{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T13:48:22Z","timestamp":1790430502934,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T00:00:00Z","timestamp":1080777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2004,4]]},"DOI":"10.1016\/j.bbrc.2004.03.046","type":"journal-article","created":{"date-parts":[[2004,3,20]],"date-time":"2004-03-20T16:11:47Z","timestamp":1079799107000},"page":"309-314","source":"Crossref","is-referenced-by-count":26,"title":["Structure of anthrax edema factor\u2013calmodulin\u2013adenosine 5\u2032-(\u03b1,\u03b2-methylene)-triphosphate complex reveals an alternative mode of ATP binding to the catalytic site"],"prefix":"10.1016","volume":"317","author":[{"given":"Yuequan","family":"Shen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia L.","family":"Zhukovskaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chester L.","family":"Drum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Bohm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei-Jen","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2004.03.046_BIB1","first-page":"189","article-title":"Bacillus anthracis calmodulin-dependent adenylate cyclase: chemical and enzymatic properties and interactions with eucaryotic cells","volume":"17","author":"Leppla","year":"1984","journal-title":"Adv. Cyclic Nucl. Prot."},{"key":"10.1016\/j.bbrc.2004.03.046_BIB2","doi-asserted-by":"crossref","first-page":"6721","DOI":"10.1093\/emboj\/cdf681","article-title":"Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins","volume":"21","author":"Shen","year":"2002","journal-title":"EMBO J."},{"key":"10.1016\/j.bbrc.2004.03.046_BIB3","doi-asserted-by":"crossref","first-page":"8595","DOI":"10.1016\/S0021-9258(18)93016-4","article-title":"Expression and characterization of calmodulin-activated (type I) adenylylcyclase","volume":"266","author":"Tang","year":"1991","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2004.03.046_BIB4","doi-asserted-by":"crossref","first-page":"36334","DOI":"10.1074\/jbc.M004778200","article-title":"An extended conformation of calmodulin induces interactions between the structural domains of adenylyl cyclase from Bacillus anthracis to promote catalysis","volume":"275","author":"Drum","year":"2000","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2004.03.046_BIB5","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1126\/science.280.5364.734","article-title":"Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor","volume":"280","author":"Duesbery","year":"1998","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2004.03.046_BIB6","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1006\/bbrc.1998.9040","article-title":"Anthrax lethal factor cleaves the N-terminus of MAPKKs and induces tyrosine\/threonine phosphorylation of MAPKs in cultured macrophages","volume":"248","author":"Vitale","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2004.03.046_BIB7","doi-asserted-by":"crossref","first-page":"3334","DOI":"10.1016\/S0021-9258(18)53698-X","article-title":"Residues 1-254 of anthrax toxin lethal factor are sufficient to cause cellular uptake of fused polypeptides","volume":"268","author":"Arora","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2004.03.046_BIB8","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1146\/annurev.cellbio.19.111301.140655","article-title":"Anthrax toxin","volume":"19","author":"Collier","year":"2003","journal-title":"Annu. Rev. Cell Dev. Biol."},{"key":"10.1016\/j.bbrc.2004.03.046_BIB9","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1046\/j.1365-2958.2001.02695.x","article-title":"Fate of germinated Bacillus anthracis spores in primary murine macrophages","volume":"42","author":"Guidi-Rontani","year":"2001","journal-title":"Mol. Microbiol."},{"key":"10.1016\/j.bbrc.2004.03.046_BIB10","doi-asserted-by":"crossref","first-page":"4432","DOI":"10.1128\/IAI.62.10.4432-4439.1994","article-title":"Anthrax edema toxin differentially regulates lipopolysaccharide-induced monocyte production of tumor necrosis factor a and interleukin-6 by increasing intracellular cyclic AMP","volume":"62","author":"Hoover","year":"1994","journal-title":"Infect. Immun."},{"key":"10.1016\/j.bbrc.2004.03.046_BIB11","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/nature01794","article-title":"Impairment of dendritic cells and adaptive immunity by anthrax lethal toxin","volume":"424","author":"Agrawal","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2004.03.046_BIB12","doi-asserted-by":"crossref","first-page":"10925","DOI":"10.1073\/pnas.1834478100","article-title":"A dually active anthrax vaccine that confers protection against both bacilli and toxins","volume":"100","author":"Rhie","year":"2003","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2004.03.046_BIB13","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1146\/annurev.micro.55.1.647","article-title":"Anthrax","volume":"55","author":"Mock","year":"2001","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.bbrc.2004.03.046_BIB14","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/S0014-5793(99)01502-1","article-title":"Anthrax lethal factor cleaves MKK3 in macrophages and inhibits the LPS\/IFNg-induced release of NO and TNFa","volume":"462","author":"Pellizzari","year":"1999","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbrc.2004.03.046_BIB15","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1146\/annurev.micro.56.012302.160616","article-title":"Bioterrorism: from threat to reality","volume":"56","author":"Atlas","year":"2002","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.bbrc.2004.03.046_BIB16","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1038\/nm1201-1271","article-title":"Bioterrorism: a clear and present danger","volume":"7","author":"Lane","year":"2001","journal-title":"Nature Med."},{"key":"10.1016\/j.bbrc.2004.03.046_BIB17","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1056\/NEJM199909093411107","article-title":"Anthrax","volume":"341","author":"Dixon","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbrc.2004.03.046_BIB18","doi-asserted-by":"crossref","first-page":"2236","DOI":"10.1001\/jama.287.17.2236","article-title":"Group on Civilian, Anthrax as a biological weapon, 2002: updated recommendations for management","volume":"287","author":"Inglesby","year":"2002","journal-title":"JAMA"},{"key":"10.1016\/j.bbrc.2004.03.046_BIB19","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1038\/415396a","article-title":"Structural basis for the activation of anthrax adenylyl cyclase exotoxin by calmodulin","volume":"415","author":"Drum","year":"2002","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2004.03.046_BIB20","doi-asserted-by":"crossref","first-page":"25990","DOI":"10.1074\/jbc.M301232200","article-title":"Structure-based inhibitor discovery against adenylyl cyclase toxins from pathogenic bacteria that cause anthrax and whooping cough","volume":"278","author":"Soelaiman","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2004.03.046_BIB21","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1107\/S0907444901014937","article-title":"Crystallization and preliminary X-ray study of the edema factor exotoxin adenylyl cyclase domain from Bacillus anthracis in the presence of its activator, calmodulin","volume":"57","author":"Drum","year":"2001","journal-title":"Acta Crystallogr. D"},{"key":"10.1016\/j.bbrc.2004.03.046_BIB22","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/S0076-6879(97)76066-X","article-title":"Processing of X-ray diffraction data collected in oscillation mode","volume":"276","author":"Otwinowski","year":"1997","journal-title":"Methods Enzymol."},{"key":"10.1016\/j.bbrc.2004.03.046_BIB23","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1038\/90394","article-title":"Structure of b-lactam synthetase reveals how to synthesize antibiotics instead of asparagine","volume":"8","author":"Miller","year":"2001","journal-title":"Nat. Struct. Biol."},{"key":"10.1016\/j.bbrc.2004.03.046_BIB24","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1110\/ps.0241803","article-title":"Crystal structure of a pantothenate synthetase from M. tuberculosis and its complexes with substrates and a reaction intermediate","volume":"12","author":"Wang","year":"2003","journal-title":"Protein Sci."},{"key":"10.1016\/j.bbrc.2004.03.046_BIB25","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/S0022-2836(03)00305-X","article-title":"Amino acid discrimination by a class I aminoacyl-tRNA synthetase specified by negative determinants","volume":"328","author":"Bullock","year":"2003","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bbrc.2004.03.046_BIB26","doi-asserted-by":"crossref","first-page":"14752","DOI":"10.1073\/pnas.232361199","article-title":"The catalytic cycle of b-lactam synthetase observed by x-ray crystallographic snapshots","volume":"99","author":"Miller","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2004.03.046_BIB27","doi-asserted-by":"crossref","first-page":"4922","DOI":"10.1021\/bi00472a024","article-title":"Characterization of ATP and calmodulin-binding properties of a truncated form of Bacillus anthracis adenylate cyclase","volume":"29","author":"Labruyure","year":"1990","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbrc.2004.03.046_BIB28","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1006\/jmbi.1996.0043","article-title":"Entropy in bi-substrate enzymes: proposed role of an alternate site in chaperoning substrate into, and products out of, thymidylate synthase","volume":"255","author":"Birdsall","year":"1996","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.bbrc.2004.03.046_BIB29","doi-asserted-by":"crossref","first-page":"2351","DOI":"10.1002\/j.1460-2075.1990.tb07409.x","article-title":"Refined crystal structures of the triphosphate conformation of H-ras p21 at 1.35A resolution: implications for the mechanism of GTP hydrolysis","volume":"9","author":"Pai","year":"1990","journal-title":"EMBO J."},{"key":"10.1016\/j.bbrc.2004.03.046_BIB30","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.1126\/science.8073283","article-title":"Structures of active conformations of Gi alpha and the mechanism of GTP hydrolysis","volume":"265","author":"Coleman","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2004.03.046_BIB31","doi-asserted-by":"crossref","first-page":"3237","DOI":"10.1021\/bi00177a014","article-title":"Role of Glutamine-61 in the hydrolysis of GTP by p21H-ras: an experimental and theoretical study","volume":"33","author":"Frech","year":"1994","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbrc.2004.03.046_BIB32","doi-asserted-by":"crossref","first-page":"3242","DOI":"10.1073\/pnas.0306552101","article-title":"Selective inhibition of anthrax edema factor by adefovir, an approved drug against the infection of hepatitis B virus","volume":"101","author":"Shen","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2004.03.046_BIB33","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1107\/S0021889891004399","article-title":"Molscript: a program to produce both detailed and schematic plots of protein structures","volume":"24","author":"Kraulis","year":"1991","journal-title":"J. Appl. Crystallogr."},{"key":"10.1016\/j.bbrc.2004.03.046_BIB34","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/S1093-3263(97)00021-1","article-title":"An extensively modified version of MolScript that includes greatly enhanced coloring capabilities","volume":"15","author":"Esnouf","year":"1997","journal-title":"J. Mol. Graph Model"},{"key":"10.1016\/j.bbrc.2004.03.046_BIB35","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1107\/S0907444994006396","article-title":"Raster3D Version 2.0. A program for photorealistic molecular graphics","volume":"50","author":"Merrit","year":"1994","journal-title":"Acta Crystallogr. D"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X04005327?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X04005327?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,15]],"date-time":"2021-06-15T05:06:25Z","timestamp":1623733585000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X04005327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4]]},"references-count":35,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,4]]}},"alternative-id":["S0006291X04005327"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2004.03.046","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2004,4]]}}}