{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T13:45:49Z","timestamp":1781703949317,"version":"3.54.5"},"reference-count":25,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2004,9,1]],"date-time":"2004-09-01T00:00:00Z","timestamp":1093996800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2004,9]]},"DOI":"10.1016\/j.bbrc.2004.07.148","type":"journal-article","created":{"date-parts":[[2004,8,11]],"date-time":"2004-08-11T14:34:09Z","timestamp":1092234849000},"page":"434-439","source":"Crossref","is-referenced-by-count":38,"title":["The P2X7 ATP receptor modulates renal cyst development in vitro"],"prefix":"10.1016","volume":"322","author":[{"given":"Kate A.","family":"Hillman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrian S.","family":"Woolf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya M.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Wade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Unwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.D.","family":"Winyard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2004.07.148_bib1","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1126\/science.272.5262.735","article-title":"The cytolytic P2Z receptor for extracellular ATP identified as a P2X receptor (P2X7)","volume":"272","author":"Surprenant","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2004.07.148_bib2","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1084\/jem.185.3.579","article-title":"Purinergic modulation of interleukin-1 beta release from microglial cells stimulated with bacterial endotoxin","volume":"185","author":"Ferrari","year":"1997","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbrc.2004.07.148_bib3","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1172\/JCI117770","article-title":"The purinergic P2Z receptor of human macrophage cells. Characterization and possible physiological role","volume":"95","author":"Falzoni","year":"1995","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2004.07.148_bib4","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1083\/jcb.138.3.697","article-title":"Spontaneous cell fusion in macrophage cultures expressing high levels of the P2Z\/P2X7 receptor","volume":"138","author":"Chiozzi","year":"1997","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbrc.2004.07.148_bib5","doi-asserted-by":"crossref","first-page":"33206","DOI":"10.1074\/jbc.274.47.33206","article-title":"Increased proliferation rate of lymphoid cells transfected with the P2X(7) ATP receptor","volume":"274","author":"Baricordi","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2004.07.148_bib6","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1006\/bbrc.1996.0031","article-title":"Role of the purinergic P2Z receptor in spontaneous cell death in J774 macrophage cultures","volume":"218","author":"Chiozzi","year":"1996","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2004.07.148_bib7","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1016\/S0028-3908(97)00137-8","article-title":"ATP-mediated cytotoxicity in microglial cells","volume":"36","author":"Ferrari","year":"1997","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbrc.2004.07.148_bib8","first-page":"F962","article-title":"Extracellular ATP causes apoptosis and necrosis of cultured mesangial cells via P2Z\/P2X7 receptors","volume":"275","author":"Schulze-Lohoff","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bbrc.2004.07.148_bib9","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1159\/000049896","article-title":"P2X (7) receptors are expressed during mouse nephrogenesis and in collecting duct cysts of the cpk\/cpk mouse","volume":"10","author":"Hillman","year":"2002","journal-title":"Exp. Nephrol."},{"key":"10.1016\/j.bbrc.2004.07.148_bib10","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1172\/JCI0214099","article-title":"Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease","volume":"109","author":"Hou","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2004.07.148_bib11","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1681\/ASN.V102218","article-title":"ATP release mechanisms in primary cultures of epithelia derived from the cysts of polycystic kidneys","volume":"10","author":"Wilson","year":"1999","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbrc.2004.07.148_bib12","doi-asserted-by":"crossref","first-page":"F763","DOI":"10.1152\/ajprenal.0337.2000","article-title":"Autocrine extracellular purinergic signaling in epithelial cells derived from polycystic kidneys","volume":"282","author":"Schwiebert","year":"2001","journal-title":"Am. J. Physiol. Renal Physiol."},{"key":"10.1016\/j.bbrc.2004.07.148_bib13","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1038\/ki.1996.18","article-title":"Deregulation of cell survival in cystic and dysplastic renal development","volume":"49","author":"Winyard","year":"1996","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbrc.2004.07.148_bib14","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/368750a0","article-title":"Taxol inhibits progression of congenital polycystic kidney disease","volume":"368","author":"Woo","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2004.07.148_bib15","doi-asserted-by":"crossref","first-page":"8199","DOI":"10.1016\/S0021-9258(18)53082-9","article-title":"Oxidized ATP. An irreversible inhibitor of the macrophage purinergic P2Z receptor","volume":"268","author":"Murgia","year":"1993","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2004.07.148_bib16","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0014-5793(95)01116-V","article-title":"An ICE-like protease is a common mediator of apoptosis induced by diverse stimuli in human monocytic THP.1 cells","volume":"374","author":"Zhu","year":"1995","journal-title":"FEBS Lett."},{"key":"10.1016\/j.bbrc.2004.07.148_bib17","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1038\/326515a0","article-title":"Cyclin\/PCNA is the auxiliary protein of DNA polymerase-delta","volume":"326","author":"Bravo","year":"1987","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2004.07.148_bib18","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/S0002-9440(10)63923-5","article-title":"Urinary outflow obstruction increases apoptosis and deregulates Bcl-2 and Bax expression in the fetal ovine bladder","volume":"162","author":"Thiruchelvam","year":"2003","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.bbrc.2004.07.148_bib19","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.4049\/jimmunol.163.4.1958","article-title":"Mouse dendritic cells express the P2X7 purinergic receptor: characterization and possible participation in antigen presentation","volume":"163","author":"Mutini","year":"1999","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbrc.2004.07.148_bib20","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1146\/annurev.pharmtox.40.1.563","article-title":"Pharmacology of cloned P2X receptors","volume":"40","author":"North","year":"2000","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"key":"10.1016\/j.bbrc.2004.07.148_bib21","first-page":"107","article-title":"International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits","volume":"53","author":"Khakh","year":"2001","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.bbrc.2004.07.148_bib22","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0092-8674(02)01283-7","article-title":"Tube morphogenesis: making and shaping biological tubes","volume":"112","author":"Lubarsky","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2004.07.148_bib23","doi-asserted-by":"crossref","first-page":"R763","DOI":"10.1152\/ajpregu.2000.278.3.R763","article-title":"Apoptosis in polycystic kidney disease: involvement of caspases","volume":"278","author":"Ali","year":"2000","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.bbrc.2004.07.148_bib24","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1046\/j.1523-1755.2003.00232.x","article-title":"Combination treatment of PKD utilizing dual inhibition of EGF-receptor activity and ligand bioavailability","volume":"64","author":"Sweeney","year":"2003","journal-title":"Kidney Int."},{"key":"10.1016\/j.bbrc.2004.07.148_bib25","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1038\/nm935","article-title":"Inhibition of renal cystic disease development and progression by a vasopressin V2 receptor antagonist","volume":"9","author":"Gattone","year":"2003","journal-title":"Nat. Med."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X04016316?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X04016316?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T05:06:24Z","timestamp":1682744784000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X04016316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,9]]},"references-count":25,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2004,9]]}},"alternative-id":["S0006291X04016316"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2004.07.148","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2004,9]]}}}