{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T21:33:14Z","timestamp":1768944794159,"version":"3.49.0"},"reference-count":46,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2003,10,1]],"date-time":"2003-10-01T00:00:00Z","timestamp":1064966400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2003,10,1]],"date-time":"2003-10-01T00:00:00Z","timestamp":1064966400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2003,10]]},"DOI":"10.1016\/j.bbrc.2003.09.108","type":"journal-article","created":{"date-parts":[[2003,10,11]],"date-time":"2003-10-11T01:52:40Z","timestamp":1065837160000},"page":"1017-1025","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":95,"title":["Ectopically expressed PDX-1 in liver initiates endocrine and exocrine pancreas differentiation but causes dysmorphogenesis"],"prefix":"10.1016","volume":"310","author":[{"given":"T","family":"Miyatsuka","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Kaneto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Kajimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Hirota","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Arakawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Fujitani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Umayahara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Watada","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Yamasaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.A","family":"Magnuson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Miyazaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Hori","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2003.09.108_BIB1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1136\/bmj.322.7277.29","article-title":"Islet and stem cell transplantation for treating diabetes","volume":"322","author":"Serup","year":"2001","journal-title":"BMJ"},{"key":"10.1016\/j.bbrc.2003.09.108_BIB2","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1126\/science.1058866","article-title":"Differentiation of embryonic stem cells to insulin-secreting structures similar to pancreatic islets","volume":"292","author":"Lumelsky","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2003.09.108_BIB3","doi-asserted-by":"crossref","first-page":"16105","DOI":"10.1073\/pnas.252618999","article-title":"Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells","volume":"99","author":"Hori","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2003.09.108_BIB4","doi-asserted-by":"crossref","first-page":"7999","DOI":"10.1073\/pnas.97.14.7999","article-title":"In vitro cultivation of human islets from expanded ductal tissue","volume":"97","author":"Bonner-Weir","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2003.09.108_BIB5","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/73128","article-title":"Reversal of insulin-dependent diabetes using islets generated in vitro from pancreatic stem cells","volume":"6","author":"Ramiya","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2003.09.108_BIB6","first-page":"1275","article-title":"Characterization of somatostatin transactivating factor-1, a novel homeobox factor that stimulates somatostatin expression in pancreatic islet cells","volume":"7","author":"Leonard","year":"1993","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.bbrc.2003.09.108_BIB7","doi-asserted-by":"crossref","first-page":"4251","DOI":"10.1002\/j.1460-2075.1993.tb06109.x","article-title":"IPF1, a homeodomain-containing transactivator of the insulin gene","volume":"12","author":"Ohlsson","year":"1993","journal-title":"EMBO J."},{"key":"10.1016\/j.bbrc.2003.09.108_BIB8","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1002\/j.1460-2075.1994.tb06363.x","article-title":"IDX-1: a new homeodomain transcription factor expressed in rat pancreatic islets and duodenum that transactivates the somatostatin gene","volume":"13","author":"Miller","year":"1994","journal-title":"EMBO J."},{"key":"10.1016\/j.bbrc.2003.09.108_BIB9","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1038\/371606a0","article-title":"Insulin-promoter-factor 1 is required for pancreas development in mice","volume":"371","author":"Jonsson","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2003.09.108_BIB10","first-page":"1327","article-title":"Transcriptional activation of the GLUT2 gene by the IPF-1\/STF-1\/IDX-1 homeobox factor","volume":"10","author":"Waeber","year":"1996","journal-title":"Mol. Endocrinol."},{"key":"10.1016\/j.bbrc.2003.09.108_BIB11","doi-asserted-by":"crossref","first-page":"1478","DOI":"10.2337\/diab.45.11.1478","article-title":"The human glucokinase gene beta-cell-type promoter: an essential role of insulin promoter factor 1\/PDX-1 in its activation in HIT-T15 cells","volume":"45","author":"Watada","year":"1996","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2003.09.108_BIB12","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1101\/gad.12.12.1763","article-title":"Beta-cell-specific inactivation of the mouse Ipf1\/Pdx1 gene results in loss of the beta-cell phenotype and maturity onset diabetes","volume":"12","author":"Ahlgren","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbrc.2003.09.108_BIB13","doi-asserted-by":"crossref","first-page":"9015","DOI":"10.1073\/pnas.93.17.9015","article-title":"Induction of insulin and islet amyloid polypeptide production in pancreatic islet glucagonoma cells by insulin promoter factor 1","volume":"93","author":"Serup","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2003.09.108_BIB14","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.2337\/diab.45.12.1826","article-title":"PDX-1 induces insulin and glucokinase gene expressions in alphaTC1 clone 6 cells in the presence of betacellulin","volume":"45","author":"Watada","year":"1996","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2003.09.108_BIB15","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.2337\/diabetes.51.5.1398","article-title":"Combined expression of pancreatic duodenal homeobox 1 and islet factor 1 induces immature enterocytes to produce insulin","volume":"51","author":"Kojima","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2003.09.108_BIB16","doi-asserted-by":"crossref","first-page":"2505","DOI":"10.2337\/diabetes.51.8.2505","article-title":"PDX-1 induces differentiation of intestinal epithelioid IEC-6 into insulin-producing cells","volume":"51","author":"Yoshida","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2003.09.108_BIB17","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/75050","article-title":"Pancreatic and duodenal homeobox gene 1 induces expression of insulin genes in liver and ameliorates streptozotocin-induced hyperglycemia","volume":"6","author":"Ferber","year":"2000","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2003.09.108_BIB18","doi-asserted-by":"crossref","first-page":"1553","DOI":"10.2337\/diabetes.50.7.1553","article-title":"Improved glucose tolerance and acinar dysmorphogenesis by targeted expression of transcription factor PDX-1 to the exocrine pancreas","volume":"50","author":"Heller","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2003.09.108_BIB19","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/sj.gt.3301846","article-title":"Beta-cell neogenesis induced by adenovirus-mediated gene delivery of transcription factor pdx-1 into mouse pancreas","volume":"10","author":"Taniguchi","year":"2003","journal-title":"Gene Ther."},{"key":"10.1016\/j.bbrc.2003.09.108_BIB20","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1074\/jbc.274.1.305","article-title":"Dual roles for glucokinase in glucose homeostasis as determined by liver and pancreatic beta cell-specific gene knock-outs using Cre recombinase","volume":"274","author":"Postic","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2003.09.108_BIB21","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1126\/science.284.5422.1998","article-title":"Initiation of mammalian liver development from endoderm by fibroblast growth factors","volume":"284","author":"Jung","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2003.09.108_BIB22","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1242\/dev.128.6.871","article-title":"A bipotential precursor population for pancreas and liver within the embryonic endoderm","volume":"128","author":"Deutsch","year":"2001","journal-title":"Development"},{"key":"10.1016\/j.bbrc.2003.09.108_BIB23","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1073\/pnas.92.1.160","article-title":"Site-specific recombination of a transgene in fertilized eggs by transient expression of Cre recombinase","volume":"92","author":"Araki","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2003.09.108_BIB24","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1101\/gad.10.13.1670","article-title":"Hepatic specification of the gut endoderm in vitro: cell signaling and transcriptional control","volume":"10","author":"Gualdi","year":"1996","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbrc.2003.09.108_BIB25","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/(SICI)1526-968X(200002)26:2<149::AID-GENE16>3.0.CO;2-V","article-title":"DNA excision in liver by an albumin-Cre transgene occurs progressively with age","volume":"26","author":"Postic","year":"2000","journal-title":"Genesis"},{"key":"10.1016\/j.bbrc.2003.09.108_BIB26","first-page":"2611","article-title":"Cell lineages and oval cell progenitors in rat liver development","volume":"51","author":"Shiojiri","year":"1991","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2003.09.108_BIB27","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/289643a0","article-title":"Mouse liver and salivary gland alpha-amylase mRNAs differ only in 5\u2032 non-translated sequences","volume":"289","author":"Hagenbuchle","year":"1981","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2003.09.108_BIB28","doi-asserted-by":"crossref","first-page":"746","DOI":"10.1006\/bbrc.1996.1875","article-title":"Involvement of the homeodomain-containing transcription factor PDX-1 in islet amyloid polypeptide gene transcription","volume":"229","author":"Watada","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2003.09.108_BIB29","doi-asserted-by":"crossref","first-page":"11986","DOI":"10.1074\/jbc.272.18.11986","article-title":"Identification of cis- and trans-active factors regulating human islet amyloid polypeptide gene expression in pancreatic beta-cells","volume":"272","author":"Carty","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2003.09.108_BIB30","doi-asserted-by":"crossref","first-page":"8078","DOI":"10.1073\/pnas.122210699","article-title":"In vitro trans-differentiation of adult hepatic stem cells into pancreatic endocrine hormone-producing cells","volume":"99","author":"Yang","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2003.09.108_BIB31","doi-asserted-by":"crossref","first-page":"5109","DOI":"10.1128\/MCB.18.9.5109","article-title":"An endocrine\u2013exocrine switch in the activity of the pancreatic homeodomain protein PDX1 through formation of a trimeric complex with PBX1b and MRG1 (MEIS2)","volume":"18","author":"Swift","year":"1998","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.bbrc.2003.09.108_BIB32","doi-asserted-by":"crossref","first-page":"34224","DOI":"10.1074\/jbc.M004981200","article-title":"Transcriptional and translational regulation of beta-cell differentiation factor Nkx6.1","volume":"275","author":"Watada","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2003.09.108_BIB33","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1242\/dev.121.1.11","article-title":"Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny","volume":"121","author":"Guz","year":"1995","journal-title":"Development"},{"key":"10.1016\/j.bbrc.2003.09.108_BIB34","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1242\/dev.129.10.2447","article-title":"Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors","volume":"129","author":"Gu","year":"2002","journal-title":"Development"},{"key":"10.1016\/j.bbrc.2003.09.108_BIB35","doi-asserted-by":"crossref","first-page":"7253","DOI":"10.1073\/pnas.1136854100","article-title":"Reversal of hyperglycemia in mice by using human expandable insulin-producing cells differentiated from fetal liver progenitor cells","volume":"100","author":"Zalzman","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2003.09.108_BIB36","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M303127200","article-title":"Functional, persistent and extended liver to pancreas transdifferentiation","author":"Ber","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2003.09.108_BIB37","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0378-1119(91)90434-D","article-title":"Efficient selection for high-expression transfectants with a novel eukaryotic vector","volume":"108","author":"Niwa","year":"1991","journal-title":"Gene"},{"key":"10.1016\/j.bbrc.2003.09.108_BIB38","doi-asserted-by":"crossref","first-page":"3311","DOI":"10.1210\/endo.140.7.6796","article-title":"Increase in PDX-1 levels suppresses insulin gene expression in RIN 1046-38 cells","volume":"140","author":"Seijffers","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbrc.2003.09.108_BIB39","doi-asserted-by":"crossref","unstructured":"J.M. Bergelson, J.A. Cunningham, G. Droguett, E.A. Kurt-Jones, A. Krithivas, J.S. Hong, M.S. Horwitz, R.L. Crowell, R.W. Finberg, Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5, Science (1997)","DOI":"10.1126\/science.275.5304.1320"},{"key":"10.1016\/j.bbrc.2003.09.108_BIB40","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/S0016-5085(98)70204-5","article-title":"Misexpression of the pancreatic homeodomain protein IDX-1 by the Hoxa-4 promoter associated with agenesis of the cecum","volume":"115","author":"Heller","year":"1998","journal-title":"Gastroenterology"},{"key":"10.1016\/j.bbrc.2003.09.108_BIB41","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1101\/gad.846001","article-title":"Key events of pancreas formation are triggered in gut endoderm by ectopic expression of pancreatic regulatory genes","volume":"15","author":"Grapin-Botton","year":"2001","journal-title":"Genes Dev."},{"key":"10.1016\/j.bbrc.2003.09.108_BIB42","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1038\/nm867","article-title":"NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice","volume":"9","author":"Kojima","year":"2003","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2003.09.108_BIB43","doi-asserted-by":"crossref","first-page":"1817","DOI":"10.2337\/diabetes.47.12.1817","article-title":"Transcribing pancreas","volume":"46","author":"Edlund","year":"1998","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2003.09.108_BIB44","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1038\/ng959","article-title":"The role of the transcriptional regulator Ptf1a in converting intestinal to pancreatic progenitors","volume":"32","author":"Kawaguchi","year":"2002","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbrc.2003.09.108_BIB45","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0960-9822(02)01434-3","article-title":"Experimental conversion of liver to pancreas","volume":"13","author":"Horb","year":"2003","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bbrc.2003.09.108_BIB46","doi-asserted-by":"crossref","first-page":"6991","DOI":"10.1073\/pnas.92.15.6991","article-title":"Conditional site-specific recombination in mammalian cells using a ligand-dependent chimeric Cre recombinase","volume":"92","author":"Metzger","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X03018874?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X03018874?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,2]],"date-time":"2025-11-02T14:08:26Z","timestamp":1762092506000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X03018874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,10]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2003,10]]}},"alternative-id":["S0006291X03018874"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2003.09.108","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2003,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ectopically expressed PDX-1 in liver initiates endocrine and exocrine pancreas differentiation but causes dysmorphogenesis","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2003.09.108","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2003 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}