-binding protein 1","volume":"278","author":"Beugnet","year":"2003","journal-title":"J. Biol. Chem"},{"key":"10.1016\/j.bbrc.2003.07.018_BIB33","doi-asserted-by":"crossref","first-page":"R785","DOI":"10.1016\/S0960-9822(02)01294-0","article-title":"Growth signaling: TSC takes its place","volume":"12","author":"Marygold","year":"2002","journal-title":"Curr. Biol"},{"key":"10.1016\/j.bbrc.2003.07.018_BIB34","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.tibs.2003.09.003","article-title":"Rheb fills a GAP between TSC and TOR","volume":"28","author":"Manning","year":"2003","journal-title":"Trends. Biochem. Sci"},{"key":"10.1016\/j.bbrc.2003.07.018_BIB35","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1097\/00019052-200004000-00001","article-title":"Tuberous sclerosis complex","volume":"13","author":"Sparagana","year":"2000","journal-title":"Curr. Opin. Neurol"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X03023453?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X03023453?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:09:52Z","timestamp":1762092592000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X03023453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,1]]}},"alternative-id":["S0006291X03023453"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2003.07.018","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2004,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Raptor, a binding partner of target of rapamycin","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2003.07.018","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2003 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}