{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T12:15:20Z","timestamp":1790943320789,"version":"4.1.0"},"reference-count":32,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2005,9,1]],"date-time":"2005-09-01T00:00:00Z","timestamp":1125532800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Biochemical and Biophysical Research Communications"],"published-print":{"date-parts":[[2005,9]]},"DOI":"10.1016\/j.bbrc.2005.07.076","type":"journal-article","created":{"date-parts":[[2005,7,28]],"date-time":"2005-07-28T17:24:29Z","timestamp":1122571469000},"page":"300-308","source":"Crossref","is-referenced-by-count":223,"title":["[6]-Gingerol, a pungent ingredient of ginger, inhibits angiogenesis in vitro and in vivo"],"prefix":"10.1016","volume":"335","author":[{"given":"Eok-Cheon","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong-Ki","family":"Min","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tae-Yoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin-Jeong","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyun-Ok","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanghwa","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Myeong","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Guen","family":"Kwon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbrc.2005.07.076_bib1","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1056\/NEJM197111182852108","article-title":"Tumor angiogenesis: therapeutic implications","volume":"285","author":"Folkman","year":"1971","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbrc.2005.07.076_bib2","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/S0092-8674(00)80108-7","article-title":"Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis","volume":"86","author":"Hanahan","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.bbrc.2005.07.076_bib3","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/nm0195-27","article-title":"Angiogenesis in cancer vascular, rheumatoid and other disease,","volume":"1","author":"Folkman","year":"1995","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbrc.2005.07.076_bib4","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1038\/386671a0","article-title":"Mechanisms of angiogenesis","volume":"386","author":"Risau","year":"1997","journal-title":"Nature (Lond.)"},{"key":"10.1016\/j.bbrc.2005.07.076_bib5","first-page":"39","article-title":"Vancouver Conference Review","volume":"9","author":"Folkman","year":"1997","journal-title":"AIDS Care"},{"key":"10.1016\/j.bbrc.2005.07.076_bib6","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1053\/j.sempedsurg.2003.09.008","article-title":"Anti-angiogenic therapy for the treatment of pediatric solid malignancies","volume":"13","author":"Davidoff","year":"2004","journal-title":"Semin. Pediatr. Surg."},{"key":"10.1016\/j.bbrc.2005.07.076_bib7","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1126\/science.1104819","article-title":"Normalization of tumor vasculature: an emerging concept in anti-angiogenic therapy","volume":"307","author":"Jain","year":"2005","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2005.07.076_bib8","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1006\/scbi.1998.0091","article-title":"VEGFs, receptors and angiogenesis","volume":"9","author":"Veikkola","year":"1999","journal-title":"Semin. Cancer Biol."},{"key":"10.1016\/j.bbrc.2005.07.076_bib9","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1634\/theoncologist.5-suppl_1-3","article-title":"VEGF receptor signaling in tumor angiogenesis","volume":"5","author":"McMahon","year":"2000","journal-title":"Oncologist"},{"key":"10.1016\/j.bbrc.2005.07.076_bib10","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.bbapap.2003.11.010","article-title":"Advances in the structural biology, design and clinical development of VEGF-R kinase inhibitors for the treatment of angiogenesis","volume":"1697","author":"Manley","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbrc.2005.07.076_bib11","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/j.1753-4887.1998.tb01670.x","article-title":"Polyphenols: chemistry, dietary sources, metabolism, and nutritional significance","volume":"56","author":"Bravo","year":"1998","journal-title":"Nutr. Rev."},{"key":"10.1016\/j.bbrc.2005.07.076_bib12","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1016\/S0002-8223(96)00273-8","article-title":"Vegetables, fruit, and cancer prevention: a review","volume":"96","author":"Steinmetz","year":"1996","journal-title":"J. Am. Diet. Assoc."},{"key":"10.1016\/j.bbrc.2005.07.076_bib13","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1002\/(SICI)1098-2825(1997)11:5<287::AID-JCLA6>3.0.CO;2-4","article-title":"Wine as a biological fluid: history, production, and role in disease prevention","volume":"11","author":"Soleas","year":"1997","journal-title":"J. Clin. Lab. Anal."},{"key":"10.1016\/j.bbrc.2005.07.076_bib14","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1023\/A:1021254725842","article-title":"Botanicals in cancer chemoprevention","volume":"21","author":"Park","year":"2002","journal-title":"Cancer Metastasis Rev."},{"key":"10.1016\/j.bbrc.2005.07.076_bib15","volume":"vol. 4.","author":"Newall","year":"1996"},{"key":"10.1016\/j.bbrc.2005.07.076_bib16","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S1383-5742(99)00057-5","article-title":"Molecular mechanisms of chemopreventive effects of selected dietary and medicinal phenolic substances","volume":"428","author":"Surh","year":"1999","journal-title":"Mutat. Res."},{"key":"10.1016\/j.bbrc.2005.07.076_bib17","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/S0304-3835(98)00081-0","article-title":"Inhibitory effects of [6]-gingerol, a major pungent principle of ginger, on phorbol ester-induced inflammation, epidermal ornithine decarboxylase activity and skin tumor promotion in ICR mice","volume":"129","author":"Park","year":"1988","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bbrc.2005.07.076_bib18","first-page":"850","article-title":"Inhibition of epidermal growth factor-induced cell transformation and activator protein 1 activation by [6]-gingerol","volume":"61","author":"Bode","year":"2001","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2005.07.076_bib19","doi-asserted-by":"crossref","first-page":"2745","DOI":"10.1172\/JCI107470","article-title":"Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria","volume":"52","author":"Jaffe","year":"1973","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbrc.2005.07.076_bib20","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1006\/bbrc.1999.1586","article-title":"Sphingosine 1-phosphate induces angiogenesis: its angiogenic action and signaling mechanism in human umbilical vein endothelial cells","volume":"264","author":"Lee","year":"1999","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbrc.2005.07.076_bib21","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/BF02624102","article-title":"Modulation of microvascular growth and morphogenesis by reconstituted basement membrane gel in three-dimensional cultures of rat aorta: a comparative study of angiogenesis in Matrigel, collagen, fibrin, and plasma clot","volume":"26","author":"Nicosia","year":"1990","journal-title":"In Vitro Cell Dev. Biol."},{"key":"10.1016\/j.bbrc.2005.07.076_bib22","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1126\/science.472760","article-title":"Angiogenesis in the mouse cornea","volume":"205","author":"Muthukkaruppan","year":"1979","journal-title":"Science"},{"key":"10.1016\/j.bbrc.2005.07.076_bib23","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.canlet.2004.07.013","article-title":"Role of chemopreventive agents in cancer therapy","volume":"215","author":"Dorai","year":"2004","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bbrc.2005.07.076_bib24","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/0304-3835(95)03833-I","article-title":"Modulating effects of ellagic acid, vanillin and quercetin in a rat medium term multi-organ carcinogenesis model","volume":"94","author":"Akagi","year":"1995","journal-title":"Cancer Lett."},{"key":"10.1016\/j.bbrc.2005.07.076_bib25","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1093\/carcin\/21.5.921","article-title":"Plant phenolics decrease intestinal tumors in an animal model of familial adenomatous polyposis","volume":"21","author":"Mahmoud","year":"2000","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.bbrc.2005.07.076_bib26","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/S0968-0004(97)01074-8","article-title":"Molecular mechanisms of blood vessel formation","volume":"22","author":"Bussolino","year":"1997","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.bbrc.2005.07.076_bib27","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1158\/0008-5472.CAN-03-3250","article-title":"Capsaicin inhibits in vitro and in vivo angiogenesis","volume":"64","author":"Min","year":"2004","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbrc.2005.07.076_bib28","first-page":"1466","article-title":"Resveratrol causes WAF-1\/p21-mediated G(1)-phase arrest of cell cycle and induction of apoptosis in human epidermoid carcinoma A431 cells","volume":"7","author":"Ahmad","year":"2001","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbrc.2005.07.076_bib29","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1067\/msy.2002.119190","article-title":"Quercetin inhibits human vascular smooth muscle cell proliferation and migration","volume":"131","author":"Alcocer","year":"2002","journal-title":"Surgery"},{"key":"10.1016\/j.bbrc.2005.07.076_bib30","first-page":"1","article-title":"[6]-Gingerol inhibits COX-2 expression by blocking the activation of p38 MAP kinase and NF-kappaB in phorbol ester-stimulated mouse skin","author":"Kim","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.bbrc.2005.07.076_bib31","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.semradonc.2004.04.009","article-title":"Therapeutic targeting of the tumor vasculature","volume":"14","author":"Tozer","year":"2004","journal-title":"Semin. Radiat. Oncol."},{"key":"10.1016\/j.bbrc.2005.07.076_bib32","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1001\/archfami.7.6.523","article-title":"A review of 12 commonly used medicinal herbs","volume":"7","author":"O\u2019Hara","year":"1998","journal-title":"Arch. Fam. Med."}],"container-title":["Biochemical and Biophysical Research Communications"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X05014543?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0006291X05014543?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,24]],"date-time":"2019-01-24T02:23:46Z","timestamp":1548296626000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0006291X05014543"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,9]]},"references-count":32,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,9]]}},"alternative-id":["S0006291X05014543"],"URL":"https:\/\/doi.org\/10.1016\/j.bbrc.2005.07.076","relation":{},"ISSN":["0006-291X"],"issn-type":[{"value":"0006-291X","type":"print"}],"subject":[],"published":{"date-parts":[[2005,9]]}}}