{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T03:35:44Z","timestamp":1790393744752,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2003,11,1]],"date-time":"2003-11-01T00:00:00Z","timestamp":1067644800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2003,11,1]],"date-time":"2003-11-01T00:00:00Z","timestamp":1067644800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2003,11,1]],"date-time":"2003-11-01T00:00:00Z","timestamp":1067644800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2003,11,1]],"date-time":"2003-11-01T00:00:00Z","timestamp":1067644800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2003,11,1]],"date-time":"2003-11-01T00:00:00Z","timestamp":1067644800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2003,11,1]],"date-time":"2003-11-01T00:00:00Z","timestamp":1067644800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2003,11,1]],"date-time":"2003-11-01T00:00:00Z","timestamp":1067644800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2003,11]]},"DOI":"10.1016\/j.bbrc.2003.10.004","type":"journal-article","created":{"date-parts":[[2003,10,17]],"date-time":"2003-10-17T13:42:29Z","timestamp":1066398149000},"page":"324-328","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":37,"title":["CNS melanocortin and leptin effects on stearoyl-CoA desaturase-1 and resistin expression"],"prefix":"10.1016","volume":"311","author":[{"given":"Ji","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang-Ho","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diane L","family":"Hartzell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ChangLong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary Anne","family":"Della-Fera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifton A","family":"Baile","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2003.10.004_BIB1","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1126\/science.7624778","article-title":"Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks","volume":"269","author":"Campfield","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2003.10.004_BIB2","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/S0031-9384(02)00652-2","article-title":"Energy metabolism and expression of uncoupling proteins 1, 2, and 3 after 21 days of recovery from intracerebroventricular mouse leptin in rats","volume":"75","author":"Gullicksen","year":"2002","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbrc.2003.10.004_BIB3","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1038\/372425a0","article-title":"Positional cloning of the mouse obese gene and its human homologue","volume":"372","author":"Zhang","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2003.10.004_BIB4","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1023\/A:1024112716024","article-title":"Leptin-induced adipose apoptosis: implications for body weight regulation","volume":"8","author":"Gullicksen","year":"2003","journal-title":"Apoptosis"},{"key":"10.1016\/j.bbrc.2003.10.004_BIB5","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1046\/j.1463-1326.2001.00112.x","article-title":"Adipocyte apoptosis in the regulation of body fat mass by leptin","volume":"3","author":"Della-Fera","year":"2001","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.bbrc.2003.10.004_BIB6","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1016\/S0026-0495(98)90336-5","article-title":"Intracerebroventricular administration of leptin markedly enhances insulin sensitivity and systemic glucose utilization in conscious rats","volume":"47","author":"Shi","year":"1998","journal-title":"Metabolism"},{"key":"10.1016\/j.bbrc.2003.10.004_BIB7","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1126\/science.1071527","article-title":"Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss","volume":"297","author":"Cohen","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2003.10.004_BIB8","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/S0166-2236(98)01292-2","article-title":"Feeding and body-weight regulation by hypothalamic neuropeptides\u2014mediation of the actions of leptin","volume":"22","author":"Inui","year":"1999","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.bbrc.2003.10.004_BIB9","doi-asserted-by":"crossref","first-page":"531","DOI":"10.2337\/diab.45.4.531","article-title":"Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob\/ob mice","volume":"45","author":"Schwartz","year":"1996","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2003.10.004_BIB10","doi-asserted-by":"crossref","first-page":"335","DOI":"10.2337\/diab.46.3.335","article-title":"Interactions between leptin and hypothalamic neuropeptide Y neurons in the control of food intake and energy homeostasis in the rat","volume":"46","author":"Wang","year":"1997","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2003.10.004_BIB11","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.2337\/diab.46.12.2119","article-title":"Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus","volume":"46","author":"Schwartz","year":"1997","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2003.10.004_BIB12","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/35078085","article-title":"Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus","volume":"411","author":"Cowley","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2003.10.004_BIB13","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.1210\/endo.141.9.7665","article-title":"The central melanocortin system can directly regulate serum insulin levels","volume":"141","author":"Fan","year":"2000","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbrc.2003.10.004_BIB14","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/oby.2002.28","article-title":"Chronic application of MTII in a rat model of obesity results in sustained weight loss","volume":"10","author":"Hamilton","year":"2002","journal-title":"Obes. Res."},{"key":"10.1016\/j.bbrc.2003.10.004_BIB15","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1523\/JNEUROSCI.21-10-03639.2001","article-title":"Hypothalamic, metabolic, and behavioral responses to pharmacological inhibition of CNS melanocortin signaling in rats","volume":"21","author":"Adage","year":"2001","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbrc.2003.10.004_BIB16","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1038\/79223","article-title":"Melanocortins and body weight: a tale of two receptors","volume":"26","author":"Cummings","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbrc.2003.10.004_BIB17","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1172\/JCI200112954","article-title":"Central melanocortin receptors regulate insulin action","volume":"108","author":"Obici","year":"2001","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2003.10.004_BIB18","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S0031-9384(03)00205-1","article-title":"Melanocortin receptors mediate leptin effects on feeding and body weight, but not adipose apoptosis","volume":"79","author":"Choi","year":"2003","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbrc.2003.10.004_BIB19","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/35053000","article-title":"The hormone resistin links obesity to diabetes","volume":"409","author":"Steppan","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2003.10.004_BIB20","unstructured":"Institute of Laboratory Animal Resources Commission on Life Sciences National Research Council. Guide for the Care and Use of Laboratory Animals, National Academy of Sciences (1996)"},{"key":"10.1016\/j.bbrc.2003.10.004_BIB21","unstructured":"SAS User\u2019s Guide, Statistical Analysis Systems Institute, Inc., Cary, NC (1999)"},{"key":"10.1016\/j.bbrc.2003.10.004_BIB22","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1096\/fj.02-0991fje","article-title":"Physiologic effect of leptin on insulin secretion is mediated mainly through central mechanisms","volume":"17","author":"Muzumdar","year":"2003","journal-title":"Faseb J."},{"key":"10.1016\/j.bbrc.2003.10.004_BIB23","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/S0304-3940(98)00401-7","article-title":"Satiety effect and sympathetic activation of leptin are mediated by hypothalamic melanocortin system","volume":"249","author":"Satoh","year":"1998","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbrc.2003.10.004_BIB24","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/S0896-6273(01)80035-0","article-title":"Leptin differentially regulates NPY and POMC neurons projecting to the lateral hypothalamic area","volume":"23","author":"Elias","year":"1999","journal-title":"Neuron"},{"key":"10.1016\/j.bbrc.2003.10.004_BIB25","doi-asserted-by":"crossref","first-page":"R50","DOI":"10.1152\/ajpregu.2000.278.1.R50","article-title":"Differential role of melanocortins in mediating leptin\u2019s central effects on feeding and reproduction","volume":"278","author":"Hohmann","year":"2000","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.bbrc.2003.10.004_BIB26","doi-asserted-by":"crossref","first-page":"4489","DOI":"10.1210\/endo.138.10.5570","article-title":"Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus","volume":"138","author":"Cheung","year":"1997","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbrc.2003.10.004_BIB27","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1097\/00041433-200306000-00005","article-title":"Recent insights into stearoyl-CoA desaturase-1","volume":"14","author":"Ntambi","year":"2003","journal-title":"Curr. Opin. Lipidol."},{"key":"10.1016\/j.bbrc.2003.10.004_BIB28","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/0163-7827(94)00010-J","article-title":"The regulation of stearoyl-CoA desaturase (SCD)","volume":"34","author":"Ntambi","year":"1995","journal-title":"Prog. Lipid Res."},{"key":"10.1016\/j.bbrc.2003.10.004_BIB29","doi-asserted-by":"crossref","first-page":"33904","DOI":"10.1074\/jbc.M304724200","article-title":"Identification and characterization of murine SCD4: a novel heart-specific stearoyl-CoA desaturase isoform regulated by leptin and dietary factors","volume":"278","author":"Miyazaki","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2003.10.004_BIB30","doi-asserted-by":"crossref","first-page":"11482","DOI":"10.1073\/pnas.132384699","article-title":"Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity","volume":"99","author":"Ntambi","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2003.10.004_BIB31","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0014-5793(01)02968-4","article-title":"Inhibition by insulin of resistin gene expression in 3T3-L1 adipocytes","volume":"507","author":"Haugen","year":"2001","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbrc.2003.10.004_BIB32","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1007\/s00125-002-1022-3","article-title":"Insulin down-regulates resistin mRNA through the synthesis of protein(s) that could accelerate the degradation of resistin mRNA in 3T3-L1 adipocytes","volume":"46","author":"Kawashima","year":"2003","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbrc.2003.10.004_BIB33","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1006\/bbrc.2001.5874","article-title":"Tumor necrosis factor alpha is a negative regulator of resistin gene expression and secretion in 3T3-L1 adipocytes","volume":"288","author":"Fasshauer","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2003.10.004_BIB34","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.2337\/diabetes.51.6.1737","article-title":"Humoral regulation of resistin expression in 3T3-L1 and mouse adipose cells","volume":"51","author":"Shojima","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2003.10.004_BIB35","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1210\/endo.143.6.8947","article-title":"Growth hormone rapidly induces resistin gene expression in white adipose tissue of spontaneous dwarf (SDR) rats","volume":"143","author":"Delhanty","year":"2002","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbrc.2003.10.004_BIB36","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0014-5793(03)00708-7","article-title":"Resistin is expressed in different rat tissues and is regulated in a tissue- and gender-specific manner","volume":"548","author":"Nogueiras","year":"2003","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbrc.2003.10.004_BIB37","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/S0003-9861(03)00279-0","article-title":"Low resistin levels in adipose tissues and serum in high-fat fed mice and genetically obese mice: development of an ELISA system for quantification of resistin","volume":"416","author":"Maebuchi","year":"2003","journal-title":"Arch. Biochem. Biophys."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X03020655?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X03020655?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T10:10:36Z","timestamp":1757758236000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X03020655"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,11]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2003,11]]}},"alternative-id":["S0006291X03020655"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2003.10.004","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2003,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CNS melanocortin and leptin effects on stearoyl-CoA desaturase-1 and resistin expression","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2003.10.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2003 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}