{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T07:00:51Z","timestamp":1791356451890,"version":"4.3.1"},"reference-count":90,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2005,3,1]],"date-time":"2005-03-01T00:00:00Z","timestamp":1109635200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2005,3]]},"DOI":"10.1016\/j.bbrc.2004.12.041","type":"journal-article","created":{"date-parts":[[2004,12,22]],"date-time":"2004-12-22T01:33:48Z","timestamp":1103679228000},"page":"700-708","source":"Crossref","is-referenced-by-count":74,"title":["Aging bone and cartilage: cross-cutting issues"],"prefix":"10.1016","volume":"328","author":[{"given":"Jill L.","family":"Carrington","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2004.12.041_bib1","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/35041682","article-title":"Why do we age?","volume":"408","author":"Kirkwood","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2004.12.041_bib2","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1111\/j.1532-5415.1997.tb03781.x","article-title":"When will the biology of aging become useful? Future landmarks in biomedical gerontology","volume":"45","author":"Miller","year":"1997","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.bbrc.2004.12.041_bib3","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1196\/annals.1297.041","article-title":"Genomic instability, aging, and cellular senescence","volume":"1019","author":"Busuttil","year":"2004","journal-title":"Ann. N Y Acad. Sci."},{"key":"10.1016\/j.bbrc.2004.12.041_bib4","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1111\/j.1749-6632.1998.tb09901.x","article-title":"Influences of caloric restriction on age-associated skeletal muscle fiber characteristics and mitochondrial changes in rats and mice","volume":"854","author":"Lee","year":"1998","journal-title":"Ann. N Y Acad. Sci."},{"key":"10.1016\/j.bbrc.2004.12.041_bib5","first-page":"1642","article-title":"Dietary intervention at middle age: caloric restriction but not dehydorepiandrosterone sulfate increases lifespan and lifetime cancer incidence in mice","volume":"59","author":"Pugh","year":"1999","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2004.12.041_bib6","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1126\/science.1099196","article-title":"Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase","volume":"305","author":"Cohen","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2004.12.041_bib7","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0531-5565(00)00228-X","article-title":"History and prospects: symposium on organisms with slow aging","volume":"36","author":"Finch","year":"2001","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.bbrc.2004.12.041_bib8","first-page":"646","article-title":"Burden of major musculoskeletal conditions","volume":"81","author":"Woolf","year":"2003","journal-title":"Bull. World Health Organ."},{"key":"10.1016\/j.bbrc.2004.12.041_bib9","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/35041687","article-title":"Oxidants, oxidative stress and the biology of ageing","volume":"408","author":"Finkel","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2004.12.041_bib10","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/35041694","article-title":"The age of cancer","volume":"408","author":"DePinho","year":"2000","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2004.12.041_bib11","first-page":"1","article-title":"The role of cellular senescence in skin aging","volume":"3","author":"Campisi","year":"1998","journal-title":"J. Investig. Dermatol. Symp. Proc."},{"key":"10.1016\/j.bbrc.2004.12.041_bib12","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0531-5565(98)00023-0","article-title":"How and Why We Age","volume":"33","author":"Hayflick","year":"1998","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.bbrc.2004.12.041_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1023\/B:BGEN.0000017682.96395.10","article-title":"Mechanisms of cellular senescence in human and mouse cells","volume":"5","author":"Itahana","year":"2004","journal-title":"Biogerontology"},{"key":"10.1016\/j.bbrc.2004.12.041_bib14","doi-asserted-by":"crossref","first-page":"9363","DOI":"10.1073\/pnas.92.20.9363","article-title":"A biomarker that identifies senescent human cells in culture and in aging skin in vivo","volume":"92","author":"Dimri","year":"1995","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.bbrc.2004.12.041_bib15","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/S0092-8674(00)81023-5","article-title":"Replicative senescence: An Old Lives\u2019 Tale?","volume":"84","author":"Campisi","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2004.12.041_bib16","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1046\/j.1532-5415.2001.04990.x","article-title":"Functional decline in aging and disease: a role for apoptosis","volume":"49","author":"Joaquin","year":"2001","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.bbrc.2004.12.041_bib17","first-page":"1","article-title":"Toward a Maillard reaction theory of aging","volume":"304","author":"Monnier","year":"1989","journal-title":"Prog. Clin. Biol. Res."},{"key":"10.1016\/j.bbrc.2004.12.041_bib18","doi-asserted-by":"crossref","first-page":"6487","DOI":"10.1074\/jbc.M309090200","article-title":"2-ammonio-6-(3-oxidopyridinium-1-yl)hexanoate (OP-lysine) is a newly identified advanced glycation end product in cataractous and aged human lenses","volume":"279","author":"Argirov","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2004.12.041_bib19","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1159\/000076770","article-title":"Age-dependent expression of advanced glycation end product receptor genes in the human heart","volume":"50","author":"Casselmann","year":"2004","journal-title":"Gerontology"},{"key":"10.1016\/j.bbrc.2004.12.041_bib20","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1002\/art.20170","article-title":"Accumulation of advanced glycation end products as a molecular mechanism for aging as a risk factor in osteoarthritis","volume":"50","author":"DeGroot","year":"2004","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bbrc.2004.12.041_bib21","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s00401-002-0523-y","article-title":"Lipid peroxidation and advanced glycation end products in the brain in normal aging and in Alzheimer\u2019s disease","volume":"104","author":"Dei","year":"2002","journal-title":"Acta Neuropathol. (Berl)"},{"key":"10.1016\/j.bbrc.2004.12.041_bib22","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.exger.2003.10.003","article-title":"Age-related changes in the glycation of human aortic elastin","volume":"39","author":"Konova","year":"2004","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.bbrc.2004.12.041_bib23","first-page":"232","article-title":"Glycoxidation: the menace of diabetes and aging","volume":"70","author":"Vlassara","year":"2003","journal-title":"Mt. Sinai J. Med."},{"key":"10.1016\/j.bbrc.2004.12.041_bib24","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/j.1749-6632.2002.tb02107.x","article-title":"The Maillard hypothesis on aging: time to focus on DNA","volume":"959","author":"Baynes","year":"2002","journal-title":"Ann. N Y Acad. Sci."},{"key":"10.1016\/j.bbrc.2004.12.041_bib25","first-page":"298","article-title":"Aging: a theory based on free radical and radiation chemistry","volume":"2","author":"Harman","year":"1957","journal-title":"J. Gerontol."},{"key":"10.1016\/j.bbrc.2004.12.041_bib26","doi-asserted-by":"crossref","first-page":"1276","DOI":"10.1126\/science.1070174","article-title":"Premature aging in mice deficient in DNA repair and transcription","volume":"296","author":"de Boer","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2004.12.041_bib27","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1126\/science.1083701","article-title":"Regulation of aging and age-related disease by DAF-16 and heat-shock factor","volume":"300","author":"Hsu","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2004.12.041_bib28","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1126\/science.1083614","article-title":"DAF-16 target genes that control C. elegans life-span and metabolism","volume":"300","author":"Lee","year":"2003","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2004.12.041_bib29","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/nature01789","article-title":"Genes that act downstream of DAF-16 to influence the lifespan of Caenorhabditis elegans","volume":"424","author":"Murphy","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2004.12.041_bib30","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1038\/nature02549","article-title":"Drosophila dFOXO controls lifespan and regulates insulin signaling in brain and fat body","volume":"429","author":"Hwangbo","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2004.12.041_bib31","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1038\/nature01298","article-title":"IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice","volume":"421","author":"Holzenberger","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.bbrc.2004.12.041_bib32","doi-asserted-by":"crossref","unstructured":"J.K. Quarrie, K.T. Riabowol, Murine models of life span extension, Sci. Aging Knowledge Environ. (2004) re5","DOI":"10.1126\/sageke.2004.31.re5"},{"key":"10.1016\/j.bbrc.2004.12.041_bib33","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1146\/annurev.med.51.1.245","article-title":"Age-associated increased interleukin-6 gene expression, late-life diseases, and frailty","volume":"51","author":"Ershler","year":"2000","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.bbrc.2004.12.041_bib34","doi-asserted-by":"crossref","first-page":"M709","DOI":"10.1093\/gerona\/55.12.M709","article-title":"Cross-sectional and prospective relationships of interleukin-6 and C-reactive protein with physical performance in elderly persons: MacArthur studies of successful aging","volume":"55","author":"Taaffe","year":"2000","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.bbrc.2004.12.041_bib35","doi-asserted-by":"crossref","first-page":"39027","DOI":"10.1074\/jbc.M006700200","article-title":"Effect of collagen turnover on the accumulation of advanced glycation end products","volume":"275","author":"Verzijl","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"Suppl. 2","key":"10.1016\/j.bbrc.2004.12.041_bib36","doi-asserted-by":"crossref","first-page":"106","DOI":"10.2106\/00004623-200300002-00014","article-title":"The role of chondrocyte senescence in the pathogenesis of osteoarthritis and in limiting cartilage repair","volume":"85-A","author":"Martin","year":"2003","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.bbrc.2004.12.041_bib37","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1016\/j.joca.2004.02.010","article-title":"Age related changes in human articular chondrocyte yield, proliferation and post-expansion chondrogenic capacity","volume":"12","author":"Barbero","year":"2004","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bbrc.2004.12.041_bib38","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1046\/j.1474-9728.2002.00008.x","article-title":"The role of chondrocyte senescence in osteoarthritis","volume":"1","author":"Price","year":"2002","journal-title":"Aging Cell"},{"key":"10.1016\/j.bbrc.2004.12.041_bib39","doi-asserted-by":"crossref","first-page":"53063","DOI":"10.1074\/jbc.M209632200","article-title":"Age-related changes in the response of human articular cartilage to IL-1alpha and transforming growth factor-beta (TGF-beta): chondrocytes exhibit a diminished sensitivity to TGF-beta","volume":"278","author":"Hickery","year":"2003","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbrc.2004.12.041_bib40","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1002\/1529-0131(200009)43:9<2110::AID-ANR23>3.0.CO;2-U","article-title":"Reduction in the chondrocyte response to insulin-like growth factor 1 in aging and osteoarthritis: studies in a non-human primate model of naturally occurring disease","volume":"43","author":"Loeser","year":"2000","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bbrc.2004.12.041_bib41","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0047-6374(97)00115-2","article-title":"Age-related decrease in the responsiveness of rat articular chondrocytes to EGF is associated with diminished number and affinity for the ligand of cell surface binding sites","volume":"100","author":"Ribault","year":"1998","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.bbrc.2004.12.041_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.joca.2003.09.015","article-title":"Cell death in cartilage","volume":"12","author":"Kuhn","year":"2004","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bbrc.2004.12.041_bib43","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1053\/joca.2001.0468","article-title":"Human chondrocyte apoptosis in response to mechanical injury","volume":"9","author":"D\u2019Lima","year":"2001","journal-title":"Osteoarthritis Cartilage"},{"issue":"Suppl. 2","key":"10.1016\/j.bbrc.2004.12.041_bib44","doi-asserted-by":"crossref","first-page":"19","DOI":"10.2106\/00004623-200100021-00004","article-title":"Cartilage injury induces chondrocyte apoptosis","volume":"83-A","author":"D\u2019Lima","year":"2001","journal-title":"J. Bone Joint Surg. Am."},{"key":"10.1016\/j.bbrc.2004.12.041_bib45","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1016\/j.orthres.2003.10.008","article-title":"Comparison of chondrocyte apoptosis in vivo and in vitro following acute osteochondral injury","volume":"22","author":"Costouros","year":"2004","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bbrc.2004.12.041_bib46","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/(SICI)1097-0185(199804)250:4<418::AID-AR4>3.0.CO;2-T","article-title":"Chondrocyte apoptosis increases with age in the articular cartilage of adult animals","volume":"250","author":"Adams","year":"1998","journal-title":"Anat. Rec."},{"key":"10.1016\/j.bbrc.2004.12.041_bib47","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1002\/ar.a.20063","article-title":"Age-related expression patterns of Bag-1 and Bcl-2 in growth plate and articular chondrocytes","volume":"279A","author":"Kinkel","year":"2004","journal-title":"Anat. Rec."},{"key":"10.1016\/j.bbrc.2004.12.041_bib48","doi-asserted-by":"crossref","first-page":"1632","DOI":"10.1002\/1529-0131(199809)41:9<1632::AID-ART14>3.0.CO;2-A","article-title":"Linkage of chondrocyte apoptosis and cartilage degradation in human osteoarthritis","volume":"41","author":"Hashimoto","year":"1998","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bbrc.2004.12.041_bib49","doi-asserted-by":"crossref","first-page":"3094","DOI":"10.1073\/pnas.95.6.3094","article-title":"Chondrocyte-derived apoptotic bodies and calcification of articular cartilage","volume":"95","author":"Hashimoto","year":"1998","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"Pt 2","key":"10.1016\/j.bbrc.2004.12.041_bib50","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1042\/bj3500381","article-title":"Age-related accumulation of Maillard reaction products in human articular cartilage collagen","volume":"350","author":"Verzijl","year":"2000","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbrc.2004.12.041_bib51","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1097\/00002281-200309000-00016","article-title":"AGEing and osteoarthritis: a different perspective","volume":"15","author":"Verzijl","year":"2003","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.bbrc.2004.12.041_bib52","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s11926-003-0081-x","article-title":"Advanced glycation endproducts and osteoarthritis","volume":"5","author":"Saudek","year":"2003","journal-title":"Curr. Rheumatol. Rep."},{"key":"10.1016\/j.bbrc.2004.12.041_bib53","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1053\/joca.2001.0469","article-title":"Accumulation of advanced glycation endproducts reduces chondrocyte-mediated extracellular matrix turnover in human articular cartilage","volume":"9","author":"DeGroot","year":"2001","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bbrc.2004.12.041_bib54","doi-asserted-by":"crossref","first-page":"3212","DOI":"10.1002\/art.10627","article-title":"Induction of advanced glycation end products and alterations of the tensile properties of articular cartilage","volume":"46","author":"Chen","year":"2002","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bbrc.2004.12.041_bib55","doi-asserted-by":"crossref","first-page":"3419","DOI":"10.1002\/art.11338","article-title":"Increased oxidative stress with aging reduces chondrocyte survival: correlation with intracellular glutathione levels","volume":"48","author":"Carlo","year":"2003","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bbrc.2004.12.041_bib56","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1093\/gerona\/59.4.B324","article-title":"Effects of oxidative damage and telomerase activity on human articular cartilage chondrocyte senescence","volume":"59","author":"Martin","year":"2004","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.bbrc.2004.12.041_bib57","doi-asserted-by":"crossref","first-page":"2349","DOI":"10.1002\/art.10496","article-title":"Detection of nitrotyrosine in aging and osteoarthritic cartilage: correlation of oxidative damage with the presence of interleukin-1beta and with chondrocyte resistance to insulin-like growth factor 1","volume":"46","author":"Loeser","year":"2002","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bbrc.2004.12.041_bib58","doi-asserted-by":"crossref","first-page":"2188","DOI":"10.1002\/art.11209","article-title":"The combination of insulin-like growth factor1 and osteogenic protein 1 promotes increased survival of and matrix synthesis by normal and osteoarthritic human articular chondrocytes","volume":"48","author":"Loeser","year":"2003","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bbrc.2004.12.041_bib59","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1002\/1529-0131(200007)43:7<1552::AID-ANR20>3.0.CO;2-W","article-title":"Autocrine stimulation by insulin-like growth factor 1 and insulin-like growth factor 2 mediates chondrocyte survival in vitro","volume":"43","author":"Loeser","year":"2000","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bbrc.2004.12.041_bib60","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S1096-6374(98)80311-0","article-title":"Effect of aging on growth hormone-induced insulin-like growth factor-I secretion from cultured rat chondrocytes","volume":"8","author":"Rousseau","year":"1998","journal-title":"Growth Horm. IGF. Res."},{"key":"10.1016\/j.bbrc.2004.12.041_bib61","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/S0047-6374(00)00107-X","article-title":"Articular chondrocytes from aging rats respond poorly to insulin-like growth factor-1: an altered signaling pathway","volume":"115","author":"Messai","year":"2000","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.bbrc.2004.12.041_bib62","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1042\/bj20020968","article-title":"Age-related changes in the composition, the molecular stoichiometry and the stability of proteoglycan aggregates extracted from human articular cartilage","volume":"370","author":"Wells","year":"2003","journal-title":"Biochem. J."},{"key":"10.1016\/j.bbrc.2004.12.041_bib63","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1002\/jemt.1070280506","article-title":"Age-related changes in cartilage proteoglycans: quantitative electron microscopic studies","volume":"28","author":"Buckwalter","year":"1994","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.bbrc.2004.12.041_bib64","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1023\/A:1020185404126","article-title":"Aging, articular cartilage chondrocyte senescence and osteoarthritis","volume":"3","author":"Martin","year":"2002","journal-title":"Biogerontology"},{"key":"10.1016\/j.bbrc.2004.12.041_bib65","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.1002\/art.10611","article-title":"Matrix homeostasis in aging normal human ankle cartilage","volume":"46","author":"Aurich","year":"2002","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.bbrc.2004.12.041_bib66","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1210\/jcem.87.4.8417","article-title":"Clinical review144: estrogen and the male skeleton","volume":"87","author":"Khosla","year":"2002","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbrc.2004.12.041_bib67","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1126\/science.1074935","article-title":"Reversal of bone loss in mice by nongenotropic signaling of sex steroids","volume":"298","author":"Kousteni","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2004.12.041_bib68","doi-asserted-by":"crossref","first-page":"46","DOI":"10.22203\/eCM.v006a05","article-title":"Bone microdamage and cell apoptosis","volume":"6","author":"Noble","year":"2003","journal-title":"Eur. Cell Mater."},{"key":"10.1016\/j.bbrc.2004.12.041_bib69","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1210\/en.2003-0990","article-title":"Glucocorticoids act directly on osteoblasts and osteocytes to induce their apoptosis and reduce bone formation and strength","volume":"145","author":"O\u2019Brien","year":"2004","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbrc.2004.12.041_bib70","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/S0736-0266(03)00006-8","article-title":"Glucose-mediated in vitro glycation modulates biomechanical integrity of the soft tissues but not hard tissues","volume":"21","author":"Reddy","year":"2003","journal-title":"J. Orthop. Res."},{"key":"10.1016\/j.bbrc.2004.12.041_bib71","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1007\/s005920170007","article-title":"Effect of advanced glycation endproducts on the secretion of insulin-like growth factor-I and its binding proteins: role in osteoblast development","volume":"38","author":"McCarthy","year":"2001","journal-title":"Acta Diabetol."},{"key":"10.1016\/j.bbrc.2004.12.041_bib72","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1359\/jbmr.1997.12.3.439","article-title":"Advanced glycation endproducts stimulate interleukin-6 production by human bone-derived cells","volume":"12","author":"Takagi","year":"1997","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.bbrc.2004.12.041_bib73","doi-asserted-by":"crossref","first-page":"M137","DOI":"10.1093\/gerona\/55.3.M137","article-title":"Effect of age and menopause on serum concentrations of pentosidine, an advanced glycation end product","volume":"55","author":"Takahashi","year":"2000","journal-title":"J. Gerontol. A Biol. Sci. Med. Sci."},{"key":"10.1016\/j.bbrc.2004.12.041_bib74","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1681\/ASN.V82260","article-title":"Advanced glycation end products enhance osteoclast-induced bone resorption in cultured mouse unfractionated bone cells and in rats implanted subcutaneously with devitalized bone particles","volume":"8","author":"Miyata","year":"1997","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbrc.2004.12.041_bib75","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1007\/BF00400353","article-title":"Inhibition of matrix-induced bone differentiation by advanced glycation end-products in rats","volume":"36","author":"Fong","year":"1993","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbrc.2004.12.041_bib76","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.bbrc.2003.12.073","article-title":"Oxidative stress inhibits osteoblastic differentiation of bone cells by ERK and NF-kappaB","volume":"314","author":"Bai","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2004.12.041_bib77","doi-asserted-by":"crossref","first-page":"1523","DOI":"10.1210\/jc.2002-021496","article-title":"Marked decrease in plasma antioxidants in aged osteoporotic women: results of a cross-sectional study","volume":"88","author":"Maggio","year":"2003","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbrc.2004.12.041_bib78","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1006\/bbrc.2001.5747","article-title":"Association between oxidative stress and bone mineral density","volume":"288","author":"Basu","year":"2001","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2004.12.041_bib79","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/S0026-0495(03)00194-X","article-title":"Effects of dietary restriction on total body, femoral, and vertebral bone in SENCAR, C57BL\/6, and DBA\/2 mice","volume":"52","author":"Brochmann","year":"2003","journal-title":"Metabolism"},{"key":"10.1016\/j.bbrc.2004.12.041_bib80","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1146\/annurev.biochem.73.011303.073651","article-title":"The Sir2 family of protein deacetylases","volume":"73","author":"Blander","year":"2004","journal-title":"Annu. Rev. Biochem."},{"key":"10.1016\/j.bbrc.2004.12.041_bib81","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/S1096-6374(03)00092-3","article-title":"Role of extracellular matrix in insulin-like growth factor (IGF) binding protein-2 regulation of IGF-II action in normal human osteoblasts","volume":"13","author":"Conover","year":"2003","journal-title":"Growth Horm. IGF. Res."},{"key":"10.1016\/j.bbrc.2004.12.041_bib82","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1007\/s00198-003-1417-0","article-title":"Role of parathyroid hormone in mediating age-related changes in bone resorption in men","volume":"14","author":"Kennel","year":"2003","journal-title":"Osteoporos. Int."},{"key":"10.1016\/j.bbrc.2004.12.041_bib83","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1385\/ENDO:23:1:01","article-title":"Osteoporosis and cardiovascular disease: brittle bones and boned arteries, is there a link?","volume":"23","author":"McFarlane","year":"2004","journal-title":"Endocrine"},{"key":"10.1016\/j.bbrc.2004.12.041_bib84","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1089\/104454904322964751","article-title":"Matrix metalloproteinases (MMPs) safeguard osteoblasts from apoptosis during transdifferentiation into osteocytes: MT1-MMP maintains osteocyte viability","volume":"23","author":"Karsdal","year":"2004","journal-title":"DNA Cell Biol."},{"issue":"Suppl. 1","key":"10.1016\/j.bbrc.2004.12.041_bib85","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1080\/03008200390181717","article-title":"Mechanisms by which extracellular matrix components induce osteoblast apoptosis","volume":"44","author":"Adams","year":"2003","journal-title":"Connect Tissue Res."},{"key":"10.1016\/j.bbrc.2004.12.041_bib86","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1097\/00062752-200305000-00001","article-title":"Genetic control of stem-cell properties and stem cells in aging","volume":"10","author":"Liang","year":"2003","journal-title":"Curr. Opin. Hematol."},{"key":"10.1016\/j.bbrc.2004.12.041_bib87","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1196\/annals.1297.027","article-title":"Insights into aging obtained from p53 mutant mouse models","volume":"1019","author":"Dumble","year":"2004","journal-title":"Ann. N Y Acad. Sci."},{"key":"10.1016\/j.bbrc.2004.12.041_bib88","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1023\/B:BGEN.0000025074.88476.e2","article-title":"Aged human bone marrow stromal cells maintaining bone forming capacity in vivo evaluated using an improved method of visualization","volume":"5","author":"Stenderup","year":"2004","journal-title":"Biogerontology"},{"key":"10.1016\/j.bbrc.2004.12.041_bib89","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0531-5565(02)00014-1","article-title":"Adipogenesis and aging: does aging make fat go MAD?","volume":"37","author":"Kirkland","year":"2002","journal-title":"Exp. Gerontol."},{"key":"10.1016\/j.bbrc.2004.12.041_bib90","doi-asserted-by":"crossref","first-page":"1522","DOI":"10.1002\/art.20269","article-title":"Identification of mesenchymal progenitor cells in normal and osteoarthritic human articular cartilage","volume":"50","author":"Alsalameh","year":"2004","journal-title":"Arthritis Rheum."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X04028347?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X04028347?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,2]],"date-time":"2021-07-02T01:52:20Z","timestamp":1625190740000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X04028347"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,3]]},"references-count":90,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,3]]}},"alternative-id":["S0006291X04028347"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2004.12.041","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2005,3]]}}}