{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,21]],"date-time":"2025-06-21T07:44:01Z","timestamp":1750491841177},"reference-count":18,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2003,12,1]],"date-time":"2003-12-01T00:00:00Z","timestamp":1070236800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2003,12]]},"DOI":"10.1016\/j.bbrc.2003.11.053","type":"journal-article","created":{"date-parts":[[2003,12,2]],"date-time":"2003-12-02T12:08:25Z","timestamp":1070366905000},"page":"1165-1170","source":"Crossref","is-referenced-by-count":10,"title":["Overexpression of leptin in transgenic mice leads to decreased basal lipolysis, PKA activity, and perilipin levels"],"prefix":"10.1016","volume":"312","author":[{"given":"Yaohuang","family":"Ke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Scott","family":"Ogus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen-Jun","family":"Shen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fredric B","family":"Kraemer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Farid F","family":"Chehab","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2003.11.053_BIB1","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/380677a0","article-title":"Role of leptin in fat regulation","volume":"380","author":"Collins","year":"1996","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2003.11.053_BIB2","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1172\/JCI119532","article-title":"Receptor-mediated regional sympathetic nerve activation by leptin","volume":"100","author":"Haynes","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2003.11.053_BIB3","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/S0021-9258(18)51690-2","article-title":"Activation of an epinephrine-sensitive lipolytic activity from adipose tissue by adenosine 3\u20325\u2032 phosphate","volume":"239","author":"Rizack","year":"1964","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2003.11.053_BIB4","first-page":"139","article-title":"Cyclic AMP, PKA, and the physiological regulation of adiposity","volume":"53","author":"McKnight","year":"1998","journal-title":"Rec. Progr. Horm. Res."},{"key":"10.1016\/j.bbrc.2003.11.053_BIB5","doi-asserted-by":"crossref","first-page":"11341","DOI":"10.1016\/S0021-9258(18)99168-4","article-title":"Perilipin, a major hormonally regulated adipocyte-specific phosphoprotein associated with the periphery of lipid storage droplets","volume":"266","author":"Greenberg","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2003.11.053_BIB6","doi-asserted-by":"crossref","first-page":"12035","DOI":"10.1073\/pnas.90.24.12035","article-title":"Isolation of cDNAs for perilipins A and B: sequence and expression of lipid droplet-associated proteins of adipocytes","volume":"90","author":"Greenberg","year":"1993","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2003.11.053_BIB7","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1126\/science.3420405","article-title":"Hormone-sensitive lipase: sequence, expression, and chromosomal localization to 19 cent-q13.3","volume":"241","author":"Holm","year":"1988","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2003.11.053_BIB8","doi-asserted-by":"crossref","first-page":"5011","DOI":"10.1074\/jbc.275.7.5011","article-title":"Translocation of hormone-sensitive lipase and perilipin upon lipolytic stimulation of rat adipocytes","volume":"275","author":"Clifford","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2003.11.053_BIB9","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1210\/endo.142.1.7909","article-title":"Transgenic mice overexpressing leptin accumulate adipose mass at an older, but not younger, age","volume":"142","author":"Qiu","year":"2001","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbrc.2003.11.053_BIB10","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1038\/ng0996-95","article-title":"Leptin activation of Stat3 in the hypothalamus of wild-type and ob\/ob mice but not db\/db mice","volume":"14","author":"Vaisse","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbrc.2003.11.053_BIB11","doi-asserted-by":"crossref","first-page":"29483","DOI":"10.1074\/jbc.270.49.29483","article-title":"Targeted disruption of the beta 3-adrenergic receptor gene","volume":"270","author":"Susulic","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2003.11.053_BIB12","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/ng0396-318","article-title":"Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin","volume":"12","author":"Chehab","year":"1996","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbrc.2003.11.053_BIB13","doi-asserted-by":"crossref","first-page":"8973","DOI":"10.1021\/bi980545u","article-title":"Mutational analysis of structural features of rat hormone-sensitive lipase","volume":"37","author":"Shen","year":"1998","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbrc.2003.11.053_BIB14","doi-asserted-by":"crossref","first-page":"17541","DOI":"10.1074\/jbc.274.25.17541","article-title":"Novel form of lipolysis induced by leptin","volume":"274","author":"Wang","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2003.11.053_BIB15","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1172\/JCI119620","article-title":"Targeted gene disruption reveals a leptin-independent role for the mouse beta3-adrenoceptor in the regulation of body composition","volume":"100","author":"Revelli","year":"1997","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2003.11.053_BIB16","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1006\/scdb.1998.0275","article-title":"Perilipins, ADRP, and other proteins that associate with intracellular neutral lipid droplets in animal cells","volume":"10","author":"Londos C","year":"1999","journal-title":"Sem. Cell Dev. Biol."},{"key":"10.1016\/j.bbrc.2003.11.053_BIB17","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1038\/82630","article-title":"Absence of perilipin results in leanness and reverses obesity in Lepr (db\/db) mice","volume":"26","author":"Martinez-Botas","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbrc.2003.11.053_BIB18","doi-asserted-by":"crossref","first-page":"6494","DOI":"10.1073\/pnas.101042998","article-title":"Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity","volume":"98","author":"Tansey","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X03023702?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X03023702?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,13]],"date-time":"2021-06-13T09:14:18Z","timestamp":1623575658000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X03023702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2003,12]]},"references-count":18,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2003,12]]}},"alternative-id":["S0006291X03023702"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2003.11.053","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2003,12]]}}}