{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:30:34Z","timestamp":1790422234933,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2004,1,1]],"date-time":"2004-01-01T00:00:00Z","timestamp":1072915200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001695","name":"Japan Science and Technology Corporation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001695","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2004,1]]},"DOI":"10.1016\/j.bbrc.2003.11.139","type":"journal-article","created":{"date-parts":[[2003,12,19]],"date-time":"2003-12-19T05:57:50Z","timestamp":1071813470000},"page":"468-474","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"title":["FBP11 regulates nuclear localization of N-WASP and inhibits N-WASP-dependent microspike formation"],"prefix":"10.1016","volume":"313","author":[{"given":"Kiyohito","family":"Mizutani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiro","family":"Suetsugu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadaomi","family":"Takenawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2003.11.139_BIB1","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/0092-8674(94)90528-2","article-title":"Isolation of a novel gene mutated in Wiskott\u2013Aldrich syndrome","volume":"78","author":"Derry","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2003.11.139_BIB2","doi-asserted-by":"crossref","first-page":"5326","DOI":"10.1002\/j.1460-2075.1996.tb00917.x","article-title":"N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases","volume":"15","author":"Miki","year":"1996","journal-title":"EMBO J."},{"key":"10.1016\/j.bbrc.2003.11.139_BIB3","doi-asserted-by":"crossref","first-page":"6932","DOI":"10.1093\/emboj\/17.23.6932","article-title":"WAVE, a novel WASP-family protein involved in actin reorganization induced by Rac.","volume":"17","author":"Miki","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.bbrc.2003.11.139_BIB4","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1016\/S0960-9822(98)00015-3","article-title":"Scar1 and the related Wiskott\u2013Aldrich syndrome protein, WASP, regulate the actin cytoskeleton through the Arp2\/3 complex","volume":"8","author":"Machesky","year":"1998","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bbrc.2003.11.139_BIB5","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1006\/bbrc.1999.0894","article-title":"Identification of two human WAVE\/SCAR homologues as general actin regulatory molecules which associate with the Arp2\/3 complex","volume":"260","author":"Suetsugu","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2003.11.139_BIB6","doi-asserted-by":"crossref","first-page":"3739","DOI":"10.1073\/pnas.96.7.3739","article-title":"Scar, a WASp-related protein, activates nucleation of actin filaments by the Arp2\/3 complex","volume":"96","author":"Machesky","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2003.11.139_BIB7","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0092-8674(00)80732-1","article-title":"The interaction between N-WASP and the Arp2\/3 complex links","volume":"97","author":"Rohatgi","year":"1999","journal-title":"Cell"},{"issue":"Pt. 10","key":"10.1016\/j.bbrc.2003.11.139_BIB8","doi-asserted-by":"crossref","first-page":"1801","DOI":"10.1242\/jcs.114.10.1801","article-title":"WASP and WAVE family proteins: key molecules for rapid rearrangement of cortical actin filaments and cell movement","volume":"114","author":"Takenawa","year":"2001","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbrc.2003.11.139_BIB9","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/34208","article-title":"Induction of filopodium formation by a WASP-related actin-depolymerizing protein N-WASP","volume":"391","author":"Miki","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2003.11.139_BIB10","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/35004513","article-title":"Autoinhibition and activation mechanisms of the Wiskott\u2013Aldrich syndrome protein","volume":"404","author":"Kim","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2003.11.139_BIB11","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1083\/jcb.150.6.1299","article-title":"Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate","volume":"150","author":"Rohatgi","year":"2000","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbrc.2003.11.139_BIB12","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1126\/science.290.5492.801","article-title":"Integration of multiple signals through cooperative regulation of the N-WASP-Arp2\/3 complex","volume":"290","author":"Prehoda","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2003.11.139_BIB13","doi-asserted-by":"crossref","first-page":"21946","DOI":"10.1074\/jbc.M000687200","article-title":"GRB2 links signaling to actin assembly by enhancing interaction of neural Wiskott\u2013Aldrich syndrome protein (N-WASp) with actin-related protein (ARP2\/3) complex","volume":"275","author":"Carlier","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2003.11.139_BIB14","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1083\/jcb.152.3.471","article-title":"A novel neural Wiskott\u2013Aldrich syndrome protein (N-WASP) binding protein, WISH, induces Arp2\/3 complex activation independent of Cdc42","volume":"152","author":"Fukuoka","year":"2001","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbrc.2003.11.139_BIB15","doi-asserted-by":"crossref","first-page":"26448","DOI":"10.1074\/jbc.M103856200","article-title":"Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2\/3 pathway","volume":"276","author":"Rohatgi","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2003.11.139_BIB16","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1016\/S1534-5807(02)00324-6","article-title":"Sustained activation of N-WASP through phosphorylation is essential for neurite extension","volume":"3","author":"Suetsugu","year":"2002","journal-title":"Dev. Cell"},{"key":"10.1016\/j.bbrc.2003.11.139_BIB17","doi-asserted-by":"crossref","first-page":"2003","DOI":"10.1182\/blood.V93.6.2003.406k13_2003_2012","article-title":"Involvement of Wiskott\u2013Aldrich syndrome protein in B-cell cytoplasmic tyrosine kinase pathway","volume":"93","author":"Baba","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.bbrc.2003.11.139_BIB18","doi-asserted-by":"crossref","first-page":"45115","DOI":"10.1074\/jbc.M203346200","article-title":"Phosphorylation of tyrosine 291 enhances the ability of WASp to stimulate actin polymerization and filopodium formation. Wiskott\u2013Aldrich Syndrome protein","volume":"277","author":"Cory","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2003.11.139_BIB19","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1016\/S1097-2765(03)00172-2","article-title":"Phosphorylation of the WASP-VCA domain increases its affinity for the Arp2\/3 complex and enhances actin polymerization by WASP","volume":"11","author":"Cory","year":"2003","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbrc.2003.11.139_BIB20","doi-asserted-by":"crossref","first-page":"42515","DOI":"10.1074\/jbc.M302177200","article-title":"Translocation of N-WASP by nuclear localization and export signals into the nucleus modulates expression of HSP90","volume":"278","author":"Suetsugu","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2003.11.139_BIB21","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/S0378-1119(97)00184-4","article-title":"Identification of N-WASP homologs in human and rat brain","volume":"196","author":"Fukuoka","year":"1997","journal-title":"Gene"},{"key":"10.1016\/j.bbrc.2003.11.139_BIB22","first-page":"669","article-title":"Essential role of neural Wiskott\u2013Aldrich syndrome protein in podosome formation and degradation of extracellular matrix in src-transformed fibroblasts","volume":"62","author":"Mizutani","year":"2002","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2003.11.139_BIB23","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1002\/j.1460-2075.1996.tb00442.x","article-title":"Formin binding proteins bear WWP\/WW domains that bind proline-rich peptides and functionally resemble SH3 domains","volume":"15","author":"Chan","year":"1996","journal-title":"EMBO J."},{"key":"10.1016\/j.bbrc.2003.11.139_BIB24","doi-asserted-by":"crossref","first-page":"10602","DOI":"10.1073\/pnas.95.18.10602","article-title":"WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif","volume":"95","author":"Bedford","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2003.11.139_BIB25","doi-asserted-by":"crossref","first-page":"1463","DOI":"10.1093\/hmg\/7.9.1463","article-title":"Huntingtin interacts with a family of WW domain proteins","volume":"7","author":"Faber","year":"1998","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbrc.2003.11.139_BIB26","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1093\/hmg\/9.14.2175","article-title":"Huntingtin\u2019s WW domain partners in Huntington\u2019s disease post-mortem brain fulfill genetic criteria for direct involvement in Huntington\u2019s disease pathogenesis","volume":"9","author":"Passani","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbrc.2003.11.139_BIB27","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/0955-0674(93)90009-F","article-title":"Nuclear organization of pre-mRNA processing","volume":"5","author":"Spector","year":"1993","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.bbrc.2003.11.139_BIB28","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/nature01031","article-title":"Comprehensive proteomic analysis of the human spliceosome","volume":"419","author":"Zhou","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2003.11.139_BIB29","doi-asserted-by":"crossref","first-page":"6516","DOI":"10.1093\/emboj\/17.22.6516","article-title":"The essential role of profilin in the assembly of actin for microspike formation","volume":"17","author":"Suetsugu","year":"1998","journal-title":"EMBO J."},{"key":"10.1016\/j.bbrc.2003.11.139_BIB30","doi-asserted-by":"crossref","first-page":"12631","DOI":"10.1073\/pnas.190351397","article-title":"Two tandem verprolin homology domains are necessary for a strong activation of Arp2\/3 complex-induced actin polymerization and induction of microspike formation N-WASP","volume":"97","author":"Yamaguchi","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X03025397?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X03025397?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T10:10:37Z","timestamp":1757758237000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X03025397"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,1]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,1]]}},"alternative-id":["S0006291X03025397"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2003.11.139","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2004,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"FBP11 regulates nuclear localization of N-WASP and inhibits N-WASP-dependent microspike formation","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2003.11.139","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"converted-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2003 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}