{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:22:52Z","timestamp":1791332572912,"version":"4.3.1"},"reference-count":17,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2005,2,1]],"date-time":"2005-02-01T00:00:00Z","timestamp":1107216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,2,1]],"date-time":"2005-02-01T00:00:00Z","timestamp":1107216000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01-DK54387"],"award-info":[{"award-number":["R01-DK54387"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["M01-RR00633"],"award-info":[{"award-number":["M01-RR00633"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["T32 DK07307"],"award-info":[{"award-number":["T32 DK07307"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2005,2]]},"DOI":"10.1016\/j.bbrc.2004.12.024","type":"journal-article","created":{"date-parts":[[2004,12,16]],"date-time":"2004-12-16T11:51:02Z","timestamp":1103197862000},"page":"446-453","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":47,"title":["Enzymatic activity of naturally occurring 1-acylglycerol-3-phosphate-O-acyltransferase 2 mutants associated with congenital generalized lipodystrophy"],"prefix":"10.1016","volume":"327","author":[{"given":"Wasim","family":"Haque","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhimanyu","family":"Garg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil K.","family":"Agarwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2004.12.024_bib1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/ng880","article-title":"AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34","volume":"31","author":"Agarwal","year":"2002","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbrc.2004.12.024_bib2","doi-asserted-by":"crossref","first-page":"4840","DOI":"10.1210\/jc.2003-030855","article-title":"Phenotypic and genetic heterogeneity in congenital generalized lipodystrophy","volume":"88","author":"Agarwal","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbrc.2004.12.024_bib3","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.2337\/diabetes.52.6.1573","article-title":"Prevalence of mutations in AGPAT2 among human lipodystrophies","volume":"52","author":"Magre","year":"2003","journal-title":"Diabetes"},{"key":"10.1016\/j.bbrc.2004.12.024_bib4","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0002-9343(99)00414-3","article-title":"Lipodystrophies","volume":"108","author":"Garg","year":"2000","journal-title":"Am. J. Med."},{"key":"10.1016\/j.bbrc.2004.12.024_bib5","doi-asserted-by":"crossref","unstructured":"J. Magre, M. Delepine, E. Khallouf, T. Gedde-Dahl Jr., L. Van Maldergem, E. Sobel, J. Papp, M. Meier, A. Megarbane, A. Bachy, A. Verloes, F.H. d\u2019Abronzo, E. Seemanova, R. Assan, N. Baudic, C. Bourut, P. Czernichow, F. Huet, F. Grigorescu, M. de Kerdanet, D. Lacombe, P. Labrune, M. Lanza, H. Loret, F. Matsuda, J. Navarro, A. Nivelon-Chevalier, M. Polak, J.J. Robert, P. Tric, N. Tubiana-Rufi, C. Vigouroux, J. Weissenbach, S. Savasta, J.A. Maassen, O. Trygstad, P. Bogalho, P. Freitas, J.L. Medina, F. Bonnicci, B.I. Joffe, G. Loyson, V.R. Panz, F.J. Raal, S. O\u2019Rahilly, T. Stephenson, C.R. Kahn, M. Lathrop, J. Capeau, Identification of the gene altered in Berardinelli\u2013Seip congenital lipodystrophy on chromosome11q13, Nat. Genet. 28 (2001) 365\u2013370","DOI":"10.1038\/ng585"},{"key":"10.1016\/j.bbrc.2004.12.024_bib6","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/S1043-2760(03)00078-X","article-title":"Congenital generalized lipodystrophy: significance of triglyceride biosynthetic pathways","volume":"14","author":"Agarwal","year":"2003","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.bbrc.2004.12.024_bib7","doi-asserted-by":"crossref","first-page":"d944","DOI":"10.2741\/Leung","article-title":"The structure and functions of human lysophosphatidic acid acyltransferases","volume":"6","author":"Leung","year":"2001","journal-title":"Front. Biosci."},{"key":"10.1016\/j.bbrc.2004.12.024_bib8","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1007\/s10038-003-0045-z","article-title":"Cloning and identification of the human LPAAT-zeta gene, a novel member of the lysophosphatidic acid acyltransferase family","volume":"48","author":"Li","year":"2003","journal-title":"J. Hum. Genet."},{"key":"10.1016\/j.bbrc.2004.12.024_bib9","doi-asserted-by":"crossref","first-page":"5764","DOI":"10.1021\/bi982805d","article-title":"Analysis of amino acid motifs diagnostic for the sn-glycerol-3-phosphate acyltransferase reaction","volume":"38","author":"Lewin","year":"1999","journal-title":"Biochemistry"},{"key":"10.1016\/j.bbrc.2004.12.024_bib10","doi-asserted-by":"crossref","first-page":"20299","DOI":"10.1074\/jbc.272.32.20299","article-title":"Human lysophosphatidic acid acyltransferase. cDNA cloning, expression, and localization to chromosome 9q34.3","volume":"272","author":"Eberhardt","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2004.12.024_bib11","doi-asserted-by":"crossref","first-page":"4096","DOI":"10.1074\/jbc.273.7.4096","article-title":"Characterization of a human lysophosphatidic acid acyltransferase that is encoded by a gene located in the class III region of the human major histocompatibility complex","volume":"273","author":"Aguado","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2004.12.024_bib12","first-page":"1067","article-title":"Inhibition of lysophosphatidic acid acyltransferase beta disrupts proliferative and survival signals in normal cells and induces apoptosis of tumor cells","volume":"2","author":"Coon","year":"2003","journal-title":"Mol. Cancer Ther."},{"key":"10.1016\/j.bbrc.2004.12.024_bib13","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1093\/ajcn\/74.3.295","article-title":"Leptin concentrations in the United States: relations with demographic and anthropometric measures","volume":"74","author":"Ruhl","year":"2001","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.bbrc.2004.12.024_bib14","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/ng578","article-title":"Increased efficiency of mRNA3\u2032 end formation: a new genetic mechanism contributing to hereditary thrombophilia","volume":"28","author":"Gehring","year":"2001","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbrc.2004.12.024_bib15","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1038\/28653","article-title":"An ancient retrotransposal insertion causes Fukuyama-type congenital muscular dystrophy","volume":"394","author":"Kobayashi","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2004.12.024_bib16","doi-asserted-by":"crossref","first-page":"12949","DOI":"10.1074\/jbc.270.22.12949","article-title":"Human lysophosphatidic acid acyltransferase. cDNA cloning, expression, and localization to chromosome 9q34.3","volume":"270","author":"Moolenaar","year":"1995","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2004.12.024_bib17","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/S1388-1981(02)00181-6","article-title":"Lysophosphatidic acid as an autocrine and paracrine mediator","volume":"1582","author":"Xie","year":"2002","journal-title":"Biochim. Biophys. Acta"}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X04027925?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X04027925?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:20:27Z","timestamp":1777389627000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X04027925"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,2]]}},"alternative-id":["S0006291X04027925"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2004.12.024","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2005,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Enzymatic activity of naturally occurring 1-acylglycerol-3-phosphate-O-acyltransferase 2 mutants associated with congenital generalized lipodystrophy","name":"articletitle","label":"Article Title"},{"value":"Biochemical and Biophysical Research Communications","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbrc.2004.12.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}