{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T23:32:39Z","timestamp":1777505559040,"version":"3.51.4"},"reference-count":28,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2004,12,1]],"date-time":"2004-12-01T00:00:00Z","timestamp":1101859200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2004,12]]},"DOI":"10.1016\/j.bbrc.2004.10.213","type":"journal-article","created":{"date-parts":[[2004,12,10]],"date-time":"2004-12-10T14:33:26Z","timestamp":1102689206000},"page":"197-202","source":"Crossref","is-referenced-by-count":63,"title":["\u03b1-Lipoic acid prevents diabetes mellitus in diabetes-prone obese rats"],"prefix":"10.1016","volume":"326","author":[{"given":"Kee-Ho","family":"Song","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woo Je","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung-Min","family":"Koh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun Sik","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji-Young","family":"Youn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hye-Sun","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eun Hee","family":"Koh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min-Seon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jang Hyun","family":"Youn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ki-Up","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joong-Yeol","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2004.10.213_bib1","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1146\/annurev.nutr.23.011702.073212","article-title":"Dietary, evolutionary, and modernizing influences on the prevalence of type 2 diabetes","volume":"23","author":"Lieberman","year":"2003","journal-title":"Annu. Rev. Nutr."},{"key":"10.1016\/j.bbrc.2004.10.213_bib2","doi-asserted-by":"crossref","first-page":"933","DOI":"10.2337\/diacare.24.5.933","article-title":"Skeletal muscle triglyceride: an aspect of regional adiposity and insulin resistance","volume":"24","author":"Kelley","year":"2001","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bbrc.2004.10.213_bib3","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1210\/edrv.23.2.0461","article-title":"Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes","volume":"23","author":"Lewis","year":"2002","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.bbrc.2004.10.213_bib4","doi-asserted-by":"crossref","first-page":"S118","DOI":"10.2337\/diabetes.50.2007.S118","article-title":"Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover","volume":"50","author":"Unger","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2004.10.213_bib5","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/S0021-9150(99)00329-9","article-title":"Cytosolic triglycerides and oxidative stress in central obesity: the missing link between excessive atherosclerosis, endothelial dysfunction, and beta-cell failure?","volume":"148","author":"Bakker","year":"2000","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.bbrc.2004.10.213_bib6","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1210\/er.2001-0039","article-title":"Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes","volume":"23","author":"Evans","year":"2002","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.bbrc.2004.10.213_bib7","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/S0306-3623(96)00474-0","article-title":"The pharmacology of the antioxidant lipoic acid","volume":"29","author":"Biewenga","year":"1997","journal-title":"Gen. Pharmacol."},{"key":"10.1016\/j.bbrc.2004.10.213_bib8","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/S0899-9007(01)00658-X","article-title":"Molecular aspects of lipoic acid in the prevention of diabetes complications","volume":"17","author":"Packer","year":"2001","journal-title":"Nutrition"},{"key":"10.1016\/j.bbrc.2004.10.213_bib9","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1096\/fasebj.13.2.411","article-title":"(R)-Alpha-lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate","volume":"13","author":"Hagen","year":"1999","journal-title":"FASEB J."},{"key":"10.1016\/j.bbrc.2004.10.213_bib10","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1007\/s001250051253","article-title":"Lipoic acid protects against oxidative stress induced impairment in insulin stimulation of protein kinase B and glucose transport in 3T3-L1 adipocytes","volume":"42","author":"Rudich","year":"1999","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbrc.2004.10.213_bib11","doi-asserted-by":"crossref","first-page":"404","DOI":"10.2337\/diabetes.50.2.404","article-title":"Protection against oxidative stress-induced insulin resistance in rat L6 muscle cells by micromolar concentrations of alpha-lipoic acid","volume":"50","author":"Maddux","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2004.10.213_bib12","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1161\/hy0202.104345","article-title":"Prevention of hypertension, insulin resistance, and oxidative stress by alpha-lipoic acid","volume":"39","author":"El Midaoui","year":"2002","journal-title":"Hypertension"},{"key":"10.1016\/j.bbrc.2004.10.213_bib13","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.2337\/diab.45.8.1024","article-title":"The antioxidant alpha-lipoic acid enhances insulin-stimulated glucose metabolism in insulin-resistant rat skeletal muscle","volume":"45","author":"Jacob","year":"1996","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2004.10.213_bib14","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0891-5849(99)00089-1","article-title":"Oral administration of RAC-alpha-lipoic acid modulates insulin sensitivity in patients with type-2 diabetes mellitus: a placebo-controlled pilot trial","volume":"27","author":"Jacob","year":"1999","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbrc.2004.10.213_bib15","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1038\/nm1061","article-title":"Anti-obesity effects of alpha-lipoic acid mediated by suppression of hypothalamic AMP-activated protein kinase","volume":"10","author":"Kim","year":"2004","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2004.10.213_bib16","doi-asserted-by":"crossref","first-page":"1422","DOI":"10.2337\/diab.41.11.1422","article-title":"Spontaneous long-term hyperglycemic rat with diabetic complications: Otsuka Long\u2013Evans Tokushima Fatty (OLETF) strain","volume":"41","author":"Kawano","year":"1992","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2004.10.213_bib17","doi-asserted-by":"crossref","first-page":"2331","DOI":"10.2337\/diabetes.52.9.2331","article-title":"Peroxisome proliferator-activated receptor (PPAR)-alpha activation prevents diabetes in OLETF rats: comparison with PPAR-gamma activation","volume":"52","author":"Koh","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2004.10.213_bib18","doi-asserted-by":"crossref","first-page":"S20","DOI":"10.2337\/diabetes.50.2007.S20","article-title":"Beta-cell turnover: its assessment and implications","volume":"50","author":"Bonner-Weir","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2004.10.213_bib19","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1007\/BF00281823","article-title":"Preliminary characterization of calcium binding in islet-cell plasma membranes","volume":"19","author":"Naber","year":"1980","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbrc.2004.10.213_bib20","doi-asserted-by":"crossref","first-page":"315","DOI":"10.2337\/diabetes.50.2.315","article-title":"Lipotoxicity of the pancreatic beta-cell is associated with glucose-dependent esterification of fatty acids into neutral lipids","volume":"50","author":"Briaud","year":"2001","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2004.10.213_bib21","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1016\/S0026-0495(99)90112-9","article-title":"Lipoic acid acutely induces hypoglycemia in fasting nondiabetic and diabetic rats","volume":"48","author":"Khamaisi","year":"1999","journal-title":"Metabolism"},{"key":"10.1016\/j.bbrc.2004.10.213_bib22","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/S0026-0495(97)90120-7","article-title":"Lipoic acid reduces glycemia and increases muscle GLUT4 content in streptozotocin-diabetic rats","volume":"46","author":"Khamaisi","year":"1997","journal-title":"Metabolism"},{"key":"10.1016\/j.bbrc.2004.10.213_bib23","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1046\/j.1463-1326.2002.00171.x","article-title":"Lipoic acid increases glucose uptake by skeletal muscles of obese-diabetic ob\/ob mice","volume":"4","author":"Eason","year":"2002","journal-title":"Diabetes Obes. Metab."},{"key":"10.1016\/j.bbrc.2004.10.213_bib24","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1007\/BF02027215","article-title":"Dihydrolipoic acid protects pancreatic islet cells from inflammatory attack","volume":"38","author":"Burkart","year":"1993","journal-title":"Agents Actions"},{"key":"10.1016\/j.bbrc.2004.10.213_bib25","doi-asserted-by":"crossref","first-page":"25078","DOI":"10.1074\/jbc.274.35.25078","article-title":"Insulin signaling is inhibited by micromolar concentrations of H2O2. Evidence for a role of H2O2 in tumor necrosis factor alpha-mediated insulin resistance","volume":"274","author":"Hansen","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2004.10.213_bib26","doi-asserted-by":"crossref","first-page":"10595","DOI":"10.1074\/jbc.274.15.10595","article-title":"Oxidative stress disrupts insulin-induced cellular redistribution of insulin receptor substrate-1 and phosphatidylinositol 3-kinase in 3T3-L1 adipocytes. A putative cellular mechanism for impaired protein kinase B activation and GLUT4 translocation","volume":"274","author":"Tirosh","year":"1999","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2004.10.213_bib27","doi-asserted-by":"crossref","first-page":"2398","DOI":"10.2337\/diabetes.48.12.2398","article-title":"Beneficial effects of antioxidants in diabetes: possible protection of pancreatic beta-cells against glucose toxicity","volume":"48","author":"Kaneto","year":"1999","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2004.10.213_bib28","doi-asserted-by":"crossref","first-page":"E788","DOI":"10.1152\/ajpendo.2001.280.5.E788","article-title":"Adaptation of \u03b2-cell mass to substrate oversupply: enhanced function with normal gene expression","volume":"280","author":"Steil","year":"2001","journal-title":"Am. J. Physiol. Endocrinol. Metab."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X04023897?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X04023897?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T22:57:25Z","timestamp":1548975445000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X04023897"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,12]]},"references-count":28,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2004,12]]}},"alternative-id":["S0006291X04023897"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2004.10.213","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2004,12]]}}}