{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T20:47:56Z","timestamp":1790974076984,"version":"4.1.0"},"reference-count":88,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2004,10,1]],"date-time":"2004-10-01T00:00:00Z","timestamp":1096588800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2004,10]]},"DOI":"10.1016\/j.bbrc.2004.08.043","type":"journal-article","created":{"date-parts":[[2004,8,31]],"date-time":"2004-08-31T13:27:23Z","timestamp":1093958843000},"page":"1364-1373","source":"Crossref","is-referenced-by-count":51,"title":["Calcium signaling and polycystin-2"],"prefix":"10.1016","volume":"322","author":[{"given":"Georgia I.","family":"Anyatonwu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara E.","family":"Ehrlich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2004.08.043_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/mgme.1999.2943","article-title":"Molecular genetics and mechanism of autosomal dominant polycystic kidney disease","volume":"69","author":"Wu","year":"2000","journal-title":"Mol. Genet. Metab."},{"key":"10.1016\/j.bbrc.2004.08.043_bib2","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1056\/NEJMra022161","article-title":"Polycystic kidney disease","volume":"350","author":"Wilson","year":"2004","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbrc.2004.08.043_bib3","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1136\/jmg.34.7.587","article-title":"A family with a milder form of adult dominant polycystic kidney disease not linked to the PKD1 (16p) or PKD2 (4q) genes","volume":"34","author":"Ariza","year":"1997","journal-title":"J. Med. Genet."},{"key":"10.1016\/j.bbrc.2004.08.043_bib4","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1016\/0888-7543(88)90146-2","article-title":"Regional localization of the autosomal dominant polycystic kidney disease locus","volume":"3","author":"Reeders","year":"1988","journal-title":"Genomics"},{"key":"10.1016\/j.bbrc.2004.08.043_bib5","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1016\/S0888-7543(11)80001-7","article-title":"Autosomal dominant polycystic kidney disease: localization of the second gene to chromosome 4q13-q23","volume":"18","author":"Kimberling","year":"1993","journal-title":"Genomics"},{"key":"10.1016\/j.bbrc.2004.08.043_bib6","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1016\/0140-6736(92)92503-8","article-title":"Phenotype and genotype heterogeneity in autosomal dominant polycystic kidney disease","volume":"340","author":"Ravine","year":"1992","journal-title":"Lancet"},{"key":"10.1016\/j.bbrc.2004.08.043_bib7","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0140-6736(98)03495-3","article-title":"Comparison of phenotypes of polycystic kidney disease types 1 and 2. European PKD1-PKD2 Study Group","volume":"353","author":"Hateboer","year":"1999","journal-title":"Lancet"},{"key":"10.1016\/j.bbrc.2004.08.043_bib8","first-page":"24","article-title":"Molecular genetics of polycystic kidney disease","volume":"11","author":"Calvet","year":"1998","journal-title":"J. Nephrol."},{"key":"10.1016\/j.bbrc.2004.08.043_bib9","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1161\/01.STR.29.1.251","article-title":"Prevalence and risk of rupture of intracranial aneurysms: a systematic review","volume":"29","author":"Rinkel","year":"1998","journal-title":"Stroke"},{"key":"10.1016\/j.bbrc.2004.08.043_bib10","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0272-6386(12)80921-8","article-title":"Autosomal dominant polycystic kidney disease","volume":"22","author":"Gabow","year":"1993","journal-title":"Am. J. Kidney Dis."},{"key":"10.1016\/j.bbrc.2004.08.043_bib11","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1067\/mlc.2003.13","article-title":"Autosomal dominant polycystic kidney disease: molecular genetics and pathophysiology","volume":"141","author":"Sutters","year":"2003","journal-title":"J. Lab. Clin. Med."},{"key":"10.1016\/j.bbrc.2004.08.043_bib12","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1681\/ASN.V1071524","article-title":"Somatic PKD2 mutations in individual kidney and liver cysts support a \u201ctwo-hit\u201d model of cystogenesis in type 2 autosomal dominant polycystic kidney disease","volume":"10","author":"Pei","year":"1999","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbrc.2004.08.043_bib13","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1097\/01.ASN.0000028643.17901.42","article-title":"Genetics and pathogenesis of polycystic kidney disease","volume":"13","author":"Igarashi","year":"2002","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbrc.2004.08.043_bib14","doi-asserted-by":"crossref","first-page":"2617","DOI":"10.1093\/hmg\/9.18.2617","article-title":"A human PKD1 transgene generates functional polycystin-1 in mice and is associated with a cystic phenotype","volume":"9","author":"Pritchard","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbrc.2004.08.043_bib15","doi-asserted-by":"crossref","first-page":"2385","DOI":"10.1093\/hmg\/10.21.2385","article-title":"Comparison of Pkd1-targeted mutants reveals that loss of polycystin-1 causes cystogenesis and bone defects","volume":"10","author":"Lu","year":"2001","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbrc.2004.08.043_bib16","doi-asserted-by":"crossref","first-page":"12174","DOI":"10.1073\/pnas.211191098","article-title":"Cardiovascular, skeletal, and renal defects in mice with a targeted disruption of the Pkd1 gene","volume":"98","author":"Boulter","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2004.08.043_bib17","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1073\/pnas.040550097","article-title":"Polycystin 1 is required for the structural integrity of blood vessels","volume":"97","author":"Kim","year":"2000","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2004.08.043_bib18","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/71724","article-title":"Cardiac defects and renal failure in mice with targeted mutations in Pkd2","volume":"24","author":"Wu","year":"2000","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbrc.2004.08.043_bib19","doi-asserted-by":"crossref","first-page":"2347","DOI":"10.1242\/dev.127.11.2347","article-title":"The Oak Ridge Polycystic Kidney (orpk) disease gene is required for left\u2013right axis determination","volume":"127","author":"Murcia","year":"2000","journal-title":"Development"},{"key":"10.1016\/j.bbrc.2004.08.043_bib20","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1083\/jcb.151.3.709","article-title":"Chlamydomonas IFT88 and its mouse homologue, polycystic kidney disease gene tg737, are required for assembly of cilia and flagella","volume":"151","author":"Pazour","year":"2000","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbrc.2004.08.043_bib21","first-page":"F451","article-title":"Distribution and developmentally regulated expression of murine polycystin","volume":"272","author":"Geng","year":"1997","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.bbrc.2004.08.043_bib22","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/ng0695-151","article-title":"The polycystic kidney disease 1 (PKD1) gene encodes a novel protein with multiple cell recognition domains","volume":"10","author":"Hughes","year":"1995","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbrc.2004.08.043_bib23","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1097\/01.ASN.0000029587.47950.25","article-title":"The polycystic kidney disease proteins, polycystin-1, polycystin-2, polaris, and cystin, are co-localized in renal cilia","volume":"13","author":"Yoder","year":"2002","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbrc.2004.08.043_bib24","doi-asserted-by":"crossref","first-page":"20763","DOI":"10.1074\/jbc.M107788200","article-title":"Identification, characterization, and localization of a novel kidney polycystin-1-polycystin-2 complex","volume":"277","author":"Newby","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2004.08.043_bib25","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1038\/35050128","article-title":"Co-assembly of polycystin-1 and -2 produces unique cation-permeable currents","volume":"408","author":"Hanaoka","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2004.08.043_bib26","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1172\/JCI5111","article-title":"Polycystin-1, the PKD1 gene product, is in a complex containing E-cadherin the catenins","volume":"104","author":"Huan","year":"1999","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2004.08.043_bib27","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1006\/geno.2002.6804","article-title":"Canine PKD1 is a single-copy gene: genomic organization and comparative analysis","volume":"80","author":"Dackowski","year":"2002","journal-title":"Genomics"},{"key":"10.1016\/j.bbrc.2004.08.043_bib28","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1016\/S1097-2765(00)00123-4","article-title":"Polycystin-1, the gene product of PKD1, induces resistance to apoptosis spontaneous tubulogenesis in MDCK cells","volume":"6","author":"Boletta","year":"2000","journal-title":"Mol. Cell"},{"key":"10.1016\/j.bbrc.2004.08.043_bib29","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1093\/hmg\/9.18.2743","article-title":"Polycystin-1, the product of the polycystic kidney disease 1 gene, co-localizes with desmosomes in MDCK cells","volume":"9","author":"Scheffers","year":"2000","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbrc.2004.08.043_bib30","doi-asserted-by":"crossref","first-page":"46544","DOI":"10.1074\/jbc.M107828200","article-title":"Polycystin-1 interacts with intermediate filaments","volume":"276","author":"Xu","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2004.08.043_bib31","doi-asserted-by":"crossref","first-page":"R585","DOI":"10.1016\/S0960-9822(99)80379-0","article-title":"A latrophilin\/CL-1-like GPS domain in polycystin-1","volume":"9","author":"Ponting","year":"1999","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bbrc.2004.08.043_bib32","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1074\/jbc.M109673200","article-title":"suREJ3, a polycystin-1 protein, is cleaved at the GPS domain and localizes to the acrosomal region of sea urchin sperm","volume":"277","author":"Mengerink","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2004.08.043_bib33","doi-asserted-by":"crossref","first-page":"1483","DOI":"10.1093\/hmg\/6.9.1483","article-title":"Comparative analysis of the polycystic kidney disease 1 (PKD1) gene reveals an integral membrane glycoprotein with multiple evolutionary conserved domains","volume":"6","author":"Sandford","year":"1997","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbrc.2004.08.043_bib34","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1006\/bbrc.1998.9514","article-title":"The polycystic kidney disease-1 protein, polycystin-1, binds and activates heterotrimeric G-proteins in vitro","volume":"251","author":"Parnell","year":"1998","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2004.08.043_bib35","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1083\/jcb.133.4.809","article-title":"The sea urchin sperm receptor for egg jelly is a modular protein with extensive homology to the human polycystic kidney disease protein, PKD1","volume":"133","author":"Moy","year":"1996","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbrc.2004.08.043_bib36","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1126\/science.272.5266.1339","article-title":"PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein","volume":"272","author":"Mochizuki","year":"1996","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2004.08.043_bib37","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1128\/MCB.23.7.2600-2607.2003","article-title":"Native polycystin 2 functions as a plasma membrane Ca2+-permeable cation channel in renal epithelia","volume":"23","author":"Luo","year":"2003","journal-title":"Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2004.08.043_bib38","doi-asserted-by":"crossref","first-page":"3934","DOI":"10.1073\/pnas.96.7.3934","article-title":"Specific association of the gene product of PKD2 with the TRPC1 channel","volume":"96","author":"Tsiokas","year":"1999","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2004.08.043_bib39","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/ncb754","article-title":"Polycystin-2 is an intracellular calcium release channel","volume":"4","author":"Koulen","year":"2002","journal-title":"Nat. Cell Biol."},{"key":"10.1016\/j.bbrc.2004.08.043_bib40","doi-asserted-by":"crossref","first-page":"R378","DOI":"10.1016\/S0960-9822(02)00877-1","article-title":"Polycystin-2 localizes to kidney cilia and the ciliary level is elevated in orpk mice with polycystic kidney disease","volume":"12","author":"Pazour","year":"2002","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bbrc.2004.08.043_bib41","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/ng1076","article-title":"Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells","volume":"33","author":"Nauli","year":"2003","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbrc.2004.08.043_bib42","doi-asserted-by":"crossref","first-page":"6965","DOI":"10.1073\/pnas.94.13.6965","article-title":"Homo- and heterodimeric interactions between the gene products of PKD1 and PKD2","volume":"94","author":"Tsiokas","year":"1997","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2004.08.043_bib43","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1006\/geno.2001.6684","article-title":"WAC, a novel WW domain-containing adapter with a coiled-coil region, is colocalized with splicing factor SC35","volume":"79","author":"Xu","year":"2002","journal-title":"Genomics"},{"key":"10.1016\/j.bbrc.2004.08.043_bib44","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/ng0697-179","article-title":"PKD1 interacts with PKD2 through a probable coiled-coil domain","volume":"16","author":"Qian","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbrc.2004.08.043_bib45","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1006\/bbrc.2001.4554","article-title":"Polycystin-2 is a novel cation channel implicated in defective intracellular Ca(2+) homeostasis in polycystic kidney disease","volume":"282","author":"Vassilev","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2004.08.043_bib46","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1073\/pnas.98.3.1182","article-title":"Polycystin-2, the protein mutated in autosomal dominant polycystic kidney disease (ADPKD), is a Ca2+-permeable nonselective cation channel","volume":"98","author":"Gonzalez-Perrett","year":"2001","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2004.08.043_bib47","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1016\/S0002-9297(07)62941-3","article-title":"Cloning of the gene encoding a novel integral membrane protein, mucolipidin and identification of the two major founder mutations causing mucolipidosis type IV","volume":"67","author":"Bassi","year":"2000","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bbrc.2004.08.043_bib48","doi-asserted-by":"crossref","first-page":"R356","DOI":"10.1016\/S0960-9822(01)00193-2","article-title":"Human disease: calcium signaling in polycystic kidney disease","volume":"11","author":"Somlo","year":"2001","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bbrc.2004.08.043_bib49","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1093\/hmg\/11.1.59","article-title":"Distinct subcellular expression of endogenous polycystin-2 in the plasma membrane and Golgi apparatus of MDCK cells","volume":"11","author":"Scheffers","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbrc.2004.08.043_bib50","doi-asserted-by":"crossref","first-page":"28557","DOI":"10.1074\/jbc.274.40.28557","article-title":"Identification and characterization of polycystin-2, the PKD2 gene product","volume":"274","author":"Cai","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2004.08.043_bib51","doi-asserted-by":"crossref","first-page":"36786","DOI":"10.1074\/jbc.M306536200","article-title":"Polycystin-1 distribution is modulated by polycystin-2 expression in mammalian cells","volume":"278","author":"Grimm","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2004.08.043_bib52","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0955-0674(02)00012-1","article-title":"The vertebrate primary cilium is a sensory organelle","volume":"15","author":"Pazour","year":"2003","journal-title":"Curr. Opin. Cell Biol."},{"key":"10.1016\/j.bbrc.2004.08.043_bib53","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1016\/S0092-8674(00)81705-5","article-title":"Randomization of left\u2013right asymmetry due to loss of nodal cilia generating leftward flow of extraembryonic fluid in mice lacking KIF3B motor protein","volume":"95","author":"Nonaka","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2004.08.043_bib54","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/S0248-4900(00)01108-4","article-title":"Length control of primary cilia: analysis of monociliate and multiciliate PtK1 cells","volume":"92","author":"Wheatley","year":"2000","journal-title":"Biol. Cell"},{"key":"10.1016\/j.bbrc.2004.08.043_bib55","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1038\/nrm952","article-title":"Intraflagellar transport","volume":"3","author":"Rosenbaum","year":"2002","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2004.08.043_bib56","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1172\/JCI0214099","article-title":"Cystin, a novel cilia-associated protein, is disrupted in the cpk mouse model of polycystic kidney disease","volume":"109","author":"Hou","year":"2002","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2004.08.043_bib57","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0896-6273(00)80510-3","article-title":"Neuronal calcium signaling","volume":"21","author":"Berridge","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.bbrc.2004.08.043_bib58","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1152\/jn.1995.74.6.2251","article-title":"Neurotransmitters acting via different G proteins inhibit N-type calcium current by an identical mechanism in rat sympathetic neurons","volume":"74","author":"Ehrlich","year":"1995","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.bbrc.2004.08.043_bib59","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1038\/351751a0","article-title":"Bell-shaped calcium-response curves of Ins(1,4,5)P3- and calcium-gated channels from endoplasmic reticulum of cerebellum","volume":"351","author":"Bezprozvanny","year":"1991","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2004.08.043_bib60","doi-asserted-by":"crossref","first-page":"20144","DOI":"10.1074\/jbc.M010771200","article-title":"Calmodulin binding and inhibition of cardiac muscle calcium release channel (ryanodine receptor)","volume":"276","author":"Balshaw","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2004.08.043_bib61","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0092-8674(00)80847-8","article-title":"PKA phosphorylation dissociates FKBP12.6 from the calcium release channel (ryanodine receptor): defective regulation in failing hearts","volume":"101","author":"Marx","year":"2000","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2004.08.043_bib62","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1016\/S0143416002001859","article-title":"IP3 receptors and their regulation by calmodulin and cytosolic Ca2+","volume":"32","author":"Taylor","year":"2002","journal-title":"Cell Calcium"},{"key":"10.1016\/j.bbrc.2004.08.043_bib63","doi-asserted-by":"crossref","first-page":"49699","DOI":"10.1074\/jbc.M309307200","article-title":"A functional interaction between chromogranin B and the inositol 1,4,5-trisphosphate receptor\/Ca2+ channel","volume":"278","author":"Thrower","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2004.08.043_bib64","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/nrm1155","article-title":"Calcium signalling: dynamics, homeostasis and remodelling","volume":"4","author":"Berridge","year":"2003","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.bbrc.2004.08.043_bib65","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/S1016-8478(23)13459-5","article-title":"Expression of excitation\u2013contraction coupling proteins during muscle differentiation","volume":"8","author":"Park","year":"1998","journal-title":"Mol. Cells"},{"key":"10.1016\/j.bbrc.2004.08.043_bib66","doi-asserted-by":"crossref","DOI":"10.1074\/jbc.M312031200","article-title":"Calcium dependence of polycystin-2 channel activity is modulated by phosphorylation at Ser812","author":"Cai","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2004.08.043_bib67","doi-asserted-by":"crossref","DOI":"10.1096\/fj.03-0687fje","article-title":"Deficiency of polycystin-2 reduces Ca2+ channel activity and cell proliferation in ADPKD lymphoblastoid cells","author":"Aguiari","year":"2004","journal-title":"FASEB J."},{"key":"10.1016\/j.bbrc.2004.08.043_bib68","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1093\/hmg\/ddg190","article-title":"Pkd2 haploinsufficiency alters intracellular calcium regulation in vascular smooth muscle cells","volume":"12","author":"Qian","year":"2003","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbrc.2004.08.043_bib69","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1007\/s00232-001-0075-4","article-title":"Bending the MDCK cell primary cilium increases intracellular calcium","volume":"184","author":"Praetorius","year":"2001","journal-title":"J. Membr. Biol."},{"key":"10.1016\/j.bbrc.2004.08.043_bib70","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1097\/00041552-200309000-00006","article-title":"The renal cell primary cilium functions as a flow sensor","volume":"12","author":"Praetorius","year":"2003","journal-title":"Curr. Opin. Nephrol. Hypertens."},{"key":"10.1016\/j.bbrc.2004.08.043_bib71","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1093\/ndt\/gfg256","article-title":"Ciliary function of polycystins: a new model for cystogenesis","volume":"18","author":"Joly","year":"2003","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.bbrc.2004.08.043_bib72","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1038\/nature02543","article-title":"Mechanotransduction through growth-factor shedding into the extracellular space","volume":"429","author":"Tschumperlin","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2004.08.043_bib73","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1002\/mrd.20033","article-title":"Polycystin-2 associates with the polycystin-1 homolog, suREJ3, and localizes to the acrosomal region of sea urchin spermatozoa","volume":"67","author":"Neill","year":"2004","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.bbrc.2004.08.043_bib74","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0092-8674(03)00511-7","article-title":"Two populations of node monocilia initiate left\u2013right asymmetry in the mouse","volume":"114","author":"McGrath","year":"2003","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2004.08.043_bib75","doi-asserted-by":"crossref","first-page":"2179","DOI":"10.1016\/j.cub.2003.12.002","article-title":"A flagellar polycystin-2 homolog required for male fertility in Drosophila","volume":"13","author":"Watnick","year":"2003","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bbrc.2004.08.043_bib76","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1002\/mrd.20042","article-title":"Polycystins: what polycystic kidney disease tells us about sperm","volume":"67","author":"Kierszenbaum","year":"2004","journal-title":"Mol. Reprod. Dev."},{"key":"10.1016\/j.bbrc.2004.08.043_bib77","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1016\/j.cub.2003.11.053","article-title":"PKD2 cation channel is required for directional sperm movement and male fertility","volume":"13","author":"Gao","year":"2003","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bbrc.2004.08.043_bib78","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1016\/S0015-0282(16)57683-3","article-title":"Polycystic kidney disease and infertility","volume":"64","author":"vander Linden","year":"1995","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.bbrc.2004.08.043_bib79","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/S0960-9822(02)00869-2","article-title":"The ion channel polycystin-2 is required for left\u2013right axis determination in mice","volume":"12","author":"Pennekamp","year":"2002","journal-title":"Curr. Biol."},{"key":"10.1016\/j.bbrc.2004.08.043_bib80","doi-asserted-by":"crossref","first-page":"3251","DOI":"10.1242\/jcs.00668","article-title":"Left\u2013right asymmetry: nodal points","volume":"116","author":"Mercola","year":"2003","journal-title":"J. Cell Sci."},{"key":"10.1016\/j.bbrc.2004.08.043_bib81","doi-asserted-by":"crossref","first-page":"3345","DOI":"10.1093\/hmg\/11.26.3345","article-title":"Expression analyses and interaction with the anaphase promoting complex protein Apc2 suggest a role for inversin in primary cilia and involvement in the cell cycle","volume":"11","author":"Morgan","year":"2002","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbrc.2004.08.043_bib82","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1046\/j.1440-169X.2001.00604.x","article-title":"Calmodulin binds to inv protein: implication for the regulation of inv function","volume":"43","author":"Yasuhiko","year":"2001","journal-title":"Dev. Growth Differ."},{"key":"10.1016\/j.bbrc.2004.08.043_bib83","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/ng1097-179","article-title":"Perinatal lethality with kidney and pancreas defects in mice with a targeted Pkd1 mutation","volume":"17","author":"Lu","year":"1997","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbrc.2004.08.043_bib84","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0092-8674(00)81570-6","article-title":"Somatic inactivation of Pkd2 results in polycystic kidney disease","volume":"93","author":"Wu","year":"1998","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2004.08.043_bib85","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0092-8674(02)00716-X","article-title":"PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2","volume":"109","author":"Bhunia","year":"2002","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2004.08.043_bib86","doi-asserted-by":"crossref","first-page":"11276","DOI":"10.1074\/jbc.M110483200","article-title":"Constitutive activation of G-proteins by polycystin-1 is antagonized by polycystin-2","volume":"277","author":"Delmas","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2004.08.043_bib87","doi-asserted-by":"crossref","first-page":"4947","DOI":"10.1074\/jbc.274.8.4947","article-title":"The polycystic kidney disease 1 gene product modulates Wnt signaling","volume":"274","author":"Kim","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2004.08.043_bib88","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1038\/ng1078","article-title":"Ciliary signaling goes down the tubes","volume":"33","author":"Calvet","year":"2003","journal-title":"Nat. Genet."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X04017814?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X04017814?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,1,14]],"date-time":"2024-01-14T08:18:47Z","timestamp":1705220327000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X04017814"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,10]]},"references-count":88,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2004,10]]}},"alternative-id":["S0006291X04017814"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2004.08.043","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2004,10]]}}}